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Title: Vaccine-elicited murine antibody WS6 neutralizes diverse beta-coronaviruses by recognizing a helical

Journal Article · · Structure

Research Organization:
Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Sponsoring Organization:
DOE - Office Of Science; National Institutes of Health (NIH)
OSTI ID:
1900848
Journal Information:
Structure, Vol. 30, Issue (9)
Country of Publication:
United States
Language:
ENGLISH

References (57)

PHENIX: a comprehensive Python-based system for macromolecular structure solution journal January 2010
Fast computation of minimum hybridization networks journal November 2011
Omicron variant of SARS‐CoV‐2: Genomics, transmissibility, and responses to current COVID‐19 vaccines journal January 2022
Structures of Human Antibodies Bound to SARS-CoV-2 Spike Reveal Common Epitopes and Recurrent Features of Antibodies journal August 2020
A Human T-Cell Leukemia Virus Type 1 Regulatory Element Enhances the Immunogenicity of Human Immunodeficiency Virus Type 1 DNA Vaccines in Mice and Nonhuman Primates journal June 2005
Quadrivalent influenza nanoparticle vaccines induce broad protection journal March 2021
Potent neutralizing antibodies from COVID-19 patients define multiple targets of vulnerability journal June 2020
Distinct conformational states of SARS-CoV-2 spike protein journal July 2020
Potent Neutralizing Antibodies against SARS-CoV-2 Identified by High-Throughput Single-Cell Sequencing of Convalescent Patients’ B Cells journal July 2020
Potent SARS-CoV-2 neutralizing antibodies directed against spike N-terminal domain target a single supersite journal May 2021
The CCP4 suite programs for protein crystallography journal September 1994
SARS-CoV-2 mRNA vaccine design enabled by prototype pathogen preparedness journal August 2020
Identification of a Novel Coronavirus in Patients with Severe Acute Respiratory Syndrome journal May 2003
Coot model-building tools for molecular graphics journal November 2004
mRNA-based COVID-19 vaccine boosters induce neutralizing immunity against SARS-CoV-2 Omicron variant journal February 2022
Stabilized coronavirus spike stem elicits a broadly protective antibody journal November 2021
A rapid micromethod for the determination of nitrogen and phosphate in biological material journal October 1974
Human neutralizing antibodies elicited by SARS-CoV-2 infection journal May 2020
Self-assembling influenza nanoparticle vaccines elicit broadly neutralizing H1N1 antibodies journal May 2013
Structures and distributions of SARS-CoV-2 spike proteins on intact virions journal August 2020
Antibody Lineages with Vaccine-Induced Antigen-Binding Hotspots Develop Broad HIV Neutralization journal July 2019
Fusion peptide of HIV-1 as a site of vulnerability to neutralizing antibody journal May 2016
Inference of Macromolecular Assemblies from Crystalline State journal September 2007
A Novel Coronavirus Associated with Severe Acute Respiratory Syndrome journal May 2003
Clustal W and Clustal X version 2.0 journal September 2007
IMGT®, the international ImMunoGeneTics information system® 25 years on journal November 2014
Structural basis and mode of action for two broadly neutralizing antibodies against SARS-CoV-2 emerging variants of concern journal January 2022
Linear epitope landscape of the SARS-CoV-2 Spike protein constructed from 1,051 COVID-19 patients journal March 2021
Striking antibody evasion manifested by the Omicron variant of SARS-CoV-2 journal December 2021
Potent neutralizing antibodies against multiple epitopes on SARS-CoV-2 spike journal July 2020
High-throughput immune repertoire analysis with IGoR journal February 2018
N-terminal domain antigenic mapping reveals a site of vulnerability for SARS-CoV-2 journal April 2021
Phaser crystallographic software journal July 2007
Efficient transfer, integration, and sustained long-term expression of the transgene in adult rat brains injected with a lentiviral vector. journal October 1996
[20] Processing of X-ray diffraction data collected in oscillation mode book January 1997
SARS-CoV-2 Omicron Variant Neutralization after mRNA-1273 Booster Vaccination journal March 2022
Broad betacoronavirus neutralization by a stem helix–specific human antibody journal September 2021
cryoSPARC: algorithms for rapid unsupervised cryo-EM structure determination journal February 2017
Convergent antibody responses to SARS-CoV-2 in convalescent individuals journal June 2020
Isolation of potent SARS-CoV-2 neutralizing antibodies and protection from disease in a small animal model journal June 2020
Structural basis for broad coronavirus neutralization journal May 2021
OLGA: fast computation of generation probabilities of B- and T-cell receptor amino acid sequences and motifs journal January 2019
Analysis of a SARS-CoV-2-Infected Individual Reveals Development of Potent Neutralizing Antibodies with Limited Somatic Mutation journal July 2020
Antibodies elicited by SARS-CoV-2 infection or mRNA vaccines have reduced neutralizing activity against Beta and Omicron pseudoviruses journal March 2022
Neutralizing and protective human monoclonal antibodies recognizing the N-terminal domain of the SARS-CoV-2 spike protein journal April 2021
A conserved immunogenic and vulnerable site on the coronavirus spike protein delineated by cross-reactive monoclonal antibodies journal March 2021
Ultrapotent antibodies against diverse and highly transmissible SARS-CoV-2 variants journal July 2021
MolProbity: More and better reference data for improved all-atom structure validation: PROTEIN SCIENCE.ORG journal November 2017
Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation journal February 2020
Focused Evolution of HIV-1 Neutralizing Antibodies Revealed by Structures and Deep Sequencing journal August 2011
Epitope-based vaccine design yields fusion peptide-directed antibodies that neutralize diverse strains of HIV-1 journal June 2018
Hemagglutinin-stem nanoparticles generate heterosubtypic influenza protection journal August 2015
Isolation of a Novel Coronavirus from a Man with Pneumonia in Saudi Arabia journal November 2012
A pneumonia outbreak associated with a new coronavirus of probable bat origin journal February 2020
Structure-Based Design with Tag-Based Purification and In-Process Biotinylation Enable Streamlined Development of SARS-CoV-2 Spike Molecular Probes journal October 2020
A Novel Coronavirus from Patients with Pneumonia in China, 2019 journal February 2020
Rapid isolation and profiling of a diverse panel of human monoclonal antibodies targeting the SARS-CoV-2 spike protein journal July 2020