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Structural basis for allostery in integrins and binding to fibrinogen-mimetic therapeutics
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A Specific Interface between Integrin Transmembrane Helices and Affinity for Ligand
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An internal ligand-bound, metastable state of a leukocyte integrin, α X β 2
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The Enantiospecific Synthesis of an Isoxazoline. A RGD Mimic Platelet GPIIb/IIIa Antagonist
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Structural specializations of α 4 β 7 , an integrin that mediates rolling adhesion
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UR-3216: A Manageable Oral GPIIb/IIIa Antagonist
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Novel Pure αVβ3 Integrin Antagonists That Do Not Induce Receptor Extension, Prime the Receptor, or Enhance Angiogenesis at Low Concentrations
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Physiological Models Are Good Tools to Predict Rat Bioavailability of EF5154 Prodrugs from In Vitro Intestinal Parameters
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Structural determinants of integrin β-subunit specificity for latent TGF-β
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Identification and characterization of antibodies that bind GPIIb/IIIa: Antagonist complexes
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Global Conformational Rearrangements in Integrin Extracellular Domains in Outside-In and Inside-Out Signaling
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Regulation of integrin α5β1 conformational states and intrinsic affinities by metal ions and the ADMIDAS
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Increased Mortality With Oral Platelet Glycoprotein IIb/IIIa Antagonists
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Crystal Structure of the Extracellular Segment of Integrin alpha Vbeta 3 in Complex with an Arg-Gly-Asp Ligand
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Clot Retraction: Cellular Mechanisms and Inhibitors, Measuring Methods, and Clinical Implications
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An anti-alpha v-integrin antibody that blocks integrin function inhibits the development of a human melanoma in nude mice
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New antithrombotic RGD-mimetics with high bioavailability
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Stabilizing the open conformation of the integrin headpiece with a glycan wedge increases affinity for ligand
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A monoclonal antibody against an activation epitope on mouse integrin chain beta 1 blocks adhesion of lymphocytes to the endothelial integrin alpha 6 beta 1.
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Firategrast for relapsing remitting multiple sclerosis: a phase 2, randomised, double-blind, placebo-controlled trial
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Integrin extension enables ultrasensitive regulation by cytoskeletal force
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Analysis of fibronectin receptor function with monoclonal antibodies: roles in cell adhesion, migration, matrix assembly, and cytoskeletal organization.
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Antibodies causing thrombocytopenia in patients treated with RGD-mimetic platelet inhibitors recognize ligand-specific conformers of αIIb/β3 integrin
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Randomized, Double-Blind, Placebo-Controlled, International Trial of the Oral IIb/IIIa Antagonist Lotrafiban in Coronary and Cerebrovascular Disease
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Structure-Guided Design of a High-Affinity Platelet Integrin IIb 3 Receptor Antagonist That Disrupts Mg2+ Binding to the MIDAS
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Closed headpiece of integrin αIIbβ3 and its complex with an αIIbβ3-specific antagonist that does not induce opening
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Stimulation of tumor growth and angiogenesis by low concentrations of RGD-mimetic integrin inhibitors
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CuI-Catalyzed Coupling Reaction of β-Amino Acids or Esters with Aryl Halides at Temperature Lower Than That Employed in the Normal Ullmann Reaction. Facile Synthesis of SB-214857
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Structure-guided design of pure orthosteric inhibitors of αIIbβ3 that prevent thrombosis but preserve hemostasis
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Platelet Glycoprotein IIb-IIIa Antagonists as Prototypical Integrin Blockers: Novel Parenteral and Potential Oral Antithrombotic Agents
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General structural features that regulate integrin affinity revealed by atypical αVβ8
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UR-3216: A New Generation Oral Platelet GPIIb / IIIa Antagonist
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Differential Antiplatelet Effects of Various Glycoprotein IIb–IIIa Antagonists
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A population pharmacokinetic-pharmacodynamic and logistic regression analysis of lotrafiban in patients
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Complete integrin headpiece opening in eight steps
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Platelet Activation and Atherothrombosis
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XDS
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First Human Use of RUC‐4: A Nonactivating Second‐Generation Small‐Molecule Platelet Glycoprotein IIb/IIIa (Integrin αIIbβ3) Inhibitor Designed for Subcutaneous Point‐of‐Care Treatment of ST‐Segment–Elevation Myocardial Infarction
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Occupancy of an adhesive glycoprotein receptor modulates expression of an antigenic site involved in cell adhesion.
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Platelet activation in patients after an acute coronary syndrome: results from the TIMI-12 trial
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Activated Conformations of Very Late Activation Integrins Detected by a Group of Antibodies (HUTS) Specific for a Novel Regulatory Region(355-425) of the Common β1 Chain
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Conformational equilibria and intrinsic affinities define integrin activation
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Orally Active Non-Peptide Fibrinogen Receptor (GpIIb/IIIa) Antagonists: Identification of 4-[4-[4-(Aminoimino methyl)phenyl]-1-piperazinyl]-1- piperidineacetic Acid as a Long-Acting, Broad-Spectrum Antithrombotic Agent
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Intrinsic Activating Properties of GP IIb/IIIa Blockers
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RUC-4: A Novel αIIbβ3 Antagonist for Prehospital Therapy of Myocardial Infarction
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Safety, Tolerability, Pharmacokinetics, and Time Course of Pharmacologic Response of the Active Metabolite of Roxifiban, XV459, a Glycoprotein IIb/IIIa Antagonist, following Oral Administration in Healthy Volunteers
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Energy landscape differences among integrins establish the framework for understanding activation
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