Validation and promise of a TCR mimic antibody for cancer immunotherapy of hepatocellular carcinoma

Liu, Chang; Liu, Hong; Dasgupta, Moumita; Hellman, Lance M.; Zhang, Xiaogang; Qu, Kai; Xue, Hui; Wang, Yun; Fan, Fenling; Chang, Qi; Yu, Duo; Ge, Linhu; Zhang, Yu; Cui, Ziyou; Zhang, Pengbo; Heller, Bradley; Zhang, Hongbing; Shi, Bingyin; Baker, Brian M.; Liu, Cheng

doi:10.1038/s41598-022-15946-5

Validation and promise of a TCR mimic antibody for cancer immunotherapy of hepatocellular carcinoma

Journal Article · 01 July 2022 · Sci. Rep.

DOI:https://doi.org/10.1038/s41598-022-15946-5· OSTI ID:1900705

Liu, Chang; Liu, Hong; Dasgupta, Moumita; Hellman, Lance M.; Zhang, Xiaogang; Qu, Kai; Xue, Hui; Wang, Yun; Fan, Fenling; Chang, Qi; Yu, Duo; Ge, Linhu; Zhang, Yu; Cui, Ziyou; Zhang, Pengbo; Heller, Bradley; Zhang, Hongbing; Shi, Bingyin; Baker, Brian M.; Liu, Cheng

Research Organization:: Advanced Photon Source (APS), Argonne National Laboratory (ANL), Argonne, IL (US)

Sponsoring Organization:: DOE - Office Of Science; NIGMS; NIH

OSTI ID:: 1900705

Journal Information:: Sci. Rep., Journal Name: Sci. Rep. Vol. 12

Country of Publication:: United States

Language:: ENGLISH

References (59)

