The nuclear egress complex of Epstein-Barr virus buds membranes through an oligomerization-driven me

Thorsen, Michael K.; Draganova, Elizabeth B.; Heldwein, Ekaterina E.

doi:10.1371/journal.ppat.1010623

The nuclear egress complex of Epstein-Barr virus buds membranes through an oligomerization-driven me

Journal Article · 01 July 2022 · PLoS Patho.

DOI:https://doi.org/10.1371/journal.ppat.1010623· OSTI ID:1878370

Thorsen, Michael K.; Draganova, Elizabeth B.; Heldwein, Ekaterina E.

Research Organization:: Advanced Photon Source (APS), Argonne National Laboratory (ANL), Argonne, IL (US)

Sponsoring Organization:: DOE - Office Of Science; NIH

OSTI ID:: 1878370

Journal Information:: PLoS Patho., Journal Name: PLoS Patho. Journal Issue: (7) Vol. 18

Country of Publication:: United States

Language:: ENGLISH

References (61)

Herpes Simplex Virus Type 1 UL34 Gene Product Is Required for Viral Envelopment Roller, R. J.; Zhou, Y.; Schnetzer, R. Journal of Virology, Vol. 74, Issue 1 https://doi.org/10.1128/JVI.74.1.117-129.2000	journal	January 2000
Collaboration gets the most out of software Morin, Andrew; Eisenbraun, Ben; Key, Jason eLife, Vol. 2 https://doi.org/10.7554/eLife.01456	journal	September 2013
Dictionary of protein secondary structure: Pattern recognition of hydrogen-bonded and geometrical features Kabsch, Wolfgang; Sander, Christian Biopolymers, Vol. 22, Issue 12 https://doi.org/10.1002/bip.360221211	journal	December 1983
Functional profiling of a human cytomegalovirus genome Dunn, Walter; Chou, Cassie; Li, Hong Proceedings of the National Academy of Sciences, Vol. 100, Issue 24 https://doi.org/10.1073/pnas.2334032100	journal	November 2003
Vesicle formation from the nuclear membrane is induced by coexpression of two conserved herpesvirus proteins Klupp, B. G.; Granzow, H.; Fuchs, W. Proceedings of the National Academy of Sciences, Vol. 104, Issue 17 https://doi.org/10.1073/pnas.0701757104	journal	April 2007
Deletion of Epstein-Barr Virus BFLF2 Leads to Impaired Viral DNA Packaging and Primary Egress as Well as to the Production of Defective Viral Particles Granato, Marisa; Feederle, Regina; Farina, Antonella Journal of Virology, Vol. 82, Issue 8 https://doi.org/10.1128/JVI.02436-07	journal	April 2008
Deep-etch EM reveals that the early poxvirus envelope is a single membrane bilayer stabilized by a geodetic “honeycomb” surface coat Heuser, John The Journal of Cell Biology, Vol. 169, Issue 2 https://doi.org/10.1083/jcb.200412169	journal	April 2005
Epstein–Barr virus: 40 years on Young, Lawrence S.; Rickinson, Alan B. Nature Reviews Cancer, Vol. 4, Issue 10 https://doi.org/10.1038/nrc1452	journal	October 2004
Unexpected features and mechanism of heterodimer formation of a herpesvirus nuclear egress complex Lye, Ming F.; Sharma, Mayuri; El Omari, Kamel The EMBO Journal, Vol. 34, Issue 23 https://doi.org/10.15252/embj.201592651	journal	October 2015
The Equine Herpesvirus 1 UL34 Gene Product Is Involved in an Early Step in Virus Egress and Can Be Efficiently Replaced by a UL34-GFP Fusion Protein Neubauer, Antonie; Rudolph, Jens; Brandmüller, Christine Virology, Vol. 300, Issue 2 https://doi.org/10.1006/viro.2002.1488	journal	September 2002
