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The BRD3 ET domain recognizes a short peptide motif through a mechanism that is conserved across chromatin remodelers and transcriptional regulators
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journal
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May 2018 |
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Critical Role of c-Myc in Acute Myeloid Leukemia Involving Direct Regulation of miR-26a and Histone Methyltransferase EZH2
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journal
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May 2011 |
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A Bead-Based Proximity Assay for BRD4 Ligand Discovery: Proximity Assay for BRD4 Ligand Discovery
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journal
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November 2015 |
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Discovery, X-ray Crystallography, and Anti-inflammatory Activity of Bromodomain-containing Protein 4 (BRD4) BD1 Inhibitors Targeting a Distinct New Binding Site
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journal
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January 2022 |
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Differential BET Bromodomain Inhibition by Dihydropteridinone and Pyrimidodiazepinone Kinase Inhibitors
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journal
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October 2021 |
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Histone Recognition and Large-Scale Structural Analysis of the Human Bromodomain Family
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journal
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March 2012 |
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Features and development of Coot
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journal
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March 2010 |
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Phase 1 Study of Molibresib (GSK525762), a Bromodomain and Extra-Terminal Domain Protein Inhibitor, in NUT Carcinoma and Other Solid Tumors
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journal
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November 2019 |
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Bromodomain: an acetyl-lysine binding domain
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journal
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January 2002 |
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First-in-human Phase 1 open label study of the BET inhibitor ODM-207 in patients with selected solid tumours
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journal
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September 2020 |
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PHENIX: a comprehensive Python-based system for macromolecular structure solution
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journal
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January 2010 |
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Clinical trials for BET inhibitors run ahead of the science
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journal
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March 2016 |
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Discovery of Epigenetic Regulator I-BET762: Lead Optimization to Afford a Clinical Candidate Inhibitor of the BET Bromodomains
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journal
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September 2013 |
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BRDT Inhibitors for Male Contraceptive Drug Discovery: Current Status
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book
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January 2018 |
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Discovery of a Highly Selective BET BD2 Inhibitor from a DNA-Encoded Library Technology Screening Hit
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journal
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July 2021 |
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Plasticity in binding confers selectivity in ligand-induced protein degradation
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journal
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June 2018 |
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Response and resistance to BET bromodomain inhibitors in triple-negative breast cancer
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journal
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January 2016 |
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MolProbity : all-atom structure validation for macromolecular crystallography
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journal
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December 2009 |
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Transcriptional plasticity promotes primary and acquired resistance to BET inhibition
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journal
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September 2015 |
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c-Myc Is a Universal Amplifier of Expressed Genes in Lymphocytes and Embryonic Stem Cells
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journal
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September 2012 |
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Selective targeting of BD1 and BD2 of the BET proteins in cancer and immunoinflammation
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journal
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March 2020 |
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Spatially constrained tandem bromodomain inhibition bolsters sustained repression of BRD4 transcriptional activity for TNBC cell growth
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journal
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July 2018 |
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BET Bromodomain Inhibitors with One-Step Synthesis Discovered from Virtual Screen
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journal
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June 2017 |
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Phase Ib Trial With Birabresib, a Small-Molecule Inhibitor of Bromodomain and Extraterminal Proteins, in Patients With Selected Advanced Solid Tumors
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journal
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October 2018 |
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Overexpression of c-myc is associated with adverse clinical features and worse overall survival in multiple myeloma
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journal
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May 2016 |
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The Conserved 12-Amino Acid Stretch in the Inter-Bromodomain Region of BET Family Proteins Functions as a Nuclear Localization Signal
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journal
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January 2012 |
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Design and characterization of bivalent BET inhibitors
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journal
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October 2016 |
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Structural Mechanism of Transcriptional Regulator NSD3 Recognition by the ET Domain of BRD4
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journal
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July 2016 |
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Importance of Purity Evaluation and the Potential of Quantitative 1 H NMR as a Purity Assay: Miniperspective
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journal
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October 2014 |
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Expression of BET genes in testis of men with different spermatogenic impairments
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journal
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January 2012 |
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Brd4 and JMJD6-Associated Anti-Pause Enhancers in Regulation of Transcriptional Pause Release
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journal
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December 2013 |
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The first bromodomain of the testis-specific double bromodomain protein Brdt is required for chromocenter organization that is modulated by genetic background
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journal
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December 2011 |
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AMPK–ULK1-Mediated Autophagy Confers Resistance to BET Inhibitor JQ1 in Acute Myeloid Leukemia Stem Cells
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journal
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May 2017 |
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Selective inhibition of the BD2 bromodomain of BET proteins in prostate cancer
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journal
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January 2020 |
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Correction to Importance of Purity Evaluation and the Potential of Quantitative 1H NMR as a Purity Assay
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journal
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November 2015 |
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Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains
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journal
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February 2019 |
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XDS
|
journal
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January 2010 |
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BET Bromodomain Inhibition as a Therapeutic Strategy to Target c-Myc
|
journal
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September 2011 |
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phenix.model_vs_data : a high-level tool for the calculation of crystallographic model and data statistics
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journal
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May 2010 |
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First-in-human phase I study of the bromodomain and extraterminal motif inhibitor BAY 1238097: emerging pharmacokinetic/pharmacodynamic relationship and early termination due to unexpected toxicity
|
journal
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March 2019 |
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4-Methyl-1,2,3-Triazoles as N -Acetyl-Lysine Mimics Afford Potent BET Bromodomain Inhibitors with Improved Selectivity
|
journal
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July 2021 |
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Discovery of N -(4-(2,4-Difluorophenoxy)-3-(6-methyl-7-oxo-6,7-dihydro-1 H -pyrrolo[2,3- c ]pyridin-4-yl)phenyl)ethanesulfonamide (ABBV-075/Mivebresib), a Potent and Orally Available Bromodomain and Extraterminal Domain (BET) Family Bromodomain Inhibitor
|
journal
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October 2017 |
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The Bromodomain Protein Brd4 Is a Positive Regulatory Component of P-TEFb and Stimulates RNA Polymerase II-Dependent Transcription
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journal
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August 2005 |
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Protacs: Chimeric molecules that target proteins to the Skp1-Cullin-F box complex for ubiquitination and degradation
|
journal
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July 2001 |
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The Brd4 Extraterminal Domain Confers Transcription Activation Independent of pTEFb by Recruiting Multiple Proteins, Including NSD3
|
journal
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May 2011 |
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Fragment-based Scaffold Hopping: Identification of Potent, Selective, and Highly Soluble Bromo and Extra Terminal Domain (BET) Second Bromodomain (BD2) Inhibitors
|
journal
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July 2021 |
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Molecular complexes at a glance: automated generation of two-dimensional complex diagrams
|
journal
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April 2006 |
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Optimization of a Series of 2,3-Dihydrobenzofurans as Highly Potent, Second Bromodomain (BD2)-Selective, Bromo and Extra-Terminal Domain (BET) Inhibitors
|
journal
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July 2021 |
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Small-Molecule Inhibition of BRDT for Male Contraception
|
journal
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August 2012 |
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Selective inhibition of BET bromodomains
|
journal
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September 2010 |
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Discovery and characterization of bromodomain 2–specific inhibitors of BRDT
|
journal
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February 2021 |
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The first bromodomain of Brdt, a testis-specific member of the BET sub-family of double-bromodomain-containing proteins, is essential for male germ cell differentiation
|
journal
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October 2007 |