Insight into Viral Hijacking of CRL4 Ubiquitin Ligase through Structural Analysis of the pUL145-DDB1

Wick, Elizaveta T.; Treadway, Colton J.; Li, Zhijun; Nicely, Nathan I.; Ren, Zhizhong; Baldwin, Albert S.; Xiong, Yue; Harrison, Joseph S.; Brown, Nicholas G.

doi:10.1128/jvi.00826-22

Title: Insight into Viral Hijacking of CRL4 Ubiquitin Ligase through Structural Analysis of the pUL145-DDB1

Journal Article · 01 September 2022 · J. Virol.

DOI:https://doi.org/10.1128/jvi.00826-22· OSTI ID:1900908

Wick, Elizaveta T.; Treadway, Colton J.; Li, Zhijun; Nicely, Nathan I.; Ren, Zhizhong; Baldwin, Albert S.; Xiong, Yue; Harrison, Joseph S.; Brown, Nicholas G.

Cite

Export

Save

Research Organization:: Argonne National Laboratory (ANL), Argonne, IL (United States). Advanced Photon Source (APS)

Sponsoring Organization:: DOE - Office Of Science; DOE - BASIC ENERGY SCIENCES; National Institutes of Health (NIH)

OSTI ID:: 1900908

Journal Information:: J. Virol., Vol. 96, Issue (17)

Country of Publication:: United States

Language:: ENGLISH

References (54)

