Chelating platform for delivery of radionuclides

Strong, Roland K.; Rupert, Peter; Abergel, Rebecca J.; Captain, Ilya; Deblonde, Gauthier J. P.

Chelating platform for delivery of radionuclides

Patent · 31 January 2022

OSTI ID:1892574

Strong, Roland K.; Rupert, Peter; Abergel, Rebecca J.; Captain, Ilya; Deblonde, Gauthier J. P.

Siderocalin-metal chelator combinations that bind metallic radioisotopes used in nuclear medicine with high affinity are described. The high affinity siderocalin-metal chelator combinations include a number of chelator backbone arrangements with functional groups that coordinate with metals. The siderocalin-metal chelator combinations can be used to deliver radionuclides for imaging and therapeutic purposes.

View Patent

Research Organization:: Fred Hutchinson Cancer Research Center, Seattle, WA (United States); Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)

Sponsoring Organization:: USDOE; National Institutes of Health (NIH)

DOE Contract Number:: AC02-05CH11231

Assignee:: Fred Hutchinson Cancer Research Center (Seattle, WA); The Regents of the University of California (Oakland, CA)

Patent Number(s):: 11,235,076

Application Number:: 16/329,178

OSTI ID:: 1892574

Country of Publication:: United States

Language:: English

References (163)