Reconciling views on T cell receptor germline bias for MHC Garcia, K. Christopher Trends in Immunology, Vol. 33, Issue 9 https://doi.org/10.1016/j.it.2012.05.005	journal	September 2012
Therapeutic Efficacy of an Fc-Enhanced TCR-like Antibody to the Intracellular WT1 Oncoprotein Veomett, Nicholas; Dao, Tao; Liu, Hong Clinical Cancer Research, Vol. 20, Issue 15 https://doi.org/10.1158/1078-0432.CCR-13-2756	journal	July 2014
Automated Structure Solution with the PHENIX Suite Zwart, Peter H.; Afonine, Pavel V.; Grosse-Kunstleve, Ralf W. Methods in Molecular Biology https://doi.org/10.1007/978-1-60327-058-8_28	book	January 2008
ContPro: A web tool for calculating amino acid contact distances in protein from 3D -structures at different distance threshold Firoz, Ahmad; Malik, Adeel; Afzal, Obaid Bioinformation, Vol. 5, Issue 2 https://doi.org/10.6026/97320630005055	journal	July 2010
Opportunities and challenges for TCR mimic antibodies in cancer therapy Chang, Aaron Y.; Gejman, Ron S.; Brea, Elliott J. Expert Opinion on Biological Therapy, Vol. 16, Issue 8 https://doi.org/10.1080/14712598.2016.1176138	journal	April 2016
T cell receptor binding affinity governs the functional profile of cancer-specific CD8+ T cells Tan, M. P.; Gerry, A. B.; Brewer, J. E. Clinical and Experimental Immunology, Vol. 180, Issue 2 https://doi.org/10.1111/cei.12570	journal	April 2015
Depleting T regulatory cells by targeting intracellular Foxp3 with a TCR mimic antibody Dao, Tao; Mun, Sung Soo; Scott, Andrew C. OncoImmunology, Vol. 8, Issue 7 https://doi.org/10.1080/2162402X.2019.1570778	journal	April 2019
PHENIX: a comprehensive Python-based system for macromolecular structure solution Adams, Paul D.; Afonine, Pavel V.; Bunkóczi, Gábor Acta Crystallographica Section D Biological Crystallography, Vol. 66, Issue 2, p. 213-221 https://doi.org/10.1107/S0907444909052925	journal	January 2010
Glypican-3 antibodies: A new therapeutic target for liver cancer Feng, Mingqian; Ho, Mitchell FEBS Letters, Vol. 588, Issue 2 https://doi.org/10.1016/j.febslet.2013.10.002	journal	October 2013
Targeting the MHC Ligandome by Use of TCR-Like Antibodies Høydahl, Lene Støkken; Frick, Rahel; Sandlie, Inger Antibodies, Vol. 8, Issue 2 https://doi.org/10.3390/antib8020032	journal	May 2019
Geometrical characterization of T cell receptor binding modes reveals class‐specific binding to maximize access to antigen Singh, Nishant K.; Abualrous, Esam T.; Ayres, Cory M. Proteins: Structure, Function, and Bioinformatics, Vol. 88, Issue 3 https://doi.org/10.1002/prot.25829	journal	October 2019
Improving T Cell Receptor On-Target Specificity via Structure-Guided Design Hellman, Lance M.; Foley, Kendra C.; Singh, Nishant K. Molecular Therapy, Vol. 27, Issue 2 https://doi.org/10.1016/j.ymthe.2018.12.010	journal	February 2019
Melanocyte Destruction after Antigen-Specific Immunotherapy of Melanoma Yee, Cassian; Thompson, John A.; Roche, Patrick Journal of Experimental Medicine, Vol. 192, Issue 11 https://doi.org/10.1084/jem.192.11.1637	journal	December 2000
Cancer Regression and Neurological Toxicity Following Anti-MAGE-A3 TCR Gene Therapy Morgan, Richard A.; Chinnasamy, Nachimuthu; Abate-Daga, Daniel Journal of Immunotherapy, Vol. 36, Issue 2 https://doi.org/10.1097/CJI.0b013e3182829903	journal	January 2013
Computational Design of the Affinity and Specificity of a Therapeutic T Cell Receptor Pierce, Brian G.; Hellman, Lance M.; Hossain, Moushumi PLoS Computational Biology, Vol. 10, Issue 2 https://doi.org/10.1371/journal.pcbi.1003478	journal	February 2014
Targeting a neoantigen derived from a common TP53 mutation Hsiue, Emily Han-Chung; Wright, Katharine M.; Douglass, Jacqueline Science, Vol. 371, Issue 6533 https://doi.org/10.1126/science.abc8697	journal	March 2021