Regulation of Viral Restriction by Post-Translational Modifications Chamontin, Célia; Bossis, Guillaume; Nisole, Sébastien Viruses, Vol. 13, Issue 11 https://doi.org/10.3390/v13112197	journal	November 2021
Species-Specific Host–Virus Interactions: Implications for Viral Host Range and Virulence Rothenburg, Stefan; Brennan, Greg Trends in Microbiology, Vol. 28, Issue 1 https://doi.org/10.1016/j.tim.2019.08.007	journal	January 2020
Ub to no good: How cytomegaloviruses exploit the ubiquitin proteasome system Le-Trilling, Vu Thuy Khanh; Trilling, Mirko Virus Research, Vol. 281 https://doi.org/10.1016/j.virusres.2020.197938	journal	May 2020
The Anaphase Promoting Complex/Cyclosome (APC/C): A Versatile E3 Ubiquitin Ligase Curtis, Natalie L.; Bolanos-Garcia, Victor M. Subcellular Biochemistry https://doi.org/10.1007/978-3-030-28151-9_18	book	January 2019
Ubiquitylation at the crossroads of development and disease Rape, Michael Nature Reviews Molecular Cell Biology, Vol. 19, Issue 1 https://doi.org/10.1038/nrm.2017.83	journal	September 2017
K63 ubiquitylation triggers proteasomal degradation by seeding branched ubiquitin chains Ohtake, Fumiaki; Tsuchiya, Hikaru; Saeki, Yasushi Proceedings of the National Academy of Sciences, Vol. 115, Issue 7 https://doi.org/10.1073/pnas.1716673115	journal	January 2018
Assembly and Function of Heterotypic Ubiquitin Chains in Cell-Cycle and Protein Quality Control Yau, Richard G.; Doerner, Kerstin; Castellanos, Erick R. Cell, Vol. 171, Issue 4 https://doi.org/10.1016/j.cell.2017.09.040	journal	November 2017
The K48-K63 Branched Ubiquitin Chain Regulates NF-κB Signaling Ohtake, Fumiaki; Saeki, Yasushi; Ishido, Satoshi Molecular Cell, Vol. 64, Issue 2 https://doi.org/10.1016/j.molcel.2016.09.014	journal	October 2016
Versatile Roles of K63-Linked Ubiquitin Chains in Trafficking Erpapazoglou, Zoi; Walker, Olivier; Haguenauer-Tsapis, Rosine Cells, Vol. 3, Issue 4 https://doi.org/10.3390/cells3041027	journal	November 2014
Why do cellular proteins linked to K63-polyubiquitin chains not associate with proteasomes? Nathan, James A.; Tae Kim, Hyoung; Ting, Lily The EMBO Journal, Vol. 32, Issue 4 https://doi.org/10.1038/emboj.2012.354	journal	January 2013
Branching Out: Improved Signaling by Heterotypic Ubiquitin Chains Haakonsen, Diane L.; Rape, Michael Trends in Cell Biology, Vol. 29, Issue 9 https://doi.org/10.1016/j.tcb.2019.06.003	journal	September 2019
Role of Virally-Encoded Deubiquitinating Enzymes in Regulation of the Virus Life Cycle Proulx, Jessica; Borgmann, Kathleen; Park, In-Woo International Journal of Molecular Sciences, Vol. 22, Issue 9 https://doi.org/10.3390/ijms22094438	journal	April 2021
Viral Manipulations of the Cullin-RING Ubiquitin Ligases Liu, Ying; Tan, Xu Advances in Experimental Medicine and Biology https://doi.org/10.1007/978-981-15-1025-0_7	book	January 2020
Ubiquitin conjugation to Gag is essential for ESCRT-mediated HIV-1 budding Sette, Paola; Nagashima, Kunio; Piper, Robert C. Retrovirology, Vol. 10, Issue 1 https://doi.org/10.1186/1742-4690-10-79	journal	July 2013
Ubiquitination of Human Immunodeficiency Virus Type 1 Gag Is Highly Dependent on Gag Membrane Association Jäger, Stefanie; Gottwein, Eva; Kräusslich, Hans-Georg Journal of Virology, Vol. 81, Issue 17 https://doi.org/10.1128/JVI.00044-07	journal	September 2007
Importance of Viral Late Domains in Budding and Release of Enveloped RNA Viruses Welker, Lisa; Paillart, Jean-Christophe; Bernacchi, Serena Viruses, Vol. 13, Issue 8 https://doi.org/10.3390/v13081559	journal	August 2021
Role of ubiquitin and the HPV E6 oncoprotein in E6AP-mediated ubiquitination Mortensen, Franziska; Schneider, Daniel; Barbic, Tanja Proceedings of the National Academy of Sciences, Vol. 112, Issue 32 https://doi.org/10.1073/pnas.1505923112	journal	July 2015
NEDD8 and ubiquitin ligation by cullin-RING E3 ligases Baek, Kheewoong; Scott, Daniel C.; Schulman, Brenda A. Current Opinion in Structural Biology, Vol. 67 https://doi.org/10.1016/j.sbi.2020.10.007	journal	April 2021
Promiscuous Targeting of Cellular Proteins by Vpr Drives Systems-Level Proteomic Remodeling in HIV-1 Infection Greenwood, Edward J. D.; Williamson, James C.; Sienkiewicz, Agata Cell Reports, Vol. 27, Issue 5 https://doi.org/10.1016/j.celrep.2019.04.025	journal	April 2019
Hepatitis B Virus X Protein Promotes Degradation of SMC5/6 to Enhance HBV Replication Murphy, Christopher M.; Xu, Yanping; Li, Feng Cell Reports, Vol. 16, Issue 11 https://doi.org/10.1016/j.celrep.2016.08.026	journal	September 2016
