Repurposing epigenetic inhibitors to target the Clostridioides difficile-specific DNA adenine methyl

Zhou, Jujun; Horton, John R.; Yu, Dan; Ren, Ren; Blumenthal, Robert M.; Zhang, Xing; Cheng, Xiaodong

doi:10.1080/15592294.2021.1976910

Repurposing epigenetic inhibitors to target the Clostridioides difficile-specific DNA adenine methyl

Journal Article · 01 September 2021 · Epigenetics

DOI:https://doi.org/10.1080/15592294.2021.1976910· OSTI ID:1900910

Zhou, Jujun; Horton, John R.; Yu, Dan; Ren, Ren; Blumenthal, Robert M.; Zhang, Xing; Cheng, Xiaodong

Research Organization:: Argonne National Laboratory (ANL), Argonne, IL (United States). Advanced Photon Source (APS)

Sponsoring Organization:: DOE - Office Of Science; National Institutes of Health (NIH); OTHER

OSTI ID:: 1900910

Journal Information:: Epigenetics, Vol. 17, Issue (9)

Country of Publication:: United States

Language:: ENGLISH

References (69)

Epigenetics and meditation No authors listed Current Opinion in Psychology https://doi.org/10.1016/j.copsyc.2018.11.010		August 2019
Advances in epigenetics link genetics to the environment and disease No authors listed Nature https://doi.org/10.1038/s41586-019-1411-0		July 2019
Diet, Nutrition, and Cancer Epigenetics No authors listed Annual Review of Nutrition https://doi.org/10.1146/annurev-nutr-121415-112634		July 2016
Epigenetics and Bacterial Infections No authors listed Cold Spring Harbor Perspectives in Medicine https://doi.org/10.1101/cshperspect.a010272		December 2012
Targeting host epigenetic machinery: TheListeriaparadigm No authors listed Cellular Microbiology https://doi.org/10.1111/cmi.13169		April 2020
Epigenetic therapy of cancer: past, present and future No authors listed Nature Reviews Drug Discovery https://doi.org/10.1038/nrd1930		January 2006
PRMTs and Arginine Methylation: Cancer’s Best-Kept Secret? No authors listed Trends in Molecular Medicine https://doi.org/10.1016/j.molmed.2019.05.007		November 2019
T herapeutic targeting of chromatin: status and opportunities No authors listed The FEBS Journal https://doi.org/10.1111/febs.15966		June 2021
Small-molecule inhibition of METTL3 as a strategy against myeloid leukaemia No authors listed Nature https://doi.org/10.1038/s41586-021-03536-w		April 2021
The antibiotic paradox: why companies can’t afford to create life-saving drugs No authors listed Nature https://doi.org/10.1038/d41586-020-02418-x		August 2020
Why big pharma has abandoned antibiotics No authors listed Nature https://doi.org/10.1038/d41586-020-02884-3		October 2020
Different drugs for bad bugs: antivirulence strategies in the age of antibiotic resistance No authors listed Nature Reviews Drug Discovery https://doi.org/10.1038/nrd.2017.23		March 2017
Possible drugs for the treatment of bacterial infections in the future: anti-virulence drugs No authors listed The Journal of Antibiotics https://doi.org/10.1038/s41429-020-0344-z		July 2020
Conserved DNA Methyltransferases: A Window into Fundamental Mechanisms of Epigenetic Regulation in Bacteria No authors listed Trends in Microbiology https://doi.org/10.1016/j.tim.2020.04.007		January 2021
Beyond Restriction Modification: Epigenomic Roles of DNA Methylation in Prokaryotes No authors listed Annual Review of Microbiology https://doi.org/10.1146/annurev-micro-040521-035040		October 2021
Trends in U.S. Burden of Clostridioides difficile Infection and Outcomes No authors listed New England Journal of Medicine https://doi.org/10.1056/NEJMoa1910215		April 2020
Pseudomembranous colitis No authors listed Disease-a-Month https://doi.org/10.1016/j.disamonth.2015.01.006		May 2015
Antibiotic Exposure and Risk for Hospital-Associated Clostridioides difficile Infection No authors listed Antimicrobial Agents and Chemotherapy https://doi.org/10.1128/AAC.02169-19		March 2020
Activity of Hospital Disinfectants against Vegetative Cells and Spores of Clostridioides difficile Embedded in Biofilms No authors listed Antimicrobial Agents and Chemotherapy https://doi.org/10.1128/AAC.01031-19		December 2019
Receipt of Antibiotics in Hospitalized Patients and Risk for Clostridium difficile Infection in Subsequent Patients Who Occupy the Same Bed No authors listed JAMA Internal Medicine https://doi.org/10.1001/jamainternmed.2016.6193		December 2016
Murine Intrarectal Instillation of Purified Recombinant Clostridioides difficile Toxins Enables Mechanistic Studies of Pathogenesis No authors listed Infection and Immunity https://doi.org/10.1128/IAI.00543-20		March 2021
The Relative Role of Toxins A and B in the Virulence of Clotridioides difficile No authors listed Journal of Clinical Medicine https://doi.org/10.3390/jcm10010096		December 2020
