LY-CoV1404 (bebtelovimab) potently neutralizes SARS-CoV-2 variants

Westendorf, Kathryn; ?entelis, Stefanie; Wang, Lingshu; Foster, Denisa; Vaillancourt, Peter; Wiggin, Matthew; Lovett, Erica; van der Lee, Robin; Hendle, Jorg; Pustilnik, Anna; Sauder, J. Michael; Kraft, Lucas; Hwang, Yuri; Siegel, Robert W.; Chen, Jinbiao; A.Heinz, Beverly; Higgs, Richard E.; Kallewaard, Nicole L.; Jepson, Kevin; Goya, Rodrigo; Smith, Maia A.; Collins, David W.; Pellacani, Davide; Xiang, Ping; de Puyraimond, Valentine; Ricicova, Marketa; Devorkin, Lindsay; Pritchard, Caitlin; O?Neill, Aoise; Dalal, Kush; Panwar, Pankaj; Dhupar, Harveer; Garces, Fabian A.; Cohen, Courtney A.; Dye, John M.; Huie, Kathleen E.; Badger, Catherine V.; Kobasa, Darwyn; Audet, Jonathan; Freitas, Joshua J.; Hassanali, Saleema; Hughes, Ina; Munoz, Luis; Palma, Holly C.; Ramamurthy, Bharathi; Cross, Robert W.; Geisbert, Thomas W.; Menachery, Vineet; Lokugamage, Kumari; Borisevich, Viktoriya; Lanz, Iliana; Anderson, Lisa; Sipahimalani, Payal; S.Corbett, Kizzmekia; SungYang, Eun; Zhang, Yi; Shi, Wei; Zhou, Tongqing; Choe, Misook; Misasi, John; Kwong, Peter D.; Sullivan, Nancy J.; Graham, Barney S.; Fernandez, Tara L.; Hansen, Carl L.; Falconer, Ester; Mascola, John R.; Jones, Bryan E.; Barnhart, Bryan C.

doi:10.1016/j.celrep.2022.110812

LY-CoV1404 (bebtelovimab) potently neutralizes SARS-CoV-2 variants

Journal Article · 01 May 2022 · Cell Reports

DOI:https://doi.org/10.1016/j.celrep.2022.110812· OSTI ID:1900749

Westendorf, Kathryn; ?entelis, Stefanie; Wang, Lingshu; Foster, Denisa; Vaillancourt, Peter; Wiggin, Matthew; Lovett, Erica; van der Lee, Robin; Hendle, Jorg; Pustilnik, Anna; Sauder, J. Michael; Kraft, Lucas; Hwang, Yuri; Siegel, Robert W.; Chen, Jinbiao; A.Heinz, Beverly; Higgs, Richard E.; Kallewaard, Nicole L.; Jepson, Kevin; Goya, Rodrigo more »

Research Organization:: Advanced Photon Source (APS), Argonne National Laboratory (ANL), Argonne, IL (US)

Sponsoring Organization:: DOE - Office Of Science; INDUSTRY

OSTI ID:: 1900749

Journal Information:: Cell Reports, Journal Name: Cell Reports Journal Issue: (7) Vol. 39

Country of Publication:: United States

Language:: ENGLISH

References (51)

