Identification of RP-6685, an Orally Bioavailable Compound that Inhibits the DNA Polymerase Activity

Bubenik, Monica; Mader, Pavel; Mochirian, Philippe; Vallee, Frederic; Clark, Jillian; Truchon, Jean-Francois; Perryman, Alexander L.; Pau, Victor; Kurinov, Igor; Zahn, Karl E.; Leclaire, Marie-Eve; Papp, Robert; Mathieu, Marie-Claude; Hamel, Martine; Duffy, Nicole M.; Godbout, Claude; Casas-Selves, Matias; Falgueyret, Jean-Pierre; Baruah, Prasamit S.; Nicolas, Olivier; Stocco, Rino; Poirier, Hugo; Martino, Giovanni; Fortin, Alexanne Bonneau; Roulston, Anne; Chefson, Amandine; Dorich, Stephane; St-Onge, Miguel; Patel, Purvish; Pellerin, Charles; Ciblat, Stephane; Pinter, Thomas; Barabe, Francis; Bakkouri, Majida El; Parikh, Paranjay; Gervais, Christian; Sfeir, Agnel; Mamane, Yael; Morris, Stephen J.; Black, W. Cameron; Sicheri, Frank; Gallant, Michel

doi:10.1021/acs.jmedchem.2c00998

Title: Identification of RP-6685, an Orally Bioavailable Compound that Inhibits the DNA Polymerase Activity

Journal Article · 01 September 2022 · J. Med. Chem.

DOI:https://doi.org/10.1021/acs.jmedchem.2c00998· OSTI ID:1901188

Bubenik, Monica; Mader, Pavel; Mochirian, Philippe; Vallee, Frederic; Clark, Jillian; Truchon, Jean-Francois; Perryman, Alexander L.; Pau, Victor; Kurinov, Igor; Zahn, Karl E.; Leclaire, Marie-Eve; Papp, Robert; Mathieu, Marie-Claude; Hamel, Martine; Duffy, Nicole M.; Godbout, Claude; Casas-Selves, Matias; Falgueyret, Jean-Pierre; Baruah, Prasamit S.; Nicolas, Olivier more »

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Research Organization:: Argonne National Laboratory (ANL), Argonne, IL (United States). Advanced Photon Source (APS)

Sponsoring Organization:: DOE - Office Of Science; FOREIGN

OSTI ID:: 1901188

Journal Information:: J. Med. Chem., Vol. 65, Issue (19)

Country of Publication:: United States

Language:: ENGLISH

References (24)

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Essential Roles for Polymerase θ-Mediated End Joining in the Repair of Chromosome Breaks Wyatt, David W.; Feng, Wanjuan; Conlin, Michael P. Molecular Cell, Vol. 63, Issue 4 https://doi.org/10.1016/j.molcel.2016.06.020	journal	August 2016
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Co-inhibition of pol θ and HR genes efficiently synergize with cisplatin to suppress cisplatin-resistant lung cancer cells survival Dai, Chun-Hua; Chen, Ping; Li, Jian Oncotarget, Vol. 7, Issue 40 https://doi.org/10.18632/oncotarget.11214	journal	August 2016
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Alternative Non-Homologous End-Joining: Error-Prone DNA Repair as Cancer’s Achilles’ Heel Caracciolo, Daniele; Riillo, Caterina; Di Martino, Maria Teresa Cancers, Vol. 13, Issue 6 https://doi.org/10.3390/cancers13061392	journal	March 2021
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