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Structural diversity of the SARS-CoV-2 Omicron spike

Journal Article · · Mol. Cell
Research Organization:
Advanced Photon Source (APS), Argonne National Laboratory (ANL), Argonne, IL (US)
Sponsoring Organization:
DOE - Office Of Science; NSF
OSTI ID:
1900683
Journal Information:
Mol. Cell, Journal Name: Mol. Cell Journal Issue: (11) Vol. 82
Country of Publication:
United States
Language:
ENGLISH

References (44)

Real-Time Conformational Dynamics of SARS-CoV-2 Spikes on Virus Particles journal December 2020
The Omicron variant is highly resistant against antibody-mediated neutralization: Implications for control of the COVID-19 pandemic journal February 2022
Structural basis for enhanced infectivity and immune evasion of SARS-CoV-2 variants journal August 2021
Effect of natural mutations of SARS-CoV-2 on spike structure, conformation, and antigenicity journal August 2021
Cross-neutralization of SARS-CoV-2 by a human monoclonal SARS-CoV antibody journal May 2020
Structure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycoprotein journal April 2020
Features and development of Coot journal March 2010
[20] Processing of X-ray diffraction data collected in oscillation mode book January 1997
SARS-CoV-2 immune evasion by the B.1.427/B.1.429 variant of concern journal July 2021
PHENIX: a comprehensive Python-based system for macromolecular structure solution journal January 2010
Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation journal February 2020
Phaser crystallographic software journal July 2007
Structure-based design of prefusion-stabilized SARS-CoV-2 spikes journal July 2020
Processing of Structurally Heterogeneous Cryo-EM Data in RELION book January 2016
A broadly cross-reactive antibody neutralizes and protects against sarbecovirus challenge in mice journal January 2022
Fab-dimerized glycan-reactive antibodies are a structural category of natural antibodies journal May 2021
Real-space refinement in PHENIX for cryo-EM and crystallography journal May 2018
RELION: Implementation of a Bayesian approach to cryo-EM structure determination journal December 2012
SARS-CoV-2 Variants Increase Kinetic Stability of Open Spike Conformations as an Evolutionary Strategy journal February 2022
ISOLDE : a physically realistic environment for model building into low-resolution electron-density maps journal April 2018
Membrane fusion and immune evasion by the spike protein of SARS-CoV-2 Delta variant journal December 2021
Considerable escape of SARS-CoV-2 Omicron to antibody neutralization journal December 2021
Broadly neutralizing antibodies overcome SARS-CoV-2 Omicron antigenic shift journal December 2021
Macromolecular structure determination using X-rays, neutrons and electrons: recent developments in Phenix journal October 2019
Molecular basis of immune evasion by the Delta and Kappa SARS-CoV-2 variants journal December 2021
New tools for automated high-resolution cryo-EM structure determination in RELION-3 journal November 2018
VMD: Visual molecular dynamics journal February 1996
A highly conserved cryptic epitope in the receptor binding domains of SARS-CoV-2 and SARS-CoV journal April 2020
Controlling the SARS-CoV-2 spike glycoprotein conformation journal July 2020
cryoSPARC: algorithms for rapid unsupervised cryo-EM structure determination journal February 2017
Cold sensitivity of the SARS-CoV-2 spike ectodomain journal January 2021
UCSF ChimeraX: Meeting modern challenges in visualization and analysis: UCSF ChimeraX Visualization System journal September 2017
UCSF Chimera?A visualization system for exploratory research and analysis journal January 2004
Broad sarbecovirus neutralization by a human monoclonal antibody journal July 2021
D614G Mutation Alters SARS-CoV-2 Spike Conformation and Enhances Protease Cleavage at the S1/S2 Junction journal January 2021
SARS-CoV-2 Omicron variant: Antibody evasion and cryo-EM structure of spike protein–ACE2 complex journal February 2022
Plasma Neutralization of the SARS-CoV-2 Omicron Variant journal February 2022
Immune correlates analysis of the mRNA-1273 COVID-19 vaccine efficacy clinical trial journal January 2022
Structures and distributions of SARS-CoV-2 spike proteins on intact virions journal August 2020
Structural and functional impact by SARS-CoV-2 Omicron spike mutations journal April 2022
Omicron escapes the majority of existing SARS-CoV-2 neutralizing antibodies journal December 2021
The Bio3D packages for structural bioinformatics journal August 2020
In vitro and in vivo functions of SARS-CoV-2 infection-enhancing and neutralizing antibodies journal August 2021
N-terminal domain antigenic mapping reveals a site of vulnerability for SARS-CoV-2 journal April 2021

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