Skip to main content
U.S. Department of Energy
Office of Scientific and Technical Information

Insight into Viral Hijacking of CRL4 Ubiquitin Ligase through Structural Analysis of the pUL145-DDB1

Journal Article · · J. Virol.
DOI:https://doi.org/10.1128/jvi.00826-22· OSTI ID:1900908

Research Organization:
Advanced Photon Source (APS), Argonne National Laboratory (ANL), Argonne, IL (US)
Sponsoring Organization:
DOE - Office Of Science; DOE - BASIC ENERGY SCIENCES; NIH
OSTI ID:
1900908
Journal Information:
J. Virol., Journal Name: J. Virol. Journal Issue: (17) Vol. 96
Country of Publication:
United States
Language:
ENGLISH

References (55)

Ubiquitin conjugation to Gag is essential for ESCRT-mediated HIV-1 budding journal July 2013
The Anaphase Promoting Complex/Cyclosome (APC/C): A Versatile E3 Ubiquitin Ligase book January 2019
Macromolecular modeling and design in Rosetta: recent methods and frameworks journal June 2020
Methyltransferase PRMT1 Is a Binding Partner of HBx and a Negative Regulator of Hepatitis B Virus Transcription journal April 2013
Better together: Elements of successful scientific software development in a distributed collaborative community journal May 2020
K63 ubiquitylation triggers proteasomal degradation by seeding branched ubiquitin chains journal January 2018
High-Definition Analysis of Host Protein Stability during Human Cytomegalovirus Infection Reveals Antiviral Factors and Viral Evasion Mechanisms journal September 2018
Water Networks Can Determine the Affinity of Ligand Binding to Proteins journal September 2019
The K48-K63 Branched Ubiquitin Chain Regulates NF-κB Signaling journal October 2016
CUL4–DDB1 ubiquitin ligase interacts with multiple WD40-repeat proteins and regulates histone methylation journal October 2006
Hepatitis B Virus HBx Protein Mediates the Degradation of Host Restriction Factors through the Cullin 4 DDB1 E3 Ubiquitin Ligase Complex journal March 2020
The Human Cytomegalovirus pUL145 Isoforms Act as Viral DDB1-Cullin-Associated Factors to Instruct Host Protein Degradation to Impede Innate Immunity journal February 2020
Jalview Version 2--a multiple sequence alignment editor and analysis workbench journal January 2009
Vpr Targets TET2 for Degradation by CRL4VprBP E3 Ligase to Sustain IL-6 Expression and Enhance HIV-1 Replication journal June 2018
Hepatitis B virus X protein identifies the Smc5/6 complex as a host restriction factor journal March 2016
Human cytomegalovirus protein RL1 degrades the antiviral factor SLFN11 via recruitment of the CRL4 E3 ubiquitin ligase complex journal February 2022
Hepatitis B Virus X Protein Promotes Degradation of SMC5/6 to Enhance HBV Replication journal September 2016
Cullin E3 Ligases and Their Rewiring by Viral Factors journal October 2014
Viral Manipulations of the Cullin-RING Ubiquitin Ligases book January 2020
Structure of DDB1 in Complex with a Paramyxovirus V Protein: Viral Hijack of a Propeller Cluster in Ubiquitin Ligase journal January 2006
Proteomic Profiling of the Human Cytomegalovirus UL35 Gene Products Reveals a Role for UL35 in the DNA Repair Response journal November 2011
Versatile Roles of K63-Linked Ubiquitin Chains in Trafficking journal November 2014
Molecular architecture and assembly of the DDB1–CUL4A ubiquitin ligase machinery journal October 2006
The V Protein of the Paramyxovirus SV5 Interacts with Damage-Specific DNA Binding Protein journal September 1998
HBx protein is indispensable for development of viraemia in human hepatocyte chimeric mice journal March 2010
The DDB1–DCAF1–Vpr–UNG2 crystal structure reveals how HIV-1 Vpr steers human UNG2 toward destruction journal August 2016
