Molecular mechanism for strengthening E-cadherin adhesionusing a monoclonal antibody

Xie, Bin; Maker, Allison; Priest, Andrew V.; Dranow, David M.; Phan, Jenny N.; Edwards, Thomas E.; Staker, Bart L.; Myler, Peter J.; Gumbiner, Barry M.; Sivasankara, Sanjeevi

doi:10.1073/pnas.2204473119

Molecular mechanism for strengthening E-cadherin adhesionusing a monoclonal antibody

Journal Article · 01 August 2022 · Proc. Natl. Acad. Sci. USA

DOI:https://doi.org/10.1073/pnas.2204473119· OSTI ID:1900704

Xie, Bin; Maker, Allison; Priest, Andrew V.; Dranow, David M.; Phan, Jenny N.; Edwards, Thomas E.; Staker, Bart L.; Myler, Peter J.; Gumbiner, Barry M.; Sivasankara, Sanjeevi

Research Organization:: Advanced Photon Source (APS), Argonne National Laboratory (ANL), Argonne, IL (US)

Sponsoring Organization:: DOE - Office Of Science; NIGMS; NIH

OSTI ID:: 1900704

Journal Information:: Proc. Natl. Acad. Sci. USA, Journal Name: Proc. Natl. Acad. Sci. USA Journal Issue: (32) Vol. 119

Country of Publication:: United States

Language:: ENGLISH

References (40)

