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Structural analysis of Plasmodium falciparum ookinete surface antigen Pfs28 relevant for malaria vac

Journal Article · · Sci. Rep.
Research Organization:
Advanced Photon Source (APS), Argonne National Laboratory (ANL), Argonne, IL (US)
Sponsoring Organization:
DOE - Office Of Science; NIH
OSTI ID:
1901305
Journal Information:
Sci. Rep., Journal Name: Sci. Rep. Vol. 12
Country of Publication:
United States
Language:
ENGLISH

References (44)

Antibodies to Cryptic Epitopes in Distant Homologues Underpin a Mechanism of Heterologous Immunity between Plasmodium vivax PvDBP and Plasmodium falciparum VAR2CSA journal October 2019
Safety and Immunogenicity of ChAd63/MVA Pfs25-IMX313 in a Phase I First-in-Human Trial journal July 2021
Poor CD4+ T Cell Immunogenicity Limits Humoral Immunity to P. falciparum Transmission-Blocking Candidate Pfs25 in Humans journal September 2021
Chimeric spike mRNA vaccines protect against Sarbecovirus challenge in mice journal August 2021
Features and development of Coot journal March 2010
Characterization of Plasmodium falciparum sexual stage antigens and their biosynthesis in synchronised gametocyte cultures journal August 1986
Fast, scalable generation of high‐quality protein multiple sequence alignments using Clustal Omega journal January 2011
Genomic epidemiology of artemisinin resistant malaria journal March 2016
PHENIX: a comprehensive Python-based system for macromolecular structure solution journal January 2010
Potent antibody lineage against malaria transmission elicited by human vaccination with Pfs25 journal September 2019
Synergy in anti-malarial pre-erythrocytic and transmission-blocking antibodies is achieved by reducing parasite density journal June 2018
A novel malaria protein, Pfs28, and Pfs25 are genetically linked and synergistic as falciparum malaria transmission-blocking vaccines journal March 1997
The essential mosquito-stage P25 and P28 proteins from Plasmodium form tile-like triangular prisms journal December 2005
AlphaFold Protein Structure Database: massively expanding the structural coverage of protein-sequence space with high-accuracy models journal November 2021
Algae-Produced Pfs25 Elicits Antibodies That Inhibit Malaria Transmission journal May 2012
Safety and immunogenicity of Pfs25H-EPA/Alhydrogel, a transmission-blocking vaccine against Plasmodium falciparum: a randomised, double-blind, comparator-controlled, dose-escalation study in healthy Malian adults journal September 2018
A time- and cost-efficient system for high-level protein production in mammalian cells journal September 2006
Saccharomyces cerevisiae -Secreted Fusion Proteins Pfs25 and Pfs28 Elicit Potent Plasmodium falciparum Transmission-Blocking Antibodies in Mice journal January 1998
Sequential expression of antigens on sexual stages of Plasmodium falciparum accessible to transmission-blocking antibodies in the mosquito. journal November 1985
Efficacy and safety of RTS,S/AS01 malaria vaccine with or without a booster dose in infants and children in Africa: final results of a phase 3, individually randomised, controlled trial journal July 2015
Transmission-Blocking Vaccines: Harnessing Herd Immunity for Malaria Elimination journal January 2021
Safety and immunogenicity of a plant-produced Pfs25 virus-like particle as a transmission blocking vaccine against malaria: A Phase 1 dose-escalation study in healthy adults journal September 2018
Mosquito Bite-Induced Controlled Human Malaria Infection with Plasmodium vivax or P. falciparum Generates Immune Responses to Homologous and Heterologous Preerythrocytic and Erythrocytic Antigens journal March 2019
Molecular definition of multiple sites of antibody inhibition of malaria transmission-blocking vaccine antigen Pfs25 journal November 2017
Minimal variation in the Pfs28 ookinete antigen from Philippine field isolates of Plasmodium falciparum1Note: The nucleotide sequence data in this paper has been submitted to GenBank™ data base with the accession No. L25843.1 journal July 1997
P25 and P28 proteins of the malaria ookinete surface have multiple and partially redundant functions journal August 2001
Highly accurate protein structure prediction with AlphaFold journal July 2021
A chimeric hemagglutinin-based universal influenza virus vaccine approach induces broad and long-lasting immunity in a randomized, placebo-controlled phase I trial journal December 2020
Rational Design of a Meningococcal Antigen Inducing Broad Protective Immunity journal July 2011
Structural vaccinology of malaria transmission-blocking vaccines journal January 2021
Evaluation of a mosaic HIV-1 vaccine in a multicentre, randomised, double-blind, placebo-controlled, phase 1/2a clinical trial (APPROACH) and in rhesus monkeys (NHP 13-19) journal July 2018
Plasmodium falciparum: Immunogenicity of Alum-Adsorbed Clinical-Grade TBV25–28, a Yeast-Secreted Malaria Transmission-Blocking Vaccine Candidate journal February 2001
XDS journal January 2010
A Phase 3 Trial of RTS,S/AS01 Malaria Vaccine in African Infants journal January 2012
Assessment of Antibodies Induced by Multivalent Transmission-Blocking Malaria Vaccines journal January 2018
Limited polymorphism in Plasmodium falciparum ookinete surface antigen, von Willebrand factor A domain-related protein from clinical isolates journal July 2006
Enhanced antibody responses to Plasmodium falciparum Pfs28 induced in mice by conjugation to ExoProtein A of Pseudomonas aeruginosa with an improved procedure journal March 2009
A new bioinformatics analysis tools framework at EMBL-EBI journal May 2010
Enhanced protective immunity against SARS-CoV-2 elicited by a VSV vector expressing a chimeric spike protein journal November 2021
Anopheles gambiae laminin interacts with the P25 surface protein of Plasmodium berghei ookinetes journal February 2001
Plasmodium P25 and P28 Surface Proteins: Potential Transmission-Blocking Vaccines journal August 2007
Immunological Cross-Reactivity between Malaria Vaccine Target Antigen P48/45 in Plasmodium vivax and P. falciparum and Cross–Boosting of Immune Responses journal July 2016
Safety and Immunogenicity of Pfs25-EPA/Alhydrogel®, a Transmission Blocking Vaccine against Plasmodium falciparum: An Open Label Study in Malaria Naïve Adults journal October 2016
Dual Plug-and-Display Synthetic Assembly Using Orthogonal Reactive Proteins for Twin Antigen Immunization journal May 2017

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