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Proprotein convertase inhibition promotes ciliated cell differentiation - a potential mechanism for the inhibition of Notch1 signalling by decanoyl-RVKR-chloromethylketone
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November 2016 |
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Evidence for airway surface dehydration as the initiating event in CF airway disease
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January 2007 |
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Role of exotoxin A in inducing severe Pseudomonas aeruginosa infections in mice
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September 1995 |
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Acute Regulation of the Epithelial Sodium Channel in Airway Epithelia by Proteases and Trafficking
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December 2010 |
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Reduced Sodium Transport With Nasal Administration of the Prostasin Inhibitor Camostat in Subjects With Cystic Fibrosis
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July 2013 |
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The biology and therapeutic targeting of the proprotein convertases
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April 2012 |
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PHENIX: a comprehensive Python-based system for macromolecular structure solution
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January 2010 |
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The proprotein convertase furin in tumour progression
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May 2017 |
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Mucus clearance as a primary innate defense mechanism for mammalian airways
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March 2002 |
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Distinct Pools of Epithelial Sodium Channels Are Expressed at the Plasma Membrane
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November 2004 |
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Furin at the cutting edge: From protein traffic to embryogenesis and disease
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October 2002 |
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Na+ transport in cystic fibrosis respiratory epithelia. Abnormal basal rate and response to adenylate cyclase activation.
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November 1986 |
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Notch1 Autoactivation via Transcriptional Regulation of Furin, Which Sustains Notch1 Signaling by Processing Notch1-Activating Proteases ADAM10 and Membrane Type 1 Matrix Metalloproteinase
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November 2015 |
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Contribution of toxin A and elastase to virulence of Pseudomonas aeruginosa in chronic lung infections of rats
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June 1982 |
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The Epithelial Sodium Channel Is a Modifier of the Long-Term Nonprogressive Phenotype Associated with F508del CFTR Mutations
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December 2017 |
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Pulmonary Epithelial Sodium-Channel Dysfunction and Excess Airway Liquid in Pseudohypoaldosteronism
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July 1999 |
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A Multibasic Cleavage Site in the Spike Protein of SARS-CoV-2 Is Essential for Infection of Human Lung Cells
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May 2020 |
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Cell entry mechanisms of SARS-CoV-2
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May 2020 |
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Potentiator ivacaftor abrogates pharmacological correction of ΔF508 CFTR in cystic fibrosis
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July 2014 |
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Epithelial Sodium Channels Are Activated by Furin-dependent Proteolysis
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April 2004 |
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Processing of Pseudomonas exotoxin by a cellular protease results in the generation of a 37,000-Da toxin fragment that is translocated to the cytosol
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Therapeutic uses of furin and its inhibitors: a patent review
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January 2015 |
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The Relative Roles of Passive Surface Forces and Active Ion Transport in the Modulation of Airway Surface Liquid Volume and Composition
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July 2001 |
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Tgf-β1 Inhibits Cftr Biogenesis and Prevents Functional Rescue of ΔF508-Cftr in Primary Differentiated Human Bronchial Epithelial Cells
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May 2013 |
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The spike glycoprotein of the new coronavirus 2019-nCoV contains a furin-like cleavage site absent in CoV of the same clade
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April 2020 |
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Loss of furin cleavage site attenuates SARS-CoV-2 pathogenesis
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January 2021 |
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The Notch1 receptor is cleaved constitutively by a furin-like convertase
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July 1998 |
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Coot model-building tools for molecular graphics
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November 2004 |
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Kinetics of the reversible inhibition of enzyme-catalysed reactions by tight-binding inhibitors
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August 1969 |
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Epithelial Na+ Channels Are Fully Activated by Furin- and Prostasin-dependent Release of an Inhibitory Peptide from the γ-Subunit
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March 2007 |
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Modulation of the Epithelial Sodium Channel (ENaC) by Bacterial Metalloproteases and Protease Inhibitors
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June 2014 |
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BacMam production and crystal structure of nonglycosylated apo human furin at 1.89 Å resolution
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March 2019 |
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FurinDB: A Database of 20-Residue Furin Cleavage Site Motifs, Substrates and Their Associated Drugs
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February 2011 |
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X-ray Structures of the Proprotein Convertase Furin Bound with Substrate Analogue Inhibitors Reveal Substrate Specificity Determinants beyond the S4 Pocket
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January 2018 |
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Neutrophil elastase activates near-silent epithelial Na+channels and increases airway epithelial Na+transport
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May 2005 |
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Elevated furin levels in human cystic fibrosis cells result in hypersusceptibility to exotoxin A–induced cytotoxicity
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November 2007 |
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Furin Inhibitors Block SARS-CoV-2 Spike Protein Cleavage to Suppress Virus Production and Cytopathic Effects
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October 2020 |
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Production of elastase, exotoxin A, and alkaline protease in sputa during pulmonary exacerbation of cystic fibrosis in patients chronically infected by Pseudomonas aeruginosa
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April 1995 |
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Development of cystic fibrosis and noncystic fibrosis airway cell lines
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May 2003 |
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A Selective Irreversible Inhibitor of Furin Does Not Prevent Pseudomonas Aeruginosa Exotoxin A-Induced Airway Epithelial Cytotoxicity
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July 2016 |
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Camostat Attenuates Airway Epithelial Sodium Channel Function in Vivo through the Inhibition of a Channel-Activating Protease
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February 2009 |
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Inhibition of Protease–Epithelial Sodium Channel Signaling Improves Mucociliary Function in Cystic Fibrosis Airways
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September 2016 |
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Emerging Concepts and Therapies for Mucoobstructive Lung Disease
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November 2018 |
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Regulation of Airway Surface Liquid Volume and Mucus Transport by Active Ion Transport
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January 2004 |
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CFTR as a cAMP-Dependent Regulator of Sodium Channels
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August 1995 |
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Pseudomonas aeruginosa and other predictors of mortality and morbidity in young children with cystic fibrosis
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July 2002 |
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X-ray Structures of Human Furin in Complex with Competitive Inhibitors
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April 2014 |
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A Segment of γ ENaC Mediates Elastase Activation of Na+ Transport
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November 2007 |