skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Structure and Function of a Dehydrating Condensation Domain in Nonribosomal Peptide Biosynthesis

Journal Article · · J. Am. Chem. Soc.
DOI:· OSTI ID:1900853

Research Organization:
Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Sponsoring Organization:
DOE - Office Of Science; National Science Foundation (NSF)
Journal Information:
J. Am. Chem. Soc., Vol. 144, Issue (31)
Country of Publication:
United States

References (65)

Structure and Mechanism of the Lantibiotic Cyclase Involved in Nisin Biosynthesis journal March 2006
Characterization of a Gene Cluster Responsible for the Biosynthesis of Anticancer Agent FK228 in Chromobacterium violaceum No. 968 journal June 2007
Structural organization of microcystin biosynthesis in Microcystis aeruginosa PCC7806: an integrated peptide–polyketide synthetase system journal October 2000
Dehydroamino acids: chemical multi-tools for late-stage diversification journal January 2019
Synthesis of modified proteins via functionalization of dehydroalanine journal October 2018
Mechanistic Understanding of Lanthipeptide Biosynthetic Enzymes journal January 2017
Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature journal January 2013
The biosynthetic gene cluster for the antitumor drug bleomycin from Streptomyces verticillus ATCC15003 supporting functional interactions between nonribosomal peptide synthetases and a polyketide synthase journal August 2000
Discovery and Biosynthesis of Azabicyclene, a Conserved Nonribosomal Peptide in Pseudomonas aeruginosa journal May 2019
Insights into the chemical logic and enzymatic machinery of NRPS assembly lines journal January 2016
Nonribosomal Peptide Synthesis-Principles and Prospects journal March 2017
Predictive, structure-based model of amino acid recognition by nonribosomal peptide synthetase adenylation domains journal March 2000
The specificity-conferring code of adenylation domains in nonribosomal peptide synthetases journal August 1999
The Natural Product Domain Seeker NaPDoS: A Phylogeny Based Bioinformatic Tool to Classify Secondary Metabolite Gene Diversity journal March 2012
In Vitro Biosynthesis of the Nonproteinogenic Amino Acid Methoxyvinylglycine journal May 2018
Discovery and Biosynthetic Investigation of a New Antibacterial Dehydrated Non‐Ribosomal Tripeptide journal December 2020
Evolutionary and functional analysis of an NRPS condensation domain integrates β-lactam, ᴅ-amino acid, and dehydroamino acid synthesis journal April 2021
Acyl Donor Stringency and Dehydroaminoacyl Intermediates in β-Lactam Formation by a Non-ribosomal Peptide Synthetase journal April 2021
The plant pathogen Pseudomonas aeruginosa triggers a DELLA-dependent seed germination arrest in Arabidopsis journal August 2018
Biochemical Determination of Enzyme-Bound Metabolites: Preferential Accumulation of a Programmed Octaketide on the Enediyne Polyketide Synthase CalE8 journal September 2013
Structural and functional aspects of the nonribosomal peptide synthetase condensation domain superfamily: discovery, dissection and diversity journal November 2017
Crystal Structures of the First Condensation Domain of CDA Synthetase Suggest Conformational Changes during the Synthetic Cycle of Nonribosomal Peptide Synthetases journal September 2013
Structures of a non-ribosomal peptide synthetase condensation domain suggest the basis of substrate selectivity journal May 2021
FilterDCA: Interpretable supervised contact prediction using inter-domain coevolution journal October 2020
Structures of a dimodular nonribosomal peptide synthetase reveal conformational flexibility journal November 2019
Crystal Structure of the Termination Module of a Nonribosomal Peptide Synthetase journal August 2008
The structural basis of N-acyl-α-amino-β-lactone formation catalyzed by a nonribosomal peptide synthetase journal July 2019
Structures of two distinct conformations of holo-non-ribosomal peptide synthetases journal January 2016
Structures of a Nonribosomal Peptide Synthetase Module Bound to MbtH-like Proteins Support a Highly Dynamic Domain Architecture journal September 2016
X-Ray Crystallography and Electron Microscopy of Cross- and Multi-Module Nonribosomal Peptide Synthetase Proteins Reveal a Flexible Architecture journal May 2017
Structures of teixobactin-producing nonribosomal peptide synthetase condensation and adenylation domains journal January 2020
