skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Structural basis of AMPA receptor inhibition by trans -4-butylcyclohexane carboxylic acid

Journal Article · · BJP -- Brit. J. Pharm.
DOI:https://doi.org/10.1111/bph.15254· OSTI ID:1878393

Research Organization:
Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Sponsoring Organization:
DOE - Office Of Science; National Institutes of Health (NIH); National Science Foundation (NSF)
OSTI ID:
1878393
Journal Information:
BJP -- Brit. J. Pharm., Vol. 179, Issue (14)
Country of Publication:
United States
Language:
ENGLISH

References (100)

Functional changes of AMPA responses in human induced pluripotent stem cell–derived neural progenitors in fragile X syndrome journal January 2018
PHENIX : building new software for automated crystallographic structure determination journal October 2002
THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: Ion channels journal November 2019
Teratogenicity of sodium valproate journal March 2005
Argiopin blocks the glutamate responses and sensorimotor transmission in motoneurones of isolated frog spinal cord journal December 1987
CHEMICAL STRUCTURE OF JORO SPIDER TOXIN (JSTX) journal January 1987
Mechanisms of action for the medium-chain triglyceride ketogenic diet in neurological and metabolic disorders journal January 2018
Perampanel and decanoic acid show synergistic action against AMPA receptors and seizures journal October 2018
Functional Assembly of AMPA and Kainate Receptors Is Mediated by Several Discrete Protein-Protein Interactions journal July 2001
How do we choose the appropriate animal model for antiseizure therapy development? journal June 2019
NMDAR Channel Segments Forming the Extracellular Vestibule Inferred from the Accessibility of Substituted Cysteines journal March 1999
Anticonvulsant Mechanisms of the Ketogenic Diet journal January 2007
Inward rectification of both AMPA and kainate subtype glutamate receptors generated by polyamine-mediated ion channel block journal August 1995
Divalent ion permeability of AMPA receptor channels is dominated by the edited form of a single subunit journal January 1992
AMPA Exposures Induce Mitochondrial Ca 2+ Overload and ROS Generation in Spinal Motor Neurons In Vitro journal January 2000
Rapid Ca 2+ Entry through Ca 2+ -Permeable AMPA/Kainate Channels Triggers Marked Intracellular Ca 2+ Rises and Consequent Oxygen Radical Production journal October 1998
Motor Neurons Are Selectively Vulnerable to AMPA/Kainate Receptor-Mediated Injury In Vitro journal July 1996
The Activation Gate and Gating Mechanism of the NMDA Receptor journal February 2008
Seizure control by decanoic acid through direct AMPA receptor inhibition journal November 2015
The antiepileptic drug valproic acid and other medium-chain fatty acids acutely reduce phosphoinositide levels independently of inositol in Dictyostelium journal January 2012
Seizure control by ketogenic diet-associated medium chain fatty acids journal June 2013
Seizure-induced reduction in PIP3 levels contributes to seizure-activity and is rescued by valproic acid journal February 2014
Seizure Control by Derivatives of Medium Chain Fatty Acids Associated with the Ketogenic Diet Show Novel Branching-Point Structure for Enhanced Potency journal October 2014
FACS-optimized mutants of the green fluorescent protein (GFP) journal January 1996
Clinical experience with perampanel: Focus on psychiatric adverse effects journal December 2014
Soluble Tumor Necrosis Factor Alpha Promotes Retinal Ganglion Cell Death in Glaucoma via Calcium-Permeable AMPA Receptor Activation journal September 2015
Experimental design and analysis and their reporting: new guidance for publication in BJP: Editorial journal June 2015
Particle mesh Ewald: An N ⋅log( N ) method for Ewald sums in large systems journal June 1993
Lipid14: The Amber Lipid Force Field journal January 2014
Intracellular polyamines mediate inward rectification of Ca(2+)-permeable alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors. journal September 1995
Atomistic mechanism for the activation and desensitization of an AMPA-subtype glutamate receptor journal June 2011
Structure and synthesis of a potent glutamate receptor antagonist in wasp venom. journal July 1988
Coot model-building tools for molecular graphics journal November 2004
ModLoop: automated modeling of loops in protein structures journal December 2003
Perampanel: A Review in Drug-Resistant Epilepsy journal September 2015
Peripheral calcium-permeable AMPA receptors regulate chronic inflammatory pain in mice journal April 2011
Screening and large-scale expression of membrane proteins in mammalian cells for structural studies journal October 2014
Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cells journal December 2001
Structure and function of AMPA receptors: Structure and function of AMPA receptors journal January 2004
Histone Deacetylase Is a Target of Valproic Acid-Mediated Cellular Differentiation journal February 2004
Cloning by functional expression of a member of the glutamate receptor family journal December 1989
Identification of a site in glutamate receptor subunits that controls calcium permeability journal August 1991
VMD: Visual molecular dynamics journal February 1996
The NMDA Receptor M3 Segment Is a Conserved Transduction Element Coupling Ligand Binding to Channel Opening journal March 2002
XDS journal January 2010
Intracellular spermine confers rectification on rat calcium-permeable AMPA and kainate receptors. journal July 1995
Channel Blockers Acting at N -Methyl-d-aspartate Receptors: Differential Effects of Mutations in the Vestibule and Ion Channel Pore journal March 2002
Mechanical coupling maintains the fidelity of NMDA receptor–mediated currents journal May 2014
A family of AMPA-selective glutamate receptors journal August 1990
