Skip to main content
U.S. Department of Energy
Office of Scientific and Technical Information

Effects of N7-Alkylguanine Conformation and Metal Cofactors on the Translesion Synthesis by Human DN

Journal Article · · Chem. Res. Toxicol.
Research Organization:
Advanced Photon Source (APS), Argonne National Laboratory (ANL), Argonne, IL (US)
Sponsoring Organization:
DOE - Office Of Science
OSTI ID:
1901097
Journal Information:
Chem. Res. Toxicol., Journal Name: Chem. Res. Toxicol. Journal Issue: (3) Vol. 35
Country of Publication:
United States
Language:
ENGLISH

References (64)

Mechanism of mutagenesis by O6-methylguanine journal March 1984
The Spacious Active Site of a Y-Family DNA Polymerase Facilitates Promiscuous Nucleotide Incorporation Opposite a Bulky Carcinogen-DNA Adduct journal August 2004
Expression of cytochrome P450 2A3 in rat esophagus: relevance to N-nitrosobenzylmethylamine journal May 1999
On the fidelity of DNA replication. Studies with human placenta DNA polymerases. journal June 1979
Molecular replacement with MOLREP journal December 2009
Reactivity, SCE induction and mutagenicity of benzyl chloride derivatives journal August 1983
Mechanisms of accurate translesion synthesis by human DNA polymerase eta journal June 2000
Biologically Relevant Chemical Reactions of N7-Alkylguanine Residues in DNA journal July 2004
The structural basis for the mutagenicity of O6-methyl-guanine lesions journal December 2006
Ribonucleotides and manganese ions improve non-homologous end joining by human Polµ journal December 2012
Structural insights into the bypass of the major deaminated purines by translesion synthesis DNA polymerase journal December 2020
Structural basis of DNA synthesis opposite 8-oxoguanine by human PrimPol primase-polymerase journal June 2021
Highly error-free role of DNA polymerase   in the replicative bypass of UV-induced pyrimidine dimers in mouse and human cells journal October 2009
Structural evidence for the rare tautomer hypothesis of spontaneous mutagenesis journal October 2011
Molecular structure of a left-handed double helical DNA fragment at atomic resolution journal December 1979
Fidelity of Dpo4: effect of metal ions, nucleotide selection and pyrophosphorolysis journal August 2005
NMR Studies on the syn-anti Dynamic Equilibrium in Purine Nucleosides and Nucleotides journal July 1980
Kinetics, Structure, and Mechanism of 8-Oxo-7,8-dihydro-2′-deoxyguanosine Bypass by Human DNA Polymerase η journal April 2014
Mutational properties of the primary aflatoxin B1-DNA adduct. journal February 1996
Alkylation damage in DNA and RNA—repair mechanisms and medical significance journal November 2004
An Incoming Nucleotide Imposes an anti to syn Conformational Change on the Templating Purine in the Human DNA Polymerase-ι Active Site journal April 2006
Intrinsic Conformational Energetics Associated with the Glycosyl Torsion in DNA: A Quantum Mechanical Study journal March 2002
Efficient and accurate replication in the presence of 7,8-dihydro-8-oxoguanine by DNA polymerase η journal August 2000
On the fidelity of DNA replication. Metal activation of Escherichia coli DNA polymerase I. journal January 1979
Synthesis and Structure of Duplex DNA Containing the Genotoxic Nucleobase Lesion N7-Methylguanine journal September 2008
Macromolecular structure determination using X-rays, neutrons and electrons: recent developments in Phenix journal October 2019
Attempts to initiate skin tumours in mice in the 2-stage system using 4-chloromethylbiphenyl (4CMB), 4-hydroxymethylbiphenyl (4HMB), and benzyl chloride (BC). Report of the experiment at 10 months journal January 1982
Abasic sites in DNA: repair and biological consequences in Saccharomyces cerevisiae journal January 2004
The Escherichia coli 3-Methyladenine DNA Glycosylase AlkA Has a Remarkably Versatile Active Site journal May 2004