Virus-derived peptide inhibitors of the herpes simplex virus type 1 nuclear egress complex Draganova, Elizabeth B.; Heldwein, Ekaterina E. Scientific Reports, Vol. 11, Issue 1 https://doi.org/10.1038/s41598-021-83402-x	journal	February 2021
Features and development of Coot Emsley, P.; Lohkamp, B.; Scott, W. G. Acta Crystallographica Section D Biological Crystallography, Vol. 66, Issue 4 https://doi.org/10.1107/S0907444910007493	journal	March 2010
BFRF1 of Epstein-Barr Virus Is Essential for Efficient Primary Viral Envelopment and Egress Farina, Antonella; Feederle, Regina; Raffa, Salvatore Journal of Virology, Vol. 79, Issue 6 https://doi.org/10.1128/JVI.79.6.3703-3712.2005	journal	March 2005
Structural basis of membrane budding by the nuclear egress complex of herpesviruses Bigalke, Janna M.; Heldwein, Ekaterina E. The EMBO Journal, Vol. 34, Issue 23 https://doi.org/10.15252/embj.201592359	journal	October 2015
Structure of a herpesvirus nuclear egress complex subunit reveals an interaction groove that is essential for viral replication Leigh, Kendra E.; Sharma, Mayuri; Mansueto, My Sam Proceedings of the National Academy of Sciences, Vol. 112, Issue 29 https://doi.org/10.1073/pnas.1511140112	journal	July 2015
The null mutant of the U(L)31 gene of herpes simplex virus 1: construction and phenotype in infected cells Chang, Y. E.; Van Sant, C.; Krug, P. W. Journal of Virology, Vol. 71, Issue 11 https://doi.org/10.1128/jvi.71.11.8307-8315.1997	journal	November 1997
The Interacting UL31 and UL34 Gene Products of Pseudorabies Virus Are Involved in Egress from the Host-Cell Nucleus and Represent Components of Primary Enveloped but Not Mature Virions Fuchs, W.; Klupp, B. G.; Granzow, H. Journal of Virology, Vol. 76, Issue 1 https://doi.org/10.1128/JVI.76.1.364-378.2002	journal	January 2002
Nuclear Exodus: Herpesviruses Lead the Way Bigalke, Janna M.; Heldwein, Ekaterina E. Annual Review of Virology, Vol. 3, Issue 1 https://doi.org/10.1146/annurev-virology-110615-042215	journal	September 2016
PHENIX: a comprehensive Python-based system for macromolecular structure solution Adams, Paul D.; Afonine, Pavel V.; Bunkóczi, Gábor Acta Crystallographica Section D Biological Crystallography, Vol. 66, Issue 2, p. 213-221 https://doi.org/10.1107/S0907444909052925	journal	January 2010
A Single Herpesvirus Protein Can Mediate Vesicle Formation in the Nuclear Envelope Lorenz, Michael; Vollmer, Benjamin; Unsay, Joseph D. Journal of Biological Chemistry, Vol. 290, Issue 11 https://doi.org/10.1074/jbc.M114.627521	journal	January 2015
Crystal Structure of the Herpesvirus Nuclear Egress Complex Provides Insights into Inner Nuclear Membrane Remodeling Zeev-Ben-Mordehai, Tzviya; Weberruß, Marion; Lorenz, Michael Cell Reports, Vol. 13, Issue 12 https://doi.org/10.1016/j.celrep.2015.11.008	journal	December 2015
Characterization of Conserved Region 2-Deficient Mutants of the Cytomegalovirus Egress Protein pM53 Pogoda, Madlen; Bosse, Jens B.; Wagner, Felicia M. Journal of Virology, Vol. 86, Issue 23 https://doi.org/10.1128/JVI.00471-12	journal	December 2012
