|
Design, synthesis and crystallographic analysis of nitrile-based broad-spectrum peptidomimetic inhibitors for coronavirus 3C-like proteases
|
journal
|
January 2013 |
|
Identification of mutation resistance coldspots for targeting the SARS‐CoV2 main protease
|
journal
|
March 2021 |
|
Crystallographic and electrophilic fragment screening of the SARS-CoV-2 main protease
|
journal
|
October 2020 |
|
Defining the substrate envelope of SARS-CoV-2 main protease to predict and avoid drug resistance
|
journal
|
June 2022 |
|
Malleability of the SARS-CoV-2 3CL Mpro Active-Site Cavity Facilitates Binding of Clinical Antivirals
|
journal
|
December 2020 |
|
Features and development of Coot
|
journal
|
March 2010 |
|
A new coronavirus associated with human respiratory disease in China
|
journal
|
February 2020 |
|
Structural plasticity of SARS-CoV-2 3CL Mpro active site cavity revealed by room temperature X-ray crystallography
|
journal
|
June 2020 |
|
Critical Assessment of Important Regions in the Subunit Association and Catalytic Action of the Severe Acute Respiratory Syndrome Coronavirus Main Protease
|
journal
|
April 2005 |
|
Crystallographic structure of wild-type SARS-CoV-2 main protease acyl-enzyme intermediate with physiological C-terminal autoprocessing site
|
journal
|
November 2020 |
|
MolProbity : all-atom structure validation for macromolecular crystallography
|
journal
|
December 2009 |
|
Phaser crystallographic software
|
journal
|
July 2007 |
|
The SARS-CoV-2 main protease as drug target
|
journal
|
September 2020 |
|
Both Boceprevir and GC376 efficaciously inhibit SARS-CoV-2 by targeting its main protease
|
journal
|
September 2020 |
|
Activation and maturation of SARS-CoV main protease
|
journal
|
April 2011 |
|
Characterization of SARS main protease and inhibitor assay using a fluorogenic substrate
|
journal
|
June 2004 |
|
Potent Noncovalent Inhibitors of the Main Protease of SARS-CoV-2 from Molecular Sculpting of the Drug Perampanel Guided by Free Energy Perturbation Calculations
|
journal
|
February 2021 |
|
Mechanistic insights into COVID-19 by global analysis of the SARS-CoV-2 3CLpro substrate degradome
|
journal
|
October 2021 |
|
Structure-guided design of a perampanel-derived pharmacophore targeting the SARS-CoV-2 main protease
|
journal
|
August 2021 |
|
SARS-CoV-2 Mpro inhibitors and activity-based probes for patient-sample imaging
|
journal
|
October 2020 |
|
Inference of Macromolecular Assemblies from Crystalline State
|
journal
|
September 2007 |
|
ACHESYM : an algorithm and server for standardized placement of macromolecular models in the unit cell
|
journal
|
November 2014 |
|
Covid-19: Pfizer’s paxlovid is 89% effective in patients at risk of serious illness, company reports
|
journal
|
November 2021 |
|
Overview of the CCP 4 suite and current developments
|
journal
|
March 2011 |
|
Highly accurate protein structure prediction with AlphaFold
|
journal
|
July 2021 |
|
PHENIX : building new software for automated crystallographic structure determination
|
journal
|
October 2002 |
|
Crystal structure of SARS-CoV-2 main protease provides a basis for design of improved α-ketoamide inhibitors
|
journal
|
March 2020 |
|
Essential covalent linkage between the chymotrypsin-like domain and the extra domain of the SARS-CoV main protease
|
journal
|
August 2010 |
|
Ultralarge Virtual Screening Identifies SARS-CoV-2 Main Protease Inhibitors with Broad-Spectrum Activity against Coronaviruses
|
journal
|
February 2022 |
|
Conservation of substrate specificities among coronavirus main proteases
|
journal
|
March 2002 |
|
Three-dimensional domain swapping as a mechanism to lock the active conformation in a super-active octamer of SARS-CoV main protease
|
journal
|
April 2010 |
|
Michaelis-like complex of SARS-CoV-2 main protease visualized by room-temperature X-ray crystallography
|
journal
|
October 2021 |
|
Main protease mutants of SARS-CoV-2 variants remain susceptible to nirmatrelvir
|
journal
|
April 2022 |
|
A pneumonia outbreak associated with a new coronavirus of probable bat origin
|
journal
|
February 2020 |
|
xia2 : an expert system for macromolecular crystallography data reduction
|
journal
|
December 2009 |
|
XDS
|
journal
|
January 2010 |
|
Polder maps: improving OMIT maps by excluding bulk solvent
|
journal
|
February 2017 |
|
Structural, Electronic, and Electrostatic Determinants for Inhibitor Binding to Subsites S1 and S2 in SARS-CoV-2 Main Protease
|
journal
|
October 2021 |
|
Structural basis for replicase polyprotein cleavage and substrate specificity of main protease from SARS-CoV-2
|
journal
|
April 2022 |
|
Feline coronavirus drug inhibits the main protease of SARS-CoV-2 and blocks virus replication
|
journal
|
August 2020 |
|
How good are my data and what is the resolution?
|
journal
|
June 2013 |
|
Design and synthesis of new tripeptide-type SARS-CoV 3CL protease inhibitors containing an electrophilic arylketone moiety
|
journal
|
January 2013 |
|
Proteases Universally Recognize Beta Strands In Their Active Sites
|
journal
|
March 2005 |
|
Development of potent dipeptide-type SARS-CoV 3CL protease inhibitors with novel P3 scaffolds: Design, synthesis, biological evaluation, and docking studies
|
journal
|
October 2013 |
|
Unusual zwitterionic catalytic site of SARS–CoV-2 main protease revealed by neutron crystallography
|
journal
|
October 2020 |
|
A drug repurposing screen identifies hepatitis C antivirals as inhibitors of the SARS-CoV2 main protease
|
journal
|
February 2021 |
|
N‐Terminomics for the Identification of In Vitro Substrates and Cleavage Site Specificity of the SARS‐CoV‐2 Main Protease
|
journal
|
November 2020 |
|
Boceprevir, GC-376, and calpain inhibitors II, XII inhibit SARS-CoV-2 viral replication by targeting the viral main protease
|
journal
|
June 2020 |
|
Recognition of Divergent Viral Substrates by the SARS-CoV-2 Main Protease
|
journal
|
August 2021 |
|
Structure of Mpro from SARS-CoV-2 and discovery of its inhibitors
|
journal
|
April 2020 |
|
Processing of the SARS-CoV pp1a/ab nsp7–10 region
|
journal
|
March 2020 |
|
Design of Wide-Spectrum Inhibitors Targeting Coronavirus Main Proteases
|
journal
|
September 2005 |
|
Viral cysteine proteinases
|
journal
|
December 1996 |
|
Crowdsourcing drug discovery for pandemics
|
journal
|
June 2020 |
|
An oral SARS-CoV-2 M pro inhibitor clinical candidate for the treatment of COVID-19
|
journal
|
December 2021 |
|
N-Terminomics TAILS Identifies Host Cell Substrates of Poliovirus and Coxsackievirus B3 3C Proteinases That Modulate Virus Infection
|
journal
|
April 2018 |
|
Discovery of Ketone-Based Covalent Inhibitors of Coronavirus 3CL Proteases for the Potential Therapeutic Treatment of COVID-19
|
journal
|
October 2020 |