Anti-virulence strategies for Clostridioides difficile infection: advances and roadblocks No authors listed Gut Microbes https://doi.org/10.1080/19490976.2020.1802865		October 2020
Insights into the Role of Human Gut Microbiota in Clostridioides difficile Infection No authors listed Microorganisms https://doi.org/10.3390/microorganisms8020200		January 2020
Clostridioides (Clostridium) difficile infection: current and alternative therapeutic strategies No authors listed Future Microbiology https://doi.org/10.2217/fmb-2017-0203		March 2018
Therapies to modulate gut microbiota: Past, present and future No authors listed World Journal of Gastroenterology https://doi.org/10.3748/wjg.v26.i8.777		February 2020
Bacteriophage endolysins as a potential weapon to combat Clostridioides difficile infection No authors listed Gut Microbes https://doi.org/10.1080/19490976.2020.1813533		September 2020
Increasing antibiotic resistance in Clostridioides difficile: A systematic review and meta-analysis No authors listed Anaerobe https://doi.org/10.1016/j.anaerobe.2019.102072		August 2019
Haem is crucial for medium-dependent metronidazole resistance in clinical isolates of Clostridioides difficile No authors listed Journal of Antimicrobial Chemotherapy https://doi.org/10.1093/jac/dkab097		April 2021
The Integrity of Heme Is Essential for Reproducible Detection of Metronidazole-Resistant Clostridioides difficile by Agar Dilution Susceptibility Tests No authors listed Journal of Clinical Microbiology https://doi.org/10.1128/JCM.00585-21		August 2021
Clearance of Clostridioides difficile Colonization Is Associated with Antibiotic-Specific Bacterial Changes No authors listed mSphere https://doi.org/10.1128/mSphere.01238-20		June 2021
Epigenomic characterization of Clostridioides difficile finds a conserved DNA methyltransferase that mediates sporulation and pathogenesis No authors listed Nature Microbiology https://doi.org/10.1038/s41564-019-0613-4		November 2019
Cephamycins inhibit pathogen sporulation and effectively treat recurrent Clostridioides difficile infection No authors listed Nature Microbiology https://doi.org/10.1038/s41564-019-0519-1		August 2019
The early stage peptidoglycan biosynthesis Mur enzymes are antibacterial and antisporulation drug targets for recurrent Clostridioides difficile infection No authors listed Anaerobe https://doi.org/10.1016/j.anaerobe.2019.102129		February 2020
Clostridioides difficile specific DNA adenine methyltransferase CamA squeezes and flips adenine out of DNA helix No authors listed Nature Communications https://doi.org/10.1038/s41467-021-23693-w		June 2021
Many paths to methyltransfer: a chronicle of convergence No authors listed Trends in Biochemical Sciences https://doi.org/10.1016/S0968-0004(03)00090-2		June 2003
Crystal structure of the conserved core of protein arginine methyltransferase PRMT3 No authors listed The EMBO Journal https://doi.org/10.1093/emboj/19.14.3509		July 2000
Insights into histone code syntax from structural and biochemical studies of CARM1 methyltransferase No authors listed The EMBO Journal https://doi.org/10.1038/sj.emboj.7601856		September 2007
Structural insights into protein arginine symmetric dimethylation by PRMT5 No authors listed Proceedings of the National Academy of Sciences https://doi.org/10.1073/pnas.1106946108		December 2011
Structure and Substrate Recognition of the Escherichia coli DNA Adenine Methyltransferase No authors listed Journal of Molecular Biology https://doi.org/10.1016/j.jmb.2006.02.028		April 2006
Transition from Nonspecific to Specific DNA Interactions along the Substrate-Recognition Pathway of Dam Methyltransferase No authors listed Cell https://doi.org/10.1016/j.cell.2005.02.021		May 2005
The cell cycle-regulated DNA adenine methyltransferase CcrM opens a bubble at its DNA recognition site No authors listed Nature Communications https://doi.org/10.1038/s41467-019-12498-7		October 2019
Human MettL3–MettL14 complex is a sequence-specific DNA adenine methyltransferase active on single-strand and unpaired DNA in vitro No authors listed Cell Discovery https://doi.org/10.1038/s41421-019-0136-4		December 2019
Human MettL3-MettL14 RNA adenine methyltransferase complex is active on double-stranded DNA containing lesions No authors listed Nucleic Acids Research https://doi.org/10.1093/nar/gkab460		June 2021
Enzymatic characterization of three human RNA adenosine methyltransferases reveals diverse substrate affinities and reaction optima No authors listed Journal of Biological Chemistry https://doi.org/10.1016/j.jbc.2021.100270		January 2021