Calcium-permeable AMPA receptors are involved in the induction and expression of l-DOPA-induced dyskinesia in Parkinson’s disease: Calcium-permeable AMPA receptors and dyskinesia journal April 2010
Block of native Ca(2+)-permeable AMPA receptors in rat brain by intracellular polyamines generates double rectification. journal July 1995
Mutation of a glutamate receptor motif reveals its role in gating and δ2 receptor channel properties journal April 2000
Blocking effect of 1-naphthyl acetyl spermine on Ca2+-permeable AMPA receptors in cultured rat hippocampal neurons journal September 1997
Secondary-structure matching (SSM), a new tool for fast protein structure alignment in three dimensions journal November 2004
Early-life seizures alter synaptic calcium-permeable AMPA receptor function and plasticity journal October 2016
Expression of Ca2+-Permeable AMPA Receptor Channels Primes Cell Death in Transient Forebrain Ischemia journal July 2004
ff14SB: Improving the Accuracy of Protein Side Chain and Backbone Parameters from ff99SB journal July 2015
Cocaine inverts rules for synaptic plasticity of glutamate transmission in the ventral tegmental area journal February 2011
Solving structures of protein complexes by molecular replacement with Phaser journal December 2006
Potentiation of NMDA receptor currents by arachidonic acid journal February 1992
AMPA Receptor Noncompetitive Inhibitors Occupy a Promiscuous Binding Site journal October 2019
A randomized trial of classical and medium-chain triglyceride ketogenic diets in the treatment of childhood epilepsy journal May 2009
[20] Processing of X-ray diffraction data collected in oscillation mode book January 1997
Persistent Inflammation Induces GluR2 Internalization via NMDA Receptor-Triggered PKC Activation in Dorsal Horn Neurons journal March 2009
Calcium-permeable AMPA receptors are expressed in a rodent model of status epilepticus journal July 2012
PTRAJ and CPPTRAJ: Software for Processing and Analysis of Molecular Dynamics Trajectory Data journal June 2013
Revisiting AMPA Receptors as an Antiepileptic Drug Target: Revisiting AMPA Receptors as an Antiepileptic Drug Target journal March 2011
AMPA receptors as a molecular target in epilepsy therapy journal March 2013
Adverse effects and safety profile of perampanel: A review of pooled data journal January 2014
ADAR2-dependent GluA2 editing regulates cocaine seeking journal October 2014
C9ORF72 repeat expansion causes vulnerability of motor neurons to Ca2+-permeable AMPA receptor-mediated excitotoxicity journal January 2018
Subunit-specific Contribution of Pore-forming Domains to NMDA Receptor Channel Structure and Gating journal May 2007
X-ray structure, symmetry and mechanism of an AMPA-subtype glutamate receptor journal November 2009
Different Gating Mechanisms in Glutamate Receptor and K + Channels journal August 2003
A multicenter survey of clinical experiences with perampanel in real life in Germany and Austria journal July 2014
Agonist selectivity of glutamate receptors is specified by two domains structurally related to bacterial amino acid-binding proteins journal December 1994
TARP γ-2 Is Required for Inflammation-Associated AMPA Receptor Plasticity within Lamina II of the Spinal Cord Dorsal Horn journal May 2017
Potent and long-lasting anticonvulsant effects of 1-naphthylacetyl spermine, an analogue of Joro spider toxin, against amygdaloid kindled seizures in rats journal January 1996
Developmental regulation of α-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid receptor subunit expression in forebrain and relationship to regional susceptibility to hypoxic/ischemic injury. II. Human cerebral white matter and cortex journal July 2006
Calcium-permeable AMPA receptors promote misfolding of mutant SOD1 protein and development of amyotrophic lateral sclerosis in a transgenic mouse model journal August 2004
Glutamate Receptor Ion Channels: Structure, Regulation, and Function journal August 2010
Structural Mechanisms of Gating in Ionotropic Glutamate Receptors journal October 2017
Channel opening and gating mechanism in AMPA-subtype glutamate receptors journal July 2017
Mechanisms of Channel Block in Calcium-Permeable AMPA Receptors journal September 2018
GluR2 Deficiency Accelerates Motor Neuron Degeneration in a Mouse Model of Amyotrophic Lateral Sclerosis journal January 2005
Glutamatergic synaptic input to glioma cells drives brain tumour progression journal September 2019
Electrical and synaptic integration of glioma into neural circuits journal September 2019
Development and testing of a general amber force field journal January 2004
All You Need Is Fats—for Seizure Control: Using Amoeba to Advance Epilepsy Research journal July 2018
Ca2+ Permeable AMPA Channels in Diseases of the Nervous System journal January 2011
Ca2+-permeable AMPA receptor: A new perspective on amyloid-beta mediated pathophysiology of Alzheimer's disease journal January 2017
Inhibition of rat neuronal kainate receptors by cis -unsaturated fatty acids journal December 1998
Fatty acid modulation and polyamine block of GluK2 kainate receptors analyzed by scanning mutagenesis journal August 2010
Amino Acid Substitutions in the Pore Helix of GluR6 Control Inhibition by Membrane Fatty Acids journal June 2008
Acute anticonvulsant effects of capric acid in seizure tests in mice journal March 2015
Structure and gating of the glutamate receptor ion channel journal June 2004
Structure of an agonist-bound ionotropic glutamate receptor journal August 2014
Structural Bases of Noncompetitive Inhibition of AMPA-Subtype Ionotropic Glutamate Receptors by Antiepileptic Drugs journal September 2016
TNF-α triggers rapid membrane insertion of Ca2+ permeable AMPA receptors into adult motor neurons and enhances their susceptibility to slow excitotoxic injury journal December 2012
Modulation of AMPA Receptor Gating by the Anticonvulsant Drug, Perampanel journal October 2018