Synthesis and Structural Characterization of Novel Trihalo-sulfone Inhibitors of WNK1

Rodriguez, Melanie; Kannangara, Ashari; Chlebowicz, Julita; Akella, Radha; He, Haixia; Tambar, Uttam K.; Goldsmith, Elizabeth J.

doi:10.1021/acsmedchemlett.2c00216

Synthesis and Structural Characterization of Novel Trihalo-sulfone Inhibitors of WNK1

Journal Article · 01 January 2022 · ACS Med. Chem. Lett.

DOI:https://doi.org/10.1021/acsmedchemlett.2c00216· OSTI ID:1901196

Rodriguez, Melanie; Kannangara, Ashari; Chlebowicz, Julita; Akella, Radha; He, Haixia; Tambar, Uttam K.; Goldsmith, Elizabeth J.

Research Organization:: Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)

Sponsoring Organization:: DOE - Office Of Science; AHA

OSTI ID:: 1901196

Journal Information:: ACS Med. Chem. Lett., Vol. 13, Issue (10)

Country of Publication:: United States

Language:: ENGLISH

References (25)

WNK1, a Novel Mammalian Serine/Threonine Protein Kinase Lacking the Catalytic Lysine in Subdomain II Xu, Bing-e; English, Jessie M.; Wilsbacher, Julie L. Journal of Biological Chemistry, Vol. 275, Issue 22 https://doi.org/10.1074/jbc.275.22.16795	journal	May 2000
Phosphoregulation of the Na–K–2Cl and K–Cl cotransporters by the WNK kinases Kahle, Kristopher T.; Rinehart, Jesse; Lifton, Richard P. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Vol. 1802, Issue 12 https://doi.org/10.1016/j.bbadis.2010.07.009	journal	December 2010
Influence of WNK3 on intracellular chloride concentration and volume regulation in HEK293 cells Cruz-Rangel, Silvia; Gamba, Gerardo; Ramos-Mandujano, Gerardo Pflügers Archiv - European Journal of Physiology, Vol. 464, Issue 3 https://doi.org/10.1007/s00424-012-1137-4	journal	August 2012
Evolutionarily conserved WNK and Ste20 kinases are essential for acute volume recovery and survival after hypertonic shrinkage in Caenorhabditis elegans Choe, Keith P.; Strange, Kevin American Journal of Physiology-Cell Physiology, Vol. 293, Issue 3 https://doi.org/10.1152/ajpcell.00126.2007	journal	September 2007
WNK1 is required for mitosis and abscission Tu, Szu-wei; Bugde, Abhijit; Luby-Phelps, Katherine Proceedings of the National Academy of Sciences, Vol. 108, Issue 4 https://doi.org/10.1073/pnas.1018567108	journal	January 2011
Wnk1 kinase deficiency lowers blood pressure in mice: A gene-trap screen to identify potential targets for therapeutic intervention Zambrowicz, Brian P.; Abuin, Alejandro; Ramirez-Solis, Ramiro Proceedings of the National Academy of Sciences, Vol. 100, Issue 24 https://doi.org/10.1073/pnas.2336103100	journal	November 2003
A minor role of WNK3 in regulating phosphorylation of renal NKCC2 and NCC co-transporters in vivo Oi, Katsuyuki; Sohara, Eisei; Rai, Tatemitsu Biology Open, Vol. 1, Issue 2 https://doi.org/10.1242/bio.2011048	journal	November 2011
Somatic Mutations of the Protein Kinase Gene Family in Human Lung Cancer Davies, Helen; Hunter, Chris; Smith, Raffaella Cancer Research, Vol. 65, Issue 17 https://doi.org/10.1158/0008-5472.CAN-05-1855	journal	September 2005
Oncoproteomic Analysis Reveals Co-Upregulation of RELA and STAT5 in Carboplatin Resistant Ovarian Carcinoma Jinawath, Natini; Vasoontara, Chanont; Jinawath, Artit PLoS ONE, Vol. 5, Issue 6 https://doi.org/10.1371/journal.pone.0011198	journal	June 2010
WNK1-OSR1 kinase-mediated phospho-activation of Na+-K+-2Cl- cotransporter facilitates glioma migration Zhu, Wen; Begum, Gulnaz; Pointer, Kelli Molecular Cancer, Vol. 13, Issue 1 https://doi.org/10.1186/1476-4598-13-31	journal	February 2014