A Strategy to Achieve Efficient Dual-Mode Luminescence of Eu3+ in Lanthanides Doped Multifunctional NaGdF4 Nanocrystals Liu, Yongsheng; Tu, Datao; Zhu, Haomiao Advanced Materials, Vol. 22, Issue 30 https://doi.org/10.1002/adma.201000128	journal	June 2010
Highly Luminescent and Stable Hydroxypyridinonate Complexes: A Step Towards New Curium Decontamination Strategies Sturzbecher-Hoehne, Manuel; Kullgren, Birgitta; Jarvis, Erin E. Chemistry - A European Journal, Vol. 20, Issue 32 https://doi.org/10.1002/chem.201402103	journal	July 2014
Unprecedented Inversion of Selectivity and Extraordinary Difference in the Complexation of Trivalent f Elements by Diastereomers of a Methylated Diglycolamide Wilden, Andreas; Kowalski, Piotr M.; Klaß, Larissa Chemistry – A European Journal, Vol. 25, Issue 21 https://doi.org/10.1002/chem.201806161	journal	March 2019
Significance of Single Variables in Defining Adequate Animal Models to Assess the Efficacy of New Radionuclide Decorporation Agents: Using the Contamination Dose as an Example: Animal Models for Chelating Agents Efficacy Jarvis, Erin E.; An, Dahlia D.; Kullgren, Birgitta Drug Development Research, Vol. 73, Issue 5 https://doi.org/10.1002/ddr.21020	journal	August 2012
Radiation Drugs-A Hot Topic: Radiation Drugs Moos, Walter H.; Shankar, Gita N. Drug Development Research, Vol. 73, Issue 5 https://doi.org/10.1002/ddr.21023	journal	August 2012
Biodistribution of the Multidentate Hydroxypyridinonate Ligand [ ¹⁴ C]-3,4,3-LI(1,2-HOPO), a Potent Actinide Decorporation Agent : BIODISTRIBUTION OF 3,4,3-LI(1,2-HOPO) Choi, Taylor A.; Endsley, Aaron N.; Bunin, Deborah I. Drug Development Research, Vol. 76, Issue 3 https://doi.org/10.1002/ddr.21246	journal	April 2015
Synthesis of 3,4,3 LI 1,2 HOPO labelled with ¹⁴C: Synthesis of 3,4,3 Burgada, R.; Bailly, T.; Noël, J. P. Journal of Labelled Compounds and Radiopharmaceuticals, Vol. 44, Issue 1, p. 13-19 https://doi.org/10.1002/jlcr.427	journal	February 2001
In Vitro Metabolism and Stability of the Actinide Chelating Agent 3,4,3-LI(1,2-HOPO) Choi, Taylor A.; Furimsky, Anna M.; Swezey, Robert Journal of Pharmaceutical Sciences, Vol. 104, Issue 5 https://doi.org/10.1002/jps.24394	journal	May 2015
Energy Transfer Lakowicz, Joseph R. Principles of Fluorescence Spectroscopy https://doi.org/10.1007/978-1-4757-3061-6_13	book	January 1999
Understanding the Health Impacts and Risks of Exposure to Radiation Choi, Taylor A.; Costes, Sylvain V.; Abergel, Rebecca J. Reflections on the Fukushima Daiichi Nuclear Accident https://doi.org/10.1007/978-3-319-12090-4_13	book	December 2014
Antibodies from Escherichia coli Plückthun, A. The Pharmacology of Monoclonal Antibodies https://doi.org/10.1007/978-3-642-78432-3_11	book	January 1994
Extraction of tetravalent berkelium by high molecular weight amines in the presence of heteropolyanions Milyukova, M. S.; Malikov, D. A.; Kuzovkina, E. V. Journal of Radioanalytical and Nuclear Chemistry Letters, Vol. 104, Issue 2 https://doi.org/10.1007/BF02166922	journal	March 1986
The separation of berkelium(III) from cerium(III) Chudinov, E. G.; Pirozhkov, S. V. Journal of Radioanalytical Chemistry, Vol. 10, Issue 1 https://doi.org/10.1007/BF02518764	journal	February 1972
Procedures for a fast separation of berkelium from complex mixtures of reaction products Liu, Yuan-Fang; Luo, Cheng; Moody, K. J. Journal of Radioanalytical Chemistry, Vol. 76, Issue 1 https://doi.org/10.1007/BF02519662	journal	March 1983
Siderocalins: siderophore-binding proteins of the innate immune system Clifton, Matthew C.; Corrent, Colin; Strong, Roland K. BioMetals, Vol. 22, Issue 4 https://doi.org/10.1007/s10534-009-9207-6	journal	January 2009
Solvent extraction studies of plutonium(IV) and americium(III) in room temperature ionic liquid (RTIL) by di-2-ethyl hexyl phosphoric acid (HDEHP) as extractant Lohithakshan, K. V.; Patil, Prashant; Aggarwal, S. K. Journal of Radioanalytical and Nuclear Chemistry, Vol. 301, Issue 1 https://doi.org/10.1007/s10967-014-3119-9	journal	April 2014
Extraction chromatographic behavior of actinium and REE on DGA, Ln and TRU resins in nitric acid solutions Ostapenko, V.; Vasiliev, A.; Lapshina, E. Journal of Radioanalytical and Nuclear Chemistry, Vol. 306, Issue 3 https://doi.org/10.1007/s10967-015-4331-y	journal	August 2015
Extraction of trivalent americium and europium with TODGA homologs from HNO3 solution Wang, Zhipeng; Huang, Huang; Ding, Songdong Journal of Radioanalytical and Nuclear Chemistry, Vol. 313, Issue 2 https://doi.org/10.1007/s10967-017-5317-8	journal	June 2017
Ligand-dependent luminescence of ultra-small Eu3+-doped NaYF4 nanoparticles Wawrzynczyk, Dominika; Bednarkiewicz, Artur; Nyk, Marcin Journal of Nanoparticle Research, Vol. 15, Issue 6 https://doi.org/10.1007/s11051-013-1707-1	journal	May 2013
An overview of targeted alpha therapy Kim, Young-Seung; Brechbiel, Martin W. Tumor Biology, Vol. 33, Issue 3 https://doi.org/10.1007/s13277-011-0286-y	journal	December 2011
Characterization and Leaching of Neodymium Magnet Waste and Solvent Extraction of the Rare-Earth Elements Using TODGA Gergoric, Marino; Ekberg, Christian; Foreman, Mark R. St J. Journal of Sustainable Metallurgy, Vol. 3, Issue 3 https://doi.org/10.1007/s40831-017-0122-8	journal	April 2017
The absorption spectra of Bk3+ and Bk4+ in solution Gutmacher, R. G.; Hulet, E. K.; Lougheed, R. Journal of Inorganic and Nuclear Chemistry, Vol. 29, Issue 9 https://doi.org/10.1016/0022-1902(67)80289-6	journal	September 1967
Absorption spectra of Bk(III) and Bk(IV) in several media Baybarz, R. D.; Stokely, J. R.; Peterson, J. R. Journal of Inorganic and Nuclear Chemistry, Vol. 34, Issue 2 https://doi.org/10.1016/0022-1902(72)80456-1	journal	February 1972
The stability of tetravalent berkelium in acid solution and the absorption spectra of Bk(IV) and Bk(III) Gutmacher, R. G.; Bodé, D. D.; Lougheed, R. W. Journal of Inorganic and Nuclear Chemistry, Vol. 35, Issue 3 https://doi.org/10.1016/0022-1902(73)80469-5	journal	March 1973
