Inhibition of the angiotensin II type 2 receptor AT[subscript 2]R is a novel therapeutic strategy fo

Perryman, Richard; Renziehausena, Alexander; Shayeb, Hamidreza; Kostagianni, Androniki D.; Tsiailanis, Antonis D.; Thorne, Thomas; Chatziathanasiadou, Maria V.; Sivolapenko, Gregory B.; Mubarak, Mohamed Ahmed El; Han, Gye Won; Zarzyck, Barbara; Katritch, Vsevolod; Lebon, Guillaume; Nigro, Cristiana Lo; Lattanzio, Laura; Morse, Sophie V.; Choi, James J.; O?Neill, Kevin; Kanaki, Zoi; Klinakis, Apostolos; Crook, Tim; Cherezov, Vadim; Tzakosd, Andreas G.; Syeda, Nelofer

doi:10.1073/pnas.2116289119

Inhibition of the angiotensin II type 2 receptor AT[subscript 2]R is a novel therapeutic strategy fo

Journal Article · 01 August 2022 · Proc. Natl. Acad. Sci. USA

DOI:https://doi.org/10.1073/pnas.2116289119· OSTI ID:1900812

Perryman, Richard; Renziehausena, Alexander; Shayeb, Hamidreza; Kostagianni, Androniki D.; Tsiailanis, Antonis D.; Thorne, Thomas; Chatziathanasiadou, Maria V.; Sivolapenko, Gregory B.; Mubarak, Mohamed Ahmed El; Han, Gye Won; Zarzyck, Barbara; Katritch, Vsevolod; Lebon, Guillaume; Nigro, Cristiana Lo; Lattanzio, Laura; Morse, Sophie V.; Choi, James J.; O?Neill, Kevin; Kanaki, Zoi; Klinakis, Apostolos more »

Research Organization:: Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)

Sponsoring Organization:: DOE - Office Of Science

OSTI ID:: 1900812

Journal Information:: Proc. Natl. Acad. Sci. USA, Vol. 119, Issue (32)

Country of Publication:: United States

Language:: ENGLISH

References (37)

