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Title: Probing the Link between Pancratistatin and Mitochondrial Apoptosis through Changes in the Membrane

Journal Article · · Mol. Pharmaceutics

Research Organization:
Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Sponsoring Organization:
DOE - Office Of Science; FOREIGN
Journal Information:
Mol. Pharmaceutics, Vol. 19, Issue (6)
Country of Publication:
United States

References (98)

Analysis of anticancer drugs: A review journal October 2011
Pancratistatin: A natural anti-cancer compound that targets mitochondria specifically in cancer cells to induce apoptosis journal May 2005
Isolation and structure of pancratistatin journal January 1984
Induction of Apoptotic Cell Death Specifically in Rat and Human Cancer Cells by Pancratistatin journal January 2005
Pancratistatin induces apoptosis and autophagy in metastatic prostate cancer cells journal March 2011
Narciclasine: an Antimitotic Substance from Narcissus Bulbs journal February 1967
The Amaryllidaceae Alkaloid Haemanthamine Binds the Eukaryotic Ribosome to Repress Cancer Cell Growth journal March 2018
Narciclasine – an Amaryllidaceae Alkaloid with Potent Antitumor and Anti-Inflammatory Properties journal August 2016
Antimalarial activity screening of some alkaloids and the plant extracts from Amaryllidaceae journal January 2003
Pancratistatin causes early activation of caspase-3 and the flipping of phosphatidyl serine followed by rapid apoptosis specifically in human lymphoma cells journal February 2005
Pancratistatin induces apoptosis in clinical leukemia samples with minimal effect on non-cancerous peripheral blood mononuclear cells journal March 2010
Role of mitochondrial membrane permeabilization in apoptosis and cancer journal April 2004
Mitochondrial Regulation of Apoptosis journal June 2003
A Distinct Pathway Remodels Mitochondrial Cristae and Mobilizes Cytochrome c during Apoptosis journal January 2002
Injected cytochrome c induces apoptosis journal January 1998
Cytochrome C -Mediated Apoptosis journal June 2004
Role of cardiolipin in cytochrome c release from mitochondria journal April 2007
Cytochrome c/cardiolipin relations in mitochondria: a kiss of death journal June 2009
Cardiolipin oxidation sets cytochrome c free journal September 2005
Cytochrome c acts as a cardiolipin oxygenase required for release of proapoptotic factors journal August 2005
Cardiolipin acts as a mitochondrial signalling platform to launch apoptosis journal October 2009
Cardiolipin: Setting the beat of apoptosis journal February 2007
A Mechanical Mechanism for Vitamin E Acetate in E-cigarette/Vaping-Associated Lung Injury journal August 2020
Relationship between Viscosity and Acyl Tail Dynamics in Lipid Bilayers journal August 2021
Stiffening Effect of the [Bmim][Cl] Ionic Liquid on the Bending Dynamics of DMPC Lipid Vesicles journal June 2021
Capsaicin Regulates Voltage-Dependent Sodium Channels by Altering Lipid Bilayer Elasticity journal June 2005
Line Tension and Interaction Energies of Membrane Rafts Calculated from Lipid Splay and Tilt journal February 2005
Drug-Membrane Interactions: Significance for Medicinal Chemistry journal June 2010
Structural details of an interaction between cardiolipin and an integral membrane protein journal December 1999
Cardiolipin-enriched raft-like microdomains are essential activating platforms for apoptotic signals on mitochondria journal July 2009
The 30 m Small-Angle Neutron Scattering Instruments at the National Institute of Standards and Technology journal June 1998
Reduction and analysis of SANS and USANS data using IGOR Pro journal November 2006
Vesicle Viewer: Online visualization and analysis of small-angle scattering from lipid vesicles journal November 2021
DAVE: A Comprehensive Software Suite for the Reduction, Visualization, and Analysis of Low Energy Neutron Spectroscopic Data
  • Azuah, Richard Tumanjong; Kneller, Larry R.; Qiu, Yiming
  • Journal of Research of the National Institute of Standards and Technology, Vol. 114, Issue 6
journal November 2009
Viscous Modes of Fluid Bilayer Membranes journal July 1993
Interpreting Membrane Scattering Experiments at the Mesoscale: The Contribution of Dissipation within the Bilayer journal March 2010
Probing Elastic and Viscous Properties of Phospholipid Bilayers Using Neutron Spin Echo Spectroscopy journal September 2017
GROMACS: A message-passing parallel molecular dynamics implementation journal September 1995
Update of the CHARMM All-Atom Additive Force Field for Lipids: Validation on Six Lipid Types journal June 2010
Automation of the CHARMM General Force Field (CGenFF) II: Assignment of Bonded Parameters and Partial Atomic Charges journal November 2012
Automation of the CHARMM General Force Field (CGenFF) I: Bond Perception and Atom Typing journal November 2012
CHARMM-GUI Input Generator for NAMD, GROMACS, AMBER, OpenMM, and CHARMM/OpenMM Simulations Using the CHARMM36 Additive Force Field journal December 2015
Molecular dynamics with coupling to an external bath journal October 1984
Canonical sampling through velocity rescaling journal January 2007
Polymorphic transitions in single crystals: A new molecular dynamics method journal December 1981
Structural changes in lipid bilayers and biological membranes caused by hydrostatic pressure journal November 1986
A smooth particle mesh Ewald method journal November 1995
VMD: Visual molecular dynamics journal February 1996
Determination of bending rigidity and tilt modulus of lipid membranes from real-space fluctuation analysis of molecular dynamics simulations journal January 2017
Erratum to: Implementation of a methodology for determining elastic properties of lipid assemblies from molecular dynamics simulations journal June 2016