The inactive Dnmt3b3 isoform preferentially enhances Dnmt3b-mediated DNA methylation No authors listed Genes & Development https://doi.org/10.1101/gad.341925.120		October 2020
Recognition and potential mechanisms for replication and erasure of cytosine hydroxymethylation No authors listed Nucleic Acids Research https://doi.org/10.1093/nar/gks155		February 2012
Methyltransferase-Glo: a universal, bioluminescent and homogenous assay for monitoring all classes of methyltransferases No authors listed Epigenomics https://doi.org/10.2217/epi.15.113		March 2016
Towards automated crystallographic structure refinement with phenix.refine No authors listed Acta Crystallographica Section D Biological Crystallography https://doi.org/10.1107/S0907444912001308		March 2012
Features and development of Coot No authors listed Acta Crystallographica Section D Biological Crystallography https://doi.org/10.1107/S0907444910007493		March 2010
A New Generation of Crystallographic Validation Tools for the Protein Data Bank No authors listed Structure https://doi.org/10.1016/j.str.2011.08.006		October 2011
The Escherichia coli Dam DNA Methyltransferase Modifies DNA in a Highly Processive Reaction No authors listed Journal of Molecular Biology https://doi.org/10.1016/S0022-2836(02)00371-6		June 2002
The double role of methyl donor and allosteric effector of S-adenosyl-methionine for Dam methylase of E. coli No authors listed Nucleic Acids Research https://doi.org/10.1093/nar/18.15.4369		August 1990
Dam methylase from Escherichia coli : kinetic studies using modified DNA oligomers: hemimethylated substrates No authors listed Nucleic Acids Research https://doi.org/10.1093/nar/23.18.3648		January 1995
Phage T4 DNA [N ⁶ -Adenine] Methyltransferase: Kinetic Studies Using Oligonucleotides Containing Native or Modified Recognition Sites No authors listed Biological Chemistry https://doi.org/10.1515/bchm.1998.379.4-5.481		January 1998
Differential binding of S -adenosylmethionine S -adenosylhomocysteine and Sinefungin to the adenine-specific DNA methyltransferase M. Taq I 1 1Edited by T. Richmond No authors listed Journal of Molecular Biology https://doi.org/10.1006/jmbi.1996.0711		January 1997
Catalytic site remodelling of the DOT1L methyltransferase by selective inhibitors No authors listed Nature Communications https://doi.org/10.1038/ncomms2304		January 2012
Selective Killing of Mixed Lineage Leukemia Cells by a Potent Small-Molecule DOT1L Inhibitor No authors listed Cancer Cell https://doi.org/10.1016/j.ccr.2011.06.009		July 2011
537MO First-in-human study of JNJ-64619178, a protein arginine methyltransferase 5 (PRMT5) inhibitor, in patients with advanced cancers No authors listed Annals of Oncology https://doi.org/10.1016/j.annonc.2020.08.651		September 2020
Pharmacological inhibition of PRMT7 links arginine monomethylation to the cellular stress response No authors listed Nature Communications https://doi.org/10.1038/s41467-020-16271-z		May 2020
Potent inhibition of DOT1L as treatment of MLL-fusion leukemia No authors listed Blood https://doi.org/10.1182/blood-2013-04-497644		August 2013
Inhibition of Methyltransferase DOT1L Sensitizes to Sorafenib Treatment AML Cells Irrespective of MLL-Rearrangements: A Novel Therapeutic Strategy for Pediatric AML No authors listed Cancers https://doi.org/10.3390/cancers12071972		July 2020
Substituted purine and 7-deazapurine compounds as modulators of epigenetic enzymes: a patent evaluation (WO2012075381) No authors listed Expert Opinion on Therapeutic Patents https://doi.org/10.1517/13543776.2013.776040		March 2013
Cancer synthetic vulnerabilities to protein arginine methyltransferase inhibitors No authors listed Current Opinion in Pharmacology https://doi.org/10.1016/j.coph.2021.04.004		August 2021
Chemical probes for protein arginine methyltransferases No authors listed Methods https://doi.org/10.1016/j.ymeth.2019.11.017		March 2020
The architecture of the Gram-positive bacterial cell wall No authors listed Nature https://doi.org/10.1038/s41586-020-2236-6		April 2020
The CWB2 Cell Wall-Anchoring Module Is Revealed by the Crystal Structures of the Clostridium difficile Cell Wall Proteins Cwp8 and Cwp6 No authors listed Structure https://doi.org/10.1016/j.str.2016.12.018		March 2017
New class of precision antimicrobials redefines role of Clostridium difficile S-layer in virulence and viability No authors listed Science Translational Medicine https://doi.org/10.1126/scitranslmed.aah6813		September 2017
Phospholipid profiles of Clostridium difficile No authors listed Journal of Bacteriology https://doi.org/10.1128/jb.178.19.5844-5846.1996		October 1996

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