Phaser crystallographic software McCoy, Airlie J.; Grosse-Kunstleve, Ralf W.; Adams, Paul D. Journal of Applied Crystallography, Vol. 40, Issue 4 https://doi.org/10.1107/S0021889807021206	journal	July 2007
How structural adaptability exists alongside HLA-A2 bias in the human αβ TCR repertoire Blevins, Sydney J.; Pierce, Brian G.; Singh, Nishant K. Proceedings of the National Academy of Sciences, Vol. 113, Issue 9 https://doi.org/10.1073/pnas.1522069113	journal	February 2016
A recombinant antibody with the antigen-specific, major histocompatibility complex-restricted specificity of T cells. Andersen, P. S.; Stryhn, A.; Hansen, B. E. Proceedings of the National Academy of Sciences, Vol. 93, Issue 5 https://doi.org/10.1073/pnas.93.5.1820	journal	March 1996
Structural interplay between germline interactions and adaptive recognition determines the bandwidth of TCR-peptide-MHC cross-reactivity Adams, Jarrett J.; Narayanan, Samanthi; Birnbaum, Michael E. Nature Immunology, Vol. 17, Issue 1 https://doi.org/10.1038/ni.3310	journal	November 2015
A novel antibody-TCR (AbTCR) platform combines Fab-based antigen recognition with gamma/delta-TCR signaling to facilitate T-cell cytotoxicity with low cytokine release Xu, Yiyang; Yang, Zhiyuan; Horan, Lucas H. Cell Discovery, Vol. 4, Issue 1 https://doi.org/10.1038/s41421-018-0066-6	journal	November 2018
Chimeric antigen receptor T cells form nonclassical and potent immune synapses driving rapid cytotoxicity Davenport, A. J.; Cross, R. S.; Watson, K. A. Proceedings of the National Academy of Sciences, Vol. 115, Issue 9 https://doi.org/10.1073/pnas.1716266115	journal	February 2018
TCR-mimic bispecific antibodies targeting LMP2A show potent activity against EBV malignancies Ahmed, Mahiuddin; Lopez-Albaitero, Andres; Pankov, Dmitry JCI Insight, Vol. 3, Issue 4 https://doi.org/10.1172/jci.insight.97805	journal	February 2018
MoRDa , an automatic molecular replacement pipeline Vagin, Alexey; Lebedev, Andrey Acta Crystallographica Section A Foundations and Advances, Vol. 71, Issue a1 https://doi.org/10.1107/S2053273315099672	journal	August 2015
A Molecular Signature to Discriminate Dysplastic Nodules From Early Hepatocellular Carcinoma in HCV Cirrhosis Llovet, Josep M.; Chen, Yingbei; Wurmbach, Elisa Gastroenterology, Vol. 131, Issue 6 https://doi.org/10.1053/j.gastro.2006.09.014	journal	December 2006
Epidemiology and surveillance for hepatocellular carcinoma: New trends Singal, Amit G.; Lampertico, Pietro; Nahon, Pierre Journal of Hepatology, Vol. 72, Issue 2 https://doi.org/10.1016/j.jhep.2019.08.025	journal	February 2020
Identification of a Titin-Derived HLA-A1–Presented Peptide as a Cross-Reactive Target for Engineered MAGE A3–Directed T Cells Cameron, Brian J.; Gerry, Andrew B.; Dukes, Joseph Science Translational Medicine, Vol. 5, Issue 197 https://doi.org/10.1126/scitranslmed.3006034	journal	August 2013
Impaired assembly and transport of HLA-A and -B antigens in a mutant TxB cell hybrid. Salter, R. D.; Cresswell, P. The EMBO Journal, Vol. 5, Issue 5 https://doi.org/10.1002/j.1460-2075.1986.tb04307.x	journal	May 1986
How tcrs bind Mhcs, Peptides, and Coreceptors Rudolph, Markus G.; Stanfield, Robyn L.; Wilson, Ian A. Annual Review of Immunology, Vol. 24, Issue 1 https://doi.org/10.1146/annurev.immunol.23.021704.115658	journal	April 2006
Structural analysis of glycoproteins: building N-linked glycans with Coot Emsley, Paul; Crispin, Max Acta Crystallographica Section D Structural Biology, Vol. 74, Issue 4 https://doi.org/10.1107/S2059798318005119	journal	April 2018
