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Identification and structure-based drug design of cell-active inhibitors of interleukin 17A at a nov

Journal Article · · Sci. Rep.
Research Organization:
Advanced Photon Source (APS), Argonne National Laboratory (ANL), Argonne, IL (US)
Sponsoring Organization:
DOE - Office Of Science; INDUSTRY
DOE Contract Number:
NONE;
OSTI ID:
1900876
Journal Information:
Sci. Rep., Journal Name: Sci. Rep. Vol. 12
Country of Publication:
United States
Language:
ENGLISH

References (30)

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IL-17 Signaling: The Yin and the Yang journal May 2017
Discovery of an Oral, Rule of 5 Compliant, Interleukin 17A Protein–Protein Interaction Modulator for the Potential Treatment of Psoriasis and Other Inflammatory Diseases journal June 2022
Crystal structures of interleukin 17A and its complex with IL-17 receptor A journal May 2013
The adaptor Act1 is required for interleukin 17–dependent signaling associated with autoimmune and inflammatory disease journal February 2007
The IL-23–IL-17 immune axis: from mechanisms to therapeutic testing journal August 2014
The IL-23–IL-17 axis in inflammatory arthritis journal April 2015
Effects of the IL-23–IL-17 pathway on bone in spondyloarthritis journal September 2018
IL-17 receptor–based signaling and implications for disease journal November 2019
Inhibiting complex IL-17A and IL-17RA interactions with a linear peptide journal May 2016
Binding site elucidation and structure guided design of macrocyclic IL-17A antagonists journal August 2016
Act1 Adaptor Protein Is an Immediate and Essential Signaling Component of Interleukin-17 Receptor journal November 2006
Biologics that inhibit the Th17 pathway and related cytokines to treat inflammatory disorders journal August 2017
Anti IL-17 in psoriasis journal October 2019
Targeting interleukin-17 in chronic inflammatory disease: A clinical perspective journal November 2019
Interleukin-17 cytokines: Effectors and targets in psoriasis—A breakthrough in understanding and treatment journal November 2019
Phaser crystallographic software journal July 2007
Refinement of severely incomplete structures with maximum likelihood in BUSTER–TNT journal November 2004
Coot model-building tools for molecular graphics journal November 2004
Automated ligand placement and refinement with a combined force field and shape potential journal June 2006
REFMAC 5 for the refinement of macromolecular crystal structures journal March 2011
Data processing and analysis with the autoPROC toolbox journal March 2011
Macromolecular structure determination using X-rays, neutrons and electrons: recent developments in Phenix journal October 2019
Discovering High-Affinity Ligands for Proteins: SAR by NMR journal November 1996
IL-17 targeted therapies for psoriasis journal June 2013
Anti-IL-17 phase II data for psoriasis: A review journal February 2014
TRAF Regulation of IL-17 Cytokine Signaling journal June 2019

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