Neutralizing antibodies for the treatment of COVID-19 Jiang, Shibo; Zhang, Xiujuan; Yang, Yang Nature Biomedical Engineering, Vol. 4, Issue 12 https://doi.org/10.1038/s41551-020-00660-2	journal	December 2020
Convalescent-Phase Sera and Vaccine-Elicited Antibodies Largely Maintain Neutralizing Titer against Global SARS-CoV-2 Variant Spikes Tada, Takuya; Dcosta, Belinda M.; Samanovic, Marie I. mBio, Vol. 12, Issue 3 https://doi.org/10.1128/mBio.00696-21	journal	June 2021
Early Treatment for Covid-19 with SARS-CoV-2 Neutralizing Antibody Sotrovimab Gupta, Anil; Gonzalez-Rojas, Yaneicy; Juarez, Erick New England Journal of Medicine, Vol. 385, Issue 21 https://doi.org/10.1056/NEJMoa2107934	journal	November 2021
Cross-neutralization of SARS-CoV-2 by a human monoclonal SARS-CoV antibody Pinto, Dora; Park, Young-Jun; Beltramello, Martina Nature, Vol. 583, Issue 7815 https://doi.org/10.1038/s41586-020-2349-y	journal	May 2020
SARS-CoV-2 Neutralizing Antibody LY-CoV555 in Outpatients with Covid-19 Chen, Peter; Nirula, Ajay; Heller, Barry New England Journal of Medicine, Vol. 384, Issue 3 https://doi.org/10.1056/NEJMoa2029849	journal	January 2021
SARS-CoV-2 spike variants exhibit differential infectivity and neutralization resistance to convalescent or post-vaccination sera Kuzmina, Alona; Khalaila, Yara; Voloshin, Olga Cell Host & Microbe, Vol. 29, Issue 4 https://doi.org/10.1016/j.chom.2021.03.008	journal	April 2021
SARS-CoV-2 mRNA vaccine design enabled by prototype pathogen preparedness Corbett, Kizzmekia S.; Edwards, Darin K.; Leist, Sarah R. Nature, Vol. 586, Issue 7830 https://doi.org/10.1038/s41586-020-2622-0	journal	August 2020
Establishment and validation of a pseudovirus neutralization assay for SARS-CoV-2 Nie, Jianhui; Li, Qianqian; Wu, Jiajing Emerging Microbes & Infections, Vol. 9, Issue 1 https://doi.org/10.1080/22221751.2020.1743767	journal	January 2020
SARS-CoV-2 variants B.1.351 and P.1 escape from neutralizing antibodies Hoffmann, Markus; Arora, Prerna; Groß, Rüdiger Cell, Vol. 184, Issue 9 https://doi.org/10.1016/j.cell.2021.03.036	journal	April 2021
Data processing and analysis with the autoPROC toolbox Vonrhein, Clemens; Flensburg, Claus; Keller, Peter Acta Crystallographica Section D Biological Crystallography, Vol. 67, Issue 4 https://doi.org/10.1107/S0907444911007773	journal	March 2011
Persistence and Evolution of SARS-CoV-2 in an Immunocompromised Host Choi, Bina; Choudhary, Manish C.; Regan, James New England Journal of Medicine, Vol. 383, Issue 23 https://doi.org/10.1056/NEJMc2031364	journal	December 2020
Fast and accurate long-read alignment with Burrows–Wheeler transform Li, Heng; Durbin, Richard Bioinformatics, Vol. 26, Issue 5 https://doi.org/10.1093/bioinformatics/btp698	journal	January 2010
Efficient transfer, integration, and sustained long-term expression of the transgene in adult rat brains injected with a lentiviral vector. Naldini, L.; Blomer, U.; Gage, F. H. Proceedings of the National Academy of Sciences, Vol. 93, Issue 21 https://doi.org/10.1073/pnas.93.21.11382	journal	October 1996
Identification of SARS-CoV-2 spike mutations that attenuate monoclonal and serum antibody neutralization Liu, Zhuoming; VanBlargan, Laura A.; Bloyet, Louis-Marie Cell Host & Microbe, Vol. 29, Issue 3 https://doi.org/10.1016/j.chom.2021.01.014	journal	March 2021
Emergence of a Highly Fit SARS-CoV-2 Variant Baric, Ralph S. New England Journal of Medicine, Vol. 383, Issue 27 https://doi.org/10.1056/NEJMcibr2032888	journal	December 2020
The emerging plasticity of SARS-CoV-2 McCormick, Kevin D.; Jacobs, Jana L.; Mellors, John W. Science, Vol. 371, Issue 6536 https://doi.org/10.1126/science.abg4493	journal	March 2021
Generation of VSV pseudotypes using recombinant ΔG-VSV for studies on virus entry, identification of entry inhibitors, and immune responses to vaccines Whitt, Michael A. Journal of Virological Methods, Vol. 169, Issue 2 https://doi.org/10.1016/j.jviromet.2010.08.006	journal	November 2010