Automated electron microscope tomography using robust prediction of specimen movements Mastronarde, David N. Journal of Structural Biology, Vol. 152, Issue 1 https://doi.org/10.1016/j.jsb.2005.07.007	journal	October 2005
Nuclear Envelope Breakdown Can Substitute for Primary Envelopment-Mediated Nuclear Egress of Herpesviruses Klupp, B. G.; Granzow, H.; Mettenleiter, T. C. Journal of Virology, Vol. 85, Issue 16 https://doi.org/10.1128/JVI.00741-11	journal	June 2011
Crystal Structure of the Human Cytomegalovirus pUL50-pUL53 Core Nuclear Egress Complex Provides Insight into a Unique Assembly Scaffold for Virus-Host Protein Interactions Walzer, Sascha A.; Egerer-Sieber, Claudia; Sticht, Heinrich Journal of Biological Chemistry, Vol. 290, Issue 46 https://doi.org/10.1074/jbc.C115.686527	journal	November 2015
Cell lines that support replication of a novel herpes simplex virus 1 UL31 deletion mutant can properly target UL34 protein to the nuclear rim in the absence of UL31 Liang, Li; Tanaka, Michiko; Kawaguchi, Yasushi Virology, Vol. 329, Issue 1 https://doi.org/10.1016/j.virol.2004.07.030	journal	November 2004
Herpes Simplex Virus 1 pUL34 Plays a Critical Role in Cell-to-Cell Spread of Virus in Addition to Its Role in Virus Replication Haugo, Alison C.; Szpara, Moriah L.; Parsons, Lance Journal of Virology, Vol. 85, Issue 14 https://doi.org/10.1128/JVI.00262-11	journal	July 2011
Comprehensive Mutational Analysis of a Herpesvirus Gene in the Viral Genome Context Reveals a Region Essential for Virus Replication Bubeck, A.; Wagner, M.; Ruzsics, Z. Journal of Virology, Vol. 78, Issue 15 https://doi.org/10.1128/JVI.78.15.8026-8035.2004	journal	July 2004
Epstein-Barr Virus: An Important Vaccine Target for Cancer Prevention Cohen, J. I.; Fauci, A. S.; Varmus, H. Science Translational Medicine, Vol. 3, Issue 107 https://doi.org/10.1126/scitranslmed.3002878	journal	November 2011
Phaser crystallographic software McCoy, Airlie J.; Grosse-Kunstleve, Ralf W.; Adams, Paul D. Journal of Applied Crystallography, Vol. 40, Issue 4 https://doi.org/10.1107/S0021889807021206	journal	July 2007
The EMBL-EBI search and sequence analysis tools APIs in 2019 Madeira, Fábio; Park, Young mi; Lee, Joon Nucleic Acids Research, Vol. 47, Issue W1 https://doi.org/10.1093/nar/gkz268	journal	April 2019
Analysis of a Charge Cluster Mutation of Herpes Simplex Virus Type 1 UL34 and Its Extragenic Suppressor Suggests a Novel Interaction between pUL34 and pUL31 That Is Necessary for Membrane Curvature around Capsids Roller, R. J.; Bjerke, S. L.; Haugo, A. C. Journal of Virology, Vol. 84, Issue 8 https://doi.org/10.1128/JVI.01638-09	journal	January 2010
Membrane deformation and scission by the HSV-1 nuclear egress complex Bigalke, Janna M.; Heuser, Thomas; Nicastro, Daniela Nature Communications, Vol. 5, Issue 1 https://doi.org/10.1038/ncomms5131	journal	June 2014
Primary Envelopment of Pseudorabies Virus at the Nuclear Membrane Requires the UL34 Gene Product Klupp, Barbara G.; Granzow, Harald; Mettenleiter, Thomas C. Journal of Virology, Vol. 74, Issue 21 https://doi.org/10.1128/JVI.74.21.10063-10073.2000	journal	November 2000
