skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: LAG3 ectodomain structure reveals functional interfaces for ligand and antibody recognition

Journal Article · · Nat. Immunol.
; ; ; ; ; ; ; ; ; ;

Research Organization:
Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Sponsoring Organization:
DOE - Office Of Science
OSTI ID:
1900816
Journal Information:
Nat. Immunol., Vol. 23
Country of Publication:
United States
Language:
ENGLISH

References (61)

A decade of immune-checkpoint inhibitors in cancer therapy journal July 2020
Mechanism-driven biomarkers to guide immune checkpoint blockade in cancer therapy journal April 2016
A rheostat for immune responses: the unique properties of PD-1 and their advantages for clinical application journal November 2013
Clinical blockade of PD1 and LAG3 — potential mechanisms of action journal December 2014
LAG-3: a very singular immune checkpoint journal November 2018
The Next-Generation Immune Checkpoint LAG-3 and Its Therapeutic Potential in Oncology: Third Time’s a Charm journal December 2020
PD-1 and LAG-3 inhibitory co-receptors act synergistically to prevent autoimmunity in mice journal February 2011
LAG3 limits regulatory T cell proliferation and function in autoimmune diabetes journal March 2017
Resistance to PD1 blockade in the absence of metalloprotease-mediated LAG3 shedding journal July 2020
Profiling the inhibitory receptors LAG-3, TIM-3, and TIGIT in renal cell carcinoma reveals malignancy journal September 2021
A first-in-human phase I study of FS118, an anti-LAG-3/PD-L1 bispecific antibody in patients with solid tumors that have progressed on prior PD-1/PD-L1 therapy. journal May 2019
Relatlimab and Nivolumab versus Nivolumab in Untreated Advanced Melanoma journal January 2022
Inhibitory receptor agonists: the future of autoimmune disease therapeutics? journal December 2020
Gut environment-induced intraepithelial autoreactive CD4+ T cells suppress central nervous system autoimmunity via LAG-3 journal May 2016
A LAG-3–Specific Agonist Antibody for the Treatment of T Cell–Induced Autoimmune Diseases journal January 2020
CD4/major histocompatibility complex class II interaction analyzed with CD4- and lymphocyte activation gene-3 (LAG-3)-Ig fusion proteins journal September 1995
LAG-3: from molecular functions to clinical applications journal September 2020
Establishment of engineered cell-based assays mediating LAG3 and PD1 immune suppression enables potency measurement of blocking antibodies and assessment of signal transduction journal May 2018
Cutting Edge: Molecular Analysis of the Negative Regulatory Function of Lymphocyte Activation Gene-3 journal November 2002
Atypical motifs in the cytoplasmic region of the inhibitory immune co-receptor LAG-3 inhibit T cell activation journal April 2019
Lymphocyte-activation gene 3/major histocompatibility complex class II interaction modulates the antigenic response of CD4+ T lymphocytes journal December 1994
Mouse CD4 binds MHC class II with extremely low affinity journal January 1993
LAG-3 inhibits the activation of CD4+ T cells that recognize stable pMHCII through its conformation-dependent recognition of pMHCII journal October 2018
Characterization of the major histocompatibility complex class II binding site on LAG-3 protein journal May 1997
LAG3’s Enigmatic Mechanism of Action journal January 2021
Fibrinogen-like Protein 1 Is a Major Immune Inhibitory Ligand of LAG-3 journal January 2019
LSECtin Expressed on Melanoma Cells Promotes Tumor Progression by Inhibiting Antitumor T-cell Responses journal June 2014
Galectin-3 Shapes Antitumor Immune Responses by Suppressing CD8+ T Cells via LAG-3 and Inhibiting Expansion of Plasmacytoid Dendritic Cells journal April 2015
Pathological α-synuclein transmission initiated by binding lymphocyte-activation gene 3 journal September 2016
Mechanistic basis for receptor-mediated pathological α-synuclein fibril cell-to-cell transmission in Parkinson's disease journal June 2021
Development of a novel human phage display-derived anti-LAG3 scFv antibody targeting CD8+ T lymphocyte exhaustion journal October 2019
Amino acid side-chain partition energies and distribution of residues in soluble proteins journal January 1985
Tolerance of point substitution of methionine for isoleucine in hen egg white lysozyme journal June 2001
Crystal structure of the human CD4 N-terminal two-domain fragment complexed to a class II MHC molecule journal September 2001
Biochemical Analysis of the Regulatory T Cell Protein Lymphocyte Activation Gene-3 (LAG-3; CD223) journal November 2004
Antigen exposure shapes the ratio between antigen-specific Tregs and conventional T cells in human peripheral blood journal September 2016
Delineation of the minimal encephalitogenic epitope within the immunodominant region of myelin oligodendrocyte glycoprotein: diverse Vβ gene usage by T cells recognizing the core epitope encephalitogenic for T cell receptor Vβb and T cell receptor Vβa H-2b mice journal October 1996
Characterization of MHC- and TCR-binding residues of the myelin oligodendrocyte glycoprotein 38–51 peptide journal January 2004
Molecular characterization of HLA class II binding to the LAG‐3 T cell co‐inhibitory receptor journal October 2020
Regulation of MHC class II expression in human T-cell malignancies journal February 2004
Secondary-structure matching (SSM), a new tool for fast protein structure alignment in three dimensions journal November 2004
Crystal Structure of the Tetrameric Fibrinogen-like Recognition Domain of Fibrinogen C Domain Containing 1 (FIBCD1) Protein journal January 2014
Structural basis of Tie2 activation and Tie2/Tie1 heterodimerization journal April 2017
Two fibrinogen-like proteins, FGL1 and FGL2 are disulfide-linked subunits of oligomers that specifically bind nonviable spermatozoa journal November 2016
Topological control of cytokine receptor signaling induces differential effects in hematopoiesis journal May 2019
Ligand regulation of a constitutively dimeric EGF receptor journal June 2015
Dimerization of Tie2 mediated by its membrane-proximal FNIII domains journal April 2017
LAP, a lymphocyte activation gene-3 (LAG-3)-associated protein that binds to a repeated EP motif in the intracellular region of LAG-3, may participate in the down-regulation of the CD3/TCR activation pathway journal October 2001
Fibrinogen-like protein 1, a hepatocyte derived protein is an acute phase reactant journal January 2008
Integration, scaling, space-group assignment and post-refinement journal January 2010
[20] Processing of X-ray diffraction data collected in oscillation mode book January 1997
HKL -3000: the integration of data reduction and structure solution – from diffraction images to an initial model in minutes journal July 2006
Phaser crystallographic software journal July 2007
The Phyre2 web portal for protein modeling, prediction and analysis journal May 2015
PHENIX: a comprehensive Python-based system for macromolecular structure solution journal January 2010
Towards automated crystallographic structure refinement with phenix.refine journal March 2012
Coot model-building tools for molecular graphics journal November 2004
Inference of Macromolecular Assemblies from Crystalline State journal September 2007
The DynDom database of protein domain motions journal July 2003
The HADDOCK2.2 Web Server: User-Friendly Integrative Modeling of Biomolecular Complexes journal February 2016
Structural Biology in the Clouds: The WeNMR-EOSC Ecosystem journal July 2021

Similar Records

Related Subjects