MolProbity : all-atom structure validation for macromolecular crystallography Chen, Vincent B.; Arendall, W. Bryan; Headd, Jeffrey J. Acta Crystallographica Section D Biological Crystallography, Vol. 66, Issue 1 https://doi.org/10.1107/S0907444909042073	journal	December 2009
Antibody evasion by the P.1 strain of SARS-CoV-2 Dejnirattisai, Wanwisa; Zhou, Daming; Supasa, Piyada Cell https://doi.org/10.1016/j.cell.2021.03.055	journal	March 2021
Neutralizing nanobodies bind SARS-CoV-2 spike RBD and block interaction with ACE2 Huo, Jiangdong; Le Bas, Audrey; Ruza, Reinis R. Nature Structural & Molecular Biology, Vol. 27, Issue 9 https://doi.org/10.1038/s41594-020-0469-6	journal	July 2020
Structure-based design of prefusion-stabilized SARS-CoV-2 spikes Hsieh, Ching-Lin; Goldsmith, Jory A.; Schaub, Jeffrey M. Science, Vol. 369, Issue 6510 https://doi.org/10.1126/science.abd0826	journal	July 2020
Processing of Structurally Heterogeneous Cryo-EM Data in RELION Scheres, S. H. W. Methods in Enzymology https://doi.org/10.1016/bs.mie.2016.04.012	book	January 2016
Effect of Bamlanivimab as Monotherapy or in Combination With Etesevimab on Viral Load in Patients With Mild to Moderate COVID-19: A Randomized Clinical Trial Gottlieb, Robert L.; Nirula, Ajay; Chen, Peter JAMA, Vol. 325, Issue 7 https://doi.org/10.1001/jama.2021.0202	journal	February 2021
GISAID: Global initiative on sharing all influenza data – from vision to reality Shu, Yuelong; McCauley, John Eurosurveillance, Vol. 22, Issue 13 https://doi.org/10.2807/1560-7917.ES.2017.22.13.30494	journal	March 2017
Emerging SARS-CoV-2 mutation hot spots include a novel RNA-dependent-RNA polymerase variant Pachetti, Maria; Marini, Bruna; Benedetti, Francesca Journal of Translational Medicine, Vol. 18, Issue 1 https://doi.org/10.1186/s12967-020-02344-6	journal	April 2020
SARS-CoV-2 neutralizing antibody structures inform therapeutic strategies Barnes, Christopher O.; Jette, Claudia A.; Abernathy, Morgan E. Nature, Vol. 588, Issue 7839 https://doi.org/10.1038/s41586-020-2852-1	journal	October 2020
Overview of the CCP 4 suite and current developments Winn, Martyn D.; Ballard, Charles C.; Cowtan, Kevin D. Acta Crystallographica Section D Biological Crystallography, Vol. 67, Issue 4 https://doi.org/10.1107/S0907444910045749	journal	March 2011
Geographic and Genomic Distribution of SARS-CoV-2 Mutations Mercatelli, Daniele; Giorgi, Federico M. Frontiers in Microbiology, Vol. 11 https://doi.org/10.3389/fmicb.2020.01800	journal	July 2020
Five reasons why COVID herd immunity is probably impossible Aschwanden, Christie Nature, Vol. 591, Issue 7851 https://doi.org/10.1038/d41586-021-00728-2	journal	March 2021
Potent neutralizing antibodies against multiple epitopes on SARS-CoV-2 spike Liu, Lihong; Wang, Pengfei; Nair, Manoj S. Nature, Vol. 584, Issue 7821 https://doi.org/10.1038/s41586-020-2571-7	journal	July 2020
Circulating SARS-CoV-2 spike N439K variants maintain fitness while evading antibody-mediated immunity Thomson, Emma C.; Rosen, Laura E.; Shepherd, James G. Cell, Vol. 184, Issue 5 https://doi.org/10.1016/j.cell.2021.01.037	journal	March 2021
Covid-19: variants and vaccination Darby, Alistair C.; Hiscox, Julian A. BMJ https://doi.org/10.1136/bmj.n771	journal	March 2021
Structural and Functional Analysis of the D614G SARS-CoV-2 Spike Protein Variant Yurkovetskiy, Leonid; Wang, Xue; Pascal, Kristen E. Cell, Vol. 183, Issue 3 https://doi.org/10.1016/j.cell.2020.09.032	journal	October 2020
Transmission of SARS-CoV-2 on mink farms between humans and mink and back to humans Oude Munnink, Bas B.; Sikkema, Reina S.; Nieuwenhuijse, David F. Science, Vol. 371, Issue 6525 https://doi.org/10.1126/science.abe5901	journal	November 2020
The neutralizing antibody, LY-CoV555, protects against SARS-CoV-2 infection in nonhuman primates Jones, Bryan E.; Brown-Augsburger, Patricia L.; Corbett, Kizzmekia S. Science Translational Medicine, Vol. 13, Issue 593 https://doi.org/10.1126/scitranslmed.abf1906	journal	May 2021