Investigation of equilibria in solution. Determination of equilibrium constants with the HYPERQUAD suite of programs Gans, P.; Sabatini, A.; Vacca, A. Talanta, Vol. 43, Issue 10 https://doi.org/10.1016/0039-9140(96)01958-3	journal	October 1996
Designing Prodrugs and Bioprecursors Wermuth, Camille G. The Practice of Medicinal Chemistry, p. 561-585 https://doi.org/10.1016/B978-012744481-9/50037-4	book	January 2003
Hyperquad simulation and speciation (HySS): a utility program for the investigation of equilibria involving soluble and partially soluble species Alderighi, Lucia; Gans, Peter; Ienco, Andrea Coordination Chemistry Reviews, Vol. 184, Issue 1 https://doi.org/10.1016/S0010-8545(98)00260-4	journal	April 1999
Possible stabilization of the tetravalent oxidation state of berkelium and californium in acetonitrile with triphenylarsine oxide Payne, Gerard F.; Peterson, Joseph R. Inorganica Chimica Acta, Vol. 139, Issue 1-2 https://doi.org/10.1016/S0020-1693(00)84051-7	journal	December 1987
Laser induced fluorescence of 249Bk4+ in CeF4 Jursich, G. M.; Beitz, J. V.; Carnall, W. T. Inorganica Chimica Acta, Vol. 139, Issue 1-2 https://doi.org/10.1016/S0020-1693(00)84093-1	journal	December 1987
GLEE, a new computer program for glass electrode calibration Gans, P. Talanta, Vol. 51, Issue 1 https://doi.org/10.1016/S0039-9140(99)00245-3	journal	January 2000
[20] Processing of X-ray diffraction data collected in oscillation mode Otwinowski, Zbyszek; Minor, Wladek Macromolecular Crystallography Part A, 307-326 https://doi.org/10.1016/S0076-6879(97)76066-X	book	January 1997
Safety of gadolinium contrast angiography in patients with chronic renal insufficiency Sam, Albert D.; Morasch, Mark D.; Collins, Jeremy Journal of Vascular Surgery, Vol. 38, Issue 2 https://doi.org/10.1016/S0741-5214(03)00315-X	journal	August 2003
The Neutrophil Lipocalin NGAL Is a Bacteriostatic Agent that Interferes with Siderophore-Mediated Iron Acquisition Goetz, David H.; Holmes, Margaret A.; Borregaard, Niels Molecular Cell, Vol. 10, Issue 5 https://doi.org/10.1016/S1097-2765(02)00708-6	journal	November 2002
Cumulative study on solvent extraction of elements by N,N,N′,N′-tetraoctyl-3-oxapentanediamide (TODGA) from nitric acid into n-dodecane Zhu, Zhi-Xuan; Sasaki, Yuji; Suzuki, Hideya Analytica Chimica Acta, Vol. 527, Issue 2 https://doi.org/10.1016/j.aca.2004.09.023	journal	December 2004
Novel drug delivery systems for actinides (uranium and plutonium) decontamination agents Fattal, Elias; Tsapis, Nicolas; Phan, Guillaume Advanced Drug Delivery Reviews, Vol. 90 https://doi.org/10.1016/j.addr.2015.06.009	journal	August 2015
NGAL-Siderocalin in kidney disease Paragas, Neal; Qiu, Andong; Hollmen, Maria Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, Vol. 1823, Issue 9 https://doi.org/10.1016/j.bbamcr.2012.06.014	journal	September 2012
From early prophylaxis to delayed treatment: Establishing the plutonium decorporation activity window of hydroxypyridinonate chelating agents An, Dahlia D.; Kullgren, Birgitta; Jarvis, Erin E. Chemico-Biological Interactions, Vol. 267 https://doi.org/10.1016/j.cbi.2016.03.034	journal	April 2017
The size of actinoid(III) ions – structural analysis vs. common misinterpretations Lundberg, Daniel; Persson, Ingmar Coordination Chemistry Reviews, Vol. 318 https://doi.org/10.1016/j.ccr.2016.04.003	journal	July 2016
Application of ion exchange and extraction chromatography to the separation of actinium from proton-irradiated thorium metal for analytical purposes Radchenko, V.; Engle, J. W.; Wilson, J. J. Journal of Chromatography A, Vol. 1380, p. 55-63 https://doi.org/10.1016/j.chroma.2014.12.045	journal	February 2015
DARPins and other repeat protein scaffolds: advances in engineering and applications Boersma, Ykelien L.; Plückthun, Andreas Current Opinion in Biotechnology, Vol. 22, Issue 6 https://doi.org/10.1016/j.copbio.2011.06.004	journal	December 2011
Extraction chromatography of lanthanides using N,N,N′,N′-tetraoctyl diglycolamide (TODGA) as the stationary phase Husain, M.; Ansari, S. A.; Mohapatra, P. K. Desalination, Vol. 229, Issue 1-3 https://doi.org/10.1016/j.desal.2007.10.016	journal	September 2008
Distribution of plutonium, americium and interfering fission products between nitric acid and a mixed organic phase of TODGA and DMDOHEMA in kerosene, and implications for the design of the “EURO-GANEX” process Carrott, Michael; Geist, Andreas; Hères, Xavier Hydrometallurgy, Vol. 152 https://doi.org/10.1016/j.hydromet.2014.12.019	journal	February 2015
High-level bacterial secretion of single-chain αβ T-cell receptors Maynard, Jennifer; Adams, Erin J.; Krogsgaard, Michelle Journal of Immunological Methods, Vol. 306, Issue 1-2 https://doi.org/10.1016/j.jim.2005.07.022	journal	November 2005
Down conversion luminescence of Tb3+–Yb3+ codoped SrF2 precipitated glass ceramics Ye, Song; Katayama, Yumiko; Tanabe, Setsuhisa Journal of Non-Crystalline Solids, Vol. 357, Issue 11-13 https://doi.org/10.1016/j.jnoncrysol.2010.11.083	journal	June 2011
Novel sorbents for removal of gadolinium-based contrast agents in sorbent dialysis and hemoperfusion: preventive approaches to nephrogenic systemic fibrosis Yantasee, Wassana; Fryxell, Glen E.; Porter, George A. Nanomedicine: Nanotechnology, Biology and Medicine, Vol. 6, Issue 1 https://doi.org/10.1016/j.nano.2009.05.002	journal	February 2010
Studies on Separation of 90Y and 90Sr Separation from Hydrochloric Acid Solutions Using TODGA as the Extractant by SLM Method Dutta, S.; Mohapatra, P. K.; Manchanda, V. K. Procedia Chemistry, Vol. 7 https://doi.org/10.1016/j.proche.2012.10.032	journal	January 2012
Enhanced NIR downconversion luminescence by precipitating nano Ca5(PO4)3F crystals in Eu2+–Yb3+ co-doped glass Li, Chen; Song, Zhiguo; Li, Yongjin Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, Vol. 114 https://doi.org/10.1016/j.saa.2013.05.074	journal	October 2013