Glypican 3-Targeted Therapy in Hepatocellular Carcinoma Nishida, Takahiro; Kataoka, Hiroaki Cancers, Vol. 11, Issue 9 https://doi.org/10.3390/cancers11091339	journal	September 2019
Characterization of Genetically Modified T-Cell Receptors that Recognize the CEA:691-699 Peptide in the Context of HLA-A2.1 on Human Colorectal Cancer Cells Parkhurst, Maria R.; Joo, Jayne; Riley, John P. Clinical Cancer Research, Vol. 15, Issue 1 https://doi.org/10.1158/1078-0432.CCR-08-1638	journal	December 2008
Glypican 3 Expression in Human Nonneoplastic, Preneoplastic, and Neoplastic Tissues Baumhoer, Daniel; Tornillo, Luigi; Stadlmann, Sylvia American Journal of Clinical Pathology, Vol. 129, Issue 6 https://doi.org/10.1309/HCQWPWD50XHD2DW6	journal	June 2008
TCRs with high affinity for foreign pMHC show self-reactivity Holler, Phillip D.; Chlewicki, Lukasz K.; Kranz, David M. Nature Immunology, Vol. 4, Issue 1 https://doi.org/10.1038/ni863	journal	December 2002
T Cells Targeting Carcinoembryonic Antigen Can Mediate Regression of Metastatic Colorectal Cancer but Induce Severe Transient Colitis Parkhurst, Maria R.; Yang, James C.; Langan, Russell C. Molecular Therapy, Vol. 19, Issue 3 https://doi.org/10.1038/mt.2010.272	journal	March 2011
Therapeutic bispecific T-cell engager antibody targeting the intracellular oncoprotein WT1 Dao, Tao; Pankov, Dmitry; Scott, Andrew Nature Biotechnology, Vol. 33, Issue 10 https://doi.org/10.1038/nbt.3349	journal	September 2015
Genetic variation in MHC proteins is associated with T cell receptor expression biases Sharon, Eilon; Sibener, Leah V.; Battle, Alexis Nature Genetics, Vol. 48, Issue 9 https://doi.org/10.1038/ng.3625	journal	August 2016
Towards automated crystallographic structure refinement with phenix.refine Afonine, Pavel V.; Grosse-Kunstleve, Ralf W.; Echols, Nathaniel Acta Crystallographica Section D Biological Crystallography, Vol. 68, Issue 4 https://doi.org/10.1107/S0907444912001308	journal	March 2012
A therapeutic T cell receptor mimic antibody targets tumor-associated PRAME peptide/HLA-I antigens Chang, Aaron Y.; Dao, Tao; Gejman, Ron S. Journal of Clinical Investigation, Vol. 127, Issue 7 https://doi.org/10.1172/JCI92335	journal	June 2017
Targeting Alpha-Fetoprotein (AFP)–MHC Complex with CAR T-Cell Therapy for Liver Cancer Liu, Hong; Xu, Yiyang; Xiang, Jingyi Clinical Cancer Research, Vol. 23, Issue 2 https://doi.org/10.1158/1078-0432.CCR-16-1203	journal	January 2017
Optimized T-cell receptor-mimic chimeric antigen receptor T cells directed toward the intracellular Wilms Tumor 1 antigen Rafiq, S.; Purdon, T. J.; Daniyan, A. F. Leukemia, Vol. 31, Issue 8 https://doi.org/10.1038/leu.2016.373	journal	December 2016
High-Affinity TCRs Generated by Phage Display Provide CD4 ⁺ T Cells with the Ability to Recognize and Kill Tumor Cell Lines Zhao, Yangbing; Bennett, Alan D.; Zheng, Zhili The Journal of Immunology, Vol. 179, Issue 9 https://doi.org/10.4049/jimmunol.179.9.5845	journal	October 2007
Understanding the complexity and malleability of T-cell recognition Miles, John J.; McCluskey, James; Rossjohn, Jamie Immunology and Cell Biology, Vol. 93, Issue 5 https://doi.org/10.1038/icb.2014.112	journal	January 2015
Why must T cells be cross-reactive? Sewell, Andrew K. Nature Reviews Immunology, Vol. 12, Issue 9 https://doi.org/10.1038/nri3279	journal	August 2012
MolProbity: More and better reference data for improved all-atom structure validation: PROTEIN SCIENCE.ORG Williams, Christopher J.; Headd, Jeffrey J.; Moriarty, Nigel W. Protein Science, Vol. 27, Issue 1 https://doi.org/10.1002/pro.3330	journal	November 2017
CD8 ⁺ T-Cell Response-Associated Evolution of Hepatitis B Virus Core Protein and Disease Progress Zhang, Yu; Wu, Yan; Deng, Mengmeng Journal of Virology, Vol. 92, Issue 17 https://doi.org/10.1128/JVI.02120-17	journal	September 2018