X-domain of peptide synthetases recruits oxygenases crucial for glycopeptide biosynthesis journal February 2015
The structure of VibH represents nonribosomal peptide synthetase condensation, cyclization and epimerization domains journal June 2002
Mutational analysis of the C-domain in nonribosomal peptide synthesis: Catalysis of nonribosomal peptide-bond formation journal January 2002
Minimum Information about a Biosynthetic Gene cluster journal August 2015
Nonribosomal Assembly of Natural Lipocyclocarbamate Lipoprotein-Associated Phospholipase Inhibitors journal February 2013
A combination of polyunsaturated fatty acid, nonribosomal peptide and polyketide biosynthetic machinery is used to assemble the zeamine antibiotics journal January 2015
The tallysomycin biosynthetic gene cluster from Streptoalloteichus hindustanus E465-94 ATCC 31158 unveiling new insights into the biosynthesis of the bleomycin family of antitumor antibiotics journal January 2007
The biosyntheticgene cluster of zorbamycin, a member of the bleomycin family of antitumor antibiotics, from Streptomyces flavoviridis ATCC 21892 journal January 2009
Discovery of a Single Monooxygenase that Catalyzes Carbamate Formation and Ring Contraction in the Biosynthesis of the Legonmycins journal July 2015
Biosynthetic Origin of the Antibiotic Cyclocarbamate Brabantamide A (SB-253514) in Plant-AssociatedPseudomonas. journal January 2014
Single-bacterial genomics validates rich and varied specialized metabolism of uncultivated Entotheonella sponge symbionts journal February 2018
Fabclavines: Bioactive Peptide-Polyketide-Polyamino Hybrids fromXenorhabdus journal February 2014
The EFI Web Resource for Genomic Enzymology Tools: Leveraging Protein, Genome, and Metagenome Databases to Discover Novel Enzymes and Metabolic Pathways journal September 2019
Generation of D Amino Acid Residues in Assembly of Arthrofactin by Dual Condensation/Epimerization Domains journal November 2005
Structural and mutational analysis of the nonribosomal peptide synthetase heterocyclization domain provides insight into catalysis journal December 2016
Timing of Epimerization and Condensation Reactions in Nonribosomal Peptide Assembly Lines:  Kinetic Analysis of Phenylalanine Activating Elongation Modules of Tyrocidine Synthetase B journal June 2002
Catalytically Inactive Condensation Domain C1 Is Responsible for the Dimerization of the VibF Subunit of Vibriobactin Synthetase journal August 2004
Reconstruction of the saframycin core scaffold defines dual Pictet-Spengler mechanisms journal May 2010
Structural and Functional Analyses of the Tridomain‐Nonribosomal Peptide Synthetase FmoA3 for 4‐Methyloxazoline Ring Formation journal May 2021
Structural basis of keto acid utilization in nonribosomal depsipeptide synthesis journal February 2020
Recruitment and Regulation of the Non-ribosomal Peptide Synthetase Modifying Cytochrome P450 Involved in Nikkomycin Biosynthesis journal March 2017
Characterization of SyrC, an Aminoacyltransferase Shuttling Threonyl and Chlorothreonyl Residues in the Syringomycin Biosynthetic Assembly Line journal January 2007
GliP, a Multimodular Nonribosomal Peptide Synthetase in Aspergillus fumigatus , Makes the Diketopiperazine Scaffold of Gliotoxin journal November 2006
Diketopiperazine Formation in Fungi Requires Dedicated Cyclization and Thiolation Domains journal August 2019
Dissection of the EntF Condensation Domain Boundary and Active Site Residues in Nonribosomal Peptide Synthesis journal February 2003
Mutational Analysis of the Epimerization Domain in the Initiation Module PheATE of Gramicidin S Synthetase journal May 2000
Chemical Probes Allow Structural Insight into the Condensation Reaction of Nonribosomal Peptide Synthetases journal March 2016
Structure and stereochemistry of three phytotoxins, syringomycin, syringotoxin and syringostatin, produced by pseudomonas syringae pv. syringae journal January 1992
Syringopeptins, new phytotoxic lipodepsipeptides of Pseudomonas syringae pv. syringae journal October 1991
Synergistic activity of cosecreted natural products from amoebae-associated bacteria journal March 2018
How good are my data and what is the resolution? journal June 2013
PHENIX: a comprehensive Python-based system for macromolecular structure solution journal January 2010
SWISS-MODEL: homology modelling of protein structures and complexes journal May 2018
Features and development of Coot journal March 2010