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Development of a potent high-affinity human therapeutic antibody via novel application of recombinat

Journal Article · · J. Biol. Chem.

Research Organization:
Advanced Photon Source (APS), Argonne National Laboratory (ANL), Argonne, IL (US)
Sponsoring Organization:
DOE - Office Of Science; INDUSTRY
OSTI ID:
1877216
Journal Information:
J. Biol. Chem., Journal Name: J. Biol. Chem. Journal Issue: (2) Vol. 298
Country of Publication:
United States
Language:
ENGLISH

References (43)

A Functional Analysis of the Spacer of V(D)J Recombination Signal Sequences journal October 2003
Features and development of Coot journal March 2010
Identification of D segments of immunoglobulin heavy-chain genes and their rearrangement in T lymphocytes journal April 1981
Integration, scaling, space-group assignment and post-refinement journal January 2010
PHENIX: a comprehensive Python-based system for macromolecular structure solution journal January 2010
The V(D)J recombination activating gene, RAG-1 journal December 1989
Principles of protein–protein recognition journal August 1975
Single variable domains from the T cell receptor β chain function as mono- and bifunctional CARs and TCRs journal November 2019
Insertion of N regions into heavy-chain genes is correlated with expression of terminal deoxytransferase in B cells journal October 1984
Site-specific DNA recombination in mammalian cells by the Cre recombinase of bacteriophage P1. journal July 1988
Phaser crystallographic software journal July 2007
De novo protein design by citizen scientists journal June 2019
De novo design of potent and selective mimics of IL-2 and IL-15 journal January 2019
Is terminal deoxynucleotidyl transferase a somatic mutagen in lymphocytes? journal March 1974
What has de novo protein design taught us about protein folding and biophysics? journal February 2019
Affinity Improvement of a Therapeutic Antibody by Structure-Based Computational Design: Generation of Electrostatic Interactions in the Transition State Stabilizes the Antibody-Antigen Complex journal January 2014
Making Antibodies by Phage Display Technology journal April 1994
Kinetic analysis of unpurified native antigens available in very low quantities and concentrations journal July 2011
Computational affinity maturation of camelid single-domain intrabodies against the nonamyloid component of alpha-synuclein journal December 2018
Computational design of antibodies journal August 2018
Shape Complementarity at Protein/Protein Interfaces journal December 1993
Connecting the sequence dots: shedding light on the genesis of antibodies reported to be designed in silico journal May 2019
Tetracycline Repressor, tetR, rather than the tetR–Mammalian Cell Transcription Factor Fusion Derivatives, Regulates Inducible Gene Expression in Mammalian Cells journal September 1998
Inference of Macromolecular Assemblies from Crystalline State journal September 2007
Computational design of antibody-affinity improvement beyond in vivo maturation journal September 2007
Overview of the CCP 4 suite and current developments journal March 2011
Down-regulation of RAG1 and RAG2 gene expression in PreB cells after functional immunoglobulin heavy chain rearrangement journal November 1995
Conformational flexibility of an anti-IL-13 DARPin† journal December 2016
Antibody structure determination using a combination of homology modeling, energy-based refinement, and loop prediction: Antibody Structure Modeling and Refinement journal April 2014
Affinity maturation of human botulinum neurotoxin antibodies by light chain shuffling via yeast mating journal February 2010
Diversity in the CDR3 Region of VH Is Sufficient for Most Antibody Specificities journal July 2000
Computational Design of Epitope-Specific Functional Antibodies journal November 2018
XDS journal January 2010
Demonstration of an in vivo generated sub-picomolar affinity fully human monoclonal antibody to interleukin-8 journal September 2005
Substantial Energetic Improvement with Minimal Structural Perturbation in a High Affinity Mutant Antibody journal October 2004
Directed evolution of antibody fragments with monovalent femtomolar antigen-binding affinity journal September 2000
Somatic generation of antibody diversity journal April 1983
Trends in therapeutic antibody affinity maturation: From in-vitro towards next-generation sequencing approaches journal August 2019
Yeast surface display for protein engineering and characterization journal August 2007
Sequences at the somatic recombination sites of immunoglobulin light-chain genes journal July 1979
Identification and nucleotide sequence of a diversity DNA segment (D) of immunoglobulin heavy-chain genes journal April 1981
XOMA 052, a potent, high-affinity monoclonal antibody for the treatment of IL-1β-mediated diseases journal January 2011
RAG-1 and RAG-2, adjacent genes that synergistically activate V(D)J recombination journal June 1990

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