CRL4s: the CUL4-RING E3 ubiquitin ligases Jackson, Sarah; Xiong, Yue Trends in Biochemical Sciences, Vol. 34, Issue 11 https://doi.org/10.1016/j.tibs.2009.07.002	journal	November 2009
Molecular architecture and assembly of the DDB1–CUL4A ubiquitin ligase machinery Angers, Stephane; Li, Ti; Yi, Xianhua Nature, Vol. 443, Issue 7111 https://doi.org/10.1038/nature05175	journal	October 2006
DDB1 functions as a linker to recruit receptor WD40 proteins to CUL4-ROC1 ubiquitin ligases He, Y. J.; McCall, C. M.; Hu, J. Genes & Development, Vol. 20, Issue 21 https://doi.org/10.1101/gad.1483206	journal	November 2006
CUL4–DDB1 ubiquitin ligase interacts with multiple WD40-repeat proteins and regulates histone methylation Higa, Leigh Ann; Wu, Min; Ye, Tao Nature Cell Biology, Vol. 8, Issue 11 https://doi.org/10.1038/ncb1490	journal	October 2006
A Family of Diverse Cul4-Ddb1-Interacting Proteins Includes Cdt2, which Is Required for S Phase Destruction of the Replication Factor Cdt1 Jin, Jianping; Arias, Emily E.; Chen, Jing Molecular Cell, Vol. 23, Issue 5 https://doi.org/10.1016/j.molcel.2006.08.010	journal	September 2006
Hepatitis B Virus HBx Protein Mediates the Degradation of Host Restriction Factors through the Cullin 4 DDB1 E3 Ubiquitin Ligase Complex Minor, Marissa M.; Hollinger, F. Blaine; McNees, Adrienne L. Cells, Vol. 9, Issue 4 https://doi.org/10.3390/cells9040834	journal	March 2020
DCAFs, the Missing Link of the CUL4-DDB1 Ubiquitin Ligase Lee, Jennifer; Zhou, Pengbo Molecular Cell, Vol. 26, Issue 6 https://doi.org/10.1016/j.molcel.2007.06.001	journal	June 2007
The Molecular Basis of CRL4DDB2/CSA Ubiquitin Ligase Architecture, Targeting, and Activation Fischer, Eric S.; Scrima, Andrea; Böhm, Kerstin Cell, Vol. 147, Issue 5 https://doi.org/10.1016/j.cell.2011.10.035	journal	November 2011
Structural Basis of UV DNA-Damage Recognition by the DDB1–DDB2 Complex Scrima, Andrea; Koníčková, Renata; Czyzewski, Bryan K. Cell, Vol. 135, Issue 7 https://doi.org/10.1016/j.cell.2008.10.045	journal	December 2008
The DDB1–DCAF1–Vpr–UNG2 crystal structure reveals how HIV-1 Vpr steers human UNG2 toward destruction Wu, Ying; Zhou, Xiaohong; Barnes, Christopher O. Nature Structural & Molecular Biology, Vol. 23, Issue 10 https://doi.org/10.1038/nsmb.3284	journal	August 2016
A promiscuous α-helical motif anchors viral hijackers and substrate receptors to the CUL4–DDB1 ubiquitin ligase machinery Li, Ti; Robert, Eva I.; van Breugel, Pieter C. Nature Structural & Molecular Biology, Vol. 17, Issue 1 https://doi.org/10.1038/nsmb.1719	journal	December 2009
Structure of DDB1 in Complex with a Paramyxovirus V Protein: Viral Hijack of a Propeller Cluster in Ubiquitin Ligase Li, Ti; Chen, Xiujuan; Garbutt, Kenneth C. Cell, Vol. 124, Issue 1 https://doi.org/10.1016/j.cell.2005.10.033	journal	January 2006
Hepatitis B virus X protein identifies the Smc5/6 complex as a host restriction factor Decorsière, Adrien; Mueller, Henrik; van Breugel, Pieter C. Nature, Vol. 531, Issue 7594 https://doi.org/10.1038/nature17170	journal	March 2016
The V Protein of the Paramyxovirus SV5 Interacts with Damage-Specific DNA Binding Protein Lin, Grace Y.; Paterson, Reay G.; Richardson, Christopher D. Virology, Vol. 249, Issue 1 https://doi.org/10.1006/viro.1998.9317	journal	September 1998
The Human Cytomegalovirus pUL145 Isoforms Act as Viral DDB1-Cullin-Associated Factors to Instruct Host Protein Degradation to Impede Innate Immunity Le-Trilling, Vu Thuy Khanh; Becker, Tanja; Nachshon, Aharon Cell Reports, Vol. 30, Issue 7 https://doi.org/10.1016/j.celrep.2020.01.070	journal	February 2020
High-Definition Analysis of Host Protein Stability during Human Cytomegalovirus Infection Reveals Antiviral Factors and Viral Evasion Mechanisms Nightingale, Katie; Lin, Kai-Min; Ravenhill, Benjamin J. Cell Host & Microbe, Vol. 24, Issue 3 https://doi.org/10.1016/j.chom.2018.07.011	journal	September 2018
Detecting Remote Sequence Homology in Disordered Proteins: Discovery of Conserved Motifs in the N-Termini of Mononegavirales phosphoproteins Karlin, David; Belshaw, Robert PLoS ONE, Vol. 7, Issue 3 https://doi.org/10.1371/journal.pone.0031719	journal	March 2012
Water Networks Can Determine the Affinity of Ligand Binding to Proteins Darby, John F.; Hopkins, Adam P.; Shimizu, Seishi Journal of the American Chemical Society, Vol. 141, Issue 40 https://doi.org/10.1021/jacs.9b06275	journal	September 2019
Simian Virus 5 V Protein Acts as an Adaptor, Linking DDB1 to STAT2, To Facilitate the Ubiquitination of STAT1 Precious, B.; Childs, K.; Fitzpatrick-Swallow, V. Journal of Virology, Vol. 79, Issue 21 https://doi.org/10.1128/JVI.79.21.13434-13441.2005	journal	November 2005