Translesion synthesis of the major nitrogen mustard-induced DNA lesion by human DNA polymerase η journal December 2020
FaPy lesions and DNA mutations journal June 2013
Mutagenic Replication of the Major Oxidative Adenine Lesion 7,8-Dihydro-8-oxoadenine by Human DNA Polymerases journal February 2019
Synthesis, Properties, and NMR Studies of a C8-Phenylguanine Modified Oligonucleotide that Preferentially Adopts the Z DNA Conformation journal September 2003
Abasic and Oxidized Abasic Site Reactivity in DNA: Enzyme Inhibition, Cross-Linking, and Nucleosome Catalyzed Reactions journal December 2013
Structure and mechanism of human DNA polymerase η journal June 2010
Structure of Human DNA Polymerase κ Inserting dATP Opposite an 8-OxoG DNA Lesion journal June 2009
Effect of manganese ions on the incorporation of dideoxynucleotides by bacteriophage T7 DNA polymerase and Escherichia coli DNA polymerase I. journal June 1989
Structural and mechanistic studies of polymerase   bypass of phenanthriplatin DNA damage journal June 2014
N-Nitrosobenzylmethylamine Is Activated to a DNA Benzylating Agent in Rats Volume 10, Number 1, January 1997, pp 19−26 journal November 2000
On the enzymatic basis for mutagenesis by manganese. journal March 1983
Coot model-building tools for molecular graphics journal November 2004
Different Divalent Cations Alter the Kinetics and Fidelity of DNA Polymerases journal September 2016
A Role for Polymerase η in the Cellular Tolerance to Cisplatin-Induced Damage journal November 2005
Mechanism of replication blocking and bypass of Y-family polymerase   by bulky acetylaminofluorene DNA adducts journal November 2010
Repairing DNA-methylation damage journal February 2004
Mutagenicity of N3-methyladenine: A multi-translesion polymerase affair journal January 2010
[20] Processing of X-ray diffraction data collected in oscillation mode book January 1997
Viewing Human DNA Polymerase β Faithfully and Unfaithfully Bypass an Oxidative Lesion by Time-Dependent Crystallography journal April 2015
On the fidelity of DNA replication: manganese mutagenesis in vitro journal October 1985
Structural and Kinetic Studies of the Effect of Guanine N7 Alkylation and Metal Cofactors on DNA Replication journal June 2018
Mutagenesis mechanism of the major oxidative adenine lesion 7,8-dihydro-8-oxoadenine journal April 2020
Bypass of the Major Alkylative DNA Lesion by Human DNA Polymerase η journal October 2019
UCSF Chimera?A visualization system for exploratory research and analysis journal January 2004
Transition-state destabilization reveals how human DNA polymerase β proceeds across the chemically unstable lesion N7-methylguanine journal June 2014
Impact of Conformational Heterogeneity of OxoG Lesions and Their Pairing Partners on Bypass Fidelity by Y Family Polymerases journal May 2009
Human DNA Polymerase η Is Pre-Aligned for dNTP Binding and Catalysis journal January 2012
Human DNA Polymerase ι Incorporates dCTP Opposite Template G via a G.C+ Hoogsteen Base Pair journal October 2005
A Structural Basis for Metal Ion Mutagenicity and Nucleotide Selectivity in Human DNA Polymerase β , journal January 1996
Increased Catalytic Activity and Altered Fidelity of Human DNA Polymerase ι in the Presence of Manganese journal July 2007
The spontaneous replication error and the mismatch discrimination mechanisms of human DNA polymerase β journal September 2014
Insights into the mismatch discrimination mechanism of Y-family DNA polymerase Dpo4 journal May 2021
Structural Basis for Promutagenicity of 8-Halogenated Guanine journal January 2014
Promutagenic bypass of 7,8-dihydro-8-oxoadenine by translesion synthesis DNA polymerase Dpo4 journal July 2020
Effect of Different Divalent Cations on the Kinetics and Fidelity of RB69 DNA Polymerase journal April 2016

Similar Records

Related Subjects