Role of BRAF in Hepatocellular Carcinoma: A Rationale for Future Targeted Cancer Therapies Gnoni, Antonio; Licchetta, Antonella; Memeo, Riccardo Medicina, Vol. 55, Issue 12 https://doi.org/10.3390/medicina55120754	journal	November 2019
Glypicans in growth control and cancer Filmus, J. Glycobiology, Vol. 11, Issue 3 https://doi.org/10.1093/glycob/11.3.19R	journal	March 2001
Functionally distinct PI 3-kinase pathways regulate myelination in the peripheral nervous system Heller, Bradley A.; Ghidinelli, Monica; Voelkl, Jakob Journal of Cell Biology, Vol. 204, Issue 7 https://doi.org/10.1083/jcb.201307057	journal	March 2014
Deregulation of HLA-I in cancer and its central importance for immunotherapy Hazini, Ahmet; Fisher, Kerry; Seymour, Len Journal for ImmunoTherapy of Cancer, Vol. 9, Issue 8 https://doi.org/10.1136/jitc-2021-002899	journal	August 2021
Attenuated T Cell Responses to a High-Potency Ligand In Vivo Corse, Emily; Gottschalk, Rachel A.; Krogsgaard, Michelle PLoS Biology, Vol. 8, Issue 9 https://doi.org/10.1371/journal.pbio.1000481	journal	September 2010
A TCR-mimic antibody to WT1 bypasses tyrosine kinase inhibitor resistance in human BCR-ABL+ leukemias Dubrovsky, Leonid; Pankov, Dmitry; Brea, Elliott Joseph Blood, Vol. 123, Issue 21 https://doi.org/10.1182/blood-2014-01-549022	journal	May 2014
Two Different T Cell Receptors use Different Thermodynamic Strategies to Recognize the Same Peptide/MHC Ligand Davis-Harrison, Rebecca L.; Armstrong, Kathryn M.; Baker, Brian M. Journal of Molecular Biology, Vol. 346, Issue 2 https://doi.org/10.1016/j.jmb.2004.11.063	journal	February 2005
T cell receptor cross-reactivity expanded by dramatic peptide–MHC adaptability Riley, Timothy P.; Hellman, Lance M.; Gee, Marvin H. Nature Chemical Biology, Vol. 14, Issue 10 https://doi.org/10.1038/s41589-018-0130-4	journal	September 2018
SHP-1 phosphatase activity counteracts increased T cell receptor affinity Hebeisen, Michael; Baitsch, Lukas; Presotto, Danilo Journal of Clinical Investigation, Vol. 123, Issue 3 https://doi.org/10.1172/JCI65325	journal	February 2013
Cardiovascular toxicity and titin cross-reactivity of affinity-enhanced T cells in myeloma and melanoma Linette, Gerald P.; Stadtmauer, Edward A.; Maus, Marcela V. Blood, Vol. 122, Issue 6 https://doi.org/10.1182/blood-2013-03-490565	journal	August 2013
T Cell Antigen Receptor Recognition of Antigen-Presenting Molecules Rossjohn, Jamie; Gras, Stephanie; Miles, John J. Annual Review of Immunology, Vol. 33, Issue 1 https://doi.org/10.1146/annurev-immunol-032414-112334	journal	March 2015
CD28 Costimulation: From Mechanism to Therapy Esensten, Jonathan H.; Helou, Ynes A.; Chopra, Gaurav Immunity, Vol. 44, Issue 5 https://doi.org/10.1016/j.immuni.2016.04.020	journal	May 2016
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity Barretina, Jordi; Caponigro, Giordano; Stransky, Nicolas Nature, Vol. 483, Issue 7391 https://doi.org/10.1038/nature11003	journal	March 2012

Similar Records

Structure of a TCR-Mimic Antibody with Target Predicts Pharmacogenetics

Journal Article · 2015 · Journal of Molecular Biology · OSTI ID:1380035

Mathematical Modeling to Simulate the Effect of Adding Radiation Therapy to Immunotherapy and Application to Hepatocellular Carcinoma

Journal Article · 2022 · International Journal of Radiation Oncology, Biology and Physics · OSTI ID:23200894

Immunotherapy for ovarian cancer

Journal Article · 1990 · Current Opinion in Oncology; (United States) · OSTI ID:5265258

Validation and promise of a TCR mimic antibody for cancer immunotherapy of hepatocellular carcinoma

Citation Formats

References (59)

Similar Records

Related Subjects