Genes regulating membrane-associated E-cadherin and proliferation in adenomatous polyposis coli mutant colon cancer cells: High content siRNA screen King, Lauren E.; Zhang, Hui-Hua; Gould, Cathryn M. PLOS ONE, Vol. 15, Issue 10 https://doi.org/10.1371/journal.pone.0240746	journal	October 2020
Features and development of Coot Emsley, P.; Lohkamp, B.; Scott, W. G. Acta Crystallographica Section D Biological Crystallography, Vol. 66, Issue 4 https://doi.org/10.1107/S0907444910007493	journal	March 2010
Integration, scaling, space-group assignment and post-refinement Kabsch, Wolfgang Acta Crystallographica Section D Biological Crystallography, Vol. 66, Issue 2, p. 133-144 https://doi.org/10.1107/S0907444909047374	journal	January 2010
Solving structures of protein complexes by molecular replacement with Phaser McCoy, Airlie J. Acta Crystallographica Section D Biological Crystallography, Vol. 63, Issue 1 https://doi.org/10.1107/S0907444906045975	journal	December 2006
Conformational epitopes at cadherin calcium-binding sites and p120-catenin phosphorylation regulate cell adhesion Petrova, Yuliya I.; Spano, MarthaJoy M.; Gumbiner, Barry M. Molecular Biology of the Cell, Vol. 23, Issue 11 https://doi.org/10.1091/mbc.e11-12-1060	journal	June 2012
PHENIX: a comprehensive Python-based system for macromolecular structure solution Adams, Paul D.; Afonine, Pavel V.; Bunkóczi, Gábor Acta Crystallographica Section D Biological Crystallography, Vol. 66, Issue 2, p. 213-221 https://doi.org/10.1107/S0907444909052925	journal	January 2010
Anti-integrin monoclonal antibodies Byron, A.; Humphries, J. D.; Askari, J. A. Journal of Cell Science, Vol. 122, Issue 22 https://doi.org/10.1242/jcs.056770	journal	November 2009
MolProbity : all-atom structure validation for macromolecular crystallography Chen, Vincent B.; Arendall, W. Bryan; Headd, Jeffrey J. Acta Crystallographica Section D Biological Crystallography, Vol. 66, Issue 1 https://doi.org/10.1107/S0907444909042073	journal	December 2009
Evaluation and Reparametrization of the OPLS-AA Force Field for Proteins via Comparison with Accurate Quantum Chemical Calculations on Peptides ^† Kaminski, George A.; Friesner, Richard A.; Tirado-Rives, Julian The Journal of Physical Chemistry B, Vol. 105, Issue 28 https://doi.org/10.1021/jp003919d	journal	July 2001
Proteolytic E-cadherin activation followed by solution NMR and X-ray crystallography Häussinger, Daniel; Ahrens, Thomas; Aberle, Thomas The EMBO Journal, Vol. 23, Issue 8 https://doi.org/10.1038/sj.emboj.7600192	journal	April 2004
Integrin-based therapeutics: biological basis, clinical use and new drugs Ley, Klaus; Rivera-Nieves, Jesus; Sandborn, William J. Nature Reviews Drug Discovery, Vol. 15, Issue 3 https://doi.org/10.1038/nrd.2015.10	journal	January 2016
Thinking outside the cell: how cadherins drive adhesion Brasch, Julia; Harrison, Oliver J.; Honig, Barry Trends in Cell Biology, Vol. 22, Issue 6 https://doi.org/10.1016/j.tcb.2012.03.004	journal	June 2012
Relative Solvent Accessible Surface Area Predicts Protein Conformational Changes upon Binding Marsh, Joseph A.; Teichmann, Sarah A. Structure, Vol. 19, Issue 6 https://doi.org/10.1016/j.str.2011.03.010	journal	June 2011
Mapping transmembrane binding partners for E-cadherin ectodomains Shafraz, Omer; Xie, Bin; Yamada, Soichiro Proceedings of the National Academy of Sciences, Vol. 117, Issue 49 https://doi.org/10.1073/pnas.2010209117	journal	November 2020
Protein production by auto-induction in high-density shaking cultures Studier, F. William Protein Expression and Purification, Vol. 41, Issue 1, p. 207-234 https://doi.org/10.1016/j.pep.2005.01.016	journal	May 2005
Structural and energetic determinants of adhesive binding specificity in type I cadherins Vendome, Jeremie; Felsovalyi, Klara; Song, Hang Proceedings of the National Academy of Sciences, Vol. 111, Issue 40 https://doi.org/10.1073/pnas.1416737111	journal	September 2014
E-cadherin in contact inhibition and cancer Mendonsa, Alisha M.; Na, Tae-Young; Gumbiner, Barry M. Oncogene, Vol. 37, Issue 35 https://doi.org/10.1038/s41388-018-0304-2	journal	May 2018
Ideal, catch, and slip bonds in cadherin adhesion Rakshit, S.; Zhang, Y.; Manibog, K. Proceedings of the National Academy of Sciences, Vol. 109, Issue 46 https://doi.org/10.1073/pnas.1208349109	journal	October 2012
An improved SUMO fusion protein system for effective production of native proteins Lee, Chien-Der; Sun, Hui-Chien; Hu, Su-Ming Protein Science, Vol. 17, Issue 7 https://doi.org/10.1110/ps.035188.108	journal	July 2008
A new crystal structure, Ca2+ dependence and mutational analysis reveal molecular details of E-cadherin homoassociation Pertz, O. The EMBO Journal, Vol. 18, Issue 7 https://doi.org/10.1093/emboj/18.7.1738	journal	April 1999
Coot model-building tools for molecular graphics Emsley, Paul; Cowtan, Kevin Acta Crystallographica Section D Biological Crystallography, Vol. 60, Issue 12, p. 2126-2132 https://doi.org/10.1107/S0907444904019158	journal	November 2004
