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Development of BRD4 inhibitors as anti-inflammatory agents and antidotes for arsenicals

Journal Article · · Bioorg. Med. Chem. Lett.
Research Organization:
Advanced Photon Source (APS), Argonne National Laboratory (ANL), Argonne, IL (US)
Sponsoring Organization:
DOE - Office Of Science; NIH
OSTI ID:
1900998
Journal Information:
Bioorg. Med. Chem. Lett., Journal Name: Bioorg. Med. Chem. Lett. Vol. 64
Country of Publication:
United States
Language:
ENGLISH

References (28)

The toxicity of organoarsenic-based warfare agents: In vitro and in vivo studies journal February 1996
Time course of lewisite-induced skin lesions and inflammatory response in the SKH-1 hairless mouse model journal March 2014
PFI-1, a Highly Selective Protein Interaction Inhibitor, Targeting BET Bromodomains journal May 2013
Molecular Mechanism Underlying Pathogenesis of Lewisite-Induced Cutaneous Blistering and Inflammation journal October 2016
Vesicants journal October 2005
Protective role of HO‐1 against acute kidney injury caused by cutaneous exposure to arsenicals journal September 2020
SuFEx Activation with Ca(NTf2)2: A Unified Strategy to Access Sulfamides, Sulfamates, and Sulfonamides from S(VI) Fluorides journal May 2020
Bromodomains: a new target class for small molecule drug discovery journal September 2012
Bromodomain and extra-terminal motif inhibitors: a review of preclinical and clinical advances in cancer therapy journal March 2019
Selective targeting of BD1 and BD2 of the BET proteins in cancer and immunoinflammation journal March 2020
Detection of Bis(diphenylarsine)oxide, Diphenylarsinic Acid and Phenylarsonic Acid, Compounds Probably Derived from Chemical Warfare Agents, in Drinking Well Water journal January 2005
NETosis in the pathogenesis of acute lung injury following cutaneous chemical burns journal May 2021
Real-time detection of Chemical Warfare Agents at clearance decontamination levels for surface contamination: a challenge for civilian authorities journal May 2021
Suppression of inflammation by a synthetic histone mimic journal November 2010
Determination of mustard and lewisite related compounds in abandoned chemical weapons (Yellow shells) from sources in China and Japan journal January 2006
Brd4 Is Essential for IL-1β-Induced Inflammation in Human Airway Epithelial Cells journal April 2014
Are we ready to replace dimercaprol (BAL) as an arsenic antidote? journal August 1997
Identification of a Chemical Probe for Bromo and Extra C-Terminal Bromodomain Inhibition through Optimization of a Fragment-Derived Hit journal October 2012
Defining cutaneous molecular pathobiology of arsenicals using phenylarsine oxide as a prototype journal October 2016
BET inhibition blocks inflammation-induced cardiac dysfunction and SARS-CoV-2 infection journal April 2021
Cutaneous lewisite exposure causes acute lung injury journal April 2020
Long-term neurological and neuropsychological complications of sulfur mustard and Lewisite mixture poisoning in Chinese victims exposed to chemical warfare agents abandoned at the end of WWII journal September 2018
1-Hydroxy-7-azabenzotriazole. An efficient peptide coupling additive journal May 1993
BET Family Protein BRD4: An Emerging Actor in NFκB Signaling in Inflammation and Cancer journal February 2018
BRD4 directs hematopoietic stem cell development and modulates macrophage inflammatory responses journal March 2019
IL-6 in Inflammation, Immunity, and Disease journal September 2014
Brd4 is on the move during inflammation journal November 2014
Chemical warfare agents journal January 2010

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