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Title: Inactive and active state structures template selective tools for the human 5-HT[subscript 5A] rece

Journal Article · · Nat. Struct. Mol. Biol.

Research Organization:
Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Sponsoring Organization:
DOE - Office Of Science; National Institutes of Health (NIH)
OSTI ID:
1900706
Journal Information:
Nat. Struct. Mol. Biol., Vol. 29
Country of Publication:
United States
Language:
ENGLISH

References (49)

International Union of Basic and Clinical Pharmacology. CX. Classification of Receptors for 5-hydroxytryptamine; Pharmacology and Function journal December 2020
The Expanded Biology of Serotonin journal February 2009
Increased Exploratory Activity and Altered Response to LSD in Mice Lacking the 5-HT5A Receptor journal March 1999
5-hydroxytryptamine receptor subtype messenger RNAs in rat peripheral sensory and sympathetic ganglia: A polymerase chain reaction study journal January 1996
Emergence of 5-HT5A signaling in parvalbumin neurons mediates delayed antidepressant action journal February 2019
Distribution of the 5-HT5A serotonin receptor mRNA in the human brain journal May 1998
Discovery of a potent and selective 5-ht5A receptor antagonist by high-throughput chemistry journal September 2005
Novel 5-HT5A receptor antagonists ameliorate scopolamine-induced working memory deficit in mice and reference memory impairment in aged rats journal March 2015
ASP5736, a novel 5-HT5A receptor antagonist, ameliorates positive symptoms and cognitive impairment in animal models of schizophrenia journal October 2014
Structure-Based Design of a Chemical Probe Set for the 5-HT5A Serotonin Receptor journal February 2022
Two members of a distinct subfamily of 5-hydroxytryptamine receptors differentially expressed in rat brain. journal April 1993
Cloning and characterisation of the human 5-HT5Aserotonin receptor journal December 1994
The human 5-ht5A receptor couples to Gi/Go proteins and inhibits adenylate cyclase in HEK 293 cells journal November 1998
Fusion Partner Toolchest for the Stabilization and Crystallization of G Protein-Coupled Receptors journal June 2012
Generic GPCR residue numbers – aligning topology maps while minding the gaps journal January 2015
Computational design of thermostabilizing point mutations for G protein-coupled receptors journal June 2018
TRUPATH, an open-source biosensor platform for interrogating the GPCR transducerome journal May 2020
Cryo-EM structure of the serotonin 5-HT1B receptor coupled to heterotrimeric Go journal June 2018
Cryo-EM structure of an activated VIP1 receptor-G protein complex revealed by a NanoBiT tethering strategy journal August 2020
Structural insights into the lipid and ligand regulation of serotonin receptors journal March 2021
5-HT 4(a) and 5-HT 4(b) receptors have nearly identical pharmacology and are both expressed in human atrium and ventricle journal January 2001
Human 5-HT5 receptors: the 5-HT5A receptor is functional but the 5-HT5B receptor was lost during mammalian evolution journal April 2001
Structure of a Hallucinogen-Activated Gq-Coupled 5-HT2A Serotonin Receptor journal September 2020
Mini G protein probes for active G protein–coupled receptors (GPCRs) in live cells journal March 2018
How Ligands Illuminate GPCR Molecular Pharmacology journal July 2017
The Molecular Basis of G Protein–Coupled Receptor Activation journal June 2018
Structure-Function of the G Protein–Coupled Receptor Superfamily journal January 2013
Structure of the Nanobody-Stabilized Active State of the Kappa Opioid Receptor journal January 2018
Structural Connection between Activation Microswitch and Allosteric Sodium Site in GPCR Signaling journal February 2018
Allosteric sodium in class A GPCR signaling journal May 2014
Highly accurate protein structure prediction with AlphaFold journal July 2021
Relative Binding Free Energy Calculations in Drug Discovery: Recent Advances and Practical Considerations journal December 2017
Crystallizing membrane proteins using lipidic mesophases journal April 2009
Structure, function and pharmacology of human itch GPCRs journal November 2021
High-speed high-resolution data collection on a 200 keV cryo-TEM journal January 2022
Automated electron microscope tomography using robust prediction of specimen movements journal October 2005
Topaz-Denoise: general deep denoising models for cryoEM and cryoET journal October 2020
cryoSPARC: algorithms for rapid unsupervised cryo-EM structure determination journal February 2017
Non-uniform refinement: adaptive regularization improves single-particle cryo-EM reconstruction journal November 2020
Optimal Determination of Particle Orientation, Absolute Hand, and Contrast Loss in Single-particle Electron Cryomicroscopy journal October 2003
Bsoft: Image processing and molecular modeling for electron microscopy journal January 2007
DeepEMhancer: a deep learning solution for cryo-EM volume post-processing journal July 2021
UCSF Chimera?A visualization system for exploratory research and analysis journal January 2004
Coot model-building tools for molecular graphics journal November 2004
PHENIX: a comprehensive Python-based system for macromolecular structure solution journal January 2010
MolProbity : all-atom structure validation for macromolecular crystallography journal December 2009
PROPKA3: Consistent Treatment of Internal and Surface Residues in Empirical p K a Predictions journal December 2010
OPLS3: A Force Field Providing Broad Coverage of Drug-like Small Molecules and Proteins journal December 2015
Advancing Drug Discovery through Enhanced Free Energy Calculations journal July 2017