Siderocalin (Lcn 2) Also Binds Carboxymycobactins, Potentially Defending against Mycobacterial Infections through Iron Sequestration Holmes, Margaret A.; Paulsene, Wendy; Jide, Xu Structure, Vol. 13, Issue 1 https://doi.org/10.1016/j.str.2004.10.009	journal	January 2005
Distribution coefficients of 60 elements on TODGA resin: Application to Ca, Lu, Hf, U and Th isotope geochemistry Pourmand, Ali; Dauphas, Nicolas Talanta, Vol. 81, Issue 3 https://doi.org/10.1016/j.talanta.2010.01.008	journal	May 2010
New method for rapid separation of berkelium(IV) from cerium(IV) by anion exchange Moore, Fletcher Langley. Analytical Chemistry, Vol. 39, Issue 14 https://doi.org/10.1021/ac50157a066	journal	December 1967
Present Status of Cerium(IV)-Cerium(III) Potentials Wadsworth, Earl.; Duke, F. R.; Goetz, C. A. Analytical Chemistry, Vol. 29, Issue 12 https://doi.org/10.1021/ac60132a046	journal	December 1957
Liquid-liquid extraction method for the separation of cerium(IV) from berkelium(IV) and other elements Moore, Fletcher Langley. Analytical Chemistry, Vol. 41, Issue 12 https://doi.org/10.1021/ac60281a023	journal	October 1969
p -SCN-Bn-HOPO: A Superior Bifunctional Chelator for ⁸⁹ Zr ImmunoPET Deri, Melissa A.; Ponnala, Shashikanth; Kozlowski, Paul Bioconjugate Chemistry, Vol. 26, Issue 12 https://doi.org/10.1021/acs.bioconjchem.5b00572	journal	November 2015
Hydroxypyridinonate Complex Stability of Group (IV) Metals and Tetravalent f-Block Elements: The Key to the Next Generation of Chelating Agents for Radiopharmaceuticals Sturzbecher-Hoehne, Manuel; Choi, Taylor A.; Abergel, Rebecca J. Inorganic Chemistry, Vol. 54, Issue 7 https://doi.org/10.1021/acs.inorgchem.5b00033	journal	March 2015
Ligand-Sensitized Lanthanide Nanocrystals: Merging Solid-State Photophysics and Molecular Solution Chemistry Agbo, Peter; Abergel, Rebecca J. Inorganic Chemistry, Vol. 55, Issue 20 https://doi.org/10.1021/acs.inorgchem.6b00879	journal	June 2016
Engineered Recognition of Tetravalent Zirconium and Thorium by Chelator–Protein Systems: Toward Flexible Radiotherapy and Imaging Platforms Captain, Ilya; Deblonde, Gauthier J. -P.; Rupert, Peter B. Inorganic Chemistry, Vol. 55, Issue 22 https://doi.org/10.1021/acs.inorgchem.6b02041	journal	November 2016
Solution Thermodynamics and Kinetics of Metal Complexation with a Hydroxypyridinone Chelator Designed for Thorium-227 Targeted Alpha Therapy Deblonde, Gauthier J. -P.; Lohrey, Trevor D.; Booth, Corwin H. Inorganic Chemistry, Vol. 57, Issue 22 https://doi.org/10.1021/acs.inorgchem.8b02430	journal	October 2018
Enhanced Ultraviolet Photon Capture in Ligand-Sensitized Nanocrystals Agbo, Peter; Xu, Tao; Sturzbecher-Hoehne, Manuel ACS Photonics, Vol. 3, Issue 4 https://doi.org/10.1021/acsphotonics.6b00118	journal	March 2016
Lanthanide Luminescence for Biomedical Analyses and Imaging Bünzli, Jean-Claude G. Chemical Reviews, Vol. 110, Issue 5 https://doi.org/10.1021/cr900362e	journal	May 2010
Rational Design of Sequestering Agents for Plutonium and Other Actinides Gorden, Anne E. V.; Xu, Jide; Raymond, Kenneth N. Chemical Reviews, Vol. 103, Issue 11 https://doi.org/10.1021/cr990114x	journal	November 2003
Solution equilibria of enterobactin and metal-enterobactin complexes Loomis, Lawrence D.; Raymond, Kenneth N. Inorganic Chemistry, Vol. 30, Issue 5 https://doi.org/10.1021/ic00005a008	journal	March 1991
Structural Study of the N,N′ -Dimethylpropyleneurea Solvated Lanthanoid(III) Ions in Solution and Solid State with an Analysis of the Ionic Radii of Lanthanoid(III) Ions Lundberg, Daniel; Persson, Ingmar; Eriksson, Lars Inorganic Chemistry, Vol. 49, Issue 10 https://doi.org/10.1021/ic100034q	journal	May 2010
Solution Thermodynamic Stability of Complexes Formed with the Octadentate Hydroxypyridinonate Ligand 3,4,3-LI(1,2-HOPO): A Critical Feature for Efficient Chelation of Lanthanide(IV) and Actinide(IV) Ions Deblonde, Gauthier J-P.; Sturzbecher-Hoehne, Manuel; Abergel, Rebecca J. Inorganic Chemistry, Vol. 52, Issue 15 https://doi.org/10.1021/ic4010246	journal	July 2013
An Octadentate Luminescent Eu(III) 1,2-HOPO Chelate with Potent Aqueous Stability Moore, Evan G.; Jocher, Christoph J.; Xu, Jide Inorganic Chemistry, Vol. 46, Issue 14, p. 5468-5470 https://doi.org/10.1021/ic700364t	journal	July 2007
Using the Antenna Effect as a Spectroscopic Tool: Photophysics and Solution Thermodynamics of the Model Luminescent Hydroxypyridonate Complex [Eu ^III (3,4,3-LI(1,2-HOPO))] ⁻ Abergel, Rebecca J.; D’Aléo, Anthony; Ng Pak Leung, Clara Inorganic Chemistry, Vol. 48, Issue 23 https://doi.org/10.1021/ic9013703	journal	December 2009
Electron-transfer and f-d absorption bands of some lanthanide and actinide complexes and the standard (II-III) oxidation potential for each member of the lanthanide and actinide series Nugent, L. J.; Baybarz, R. D.; Burnett, J. L. The Journal of Physical Chemistry, Vol. 77, Issue 12 https://doi.org/10.1021/j100631a011	journal	June 1973
Intramolecular energy transfer and sensitized luminescence in actinide(III) β-diketone chelates Nugent, Leonard J.; Burnett, J. L.; Baybarz, R. D. The Journal of Physical Chemistry, Vol. 73, Issue 5 https://doi.org/10.1021/j100725a060	journal	May 1969
Specific sequestering agents for the actinides. 3. Polycatecholate ligands derived from 2,3-dihydroxy-5-sulfobenzoyl conjugates of diaza- and tetraazaalkanes Weitl, Frederick L.; Raymond, Kenneth N. Journal of the American Chemical Society, Vol. 102, Issue 7 https://doi.org/10.1021/ja00527a026	journal	March 1980
Chemical Properties of Berkelium Thompson, S. G.; Cunningham, B. B.; Seaborg, G. T. Journal of the American Chemical Society, Vol. 72, Issue 6 https://doi.org/10.1021/ja01162a538	journal	June 1950
A Macrocyclic Chelator with Unprecedented Th ⁴⁺ Affinity Pham, Tiffany A.; Xu, Jide; Raymond, Kenneth N. Journal of the American Chemical Society, Vol. 136, Issue 25 https://doi.org/10.1021/ja503456r	journal	June 2014
