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Title: Crystal Structure of Human CD47 in Complex with Engineered SIRP[alpha].D1(N80A)

Journal Article · · Molecules

Research Organization:
Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Sponsoring Organization:
DOE - Office Of Science; OTHER
Journal Information:
Molecules, Vol. 27, Issue (17)
Country of Publication:
United States

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Functional characterization of the selective pan-allele anti-SIRPα antibody ADU-1805 that blocks the SIRPα–CD47 innate immune checkpoint journal December 2019
Structural analysis and binding sites of inhibitors targeting the CD47/SIRPα interaction in anticancer therapy journal January 2021
Progress of CD47 immune checkpoint blockade agents in anticancer therapy: a hematotoxic perspective journal October 2021
Polymorphisms in the Human Inhibitory Signal-regulatory Protein α Do Not Affect Binding to Its Ligand CD47 journal February 2014
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The Structure of the Macrophage Signal Regulatory Protein α (SIRPα) Inhibitory Receptor Reveals a Binding Face Reminiscent of That Used by T Cell Receptors journal March 2007
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CD47-blocking immunotherapies stimulate macrophage-mediated destruction of small-cell lung cancer journal June 2016
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A SIRPαFc Fusion Protein Conjugated With the Collagen-Binding Domain for Targeted Immunotherapy of Non-Small Cell Lung Cancer journal March 2022
A SIRPα‐Fc fusion protein enhances the antitumor effect of oncolytic adenovirus against ovarian cancer journal February 2020
SIRPα-αCD123 fusion antibodies targeting CD123 in conjunction with CD47 blockade enhance the clearance of AML-initiating cells journal September 2021
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