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The Next-Generation Immune Checkpoint LAG-3 and Its Therapeutic Potential in Oncology: Third Time’s a Charm
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Pathological α-synuclein transmission initiated by binding lymphocyte-activation gene 3
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Mechanism-driven biomarkers to guide immune checkpoint blockade in cancer therapy
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Mouse CD4 binds MHC class II with extremely low affinity
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Characterization of the major histocompatibility complex class II binding site on LAG-3 protein
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Antigen exposure shapes the ratio between antigen-specific Tregs and conventional T cells in human peripheral blood
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Lymphocyte-activation gene 3/major histocompatibility complex class II interaction modulates the antigenic response of CD4+ T lymphocytes
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LSECtin Expressed on Melanoma Cells Promotes Tumor Progression by Inhibiting Antitumor T-cell Responses
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Delineation of the minimal encephalitogenic epitope within the immunodominant region of myelin oligodendrocyte glycoprotein: diverse Vβ gene usage by T cells recognizing the core epitope encephalitogenic for T cell receptor Vβb and T cell receptor Vβa H-2b mice
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Crystal Structure of the Tetrameric Fibrinogen-like Recognition Domain of Fibrinogen C Domain Containing 1 (FIBCD1) Protein
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Galectin-3 Shapes Antitumor Immune Responses by Suppressing CD8+ T Cells via LAG-3 and Inhibiting Expansion of Plasmacytoid Dendritic Cells
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Profiling the inhibitory receptors LAG-3, TIM-3, and TIGIT in renal cell carcinoma reveals malignancy
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LAG-3: from molecular functions to clinical applications
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LAG3 limits regulatory T cell proliferation and function in autoimmune diabetes
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Two fibrinogen-like proteins, FGL1 and FGL2 are disulfide-linked subunits of oligomers that specifically bind nonviable spermatozoa
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Atypical motifs in the cytoplasmic region of the inhibitory immune co-receptor LAG-3 inhibit T cell activation
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Gut environment-induced intraepithelial autoreactive CD4+ T cells suppress central nervous system autoimmunity via LAG-3
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A rheostat for immune responses: the unique properties of PD-1 and their advantages for clinical application
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LAG3’s Enigmatic Mechanism of Action
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LAG-3: a very singular immune checkpoint
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A LAG-3–Specific Agonist Antibody for the Treatment of T Cell–Induced Autoimmune Diseases
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Regulation of MHC class II expression in human T-cell malignancies
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PD-1 and LAG-3 inhibitory co-receptors act synergistically to prevent autoimmunity in mice
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Fibrinogen-like Protein 1 Is a Major Immune Inhibitory Ligand of LAG-3
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Establishment of engineered cell-based assays mediating LAG3 and PD1 immune suppression enables potency measurement of blocking antibodies and assessment of signal transduction
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Mechanistic basis for receptor-mediated pathological α-synuclein fibril cell-to-cell transmission in Parkinson's disease
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CD4/major histocompatibility complex class II interaction analyzed with CD4- and lymphocyte activation gene-3 (LAG-3)-Ig fusion proteins
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LAG-3 inhibits the activation of CD4+ T cells that recognize stable pMHCII through its conformation-dependent recognition of pMHCII
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Resistance to PD1 blockade in the absence of metalloprotease-mediated LAG3 shedding
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Development of a novel human phage display-derived anti-LAG3 scFv antibody targeting CD8+ T lymphocyte exhaustion
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