Human cytomegalovirus protein RL1 degrades the antiviral factor SLFN11 via recruitment of the CRL4 E3 ubiquitin ligase complex Nightingale, Katie; Potts, Martin; Hunter, Leah M. Proceedings of the National Academy of Sciences, Vol. 119, Issue 6 https://doi.org/10.1073/pnas.2108173119	journal	February 2022
Cullin E3 Ligases and Their Rewiring by Viral Factors Mahon, Cathal; Krogan, Nevan; Craik, Charles Biomolecules, Vol. 4, Issue 4 https://doi.org/10.3390/biom4040897	journal	October 2014
Cellular Cullin RING Ubiquitin Ligases: Druggable Host Dependency Factors of Cytomegaloviruses Becker, Tanja; Le-Trilling, Vu; Trilling, Mirko International Journal of Molecular Sciences, Vol. 20, Issue 7 https://doi.org/10.3390/ijms20071636	journal	April 2019
Methyltransferase PRMT1 Is a Binding Partner of HBx and a Negative Regulator of Hepatitis B Virus Transcription Benhenda, Shirine; Ducroux, Aurélie; Rivière, Lise Journal of Virology, Vol. 87, Issue 8 https://doi.org/10.1128/JVI.02574-12	journal	April 2013
HBx protein is indispensable for development of viraemia in human hepatocyte chimeric mice Tsuge, M.; Hiraga, N.; Akiyama, R. Journal of General Virology, Vol. 91, Issue 7 https://doi.org/10.1099/vir.0.019224-0	journal	March 2010
Enhancement of Hepatitis B Virus Replication by the Regulatory X Protein In Vitro and In Vivo Keasler, Victor V.; Hodgson, Amanda J.; Madden, Charles R. Journal of Virology, Vol. 81, Issue 6 https://doi.org/10.1128/JVI.02020-06	journal	March 2007
PIKES Analysis Reveals Response to Degraders and Key Regulatory Mechanisms of the CRL4 Network Reichermeier, Kurt M.; Straube, Ronny; Reitsma, Justin M. Molecular Cell, Vol. 77, Issue 5 https://doi.org/10.1016/j.molcel.2019.12.013	journal	March 2020
Vpr Targets TET2 for Degradation by CRL4VprBP E3 Ligase to Sustain IL-6 Expression and Enhance HIV-1 Replication Lv, Lei; Wang, Qi; Xu, Yanping Molecular Cell, Vol. 70, Issue 5 https://doi.org/10.1016/j.molcel.2018.05.007	journal	June 2018
Human cytomegalovirus interactome analysis identifies degradation hubs, domain associations and viral protein functions Nobre, Luis V.; Nightingale, Katie; Ravenhill, Benjamin J. eLife, Vol. 8 https://doi.org/10.7554/eLife.49894	journal	December 2019
Optimization of overlap extension PCR for efficient transgene construction Hilgarth, Roland S.; Lanigan, Thomas M. MethodsX, Vol. 7 https://doi.org/10.1016/j.mex.2019.12.001	journal	January 2020
High-Efficiency Solid Phase Peptide Synthesis ( HE -SPPS) Collins, Jonathan M.; Porter, Keith A.; Singh, Sandeep K. Organic Letters, Vol. 16, Issue 3 https://doi.org/10.1021/ol4036825	journal	January 2014
Jalview Version 2--a multiple sequence alignment editor and analysis workbench Waterhouse, A. M.; Procter, J. B.; Martin, D. M. A. Bioinformatics, Vol. 25, Issue 9 https://doi.org/10.1093/bioinformatics/btp033	journal	January 2009
WebLogo: A Sequence Logo Generator Crooks, Gavin E.; Hon, Gary; Chandonia, John-Marc Genome Research, Vol. 14, Issue 6, p. 1188-1190 https://doi.org/10.1101/gr.849004	journal	May 2004
Better together: Elements of successful scientific software development in a distributed collaborative community Koehler Leman, Julia; Weitzner, Brian D.; Renfrew, P. Douglas PLOS Computational Biology, Vol. 16, Issue 5 https://doi.org/10.1371/journal.pcbi.1007507	journal	May 2020
Macromolecular modeling and design in Rosetta: recent methods and frameworks Leman, Julia Koehler; Weitzner, Brian D.; Lewis, Steven M. Nature Methods, Vol. 17, Issue 7 https://doi.org/10.1038/s41592-020-0848-2	journal	June 2020

Similar Records

The tomato DWD motif-containing protein DDI1 interacts with the CUL4–DDB1-based ubiquitin ligase and plays a pivotal role in abiotic stress responses

Journal Article · 2014 · Biochemical and Biophysical Research Communications · OSTI ID:1900908

Miao, Min; Zhu, Yunye; Qiao, Maiju; +4 more

Insights into links between autophagy and the ubiquitin system from the structure of LC3B bound to the LIR motif from the E3 ligase NEDD4: Crystal Structure of LC3B Bound to LIR from NEDD4

Journal Article · 2017 · Protein Science · OSTI ID:1900908

Qiu, Yu; Zheng, Yumei; Wu, Kuen-Phon; +1 more

Structures of SPOP-Substrate Complexes: Insights into Molecular Architectures of BTB-Cul3 Ubiquitin Ligases

Journal Article · 2009 · Mol. Cell · OSTI ID:1900908

Zhuang, Min; Calabrese, Matthew F; Liu, Jiang; +11 more

Title: Insight into Viral Hijacking of CRL4 Ubiquitin Ligase through Structural Analysis of the pUL145-DDB1

Citation Formats

References (54)

Similar Records

Related Subjects