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Fk 506 for Liver, Kidney, and Pancreas Transplantation
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October 1989 |
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Identification of calcineurin as a key signalling enzyme in T-lymphocyte activation
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June 1992 |
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Effects of Voriconazole on Cryptococcus neoformans
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June 2004 |
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The Crz1/Sp1 Transcription Factor of Cryptococcus neoformans Is Activated by Calcineurin and Regulates Cell Wall Integrity
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December 2012 |
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CRZ1, a target of the calcineurin pathway inCandida albicans
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January 2006 |
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Combination Antifungal Therapy: A Review of Current Data
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January 2017 |
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Features and development of Coot
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March 2010 |
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Atomic structure of FKBP-FK506, an immunophilin-immunosuppressant complex
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May 1991 |
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Pulmonary cryptococcosis: A review of pathobiology and clinical aspects
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October 2018 |
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Diverse structures, functions and uses of FK506 binding proteins
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October 2017 |
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PHENIX: a comprehensive Python-based system for macromolecular structure solution
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January 2010 |
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Calcineurin in fungal virulence and drug resistance: Prospects for harnessing targeted inhibition of calcineurin for an antifungal therapeutic approach
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June 2016 |
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In Vitro and In Vivo Assessment of FK506 Analogs as Novel Antifungal Drug Candidates
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September 2018 |
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Leveraging Fungal and Human Calcineurin-Inhibitor Structures, Biophysical Data, and Dynamics To Design Selective and Nonimmunosuppressive FK506 Analogs
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December 2021 |
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Global burden of disease of HIV-associated cryptococcal meningitis: an updated analysis
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August 2017 |
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Announcing the worldwide Protein Data Bank
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December 2003 |
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Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes
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August 1991 |
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MolProbity : all-atom structure validation for macromolecular crystallography
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December 2009 |
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The Poor Prognosis of Central Nervous System Cryptococcosis among Nonimmunosuppressed Patients: A Call for Better Disease Recognition and Evaluation of Adjuncts to Antifungal Therapy
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May 2006 |
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Calcineurin‐dependent dephosphorylation of the transcription factor CrzA at specific sites controls conidiation, stress tolerance, and virulence of Aspergillus fumigatus
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April 2019 |
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The antifungal pipeline: a reality check
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May 2017 |
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Synergistic Antifungal Activities of Bafilomycin A1, Fluconazole, and the Pneumocandin MK-0991/Caspofungin Acetate (L-743,873) with Calcineurin Inhibitors FK506 and L-685,818 against Cryptococcus neoformans
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March 2000 |
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GROMACS: High performance molecular simulations through multi-level parallelism from laptops to supercomputers
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September 2015 |
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Components of the Calcium-Calcineurin Signaling Pathway in Fungal Cells and Their Potential as Antifungal Targets
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January 2015 |
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Structures of Pathogenic Fungal FKBP12s Reveal Possible Self-Catalysis Function
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April 2016 |
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FK-506- and CsA-sensitive activation of the interleukin-2 promoter by calcineurin
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June 1992 |
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An Automated Force Field Topology Builder (ATB) and Repository: Version 1.0
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October 2011 |
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Update on antifungal resistance in Aspergillus and Candida
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June 2014 |
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Harnessing calcineurin as a novel anti-infective agent against invasive fungal infections
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June 2007 |
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Calcineurin is essential in cyclosporin A- and FK506-sensitive yeast strains.
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June 1994 |
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Automated Topology Builder Version 3.0: Prediction of Solvation Free Enthalpies in Water and Hexane
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October 2018 |
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Calcineurin Inhibitors: 40 Years Later, Can’t Live Without …
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December 2013 |
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Elucidation of the calcineurin-Crz1 stress response transcriptional network in the human fungal pathogen Cryptococcus neoformans
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April 2017 |
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Transcriptional regulation by calcium, calcineurin, and NFAT
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September 2003 |
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UCSF Chimera?A visualization system for exploratory research and analysis
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January 2004 |
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FK-506, a novel immunosuppressant isolated from a Streptomyces. II. Immunosuppressive effect of FK-506 in vitro.
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January 1987 |
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Cryptococcal therapies and drug targets: the old, the new and the promising
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April 2016 |
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XDS
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January 2010 |
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The Integrated Resource for Reproducibility in Macromolecular Crystallography: Experiences of the first four years
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November 2019 |
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A public database of macromolecular diffraction experiments
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October 2016 |
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Characterization of FK506 Biosynthetic Intermediates Involved in Post-PKS Elaboration
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May 2013 |
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The immunosuppressant FK506 and its nonimmunosuppressive analog L-685,818 are toxic to Cryptococcus neoformans by inhibition of a common target protein.
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January 1997 |
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A calcineurin antifungal strategy with analogs of FK506
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June 2017 |
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Synthesis of ascomycin and FK 506 derivatives with modified effector domain
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May 1999 |
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Calcineurin as a multifunctional regulator: Unraveling novel functions in fungal stress responses, hyphal growth, drug resistance, and pathogenesis
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October 2014 |
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Calcineurin is required for virulence of Cryptococcus neoformans
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May 1997 |
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FR-900520 and FR-900523, novel immunosuppressants isolated from a Streptomyces. II. Fermentation, isolation and physico-chemical and biological characteristics.
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January 1988 |
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Global and Multi-National Prevalence of Fungal Diseases—Estimate Precision
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October 2017 |
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FK-506-binding protein: three-dimensional structure of the complex with the antagonist L-685,818
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May 1993 |
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Interaction of calcineurin with substrates and targeting proteins
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February 2011 |
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Harnessing calcineurin-FK506-FKBP12 crystal structures from invasive fungal pathogens to develop antifungal agents
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September 2019 |
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Studies of the Induction and Maintenance of Long-Term Graft Acceptance by Treatment with Fk506 in Heterotopic Cardiac Allotransplantation in rats
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December 1987 |
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In-vitro activity of dicationic aromatic compounds and fluconazole against Cryptococcus neoformans and Candida spp.
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August 1999 |
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Ascomycin and FK506: Pharmacology and Therapeutic Potential as Anticonvulsants and Neuroprotectants
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March 2008 |
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The Protein Data Bank
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January 2000 |