Structural Basis of Vesicle Formation at the Inner Nuclear Membrane Hagen, Christoph; Dent, Kyle C.; Zeev-Ben-Mordehai, Tzviya Cell, Vol. 163, Issue 7 https://doi.org/10.1016/j.cell.2015.11.029	journal	December 2015
Conformational Dynamics of Herpesviral NEC Proteins in Different Oligomerization States Diewald, Benedikt; Socher, Eileen; Söldner, Christian International Journal of Molecular Sciences, Vol. 19, Issue 10 https://doi.org/10.3390/ijms19102908	journal	September 2018
Protein production by auto-induction in high-density shaking cultures Studier, F. William Protein Expression and Purification, Vol. 41, Issue 1, p. 207-234 https://doi.org/10.1016/j.pep.2005.01.016	journal	May 2005
Inference of Macromolecular Assemblies from Crystalline State Krissinel, Evgeny; Henrick, Kim Journal of Molecular Biology, Vol. 372, Issue 3 https://doi.org/10.1016/j.jmb.2007.05.022	journal	September 2007
Lipid composition of nuclear membranes isolated from bovine liver Keenna, T. W.; Berezney, Ronald; Funk, Linda K. Biochimica et Biophysica Acta (BBA) - Biomembranes, Vol. 203, Issue 3 https://doi.org/10.1016/0005-2736(70)90191-4	journal	June 1970
Herpesviruses remodel host membranes for virus egress Johnson, David C.; Baines, Joel D. Nature Reviews Microbiology, Vol. 9, Issue 5 https://doi.org/10.1038/nrmicro2559	journal	April 2011
The Primary Enveloped Virion of Herpes Simplex Virus 1: Its Role in Nuclear Egress Newcomb, William W.; Fontana, Juan; Winkler, Dennis C. mBio, Vol. 8, Issue 3 https://doi.org/10.1128/mBio.00825-17	journal	July 2017
Dominant Negative Mutants of the Murine Cytomegalovirus M53 Gene Block Nuclear Egress and Inhibit Capsid Maturation Popa, Mirela; Ruzsics, Zsolt; Lötzerich, Mark Journal of Virology, Vol. 84, Issue 18 https://doi.org/10.1128/JVI.00681-10	journal	September 2010
A short history of SHELX Sheldrick, George M. Acta Crystallographica Section A Foundations of Crystallography, Vol. 64, Issue 1, p. 112-122 https://doi.org/10.1107/S0108767307043930	journal	December 2007
Effects of Charged Cluster Mutations on the Function of Herpes Simplex Virus Type 1 UL34 Protein Bjerke, S. L.; Cowan, J. M.; Kerr, J. K. Journal of Virology, Vol. 77, Issue 13 https://doi.org/10.1128/JVI.77.13.7601-7610.2003	journal	July 2003
Herpesvirus assembly: An update Mettenleiter, Thomas C.; Klupp, Barbara G.; Granzow, Harald Virus Research, Vol. 143, Issue 2 https://doi.org/10.1016/j.virusres.2009.03.018	journal	August 2009
Deciphering key features in protein structures with the new ENDscript server Robert, Xavier; Gouet, Patrice Nucleic Acids Research, Vol. 42, Issue W1 https://doi.org/10.1093/nar/gku316	journal	April 2014
XDS Kabsch, Wolfgang Acta Crystallographica Section D Biological Crystallography, Vol. 66, Issue 2 https://doi.org/10.1107/S0907444909047337	journal	January 2010
MolProbity: More and better reference data for improved all-atom structure validation: PROTEIN SCIENCE.ORG Williams, Christopher J.; Headd, Jeffrey J.; Moriarty, Nigel W. Protein Science, Vol. 27, Issue 1 https://doi.org/10.1002/pro.3330	journal	November 2017
Cryo-electron microscopy reconstruction of a poliovirus-receptor-membrane complex Bubeck, Doryen; Filman, David J.; Hogle, James M. Nature Structural & Molecular Biology, Vol. 12, Issue 7 https://doi.org/10.1038/nsmb955	journal	June 2005