Enhancement of Hepatitis B Virus Replication by the Regulatory X Protein In Vitro and In Vivo journal March 2007
Ubiquitylation at the crossroads of development and disease journal September 2017
Optimization of overlap extension PCR for efficient transgene construction journal January 2020
Importance of Viral Late Domains in Budding and Release of Enveloped RNA Viruses journal August 2021
Cellular Cullin RING Ubiquitin Ligases: Druggable Host Dependency Factors of Cytomegaloviruses journal April 2019
CRL4s: the CUL4-RING E3 ubiquitin ligases journal November 2009
Human cytomegalovirus interactome analysis identifies degradation hubs, domain associations and viral protein functions journal December 2019
A Family of Diverse Cul4-Ddb1-Interacting Proteins Includes Cdt2, which Is Required for S Phase Destruction of the Replication Factor Cdt1 journal September 2006
WebLogo: A Sequence Logo Generator journal May 2004
Why do cellular proteins linked to K63-polyubiquitin chains not associate with proteasomes? journal January 2013
High-Efficiency Solid Phase Peptide Synthesis ( HE -SPPS) journal January 2014
The Molecular Basis of CRL4DDB2/CSA Ubiquitin Ligase Architecture, Targeting, and Activation journal November 2011
Promiscuous Targeting of Cellular Proteins by Vpr Drives Systems-Level Proteomic Remodeling in HIV-1 Infection journal April 2019
Species-Specific Host–Virus Interactions: Implications for Viral Host Range and Virulence journal January 2020
PIKES Analysis Reveals Response to Degraders and Key Regulatory Mechanisms of the CRL4 Network journal March 2020
Regulation of Viral Restriction by Post-Translational Modifications journal November 2021
Ubiquitination of Human Immunodeficiency Virus Type 1 Gag Is Highly Dependent on Gag Membrane Association journal September 2007
Ub to no good: How cytomegaloviruses exploit the ubiquitin proteasome system journal May 2020
Role of Virally-Encoded Deubiquitinating Enzymes in Regulation of the Virus Life Cycle journal April 2021
A promiscuous α-helical motif anchors viral hijackers and substrate receptors to the CUL4–DDB1 ubiquitin ligase machinery journal December 2009
DDB1 functions as a linker to recruit receptor WD40 proteins to CUL4-ROC1 ubiquitin ligases journal November 2006
Structural Basis of UV DNA-Damage Recognition by the DDB1–DDB2 Complex journal December 2008
Detecting Remote Sequence Homology in Disordered Proteins: Discovery of Conserved Motifs in the N-Termini of Mononegavirales phosphoproteins journal March 2012
Assembly and Function of Heterotypic Ubiquitin Chains in Cell-Cycle and Protein Quality Control journal November 2017
Role of ubiquitin and the HPV E6 oncoprotein in E6AP-mediated ubiquitination journal July 2015
Simian Virus 5 V Protein Acts as an Adaptor, Linking DDB1 to STAT2, To Facilitate the Ubiquitination of STAT1 journal November 2005
DCAFs, the Missing Link of the CUL4-DDB1 Ubiquitin Ligase journal June 2007
NEDD8 and ubiquitin ligation by cullin-RING E3 ligases journal April 2021
Branching Out: Improved Signaling by Heterotypic Ubiquitin Chains journal September 2019

Similar Records

Structural insights into the mechanism and E2 specificity of the RBR E3 ubiquitin ligase HHARI
Journal Article · 2017 · Nature Communications · OSTI ID:1376241

Mechanistic insight into the allosteric activation of a ubiquitin-conjugating enzyme by RING-type ubiquitin ligases
Journal Article · 2015 · Proceedings of the National Academy of Sciences of the United States of America · OSTI ID:1223395

Structures of SPOP-Substrate Complexes: Insights into Molecular Architectures of BTB-Cul3 Ubiquitin Ligases
Journal Article · 2009 · Mol. Cell · OSTI ID:1005925

Related Subjects