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Crystal Structure of Human CD47 in Complex with Engineered SIRP[alpha].D1(N80A)

Journal Article · · Molecules

Research Organization:
Advanced Photon Source (APS), Argonne National Laboratory (ANL), Argonne, IL (US)
Sponsoring Organization:
DOE - Office Of Science; OTHER
OSTI ID:
1901174
Journal Information:
Molecules, Journal Name: Molecules Journal Issue: (17) Vol. 27
Country of Publication:
United States
Language:
ENGLISH

References (31)

Structural analysis and binding sites of inhibitors targeting the CD47/SIRPα interaction in anticancer therapy journal January 2021
The CD47-SIRPα Immune Checkpoint journal May 2020
Targeting CD47 for cancer immunotherapy journal October 2021
Glutaminyl cyclase is an enzymatic modifier of the CD47- SIRPα axis and a target for cancer immunotherapy journal March 2019
CD47-blocking immunotherapies stimulate macrophage-mediated destruction of small-cell lung cancer journal June 2016
CD47 Blockade by Hu5F9-G4 and Rituximab in Non-Hodgkin’s Lymphoma journal November 2018
Current Advancements in Addressing Key Challenges of Therapeutic Antibody Design, Manufacture, and Formulation journal June 2019
Paired Receptor Specificity Explained by Structures of Signal Regulatory Proteins Alone and Complexed with CD47 journal July 2008
Recent Advances of Tumor Therapy Based on the CD47-SIRPα Axis journal April 2022
A SIRPα‐Fc fusion protein enhances the antitumor effect of oncolytic adenovirus against ovarian cancer journal February 2020
The Structure of the Macrophage Signal Regulatory Protein α (SIRPα) Inhibitory Receptor Reveals a Binding Face Reminiscent of That Used by T Cell Receptors journal March 2007
Functional characterization of the selective pan-allele anti-SIRPα antibody ADU-1805 that blocks the SIRPα–CD47 innate immune checkpoint journal December 2019
Anti-leukemic activity and tolerability of anti-human CD47 monoclonal antibodies journal February 2017
The CCP4 suite programs for protein crystallography journal September 1994
Antibody stability: A key to performance - Analysis, influences and improvement journal October 2020
Polymorphisms in the Human Inhibitory Signal-regulatory Protein α Do Not Affect Binding to Its Ligand CD47 journal February 2014
Targeting CD47/SIRPα as a therapeutic strategy, where we are and where we are headed journal April 2022
First-in-Human, First-in-Class Phase I Trial of the Anti-CD47 Antibody Hu5F9-G4 in Patients With Advanced Cancers journal April 2019
Engineered SIRPα Variants as Immunotherapeutic Adjuvants to Anticancer Antibodies journal May 2013
Clinicopathological and Prognostic Significance of CD47 Expression in Lung Neuroendocrine Tumors journal June 2021
Novel SIRPα Antibodies That Induce Single-Agent Phagocytosis of Tumor Cells while Preserving T Cells journal January 2021
Coot model-building tools for molecular graphics journal November 2004
Progress of CD47 immune checkpoint blockade agents in anticancer therapy: a hematotoxic perspective journal October 2021
A SIRPαFc Fusion Protein Conjugated With the Collagen-Binding Domain for Targeted Immunotherapy of Non-Small Cell Lung Cancer journal March 2022
Polymorphism in Sirpa modulates engraftment of human hematopoietic stem cells journal November 2007
Identification of Glutaminyl Cyclase isoenzyme isoQC as a regulator of SIRPα-CD47 axis journal May 2019
Risk-Adapted, Individualized Treatment Strategies of Myelodysplastic Syndromes (MDS) and Chronic Myelomonocytic Leukemia (CMML) journal March 2021
How good are my data and what is the resolution? journal June 2013
Automatic processing of rotation diffraction data from crystals of initially unknown symmetry and cell constants journal December 1993
Antibody disulfide bond reduction and recovery during biopharmaceutical process development—A review journal June 2021
SIRPα-αCD123 fusion antibodies targeting CD123 in conjunction with CD47 blockade enhance the clearance of AML-initiating cells journal September 2021

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