skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Structural studies of antitumor compounds that target the RING domain of MDM2

Journal Article · · Protein Sci.
DOI:· OSTI ID:1878368

Research Organization:
Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Sponsoring Organization:
DOE - Office Of Science; NCI
Journal Information:
Protein Sci., Vol. 31, Issue (8)
Country of Publication:
United States

References (32)

Putting p53 in Context journal September 2017
Attenuation of p53 mutant as an approach for treatment Her2-positive cancer journal October 2020
TP53 mutations and hepatocellular carcinoma: insights into the etiology and pathogenesis of liver cancer journal April 2007
TP53 and liver carcinogenesis journal February 2003
The p53 mutation spectrum in hepatocellular carcinoma from Guangxi, China : role of chronic hepatitis B virus infection and aflatoxin B1 exposure journal January 2014
It takes a team: a gain-of-function story of p53-R249S journal January 2019
Guardian of genome on the tract: Wild type p53-mdm2 complex inhibition in healing the breast cancer journal June 2021
Mdm2-mediated ubiquitylation: p53 and beyond journal June 2009
Targeting Mouse Double Minute 2: Current Concepts in DNA Damage Repair and Therapeutic Approaches in Cancer journal May 2020
Hypomethylation-Linked Activation of PLCE1 Impedes Autophagy and Promotes Tumorigenesis through MDM2-Mediated Ubiquitination and Destabilization of p53 journal June 2020
MDM2 inhibition: an important step forward in cancer therapy journal July 2020
Small-Molecule Inhibitors of the MDM2–p53 Protein–Protein Interaction (MDM2 Inhibitors) in Clinical Trials for Cancer Treatment: Miniperspective journal November 2014
The roles and regulation of MDM2 and MDMX: it is not just about p53 journal April 2021
The C-terminal SAM domain of p73 binds to the N terminus of MDM2 journal April 2019
MDM2 Increases Drug Resistance in Cancer Cells by Inducing EMT Independent of p53 journal December 2016
MDM2 promotes genome instability by ubiquitinating the transcription factor HBP1 journal February 2019
Inulanolide A as a new dual inhibitor of NFAT1-MDM2 pathway for breast cancer therapy journal April 2016
Targeting the NFAT1-MDM2-MDMX Network Inhibits the Proliferation and Invasion of Prostate Cancer Cells, Independent of p53 and Androgen journal December 2017
MDM2-NFAT1 dual inhibitor, MA242: Effective against hepatocellular carcinoma, independent of p53 journal September 2019
Discovery and Characterization of Dual Inhibitors of MDM2 and NFAT1 for Pancreatic Cancer Therapy journal October 2018
Weakly hydrated surfaces and the binding interactions of small biological solutes journal November 2011
Structural basis for DNA damage-induced phosphoregulation of MDM2 RING domain journal April 2020
Structural analysis of MDM2 RING separates degradation from regulation of p53 transcription activity journal May 2017
Mutational analysis of Mdm2 C-terminal tail suggests an evolutionarily conserved role of its length in Mdm2 activity toward p53 and indicates structural differences between Mdm2 homodimers and Mdm2/MdmX heterodimers journal March 2012
Auto-ubiquitination of Mdm2 Enhances Its Substrate Ubiquitin Ligase Activity journal June 2013
Activation of a Primed RING E3-E2–Ubiquitin Complex by Non-Covalent Ubiquitin journal April 2015
Comprehensive Analysis of Ebola Virus GP1 in Viral Entry journal March 2005
NIH Image to ImageJ: 25 years of image analysis journal June 2012
XDS journal January 2010
Overview of the CCP 4 suite and current developments journal March 2011
PHENIX: a comprehensive Python-based system for macromolecular structure solution journal January 2010
Features and development of Coot journal March 2010