New Insights into Structure and Luminescence of Eu ^III and Sm ^III Complexes of the 3,4,3-LI(1,2-HOPO) Ligand Daumann, Lena J.; Tatum, David S.; Snyder, Benjamin E. R. Journal of the American Chemical Society, Vol. 137, Issue 8 https://doi.org/10.1021/ja5116524	journal	February 2015
Specific Sequestering Agents for the Actinides. 28. Synthesis and Initial Evaluation of Multidentate 4-Carbamoyl-3-hydroxy-1-methyl-2(1H)-pyridinone Ligands for in Vivo Plutonium(IV) Chelation Xu, Jide; Kullgren, Birgitta; Durbin, Patricia W. Journal of Medicinal Chemistry, Vol. 38, Issue 14 https://doi.org/10.1021/jm00014a013	journal	July 1995
Specific sequestering agents for the actinides. 21. Synthesis and initial biological testing of octadentate mixed catecholate-hydroxypyridinonate ligands Uhlir, Linda C.; Durbin, Patricia W.; Jeung, Nylan Journal of Medicinal Chemistry, Vol. 36, Issue 4, p. 504-509 https://doi.org/10.1021/jm00056a011	journal	February 1993
Specific sequestering agents for the actinides. 16. Synthesis and initial biological testing of polydentate oxohydroxypyridinecarboxylate ligands White, David L.; Durbin, Patricia W.; Jeung, Nylan Journal of Medicinal Chemistry, Vol. 31, Issue 1, p. 11-18 https://doi.org/10.1021/jm00396a005	journal	January 1988
Synthesis and Initial Evaluation for In Vivo Chelation of Pu(IV) of a Mixed Octadentate Spermine-Based Ligand Containing 4-Carbamoyl-3-hydroxy-1-methyl-2(1 H )-pyridinone and 6-Carbamoyl-1-hydroxy-2(1 H )-pyridinone Xu, Jide; Durbin, Patricia W.; Kullgren, Birgitta Journal of Medicinal Chemistry, Vol. 45, Issue 18 https://doi.org/10.1021/jm010564t	journal	August 2002
Alternative Chelator for ⁸⁹ Zr Radiopharmaceuticals: Radiolabeling and Evaluation of 3,4,3-(LI-1,2-HOPO) Deri, Melissa A.; Ponnala, Shashikanth; Zeglis, Brian M. Journal of Medicinal Chemistry, Vol. 57, Issue 11 https://doi.org/10.1021/jm500389b	journal	December 2013
Engineering Homogeneous Doping in Single Nanoparticle To Enhance Upconversion Efficiency Li, Xiaomin; Wang, Rui; Zhang, Fan Nano Letters, Vol. 14, Issue 6 https://doi.org/10.1021/nl501366x	journal	May 2014
Core/Shell NaGdF ₄ :Nd ³⁺ /NaGdF ₄ Nanocrystals with Efficient Near-Infrared to Near-Infrared Downconversion Photoluminescence for Bioimaging Applications Chen, Guanying; Ohulchanskyy, Tymish Y.; Liu, Sha ACS Nano, Vol. 6, Issue 4 https://doi.org/10.1021/nn2042362	journal	March 2012
Binding proteins selected from combinatorial libraries of an α-helical bacterial receptor domain Nord, Karin; Gunneriusson, Elin; Ringdahl, Jenny Nature Biotechnology, Vol. 15, Issue 8 https://doi.org/10.1038/nbt0897-772	journal	August 1997
Engineering novel binding proteins from nonimmunoglobulin domains Binz, H. Kaspar; Amstutz, Patrick; Plückthun, Andreas Nature Biotechnology, Vol. 23, Issue 10 https://doi.org/10.1038/nbt1127	journal	October 2005
Chelation and stabilization of berkelium in oxidation state +IV Deblonde, Gauthier J. -P.; Sturzbecher-Hoehne, Manuel; Rupert, Peter B. Nature Chemistry, Vol. 9, Issue 9 https://doi.org/10.1038/nchem.2759	journal	April 2017
Engineered antibodies Hudson, Peter J.; Souriau, Christelle Nature Medicine, Vol. 9, Issue 1 https://doi.org/10.1038/nm0103-129	journal	January 2003
Experimental therapy of African trypanosomiasis with a nanobody-conjugated human trypanolytic factor Baral, Toya Nath; Magez, Stefan; Stijlemans, Benoît Nature Medicine, Vol. 12, Issue 5 https://doi.org/10.1038/nm1395	journal	April 2006
Broadband dye-sensitized upconversion of near-infrared light Zou, Wenqiang; Visser, Cindy; Maduro, Jeremio A. Nature Photonics, Vol. 6, Issue 8 https://doi.org/10.1038/nphoton.2012.158	journal	July 2012
Preparation of core-shell NaGdF4 nanoparticles doped with luminescent lanthanide ions to be used as upconversion-based probes Wang, Feng; Deng, Renren; Liu, Xiaogang Nature Protocols, Vol. 9, Issue 7 https://doi.org/10.1038/nprot.2014.111	journal	June 2014
Ultra-selective ligand-driven separation of strategic actinides Deblonde, Gauthier J. -P.; Ricano, Abel; Abergel, Rebecca J. Nature Communications, Vol. 10, Issue 1 https://doi.org/10.1038/s41467-019-10240-x	journal	June 2019
Nd3+ Sensitized Up/Down Converting Dual-Mode Nanomaterials for Efficient In-vitro and In-vivo Bioimaging Excited at 800 nm Li, Xiaomin; Wang, Rui; Zhang, Fan Scientific Reports, Vol. 3, Issue 1 https://doi.org/10.1038/srep03536	journal	December 2013
Novel enterobactin analogues as potential therapeutic chelating agents: Synthesis, thermodynamic and antioxidant studies Zhang, Qingchun; Jin, Bo; Shi, Zhaotao Scientific Reports, Vol. 6, Issue 1 https://doi.org/10.1038/srep34024	journal	September 2016
Morphology- and phase-controlled synthesis of monodisperse lanthanide-doped NaGdF ₄ nanocrystals with multicolor photoluminescence Liu, Chenghui; Wang, Hui; Zhang, Xinrong J. Mater. Chem., Vol. 19, Issue 4 https://doi.org/10.1039/B815682D	journal	January 2009
Stokes emission in GdF ₃ :Nd ³⁺ nanoparticles for bioimaging probes Pokhrel, M.; Mimun, L. C.; Yust, B. Nanoscale, Vol. 6, Issue 3 https://doi.org/10.1039/C3NR03317A	journal	January 2014
Diphenyl-benzo[1,3]dioxole-4-carboxylic acid pentafluorophenyl ester: a convenient catechol precursor in the synthesis of siderophore vectors suitable for antibiotic Trojan horse strategies Baco, Etienne; Hoegy, Françoise; Schalk, Isabelle J. Org. Biomol. Chem., Vol. 12, Issue 5 https://doi.org/10.1039/C3OB41990H	journal	January 2014
An active-core/active-shell structure with enhanced quantum-cutting luminescence in Pr–Yb co-doped monodisperse nanoparticles Zhu, Wenjuan; Chen, Daqin; Lei, Lei Nanoscale, Vol. 6, Issue 18 https://doi.org/10.1039/C4NR02785J	journal	January 2014
Intramolecular sensitization of americium luminescence in solution: shining light on short-lived forbidden 5f transitions Sturzbecher-Hoehne, M.; Yang, P.; D'Aléo, A. Dalton Transactions, Vol. 45, Issue 24 https://doi.org/10.1039/C6DT00328A	journal	January 2016
Toxic heavy metal – Pb, Cd, Sn – complexation by the octadentate hydroxypyridinonate ligand archetype 3,4,3-LI(1,2-HOPO) Deblonde, Gauthier J. -P.; Lohrey, Trevor D.; An, Dahlia D. New Journal of Chemistry, Vol. 42, Issue 10 https://doi.org/10.1039/C7NJ04559J	journal	January 2018
