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Title: Structure-Guided Synthesis of FK506 and FK520 Analogs with Increased Selectivity Exhibit In Vivo The

Journal Article · · mBio
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Research Organization:
Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Sponsoring Organization:
DOE - Office Of Science; NIAID; National Institutes of Health (NIH)
OSTI ID:
1900696
Journal Information:
mBio, Vol. 13, Issue (3)
Country of Publication:
United States
Language:
ENGLISH

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The immunosuppressant FK506 and its nonimmunosuppressive analog L-685,818 are toxic to Cryptococcus neoformans by inhibition of a common target protein. journal January 1997
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Calcineurin Inhibitors: 40 Years Later, Can’t Live Without … journal December 2013
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A calcineurin antifungal strategy with analogs of FK506 journal June 2017
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Structures of Pathogenic Fungal FKBP12s Reveal Possible Self-Catalysis Function journal April 2016
Leveraging Fungal and Human Calcineurin-Inhibitor Structures, Biophysical Data, and Dynamics To Design Selective and Nonimmunosuppressive FK506 Analogs journal December 2021
Synergistic Antifungal Activities of Bafilomycin A1, Fluconazole, and the Pneumocandin MK-0991/Caspofungin Acetate (L-743,873) with Calcineurin Inhibitors FK506 and L-685,818 against Cryptococcus neoformans journal March 2000
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