Rapid and robust antibody Fab fragment crystallization utilizing edge-to-edge beta-sheet packing Lieu, Ricky; Antonysamy, Stephen; Druzina, Zhanna PLOS ONE, Vol. 15, Issue 9 https://doi.org/10.1371/journal.pone.0232311	journal	September 2020
Spike mutation D614G alters SARS-CoV-2 fitness Plante, Jessica A.; Liu, Yang; Liu, Jianying Nature https://doi.org/10.1038/s41586-020-2895-3	journal	October 2020
Neutralization of SARS-CoV-2 spike 69/70 deletion, E484K and N501Y variants by BNT162b2 vaccine-elicited sera Xie, Xuping; Liu, Yang; Liu, Jianying Nature Medicine, Vol. 27, Issue 4 https://doi.org/10.1038/s41591-021-01270-4	journal	February 2021
The effect of spike mutations on SARS-CoV-2 neutralization Rees-Spear, Chloe; Muir, Luke; Griffith, Sarah A. Cell Reports, Vol. 34, Issue 12 https://doi.org/10.1016/j.celrep.2021.108890	journal	March 2021
How good are my data and what is the resolution? Evans, Philip R.; Murshudov, Garib N. Acta Crystallographica Section D Biological Crystallography, Vol. 69, Issue 7 https://doi.org/10.1107/S0907444913000061	journal	June 2013
Immunity to SARS-CoV-2 variants of concern Altmann, Daniel M.; Boyton, Rosemary J.; Beale, Rupert Science, Vol. 371, Issue 6534 https://doi.org/10.1126/science.abg7404	journal	March 2021
Extremely potent human monoclonal antibodies from COVID-19 convalescent patients Andreano, Emanuele; Nicastri, Emanuele; Paciello, Ida Cell, Vol. 184, Issue 7 https://doi.org/10.1016/j.cell.2021.02.035	journal	April 2021
Engineering SARS-CoV-2 using a reverse genetic system Xie, Xuping; Lokugamage, Kumari G.; Zhang, Xianwen Nature Protocols, Vol. 16, Issue 3 https://doi.org/10.1038/s41596-021-00491-8	journal	January 2021
Estimated transmissibility and impact of SARS-CoV-2 lineage B.1.1.7 in England Davies, Nicholas G.; Abbott, Sam; Barnard, Rosanna C. Science, Vol. 372, Issue 6538 https://doi.org/10.1126/science.abg3055	journal	March 2021
Broad and potent activity against SARS-like viruses by an engineered human monoclonal antibody Rappazzo, C. Garrett; Tse, Longping V.; Kaku, Chengzi I. Science, Vol. 371, Issue 6531 https://doi.org/10.1126/science.abf4830	journal	February 2021
Sixteen novel lineages of SARS-CoV-2 in South Africa Tegally, Houriiyah; Wilkinson, Eduan; Lessells, Richard J. Nature Medicine, Vol. 27, Issue 3 https://doi.org/10.1038/s41591-021-01255-3	journal	February 2021
Antibody evasion properties of SARS-CoV-2 Omicron sublineages Iketani, Sho; Liu, Lihong; Guo, Yicheng Nature, Vol. 604, Issue 7906 https://doi.org/10.1038/s41586-022-04594-4	journal	March 2022
Twelve years of SAMtools and BCFtools Danecek, Petr; Bonfield, James K.; Liddle, Jennifer GigaScience, Vol. 10, Issue 2 https://doi.org/10.1093/gigascience/giab008	journal	January 2021
Studies in humanized mice and convalescent humans yield a SARS-CoV-2 antibody cocktail Hansen, Johanna; Baum, Alina; Pascal, Kristen E. Science https://doi.org/10.1126/science.abd0827	journal	June 2020
Exploiting structure similarity in refinement: automated NCS and target-structure restraints in BUSTER Smart, Oliver S.; Womack, Thomas O.; Flensburg, Claus Acta Crystallographica Section D Biological Crystallography, Vol. 68, Issue 4 https://doi.org/10.1107/S0907444911056058	journal	March 2012
Adaptation of SARS-CoV-2 in BALB/c mice for testing vaccine efficacy Gu, Hongjing; Chen, Qi; Yang, Guan Science, Vol. 369, Issue 6511 https://doi.org/10.1126/science.abc4730	journal	July 2020

Similar Records

Broadening a SARS-CoV-1–neutralizing antibody for potent SARS-CoV-2 neutralization through directed evolution

Journal Article · 2023 · Science Signaling · OSTI ID:2423886

Etesevimab in combination with JS026 neutralizing SARS-CoV-2 and its variants

Journal Article · 2022 · Emerg. Microbes Infec. · OSTI ID:1900790

LY-CoV1404 (bebtelovimab) potently neutralizes SARS-CoV-2 variants

Citation Formats

References (51)

Similar Records

Related Subjects