skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Increased slow dynamics defines ligandability of BTB domains

Journal Article · · Nat. Commun.

Research Organization:
Argonne National Laboratory (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Sponsoring Organization:
DOE - Office Of Science; FOREIGN
OSTI ID:
1901306
Journal Information:
Nat. Commun., Vol. 13
Country of Publication:
United States
Language:
ENGLISH

References (65)

Approaches to target tractability assessment – a practical perspective journal January 2018
Structure-based maximal affinity model predicts small-molecule druggability journal January 2007
The druggable genome journal September 2002
Expanding the Number of ‘Druggable’ Targets: Non-Enzymes and Protein-Protein Interactions journal December 2012
Exploring protein–ligand recognition with Binding MOAD journal May 2006
Principles of protein-protein interactions. journal January 1996
The atomic structure of protein-protein recognition sites 1 1Edited by A. R. Fersht journal February 1999
Protein-protein docking benchmark version 4.0: Protein-Protein Docking Benchmark Version 4.0 journal July 2010
Hot spot-based design of small-molecule inhibitors for protein–protein interactions journal June 2014
Reaching for high-hanging fruit in drug discovery at protein–protein interfaces journal December 2007
Small-Molecule Inhibitors of Protein-Protein Interactions: Progressing toward the Reality journal September 2014
Targeting epigenetic protein–protein interactions with small-molecule inhibitors journal July 2020
Exploiting structural information for drug-target assessment journal March 2014
Predicting protein druggability journal December 2005
Structure-based computational analysis of protein binding sites for function and druggability prediction journal June 2012
Structure-based druggability assessment—identifying suitable targets for small molecule therapeutics journal August 2011
Predicting druggable binding sites at the protein–protein interface journal February 2009
Quantitative metrics for drug–target ligandability journal June 2018
The FTMap family of web servers for determining and characterizing ligand-binding hot spots of proteins journal April 2015
FTMove: A Web Server for Detection and Analysis of Cryptic and Allosteric Binding Sites by Mapping Multiple Protein Structures journal June 2022
Exploring the structural origins of cryptic sites on proteins journal March 2018
Finding Druggable Sites in Proteins Using TACTICS journal June 2021
Druggability Indices for Protein Targets Derived from NMR-Based Screening Data journal April 2005
Targeting Protein–Protein Interactions and Fragment-Based Drug Discovery book January 2011
Fragment screening to predict druggability (ligandability) and lead discovery success journal April 2011
Born to bind: the BTB protein–protein interaction domain journal January 2006
Broad-complex, tramtrack, and bric-à-brac (BTB) proteins: Critical regulators of development: C haharbakhshi and J emc journal August 2016
Therapeutic targeting of the BCL6 oncogene for diffuse large B-cell lymphomas journal January 2008
Breaking bad in the germinal center: how deregulation of BCL6 contributes to lymphomagenesis journal June 2014
Mechanism of SMRT Corepressor Recruitment by the BCL6 BTB Domain journal December 2003
Structure of a BCOR Corepressor Peptide in Complex with the BCL6 BTB Domain Dimer journal February 2008
The Expanding Role of the BCL6 Oncoprotein as a Cancer Therapeutic Target journal November 2016
BCL6 as a therapeutic target for lymphoma journal January 2018
Identification of Thiourea-Based Inhibitors of the B-Cell Lymphoma 6 BTB Domain via NMR-Based Fragment Screening and Computer-Aided Drug Design journal July 2018
Discovery of Pyrazolo[1,5- a ]pyrimidine B-Cell Lymphoma 6 (BCL6) Binders and Optimization to High Affinity Macrocyclic Inhibitors journal May 2017
Discovery of a novel B-cell lymphoma 6 (BCL6)–corepressor interaction inhibitor by utilizing structure-based drug design journal September 2017
Discovery of an Irreversible and Cell-Active BCL6 Inhibitor Selectively Targeting Cys53 Located at the Protein–Protein Interaction Interface journal February 2018
Chemically Induced Degradation of the Oncogenic Transcription Factor BCL6 journal September 2017
Development of a Novel B-Cell Lymphoma 6 (BCL6) PROTAC To Provide Insight into Small Molecule Targeting of BCL6 journal October 2018
The p120 catenin partner Kaiso is a DNA methylation-dependent transcriptional repressor journal July 2001
Kaiso depletion attenuates the growth and survival of triple negative breast cancer cells journal March 2017
Role of LRF/Pokemon in lineage fate decisions journal April 2013
The LRF transcription factor regulates mature B cell development and the germinal center response in mice journal July 2011
Expression of leukemia/lymphoma-related factor (LRF/POKEMON) in human breast carcinoma and other cancers journal October 2010
Epidermal growth factor increases LRF/Pokemon expression in human prostate cancer cells journal October 2011
Expression of leukemia/lymphoma related factor (LRF/Pokemon) in human benign prostate hyperplasia and prostate cancer journal April 2011
The role of the transcription factor Miz-1 in lymphocyte development and lymphomagenesis—Binding Myc makes the difference journal October 2011
The Ubiquitin Ligase HectH9 Regulates Transcriptional Activation by Myc and Is Essential for Tumor Cell Proliferation journal November 2005
Identification of an atypical interaction site in the BTB domain of the MYC-interacting zinc-finger protein 1 journal November 2021
The Interaction of Myc with Miz1 Defines Medulloblastoma Subgroup Identity journal January 2016
Current perspectives in fragment-based lead discovery (FBLD) journal November 2017
Sequence and structural analysis of BTB domain proteins journal January 2005
Simple tests for the validation of multiple field spin relaxation data journal October 2009
The Quest for Simplicity: Remarks on the Free-Approach Models journal August 2015
Backbone resonance assignment of the BCL6-BTB/POZ domain journal September 2017
A Small-Molecule Inhibitor of BCL6 Kills DLBCL Cells In Vitro and In Vivo journal April 2010
Computational Fragment-Based Binding Site Identification by Ligand Competitive Saturation journal July 2009
Tumor cell‐specific inhibition of MYC function using small molecule inhibitors of the HUWE 1 ubiquitin ligase journal September 2014
TROSY in triple-resonance experiments: New perspectives for sequential NMR assignment of large proteins journal November 1998
Practical aspects of NMR signal assignment in larger and challenging proteins journal April 2014
Protein Structural Information Derived from NMR Chemical Shift with the Neural Network Program TALOS-N book November 2014
Measurement of 15N relaxation rates in perdeuterated proteins by TROSY-based methods journal June 2012
High-Resolution NMR Determination of the Dynamic Structure of Membrane Proteins journal July 2016
Dynamic 15N{1H} NOE measurements: a tool for studying protein dynamics journal September 2020
Fast evaluation of protein dynamics from deficient 15N relaxation data journal March 2018