Inducing selectivity and chirality in group IV metal coordination with high-denticity hydroxypyridinones Deblonde, Gauthier J. -P.; Lohrey, Trevor D.; Abergel, Rebecca J. Dalton Transactions, Vol. 48, Issue 23 https://doi.org/10.1039/C9DT01031A	journal	January 2019
Combinatorial design of multimeric chelating peptoids for selective metal coordination Ricano, Abel; Captain, Ilya; Carter, Korey P. Chemical Science, Vol. 10, Issue 28 https://doi.org/10.1039/C9SC01068H	journal	January 2019
Carboxylate-derived calixarenes with high selectivity for actinium-225 Chen, Xiaoyuan; Ji, Min; Wai, Chien M. Chemical Communications, Issue 3 https://doi.org/10.1039/a706776c	journal	January 1998
Taking advantage of luminescent lanthanide ions Bünzli, Jean-Claude G.; Piguet, Claude Chemical Society Reviews, Vol. 34, Issue 12 https://doi.org/10.1039/b406082m	journal	January 2005
Lanthanide ions as spectral converters for solar cells van der Ende, Bryan M.; Aarts, Linda; Meijerink, Andries Physical Chemistry Chemical Physics, Vol. 11, Issue 47 https://doi.org/10.1039/b913877c	journal	January 2009
Down- and up-conversion photoluminescence, cathodoluminescence and paramagnetic properties of NaGdF4 : Yb3+,Er3+ submicron disks assembled from primary nanocrystals Wang, Zhen-Ling; Hao, J. H.; Chan, Helen L. W. Journal of Materials Chemistry, Vol. 20, Issue 16 https://doi.org/10.1039/b924448d	journal	January 2010
3,4,3-LI(1,2-HOPO): In vitro formation of highly stable lanthanide complexes translates into efficacious in vivo europium decorporation Sturzbecher-Hoehne, Manuel; Ng Pak Leung, Clara; D'Aléo, Anthony Dalton Transactions, Vol. 40, Issue 33 https://doi.org/10.1039/c1dt10840a	journal	January 2011
NaYF4 nanocrystals with TOPO ligands: synthesis-dependent structural and luminescent properties Banski, Mateusz; Podhorodecki, Artur; Misiewicz, Jan Physical Chemistry Chemical Physics, Vol. 15, Issue 44 https://doi.org/10.1039/c3cp52865k	journal	January 2013
Bimodal imaging using neodymium doped gadolinium fluoride nanocrystals with near-infrared to near-infrared downconversion luminescence and magnetic resonance properties Mimun, L. Christopher; Ajithkumar, Gangadharan; Pokhrel, Madhab Journal of Materials Chemistry B, Vol. 1, Issue 41 https://doi.org/10.1039/c3tb20905a	journal	January 2013
Recombinant human factor VIII-specific affinity ligands selected from phage-displayed combinatorial libraries of protein A Nord, Karin; Nord, Olof; Uhlén, Mathias European Journal of Biochemistry, Vol. 268, Issue 15 https://doi.org/10.1046/j.1432-1327.2001.02344.x	journal	August 2001
Detailed Balance Limit of Efficiency of p‐n Junction Solar Cells Shockley, William; Queisser, Hans J. Journal of Applied Physics, Vol. 32, Issue 3, p. 510-519 https://doi.org/10.1063/1.1736034	journal	March 1961
Anthrax pathogen evades the mammalian immune system through stealth siderophore production Abergel, R. J.; Wilson, M. K.; Arceneaux, J. E. L. Proceedings of the National Academy of Sciences, Vol. 103, Issue 49 https://doi.org/10.1073/pnas.0607055103	journal	November 2006
Siderocalin-mediated recognition, sensitization, and cellular uptake of actinides Allred, Benjamin E.; Rupert, Peter B.; Gauny, Stacey S. Proceedings of the National Academy of Sciences, Vol. 112, Issue 33 https://doi.org/10.1073/pnas.1508902112	journal	August 2015
Protein engineering of antibody binding sites: recovery of specific activity in an anti-digoxin single-chain Fv analogue produced in Escherichia coli. Huston, J. S.; Levinson, D.; Mudgett-Hunter, M. Proceedings of the National Academy of Sciences, Vol. 85, Issue 16 https://doi.org/10.1073/pnas.85.16.5879	journal	August 1988
"Diabodies": small bivalent and bispecific antibody fragments. Holliger, P.; Prospero, T.; Winter, G. Proceedings of the National Academy of Sciences, Vol. 90, Issue 14 https://doi.org/10.1073/pnas.90.14.6444	journal	July 1993
Comprehensive Analysis of the Factors Contributing to the Stability and Solubility of Autonomous Human VH Domains Barthelemy, Pierre A.; Raab, Helga; Appleton, Brent A. Journal of Biological Chemistry, Vol. 283, Issue 6 https://doi.org/10.1074/jbc.M708536200	journal	February 2008
Neptunium Extraction and Stability in the GANEX Solvent: 0.2 M TODGA/0.5 M DMDOHEMA/Kerosene Carrot, M. J.; Gregson, C. R.; Taylor, R. J. Solvent Extraction and Ion Exchange, Vol. 31, Issue 5 https://doi.org/10.1080/07366299.2012.735559	journal	October 2012
Trivalent Lanthanide/Actinide Separation Using Aqueous-Modified TALSPEAK Chemistry Grimes, Travis S.; Tillotson, Richard D.; Martin, Leigh R. Solvent Extraction and Ion Exchange, Vol. 32, Issue 4 https://doi.org/10.1080/07366299.2013.877754	journal	May 2014
The Chemistry of TALSPEAK: A Review of the Science Nash, Kenneth L. Solvent Extraction and Ion Exchange, Vol. 33, Issue 1 https://doi.org/10.1080/07366299.2014.985912	journal	December 2014
An Advanced TALSPEAK Concept Using 2-Ethylhexylphosphonic Acid Mono-2-Ethylhexyl Ester as the Extractant Lumetta, Gregg J.; Casella, Amanda J.; Rapko, Brian M. Solvent Extraction and Ion Exchange, Vol. 33, Issue 3 https://doi.org/10.1080/07366299.2014.985920	journal	December 2014
Synergistic Extraction of U(VI), Th(IV), and Lanthanides(III) from Nitric Acid Solutions Using Mixtures of TODGA and Dinonylnaphthalene Sulfonic Acid Turanov, А. N.; Karandashev, V. К. Solvent Extraction and Ion Exchange, Vol. 36, Issue 3 https://doi.org/10.1080/07366299.2018.1459157	journal	April 2018
Applications of Diglycolamide Based Solvent Extraction Processes in Spent Nuclear Fuel Reprocessing, Part 1: TODGA Whittaker, Daniel; Geist, Andreas; Modolo, Giuseppe Solvent Extraction and Ion Exchange, Vol. 36, Issue 3 https://doi.org/10.1080/07366299.2018.1464269	journal	April 2018
Synthesis and Am/Eu extraction of novel TODGA derivatives Iqbal, Mudassir; Huskens, Jurriaan; Verboom, Willem Supramolecular Chemistry, Vol. 22, Issue 11-12 https://doi.org/10.1080/10610278.2010.506553	journal	August 2010