A Comprehensive Characterization of Genome-Wide Copy Number Aberrations in Colorectal Cancer Reveals Novel Oncogenes and Patterns of Alterations Xie, Tao; d’ Ario, Giovanni; Lamb, John R. PLoS ONE, Vol. 7, Issue 7 https://doi.org/10.1371/journal.pone.0042001	journal	July 2012
A screen of the complete protein kinase gene family identifies diverse patterns of somatic mutations in human breast cancer Stephens, Philip; Edkins, Sarah; Davies, Helen Nature Genetics, Vol. 37, Issue 6 https://doi.org/10.1038/ng1571	journal	May 2005
Transposon insertional mutagenesis in mice identifies human breast cancer susceptibility genes and signatures for stratification Chen, Liming; Jenjaroenpun, Piroon; Pillai, Andrea Mun Ching Proceedings of the National Academy of Sciences, Vol. 114, Issue 11 https://doi.org/10.1073/pnas.1701512114	journal	March 2017
WNK1 Enhances Migration and Invasion in Breast Cancer Models Jaykumar, Ankita B.; Jung, Ji-Ung; Parida, Pravat Kumar Molecular Cancer Therapeutics, Vol. 20, Issue 10 https://doi.org/10.1158/1535-7163.MCT-21-0174	journal	July 2021
Inhibition of WNK3 Kinase Signaling Reduces Brain Damage and Accelerates Neurological Recovery After Stroke Begum, Gulnaz; Yuan, Hui; Kahle, Kristopher T. Stroke, Vol. 46, Issue 7 https://doi.org/10.1161/STROKEAHA.115.008939	journal	June 2015
Selective knockout of astrocytic Na⁺/H⁺exchanger isoform 1 reduces astrogliosis, BBB damage, infarction, and improves neurological function after ischemic stroke Begum, Gulnaz; Song, Shanshan; Wang, Shaoxia Glia, Vol. 66, Issue 1 https://doi.org/10.1002/glia.23232	journal	September 2017
Small-molecule WNK inhibition regulates cardiovascular and renal function Yamada, Ken; Park, Hyi-Man; Rigel, Dean F. Nature Chemical Biology, Vol. 12, Issue 11 https://doi.org/10.1038/nchembio.2168	journal	September 2016
Discovery and Characterization of Allosteric WNK Kinase Inhibitors Yamada, Ken; Zhang, Ji-Hu; Xie, Xiaoling ACS Chemical Biology, Vol. 11, Issue 12 https://doi.org/10.1021/acschembio.6b00511	journal	October 2016
Optimization of Allosteric With-No-Lysine (WNK) Kinase Inhibitors and Efficacy in Rodent Hypertension Models Yamada, Ken; Levell, Julian; Yoon, Taeyong Journal of Medicinal Chemistry, Vol. 60, Issue 16 https://doi.org/10.1021/acs.jmedchem.7b00708	journal	August 2017
Contribution of Organofluorine Compounds to Pharmaceuticals Inoue, Munenori; Sumii, Yuji; Shibata, Norio ACS Omega, Vol. 5, Issue 19 https://doi.org/10.1021/acsomega.0c00830	journal	April 2020
Good Partnership between Sulfur and Fluorine: Sulfur-Based Fluorination and Fluoroalkylation Reagents for Organic Synthesis Ni, Chuanfa; Hu, Mingyou; Hu, Jinbo Chemical Reviews, Vol. 115, Issue 2 https://doi.org/10.1021/cr5002386	journal	August 2014
Targeting cancer with small molecule kinase inhibitors Zhang, Jianming; Yang, Priscilla L.; Gray, Nathanael S. Nature Reviews Cancer, Vol. 9, Issue 1 https://doi.org/10.1038/nrc2559	journal	January 2009
Halogen bonds involved in binding of halogenated ligands by protein kinases. Poznański, Jarosław; Winiewska, Maria; Czapinska, Honorata Acta Biochimica Polonica, Vol. 63, Issue 2 https://doi.org/10.18388/abp.2015_1106	journal	April 2016
Structural basis of inhibitor selectivity in MAP kinases Wang, Zhulun; Canagarajah, Bertram J.; Boehm, Jeffrey C. Structure, Vol. 6, Issue 9 https://doi.org/10.1016/S0969-2126(98)00113-0	journal	September 1998
Nitro-Group-Containing Drugs Nepali, Kunal; Lee, Hsueh-Yun; Liou, Jing-Ping Journal of Medicinal Chemistry, Vol. 62, Issue 6 https://doi.org/10.1021/acs.jmedchem.8b00147	journal	October 2018

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