Mechanism of E-cadherin dimerization probed by NMR relaxation dispersion Li, Ying; Altorelli, Nicole L.; Bahna, Fabiana Proceedings of the National Academy of Sciences, Vol. 110, Issue 41 https://doi.org/10.1073/pnas.1314303110	journal	September 2013
Molecular determinants of cadherin ideal bond formation: Conformation-dependent unbinding on a multidimensional landscape Manibog, Kristine; Sankar, Kannan; Kim, Sun-Ae Proceedings of the National Academy of Sciences, Vol. 113, Issue 39 https://doi.org/10.1073/pnas.1604012113	journal	September 2016
Roles for E-cadherin cell surface regulation in cancer Petrova, Yuliya I.; Schecterson, Leslayann; Gumbiner, Barry M. Molecular Biology of the Cell, Vol. 27, Issue 21 https://doi.org/10.1091/mbc.E16-01-0058	journal	November 2016
Two-step adhesive binding by classical cadherins Harrison, Oliver J.; Bahna, Fabiana; Katsamba, Phini S. Nature Structural & Molecular Biology, Vol. 17, Issue 3 https://doi.org/10.1038/nsmb.1784	journal	February 2010
The Crystal Structure of Human E-cadherin Domains 1 and 2, and Comparison with other Cadherins in the Context of Adhesion Mechanism Parisini, Emilio; Higgins, Jonathan M. G.; Liu, Jin-huan Journal of Molecular Biology, Vol. 373, Issue 2 https://doi.org/10.1016/j.jmb.2007.08.011	journal	October 2007
The Extracellular Architecture of Adherens Junctions Revealed by Crystal Structures of Type I Cadherins Harrison, Oliver J.; Jin, Xiangshu; Hong, Soonjin Structure, Vol. 19, Issue 2 https://doi.org/10.1016/j.str.2010.11.016	journal	February 2011
E-cadherin activating antibodies limit barrier dysfunction and inflammation in mouse inflammatory bowel disease Bandyopadhyay, Chirosree; Schecterson, Leslayann; Gumbiner, Barry M. Tissue Barriers, Vol. 9, Issue 4 https://doi.org/10.1080/21688370.2021.1940741	journal	August 2021
Calibration of atomic‐force microscope tips Hutter, Jeffrey L.; Bechhoefer, John Review of Scientific Instruments, Vol. 64, Issue 7 https://doi.org/10.1063/1.1143970	journal	July 1993
The functional activity of E-cadherin controls tumor cell metastasis at multiple steps Na, Tae-Young; Schecterson, Leslayann; Mendonsa, Alisha M. Proceedings of the National Academy of Sciences, Vol. 117, Issue 11 https://doi.org/10.1073/pnas.1918167117	journal	March 2020
Resolving cadherin interactions and binding cooperativity at the single-molecule level Zhang, Y.; Sivasankar, S.; Nelson, W. J. Proceedings of the National Academy of Sciences, Vol. 106, Issue 1, p. 109-114 https://doi.org/10.1073/pnas.0811350106	journal	December 2008
Integrins as Therapeutic Targets: Successes and Cancers Raab-Westphal, Sabine; Marshall, John; Goodman, Simon Cancers, Vol. 9, Issue 12 https://doi.org/10.3390/cancers9090110	journal	August 2017
E-cadherin negatively regulates neoplastic growth in non-small cell lung cancer: role of Rho GTPases Asnaghi, L.; Vass, W. C.; Quadri, R. Oncogene, Vol. 29, Issue 19 https://doi.org/10.1038/onc.2010.39	journal	March 2010
Cadherin exits the junction by switching its adhesive bond Hong, Soonjin; Troyanovsky, Regina B.; Troyanovsky, Sergey M. Journal of Cell Biology, Vol. 192, Issue 6 https://doi.org/10.1083/jcb.201006113	journal	March 2011
Characterizing the Initial Encounter Complex in Cadherin Adhesion Sivasankar, Sanjeevi; Zhang, Yunxiang; Nelson, W. James Structure, Vol. 17, Issue 8, p. 1075-1081 https://doi.org/10.1016/j.str.2009.06.012	journal	August 2009
Molecular design principles underlying β-strand swapping in the adhesive dimerization of cadherins Vendome, Jeremie; Posy, Shoshana; Jin, Xiangshu Nature Structural & Molecular Biology, Vol. 18, Issue 6 https://doi.org/10.1038/nsmb.2051	journal	May 2011
The molecular mechanisms underlying reduced E-cadherin expression in invasive ductal carcinoma of the breast: high throughput analysis of large cohorts Alsaleem, Mansour; Toss, Michael S.; Joseph, Chitra Modern Pathology, Vol. 32, Issue 7 https://doi.org/10.1038/s41379-019-0209-9	journal	February 2019
Transient Mammalian Cell Transfection with Polyethylenimine (PEI) Longo, Patti A.; Kavran, Jennifer M.; Kim, Min-Sung Methods in Enzymology https://doi.org/10.1016/B978-0-12-418687-3.00018-5	book	January 2013
E-cadherin-defective gastric cancer cells depend on Laminin to survive and invade Caldeira, Joana; Figueiredo, Joana; Brás-Pereira, Catarina Human Molecular Genetics, Vol. 24, Issue 20 https://doi.org/10.1093/hmg/ddv312	journal	August 2015
Inside-out regulation of E-cadherin conformation and adhesion Koirala, Ramesh; Priest, Andrew Vae; Yen, Chi-Fu Proceedings of the National Academy of Sciences, Vol. 118, Issue 30 https://doi.org/10.1073/pnas.2104090118	journal	July 2021

Similar Records

No ordinary proteins: Adsorption and molecular orientation of monoclonal antibodies

Journal Article · 2021 · Science Advances · OSTI ID:1825761

Monoclonal antibodies and neuroblastoma

Journal Article · 1989 · Seminars in Nuclear Medicine; (USA) · OSTI ID:5226456

Resolving the molecular mechanism of cadherin catch bond formation

Journal Article · 2014 · Nature Communications · OSTI ID:1159301

Molecular mechanism for strengthening E-cadherin adhesionusing a monoclonal antibody

Citation Formats

References (40)

Similar Records

Related Subjects