Phospholipid composition, phospholipase A2 and sphingomyelinase activities in rat liver nuclear membrane and matrix Neitcheva, Tania; Peeva, Diana The International Journal of Biochemistry & Cell Biology, Vol. 27, Issue 10 https://doi.org/10.1016/1357-2725(95)00087-6	journal	October 1995
Reconstitution of the Kaposi's Sarcoma-Associated Herpesvirus Nuclear Egress Complex and Formation of Nuclear Membrane Vesicles by Coexpression of ORF67 and ORF69 Gene Products Desai, P. J.; Pryce, E. N.; Henson, B. W. Journal of Virology, Vol. 86, Issue 1 https://doi.org/10.1128/JVI.05988-11	journal	October 2011
Highly Basic Clusters in the Herpes Simplex Virus 1 Nuclear Egress Complex Drive Membrane Budding by Inducing Lipid Ordering Thorsen, Michael K.; Lai, Alex; Lee, Michelle W. mBio, Vol. 12, Issue 4 https://doi.org/10.1128/mBio.01548-21	journal	August 2021
Structure and assembly of immature HIV Briggs, J. A. G.; Riches, J. D.; Glass, B. Proceedings of the National Academy of Sciences, Vol. 106, Issue 27 https://doi.org/10.1073/pnas.0903535106	journal	June 2009
MolProbity: all-atom contacts and structure validation for proteins and nucleic acids Davis, I. W.; Leaver-Fay, A.; Chen, V. B. Nucleic Acids Research, Vol. 35, Issue Web Server https://doi.org/10.1093/nar/gkm216	journal	May 2007
Fiji: an open-source platform for biological-image analysis Schindelin, Johannes; Arganda-Carreras, Ignacio; Frise, Erwin Nature Methods, Vol. 9, Issue 7 https://doi.org/10.1038/nmeth.2019	journal	June 2012
Characterization and Intracellular Localization of the Epstein-Barr Virus Protein BFLF2: Interactions with BFRF1 and with the Nuclear Lamina Gonnella, Roberta; Farina, Antonella; Santarelli, Roberta Journal of Virology, Vol. 79, Issue 6 https://doi.org/10.1128/JVI.79.6.3713-3727.2005	journal	March 2005
The Immunology of Epstein-Barr Virus–Induced Disease Taylor, Graham S.; Long, Heather M.; Brooks, Jill M. Annual Review of Immunology, Vol. 33, Issue 1 https://doi.org/10.1146/annurev-immunol-032414-112326	journal	March 2015
Functional Domains of Murine Cytomegalovirus Nuclear Egress Protein M53/p38 Lötzerich, Mark; Ruzsics, Zsolt; Koszinowski, Ulrich H. Journal of Virology, Vol. 80, Issue 1 https://doi.org/10.1128/JVI.80.1.73-84.2006	journal	January 2006
Structure of the immature HIV-1 capsid in intact virus particles at 8.8 Å resolution Schur, Florian K. M.; Hagen, Wim J. H.; Rumlová, Michaela Nature, Vol. 517, Issue 7535 https://doi.org/10.1038/nature13838	journal	November 2014
Roles of the Interhexamer Contact Site for Hexagonal Lattice Formation of the Herpes Simplex Virus 1 Nuclear Egress Complex in Viral Primary Envelopment and Replication Arii, Jun; Takeshima, Kosuke; Maruzuru, Yuhei Journal of Virology, Vol. 93, Issue 14 https://doi.org/10.1128/JVI.00498-19	journal	May 2019
Functional map of human cytomegalovirus AD169 defined by global mutational analysis Yu, Dong; Silva, Maria C.; Shenk, Thomas Proceedings of the National Academy of Sciences, Vol. 100, Issue 21 https://doi.org/10.1073/pnas.1635160100	journal	September 2003

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