Implementation of a methodology for determining elastic properties of lipid assemblies from molecular dynamics simulations journal April 2016
Lipids of mitochondria journal October 2013
Analysis of cardiolipin molecular species by high-performance liquid chromatography of its derivative 1,3-bisphosphatidyl-2-benzoyl-sn-glycerol dimethyl ester journal June 1991
Molecular symmetry in mitochondrial cardiolipins journal December 2005
Undulations and Dynamic Structure Factor of Membranes journal December 1996
Softening of phospholipid membranes by the adhesion of silica nanoparticles – as seen by neutron spin-echo (NSE) journal January 2014
Structure of Fully Hydrated Fluid Phase Lipid Bilayers with Monounsaturated Chains journal January 2006
Stiffening Effect of Cholesterol on Disordered Lipid Phases: A Combined Neutron Spin Echo + Dynamic Light Scattering Analysis of the Bending Elasticity of Large Unilamellar Vesicles journal May 2009
X-ray structure, thermodynamics, elastic properties and MD simulations of cardiolipin/dimyristoylphosphatidylcholine mixed membranes journal February 2014
Structural Significance of Lipid Diversity as Studied by Small Angle Neutron and X-ray Scattering journal September 2015
Model-based approaches for the determination of lipid bilayer structure from small-angle neutron and X-ray scattering data journal May 2012
DMSO Induces Dehydration near Lipid Membrane Surfaces journal July 2015
A Comparative Study on DMSO-Induced Modulation of the Structural and Dynamical Properties of Model Bilayer Membranes journal February 2021
On the Calculation of Acyl Chain Order Parameters from Lipid Simulations journal October 2017
Interactions of the Anticancer Drug Tamoxifen with Lipid Membranes journal May 2015
Acyl chain order parameter profiles in phospholipid bilayers: computation from molecular dynamics simulations and comparison with 2H NMR experiments journal June 2007
Cholesterol and POPC segmental order parameters in lipid membranes: solid state 1 H– 13 C NMR and MD simulation studies journal January 2013
A Critical Comparison of Biomembrane Force Fields: Structure and Dynamics of Model DMPC, POPC, and POPE Bilayers journal April 2016
Membrane models of E. coli containing cyclic moieties in the aliphatic lipid chain journal May 2012
Recent developments in the field of bending rigidity measurements on membranes journal June 2014
The organization of melatonin in lipid membranes journal April 2015
Cardiolipin mediates curcumin interactions with mitochondrial membranes journal January 2019
A biophysical approach to daunorubicin interaction with model membranes: relevance for the drug's biological activity journal August 2017
Alterations in mitochondrial structure and function are early events of dexamethasone-induced thymocyte apoptosis. journal July 1995
Cancer Cell Mitochondria Targeting by Pancratistatin Analogs is Dependent on Functional Complex II and III journal February 2017
Scaling relationships for the elastic moduli and viscosity of mixed lipid membranes journal September 2020
Entropy-driven tension and bending elasticity in condensed-fluid membranes journal April 1990
Depletion of cardiolipin and cytochrome c during ischemia increases hydrogen peroxide production from the electron transport chain journal March 2006
Mitochondrial Lipid Abnormality and Electron Transport Chain Impairment in Mice Lacking α-Synuclein journal November 2005
Cardiolipin and electron transport chain abnormalities in mouse brain tumor mitochondria: lipidomic evidence supporting the Warburg theory of cancer journal August 2008
Mechanism of Coupling of Oxidative Phosphorylation and the Membrane Potential of Mitochondria journal June 1969
Structures of mitochondrial oxidative phosphorylation supercomplexes and mechanisms for their stabilisation journal April 2014
Caspases: the proteases of the apoptotic pathway journal December 1998
Loss of Molecular Interaction between Cytochrome c and Cardiolipin Due to Lipid Peroxidation journal October 1999
Reversibility of the Binding of Cytochrome c to Liposomes journal February 1995
Preferred conformation and dynamics of the glycerol backbone in phospholipids. An NMR and x-ray single-crystal analysis journal December 1988
Structural investigation of the covalent and electrostatic binding of yeast cytochrome c to the surface of various ultrathin lipid multilayers using x-ray diffraction journal April 1991
Lipid dynamics and peripheral interactions of proteins with membrane surfaces journal September 1994
Mitochondrial alkaline pH-responsive drug release mediated by Celastrol loaded glycolipid-like micelles for cancer therapy journal February 2018
Reversible, nonionic, and pH-dependent association of cytochrome c with cardiolipin-phosphatidylcholine liposomes. journal November 1992
Lipid fluidity and membrane protein dynamics journal November 1987
Targeting the Mitochondrial Electron Transport Chain Complexes for the Induction of Apoptosis and Cancer Treatment journal February 2013
Membrane stiffness is modified by integral membrane proteins journal January 2016
The random collision model and a critical assessment of diffusion and collision in mitochondrial electron transport journal October 1986
Lateral diffusion of phospholipids in the lipid surface of human low-density lipoprotein measured with a pyrenyl phospholipid probe journal December 1989
Lateral diffusion of a protein on a fluctuating membrane journal September 2005
Targeting mitochondrial cardiolipin and the cytochrome c /cardiolipin complex to promote electron transport and optimize mitochondrial ATP synthesis: SS-31 restores electron transport journal March 2014
Cytochrome c phosphorylation: Control of mitochondrial electron transport chain flux and apoptosis journal April 2020