Discovery of substituted benzyloxy-benzylamine inhibitors of acetyltransferase Eis and their anti-my

Pang, Allan H.; Green, Keith D.; Chandrika, Nishad Thamban; Garzan, Atefeh; Punetha, Ankita; Holbrook, Selina Y.L.; Willby, Melisa J.; Posey, James E.; Tsodikov, Oleg V.; Garneau-Tsodikova, Sylvie

doi:10.1016/j.ejmech.2022.114698

Title: Discovery of substituted benzyloxy-benzylamine inhibitors of acetyltransferase Eis and their anti-my

Journal Article · 01 November 2022 · Eur. J. Med. Chem.

DOI:https://doi.org/10.1016/j.ejmech.2022.114698· OSTI ID:1900973

Pang, Allan H.; Green, Keith D.; Chandrika, Nishad Thamban; Garzan, Atefeh; Punetha, Ankita; Holbrook, Selina Y.L.; Willby, Melisa J.; Posey, James E.; Tsodikov, Oleg V.; Garneau-Tsodikova, Sylvie

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Research Organization:: Argonne National Laboratory (ANL), Argonne, IL (United States). Advanced Photon Source (APS)

Sponsoring Organization:: DOE - Office Of Science; National Institutes of Health (NIH); OTHER

OSTI ID:: 1900973

Journal Information:: Eur. J. Med. Chem., Vol. 242

Country of Publication:: United States

Language:: ENGLISH

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Aminoglycoside Cross-Resistance in Mycobacterium tuberculosis Due to Mutations in the 5′ Untranslated Region of whiB7 Reeves, Analise Z.; Campbell, Patricia J.; Sultana, Razvan Antimicrobial Agents and Chemotherapy, Vol. 57, Issue 4 https://doi.org/10.1128/AAC.02191-12	journal	February 2013
Unusual regioversatility of acetyltransferase Eis, a cause of drug resistance in XDR-TB Chen, Wenjing; Biswas, Tapan; Porter, Vanessa R. Proceedings of the National Academy of Sciences, Vol. 108, Issue 24 https://doi.org/10.1073/pnas.1105379108	journal	May 2011
Aminoglycoside Multiacetylating Activity of the Enhanced Intracellular Survival Protein from Mycobacterium smegmatis and Its Inhibition Chen, Wenjing; Green, Keith D.; Tsodikov, Oleg V. Biochemistry, Vol. 51, Issue 24 https://doi.org/10.1021/bi3004473	journal	June 2012
Biochemical and Structural Analysis of an Eis Family Aminoglycoside Acetyltransferase from Bacillus anthracis Green, Keith D.; Biswas, Tapan; Chang, Changsoo Biochemistry, Vol. 54, Issue 20 https://doi.org/10.1021/acs.biochem.5b00244	journal	May 2015
Comparative Study of Eis-like Enzymes from Pathogenic and Nonpathogenic Bacteria Green, Keith D.; Pricer, Rachel E.; Stewart, Megan N. ACS Infectious Diseases, Vol. 1, Issue 6 https://doi.org/10.1021/acsinfecdis.5b00036	journal	May 2015
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Potent Inhibitors of Acetyltransferase Eis Overcome Kanamycin Resistance in Mycobacterium tuberculosis Willby, Melisa J.; Green, Keith D.; Gajadeera, Chathurada S. ACS Chemical Biology, Vol. 11, Issue 6 https://doi.org/10.1021/acschembio.6b00110	journal	April 2016
Sulfonamide-Based Inhibitors of Aminoglycoside Acetyltransferase Eis Abolish Resistance to Kanamycin in Mycobacterium tuberculosis Garzan, Atefeh; Willby, Melisa J.; Green, Keith D. Journal of Medicinal Chemistry, Vol. 59, Issue 23 https://doi.org/10.1021/acs.jmedchem.6b01161	journal	November 2016
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Potent 1,2,4-Triazino[5,6 b ]indole-3-thioether Inhibitors of the Kanamycin Resistance Enzyme Eis from Mycobacterium tuberculosis Ngo, Huy X.; Green, Keith D.; Gajadeera, Chathurada S. ACS Infectious Diseases, Vol. 4, Issue 6 https://doi.org/10.1021/acsinfecdis.8b00074	journal	March 2018
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Structure-based design of haloperidol analogues as inhibitors of acetyltransferase Eis from Mycobacterium tuberculosis to overcome kanamycin resistance Punetha, Ankita; Green, Keith D.; Garzan, Atefeh RSC Medicinal Chemistry, Vol. 12, Issue 11 https://doi.org/10.1039/D1MD00239B	journal	January 2021
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