N,N,N′,N′‐Tetraoctyl Diglycolamide (TODGA): A Promising Extractant for Actinide‐Partitioning from High‐Level Waste (HLW) Ansari, S. A.; Pathak, P. N.; Manchanda, V. K. Solvent Extraction and Ion Exchange, Vol. 23, Issue 4 https://doi.org/10.1081/SEI-200066296	journal	July 2005
Construction and binding analysis of recombinant single-chain TCR derived from tumor-infiltrating lymphocytes and a cytotoxic T lymphocyte clone directed against MAGE-1 Lake, D. F.; Salgaller, M. L.; van der Bruggen, P. International Immunology, Vol. 11, Issue 5 https://doi.org/10.1093/intimm/11.5.745	journal	May 1999
MolProbity: all-atom contacts and structure validation for proteins and nucleic acids Davis, I. W.; Leaver-Fay, A.; Chen, V. B. Nucleic Acids Research, Vol. 35, Issue Web Server https://doi.org/10.1093/nar/gkm216	journal	May 2007
A combinatorial library of an α-helical bacterial receptor domain Nord, Karin; Nilsson, Joakim; Nilsson, Björn "Protein Engineering, Design and Selection", Vol. 8, Issue 6 https://doi.org/10.1093/protein/8.6.601	journal	January 1995
Treatment of actinide exposures: a review of Ca-DTPA injections inside CEA-COGEMA plants Grappin, L.; Berard, P.; Menetrier, F. Radiation Protection Dosimetry, Vol. 127, Issue 1-4 https://doi.org/10.1093/rpd/ncm296	journal	June 2007
Treatment of human contamination with plutonium and americium: would orally administered Ca- or Zn-DTPA be effective? Taylor, D. M.; Hodgson, S. A.; Stradling, N. Radiation Protection Dosimetry, Vol. 127, Issue 1-4 https://doi.org/10.1093/rpd/ncm299	journal	June 2007
Chelation of 238Pu ( IV ) in Vivo by 3,4,3-LICAM ( C ) Effects of Ligand Methylation and Ph Durbin, Patricia W.; White, David L.; Jeung, Nylan Health Physics, Vol. 56, Issue 6 https://doi.org/10.1097/00004032-198906000-00002	journal	June 1989
Gross Composition and Plasma and Extracellular Water Volumes of Tissues of a Reference Mouse Durbin, P. W.; Jeung, N.; Kullgren, B. Health Physics, Vol. 63, Issue 4 https://doi.org/10.1097/00004032-199210000-00007	journal	January 1992
Chelating Agents for Uranium(Vi): 2. Efficacy and Toxicity of Tetradentate Catecholate and Hydroxypyridinonate Ligands in mice Durbin, Patricia W.; Kullgren, Birgitta; Ebbe, Shirley N. Health Physics, Vol. 78, Issue 5 https://doi.org/10.1097/00004032-200005000-00008	journal	January 2000
Lauriston s. Taylor Lecture: the Quest for Therapeutic Actinide Chelators Durbin, Patricia W. Health Physics, Vol. 95, Issue 5 https://doi.org/10.1097/01.HP.0000326345.41816.c2	journal	January 2008
A Public Health Perspective on the U.S. Response to the Fukushima Radiological Emergency Whitcomb, Robert C.; Ansari, Armin J.; Buzzell, Jennifer J. Health Physics, Vol. 108, Issue 3 https://doi.org/10.1097/HP.0000000000000198	journal	January 2015
Development of the Plutonium-DTPA Biokinetic Model Konzen, Kevin; Brey, Richard Health Physics, Vol. 108, Issue 6 https://doi.org/10.1097/HP.0000000000000283	journal	January 2015
Structure of a Single Model to Describe Plutonium and Americium Decorporation by dtpa Treatments Fritsch, P.; Sérandour, A. L.; Grémy, O. Health Physics, Vol. 99, Issue 4 https://doi.org/10.1097/HP.0b013e3181c1cccd	journal	January 2010
Biomimetic Actinide Chelators: an Update on the Preclinical Development of the Orally Active Hydroxypyridonate Decorporation Agents 3,4,3-Li(1,2-Hopo) and 5-Lio(Me-3,2-Hopo) Abergel, Rebecca J.; Durbin, Patricia W.; Kullgren, Birgitta Health Physics, Vol. 99, Issue 3 https://doi.org/10.1097/HP.0b013e3181c21273	journal	January 2010
Element 97 Thompson, S. G.; Ghiorso, A.; Seaborg, G. T. Physical Review, Vol. 77, Issue 6 https://doi.org/10.1103/PhysRev.77.838.2	journal	March 1950
PROCHECK: a program to check the stereochemical quality of protein structures Laskowski, R. A.; MacArthur, M. W.; Moss, D. S. Journal of Applied Crystallography, Vol. 26, Issue 2 https://doi.org/10.1107/S0021889892009944	journal	April 1993
MOLREP an Automated Program for Molecular Replacement Vagin, A.; Teplyakov, A. Journal of Applied Crystallography, Vol. 30, Issue 6, p. 1022-1025 https://doi.org/10.1107/S0021889897006766	journal	December 1997
Revised effective ionic radii and systematic studies of interatomic distances in halides and chalcogenides Shannon, R. D. Acta Crystallographica Section A, Vol. 32, Issue 5, p. 751-767 https://doi.org/10.1107/S0567739476001551	journal	September 1976
Refinement of Macromolecular Structures by the Maximum-Likelihood Method Murshudov, G. N.; Vagin, A. A.; Dodson, E. J. Acta Crystallographica Section D Biological Crystallography, Vol. 53, Issue 3 https://doi.org/10.1107/S0907444996012255	journal	May 1997
Gadolinium and nephrogenic systemic fibrosis: Association or causation (Review Article) Kurtkoti, Jagadeesh; Snow, Thomas; Hiremagalur, Balaji Nephrology, Vol. 13, Issue 3 https://doi.org/10.1111/j.1440-1797.2007.00912.x	journal	April 2008
Improving the Oral Bioavailability of Sulpiride by Sodium Oleate in Rabbits Naasani, Imad; Kohri, Naonori; Iseki, Ken Journal of Pharmacy and Pharmacology, Vol. 47, Issue 6 https://doi.org/10.1111/j.2042-7158.1995.tb05833.x	journal	April 2011
Tumor Therapy with Targeted Atomic Nanogenerators McDevitt, M. R. Science, Vol. 294, Issue 5546 https://doi.org/10.1126/science.1064126	journal	November 2001
Single-chain antigen-binding proteins Bird, R.; Hardman, K.; Jacobson, J. Science, Vol. 242, Issue 4877 https://doi.org/10.1126/science.3140379	journal	October 1988
Efficient Cancer Therapy with a Nanobody-Based Conjugate Cortez-Retamozo, Virna; Backmann, Natalija; Senter, Peter D. Cancer Research, Vol. 64, Issue 8 https://doi.org/10.1158/0008-5472.CAN-03-3935	journal	April 2004
Use of DTPA for Increasing the Rate of Elimination of Plutonium-238 and Americium-241 from Rodents after their Inhalation as the Nitrates Stather, J. W.; Stradling, G. N.; Gray, S. A. Human Toxicology, Vol. 4, Issue 6 https://doi.org/10.1177/096032718500400603	journal	November 1985