Physiology of Local Renin-Angiotensin Systems No authors listed Physiological Reviews https://doi.org/10.1152/physrev.00036.2005		July 2006
The renin angiotensin system (RAS) mediates bifunctional growth regulation in melanoma and is a novel target for therapeutic intervention No authors listed Oncogene https://doi.org/10.1038/s41388-018-0563-y		November 2018
The renin–angiotensin system and cancer: old dog, new tricks No authors listed Nature Reviews Cancer https://doi.org/10.1038/nrc2945		October 2010
The renin-angiotensin system meets the hallmarks of cancer No authors listed Journal of the Renin-Angiotensin-Aldosterone System https://doi.org/10.1177/1470320313496858		August 2013
Renin angiotensin system and its role in biomarkers and treatment in gliomas No authors listed Journal of Neuro-Oncology https://doi.org/10.1007/s11060-018-2789-5		February 2018
Blockage of angiotensin II type I receptor decreases the synthesis of growth factors and induces apoptosis in C6 cultured cells and C6 rat glioma No authors listed British Journal of Cancer https://doi.org/10.1038/sj.bjc.6602483		March 2005
Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial No authors listed The Lancet Oncology https://doi.org/10.1016/S1470-2045(09)70025-7		May 2009
Impact of renin-angiotensin system blockade on clinical outcome in glioblastoma No authors listed European Journal of Neurology https://doi.org/10.1111/ene.12746		June 2015
CUSP9* treatment protocol for recurrent glioblastoma: aprepitant, artesunate, auranofin, captopril, celecoxib, disulfiram, itraconazole, ritonavir, sertraline augmenting continuous low dose temozolomide No authors listed Oncotarget https://doi.org/10.18632/oncotarget.2408		August 2014
Review: Angiotensin II type 1 receptor blockers: class effects versus molecular effects No authors listed Journal of the Renin-Angiotensin-Aldosterone System https://doi.org/10.1177/1470320310370852		July 2010
PD123319, angiotensin II type II receptor antagonist, inhibits oxidative stress and inflammation in 2, 4-dinitrobenzene sulfonic acid-induced colitis in rat and ameliorates colonic contractility No authors listed Inflammopharmacology https://doi.org/10.1007/s10787-019-00619-z		July 2019
Dual targeting of angiotensin receptors (AGTR1 and AGTR2) in epithelial ovarian carcinoma No authors listed Gynecologic Oncology https://doi.org/10.1016/j.ygyno.2014.06.031		October 2014
AT2 receptor agonists No authors listed Current Opinion in Nephrology and Hypertension https://doi.org/10.1097/MNH.0b013e328350261b		March 2012
Electronic Sculpting of Ligand-GPCR Subtype Selectivity: The Case of Angiotensin II No authors listed ACS Chemical Biology https://doi.org/10.1021/cb500063y		May 2014
Single Peptide Backbone Surrogate Mutations to Regulate Angiotensin GPCR Subtype Selectivity No authors listed Chemistry – A European Journal https://doi.org/10.1002/chem.202000924		July 2020
Using conformational constraints at position 6 of Angiotensin II to generate compounds with enhanced AT2R selectivity and proteolytic stability No authors listed Bioorganic & Medicinal Chemistry Letters https://doi.org/10.1016/j.bmcl.2021.128086		July 2021
EMA401, an orally administered highly selective angiotensin II type 2 receptor antagonist, as a novel treatment for postherpetic neuralgia: a randomised, double-blind, placebo-controlled phase 2 clinical trial No authors listed The Lancet https://doi.org/10.1016/S0140-6736(13)62337-5		May 2014
Small Molecule Angiotensin II Type 2 Receptor (AT ₂ R) Antagonists as Novel Analgesics for Neuropathic Pain: Comparative Pharmacokinetics, Radioligand Binding, and Efficacy in Rats No authors listed Pain Medicine https://doi.org/10.1111/pme.12063		May 2013
Structural basis for selectivity and diversity in angiotensin II receptors No authors listed Nature https://doi.org/10.1038/nature22035		April 2017
Structure and dynamics of GPCR signaling complexes No authors listed Nature Structural & Molecular Biology https://doi.org/10.1038/s41594-017-0011-7		January 2018
The Crystal Structure of Angiotensin II Type 2 Receptor with Endogenous Peptide Hormone No authors listed Structure https://doi.org/10.1016/j.str.2019.12.003		April 2020
Crystal structure of the human angiotensin II type 2 receptor bound to an angiotensin II analog No authors listed Nature Structural & Molecular Biology https://doi.org/10.1038/s41594-018-0079-8		July 2018
Targeting angiotensin II type 2 receptor pathways to treat neuropathic pain and inflammatory pain No authors listed Expert Opinion on Therapeutic Targets https://doi.org/10.1517/14728222.2014.957673		October 2014
Angiotensin II type 2 receptor (AT ₂ R) localization and antagonist-mediated inhibition of capsaicin responses and neurite outgrowth in human and rat sensory neurons : AT No authors listed European Journal of Pain https://doi.org/10.1002/j.1532-2149.2012.00269.x		December 2012
Co-delivery of doxorubicin and siRNA for glioma therapy by a brain targeting system: angiopep-2-modified poly(lactic-co-glycolic acid) nanoparticles No authors listed Journal of Drug Targeting https://doi.org/10.3109/1061186X.2015.1025077		April 2015
Angiopep2-functionalized polymersomes for targeted doxorubicin delivery to glioblastoma cells No authors listed International Journal of Pharmaceutics https://doi.org/10.1016/j.ijpharm.2016.07.066		September 2016
Angiopep-2 and Activatable Cell-Penetrating Peptide Dual-Functionalized Nanoparticles for Systemic Glioma-Targeting Delivery No authors listed Molecular Pharmaceutics https://doi.org/10.1021/mp500113p		July 2014
Identification and characterization of a functional mitochondrial angiotensin system No authors listed Proceedings of the National Academy of Sciences https://doi.org/10.1073/pnas.1101507108		August 2011
Non‐clinical characterization of the disposition of EMA401, a novel small molecule angiotensin II type 2 receptor (AT2R) antagonist No authors listed Biopharmaceutics & Drug Disposition https://doi.org/10.1002/bdd.2226		April 2020
Mitochondrial angiotensin receptors in dopaminergic neurons. Role in cell protection and aging-related vulnerability to neurodegeneration No authors listed Cell Death & Disease https://doi.org/10.1038/cddis.2016.327		October 2016
Six Commercially Available Angiotensin II AT1 Receptor Antibodies are Non-specific No authors listed Cellular and Molecular Neurobiology https://doi.org/10.1007/s10571-012-9862-y		July 2012
Sirtuin 3 governs autophagy‐dependent glycolysis during Angiotensin II‐induced endothelial‐to‐mesenchymal transition No authors listed The FASEB Journal https://doi.org/10.1096/fj.202001494R		November 2020
Constitutively Active Homo-oligomeric Angiotensin II Type 2 Receptor Induces Cell Signaling Independent of Receptor Conformation and Ligand Stimulation No authors listed Journal of Biological Chemistry https://doi.org/10.1074/jbc.M500639200		May 2005
Over-expression of angiotensin II type 2 receptor gene induces cell death in lung adenocarcinoma cells No authors listed Cancer Biology & Therapy https://doi.org/10.4161/cbt.9.4.10643		February 2010
Involvement of angiotensin II type 2 receptor (AT2R) signaling in human pancreatic ductal adenocarcinoma (PDAC): a novel AT2R agonist effectively attenuates growth of PDAC grafts in mice No authors listed Cancer Biology & Therapy https://doi.org/10.1080/15384047.2014.1002357		February 2015
Disruption of astrocyte–vascular coupling and the blood–brain barrier by invading glioma cells No authors listed Nature Communications https://doi.org/10.1038/ncomms5196		June 2014
OPM database and PPM web server: resources for positioning of proteins in membranes No authors listed Nucleic Acids Research https://doi.org/10.1093/nar/gkr703		September 2011

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