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Title: Inhibition of the angiotensin II type 2 receptor AT[subscript 2]R is a novel therapeutic strategy fo

Journal Article · · Proc. Natl. Acad. Sci. USA

Research Organization:
Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Sponsoring Organization:
DOE - Office Of Science
Journal Information:
Proc. Natl. Acad. Sci. USA, Vol. 119, Issue (32)
Country of Publication:
United States

References (37)

Physiology of Local Renin-Angiotensin Systems journal July 2006
The renin angiotensin system (RAS) mediates bifunctional growth regulation in melanoma and is a novel target for therapeutic intervention journal November 2018
The renin–angiotensin system and cancer: old dog, new tricks journal October 2010
The renin-angiotensin system meets the hallmarks of cancer journal August 2013
Renin angiotensin system and its role in biomarkers and treatment in gliomas journal February 2018
Blockage of angiotensin II type I receptor decreases the synthesis of growth factors and induces apoptosis in C6 cultured cells and C6 rat glioma journal March 2005
Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial journal May 2009
Impact of renin-angiotensin system blockade on clinical outcome in glioblastoma journal June 2015
CUSP9* treatment protocol for recurrent glioblastoma: aprepitant, artesunate, auranofin, captopril, celecoxib, disulfiram, itraconazole, ritonavir, sertraline augmenting continuous low dose temozolomide journal August 2014
Review: Angiotensin II type 1 receptor blockers: class effects versus molecular effects journal July 2010
PD123319, angiotensin II type II receptor antagonist, inhibits oxidative stress and inflammation in 2, 4-dinitrobenzene sulfonic acid-induced colitis in rat and ameliorates colonic contractility journal July 2019
Dual targeting of angiotensin receptors (AGTR1 and AGTR2) in epithelial ovarian carcinoma journal October 2014
AT2 receptor agonists journal March 2012
Electronic Sculpting of Ligand-GPCR Subtype Selectivity: The Case of Angiotensin II journal May 2014
Single Peptide Backbone Surrogate Mutations to Regulate Angiotensin GPCR Subtype Selectivity journal July 2020
Using conformational constraints at position 6 of Angiotensin II to generate compounds with enhanced AT2R selectivity and proteolytic stability journal July 2021
EMA401, an orally administered highly selective angiotensin II type 2 receptor antagonist, as a novel treatment for postherpetic neuralgia: a randomised, double-blind, placebo-controlled phase 2 clinical trial journal May 2014
Small Molecule Angiotensin II Type 2 Receptor (AT 2 R) Antagonists as Novel Analgesics for Neuropathic Pain: Comparative Pharmacokinetics, Radioligand Binding, and Efficacy in Rats journal May 2013
Structural basis for selectivity and diversity in angiotensin II receptors journal April 2017
Structure and dynamics of GPCR signaling complexes journal January 2018
The Crystal Structure of Angiotensin II Type 2 Receptor with Endogenous Peptide Hormone journal April 2020
Crystal structure of the human angiotensin II type 2 receptor bound to an angiotensin II analog journal July 2018
Targeting angiotensin II type 2 receptor pathways to treat neuropathic pain and inflammatory pain journal October 2014
Angiotensin II type 2 receptor (AT 2 R) localization and antagonist-mediated inhibition of capsaicin responses and neurite outgrowth in human and rat sensory neurons : AT journal December 2012
Co-delivery of doxorubicin and siRNA for glioma therapy by a brain targeting system: angiopep-2-modified poly(lactic-co-glycolic acid) nanoparticles journal April 2015
Angiopep2-functionalized polymersomes for targeted doxorubicin delivery to glioblastoma cells journal September 2016
Angiopep-2 and Activatable Cell-Penetrating Peptide Dual-Functionalized Nanoparticles for Systemic Glioma-Targeting Delivery journal July 2014
Identification and characterization of a functional mitochondrial angiotensin system journal August 2011
Non‐clinical characterization of the disposition of EMA401, a novel small molecule angiotensin II type 2 receptor (AT2R) antagonist
  • Murgasova, Renata; Carreras, Ester Tor; Suetterlin‐Hachmann, Martina
  • Biopharmaceutics & Drug Disposition, Vol. 41, Issue 4-5
journal April 2020
Mitochondrial angiotensin receptors in dopaminergic neurons. Role in cell protection and aging-related vulnerability to neurodegeneration journal October 2016
Six Commercially Available Angiotensin II AT1 Receptor Antibodies are Non-specific journal July 2012
Sirtuin 3 governs autophagy‐dependent glycolysis during Angiotensin II‐induced endothelial‐to‐mesenchymal transition journal November 2020
Constitutively Active Homo-oligomeric Angiotensin II Type 2 Receptor Induces Cell Signaling Independent of Receptor Conformation and Ligand Stimulation journal May 2005
Over-expression of angiotensin II type 2 receptor gene induces cell death in lung adenocarcinoma cells journal February 2010
Involvement of angiotensin II type 2 receptor (AT2R) signaling in human pancreatic ductal adenocarcinoma (PDAC): a novel AT2R agonist effectively attenuates growth of PDAC grafts in mice journal February 2015
Disruption of astrocyte–vascular coupling and the blood–brain barrier by invading glioma cells journal June 2014
OPM database and PPM web server: resources for positioning of proteins in membranes journal September 2011