Octadentate catecholamide ligands for Pu(IV) based on linear or preorganized molecular backbones Durbin, Pw; Kullgren, B.; Jeung, N. Human & Experimental Toxicology, Vol. 15, Issue 4 https://doi.org/10.1177/096032719601500412	journal	April 1996
Application of dual affinity retargeting molecules to achieve optimal redirected T-cell killing of B-cell lymphoma Moore, Paul A.; Zhang, Wenjun; Rainey, G. Jonah Blood, Vol. 117, Issue 17 https://doi.org/10.1182/blood-2010-09-306449	journal	April 2011
Phase I Trial Of The Targeted Alpha-Particle Nano-Generator Actinium-225 (225Ac)-Lintuzumab (Anti-CD33) In Combination With Low-Dose Cytarabine (LDAC) For Older Patients With Untreated Acute Myeloid Leukemia (AML) Jurcic, Joseph G.; Ravandi, Farhad; Pagel, John M. Blood, Vol. 122, Issue 21 https://doi.org/10.1182/blood.V122.21.1460.1460	journal	November 2013
Enhanced cooperative quantum cutting in Tm^3+- Yb^3+ codoped glass ceramics containing LaF_3 nanocrystals Ye, Song; Zhu, Bin; Luo, Jin Optics Express, Vol. 16, Issue 12 https://doi.org/10.1364/OE.16.008989	journal	January 2008
Bright dual-mode green emission from selective set of dopant ions in β-Na(Y,Gd)F ₄ :Yb,Er/β-NaGdF ₄ :Ce,Tb core/shell nanocrystals Jang, Ho Seong; Woo, Kyoungja; Lim, Kipil Optics Express, Vol. 20, Issue 15 https://doi.org/10.1364/OE.20.017107	journal	January 2012
Fractionated Therapy of HER2-Expressing Breast and Ovarian Cancer Xenografts in Mice with Targeted Alpha Emitting 227Th-DOTA-p-benzyl-trastuzumab Heyerdahl, Helen; Abbas, Nasir; Brevik, Ellen Mengshoel PLoS ONE, Vol. 7, Issue 8 https://doi.org/10.1371/journal.pone.0042345	journal	August 2012
Voltammetric Investigation of the Berkelium(IV/III) Couple in Concentrated Aqueous Carbonate Solutions Morris, D. E.; Hobart, D. E.; Palmer, P. D. Radiochimica Acta, Vol. 49, Issue 3 https://doi.org/10.1524/ract.1990.49.3.125	journal	January 1990
Berkelium redox speciation Antonio, M. R.; Williams, C. W.; Soderholm, L. Radiochimica Acta, Vol. 90, Issue 12 https://doi.org/10.1524/ract.2002.90.12_2002.851	journal	January 2002
Extraction of actinides using N, N, N′, N′-tetraoctyl diglycolamide (TODGA): a thermodynamic study Ansari, S. A.; Pathak, P. N.; Husain, M. Radiochimica Acta, Vol. 94, Issue 6-7 https://doi.org/10.1524/ract.2006.94.6.307	journal	January 2006
Recovery of actinides and lanthanides from high-level liquid waste by extraction chromatography using TODGA+TBP impregnated resins Modolo, G.; Asp, H.; Schreinemachers, C. Radiochimica Acta, Vol. 95, Issue 7 https://doi.org/10.1524/ract.2007.95.7.391	journal	January 2007
Solution thermodynamic evaluation of hydroxypyridinonate chelators 3,4,3-LI(1,2-HOPO) and 5-LIO(Me-3,2-HOPO) for UO ₂ (VI) and Th(IV) decorporation Sturzbecher-Hoehne, M.; Deblonde, G. J. -P.; Abergel, R. J. Radiochimica Acta, Vol. 101, Issue 6 https://doi.org/10.1524/ract.2013.2047	journal	June 2013
Extraction and separation of Am(III) and Sr(II) by N,N,N´,N´-tetraoctyl-3-oxapentanediamide (TODGA) Suzuki, H.; Sasaki, Y.; Sugo, Y. Radiochimica Acta, Vol. 92, Issue 8 https://doi.org/10.1524/ract.92.8.463.39276	journal	January 2004
Medical Countermeasures against Nuclear Threats: Radionuclide Decorporation Agents Cassatt, David R.; Kaminski, Joseph M.; Hatchett, Richard J. Radiation Research, Vol. 170, Issue 4 https://doi.org/10.1667/RR1485.1	journal	October 2008
Dose-Dependent Efficacy and Safety Toxicology of Hydroxypyridinonate Actinide Decorporation Agents in Rodents: Towards a Safe and Effective Human Dosing Regimen Bunin, Deborah I.; Chang, Polly Y.; Doppalapudi, Rupa S. Radiation Research, Vol. 179, Issue 2 https://doi.org/10.1667/RR3115.1	journal	February 2013
A Systematic Analysis of the Spectra of Trivalent Actinide Chlorides in D_3h Site Symmetry Carnall, William T. Report Argonne National Laboratory https://doi.org/10.2172/7017566	report	November 1989
Action of DTPA on Hepatic Plutonium: III. Evidence for a Direct Chelation Mechanism for DTPA-Induced Excretion of Monomeric Plutonium into Rat Bile Bhattacharyya, M. H.; Peterson, D. P. Radiation Research, Vol. 80, Issue 1 https://doi.org/10.2307/3575119	journal	October 1979
Multidentate Terephthalamidate and Hydroxypyridonate Ligands: Towards New Orally Active Chelators Abergel, Rebecca J.; Raymond, Kenneth N. Hemoglobin, Vol. 35, Issue 3 https://doi.org/10.3109/03630269.2011.560771	journal	May 2011
²³⁸ Pu elimination profiles after delayed treatment with 3,4,3LI(1,2HOPO) in female and male Swiss-Webster mice An, Dahlia D.; Villalobos, Jonathan A.; Morales-Rivera, Joel A. International Journal of Radiation Biology, Vol. 90, Issue 11 https://doi.org/10.3109/09553002.2014.925150	journal	August 2014
Actinide chelation: biodistribution and in vivo complex stability of the targeted metal ions Kullgren, Birgitta; Jarvis, Erin E.; An, Dahlia D. Toxicology Mechanisms and Methods, Vol. 23, Issue 1 https://doi.org/10.3109/15376516.2012.728641	journal	October 2012
A Critical Review of Alpha Radionuclide Therapy—How to Deal with Recoiling Daughters? de Kruijff, Robin; Wolterbeek, Hubert; Denkova, Antonia Pharmaceuticals, Vol. 8, Issue 2 https://doi.org/10.3390/ph8020321	journal	June 2015
CD19 monoclonal antibody HD37 inhibits anti-immunoglobulin-induced B cell activation and proliferation. Pezzutto, A.; Dörken, B.; Rabinovitch, P. S. The Journal of Immunology, Vol. 138, Issue 9 https://doi.org/10.4049/jimmunol.138.9.2793	journal	May 1987

Similar Records

Engineered Recognition of Tetravalent Zirconium and Thorium by Chelator–Protein Systems: Toward Flexible Radiotherapy and Imaging Platforms

Journal Article · 2016 · Inorganic Chemistry · OSTI ID:1458481

Natural chelating agents for radionuclide decorporation

Patent · 1985 · OSTI ID:5325282

Method of radioactively labeling diagnostic and therapeutic agents containing a chelating group

Patent · 1987 · OSTI ID:5846629

Chelating platform for delivery of radionuclides

Citation Formats

References (163)

Similar Records

Related Subjects