skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: A peroxisomal ubiquitin ligase complex forms a retrotranslocation channel

Journal Article · · Nature

Research Organization:
Argonne National Laboratory (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Sponsoring Organization:
DOE - Office Of Science; NIGMS; National Institutes of Health (NIH)
OSTI ID:
1877211
Journal Information:
Nature, Vol. 607
Country of Publication:
United States
Language:
ENGLISH

References (58)

Peroxisome biogenesis, membrane contact sites, and quality control journal November 2018
Current Advances in Protein Import into Peroxisomes journal May 2019
Protein transport into peroxisomes: Knowns and unknowns journal August 2017
Recent insights into peroxisome biogenesis and associated diseases journal May 2020
The RING-type ubiquitin ligases Pex2p, Pex10p and Pex12p form a heteromeric complex that displays enhanced activity in an ubiquitin conjugating enzyme-selective manner: The RING-type ubiquitin ligases journal May 2012
Peroxisome Biogenesis Disorders journal September 2003
The Human Peroxisomal Targeting Signal Receptor, Pex5p, Is Translocated into the Peroxisomal Matrix and Recycled to the Cytosol journal April 2001
The peroxisomal importomer constitutes a large and highly dynamic pore journal February 2010
Dynamics of the peroxisomal import cycle of PpPex20p: Ubiquitin-dependent localization and regulation journal January 2006
Uniqueness of the mechanism of protein import into the peroxisome matrix: Transport of folded, co-factor-bound and oligomeric proteins by shuttling receptors journal December 2006
Insights into ubiquitin-conjugating enzyme/ co-activator interactions from the structure of the Pex4p:Pex22p complex: Crystal structure of the Pex4p:Pex22p complex journal November 2011
Pex2 and Pex12 Function as Protein-Ubiquitin Ligases in Peroxisomal Protein Import journal August 2009
Pex10p functions as an E3 ligase for the Ubc4p-dependent ubiquitination of Pex5p journal October 2008
Mechanistic insights into ER-associated protein degradation journal August 2018
The exportomer: the peroxisomal receptor export machinery journal September 2012
Towards repurposing the yeast peroxisome for compartmentalizing heterologous metabolic pathways journal March 2016
The rat liver peroxisomal membrane forms a permeability barrier for cofactors but not for small metabolites in vitro journal November 2004
RING Domain E3 Ubiquitin Ligases journal June 2009
Structure of an E3:E2∼Ub Complex Reveals an Allosteric Mechanism Shared among RING/U-box Ligases journal September 2012
Structure of a RING E3 ligase and ubiquitin-loaded E2 primed for catalysis journal July 2012
BIRC7–E2 ubiquitin conjugate structure reveals the mechanism of ubiquitin transfer by a RING dimer journal August 2012
Genetic classification and mutational spectrum of more than 600 patients with a Zellweger syndrome spectrum disorder journal December 2010
Insights into the Role of the Peroxisomal Ubiquitination Machinery in Pex13p Degradation in the Yeast Hansenula polymorpha journal May 2018
A Conserved Cysteine Residue of Pichia pastoris Pex20p Is Essential for Its Recycling from the Peroxisome to the Cytosol journal March 2007
Pex18p Is Constitutively Degraded during Peroxisome Biogenesis journal December 2001
Ubiquitination of the peroxisomal import receptor Pex5p is required for its recycling journal April 2007
A Conserved Cysteine Is Essential for Pex4p-dependent Ubiquitination of the Peroxisomal Import Receptor Pex5p journal June 2007
Peroxisomal protein import and ERAD: variations on a common theme journal November 2010
Structural basis of ER-associated protein degradation mediated by the Hrd1 ubiquitin ligase complex journal April 2020
X-ray structure of a protein-conducting channel journal December 2003
Structure of the Sec61 channel opened by a signal sequence journal December 2015
Crystal structure of a substrate-engaged SecY protein-translocation channel journal March 2016
A Facile Method for High-throughput Co-expression of Protein Pairs journal July 2004
High-efficiency yeast transformation using the LiAc/SS carrier DNA/PEG method journal January 2007
Reconstitution of the tubular endoplasmic reticulum network with purified components journal February 2017
Allosteric control of ligand-binding affinity using engineered conformation-specific effector proteins journal March 2011
Conformational Chaperones for Structural Studies of Membrane Proteins Using Antibody Phage Display with Nanodiscs journal February 2016
Generating Conformation and Complex-Specific Synthetic Antibodies book January 2017
Structure and drug resistance of the Plasmodium falciparum transporter PfCRT journal November 2019
Structure of the post-translational protein translocation machinery of the ER membrane journal December 2018
MotionCor2: anisotropic correction of beam-induced motion for improved cryo-electron microscopy journal February 2017
CTFFIND4: Fast and accurate defocus estimation from electron micrographs journal November 2015
New tools for automated high-resolution cryo-EM structure determination in RELION-3 journal November 2018
Quantifying the local resolution of cryo-EM density maps journal November 2013
Addressing preferred specimen orientation in single-particle cryo-EM through tilting journal July 2017
Collaboration gets the most out of software journal September 2013
Current developments in Coot for macromolecular model building of Electron Cryo‐microscopy and Crystallographic Data journal March 2020
Macromolecular structure determination using X-rays, neutrons and electrons: recent developments in Phenix journal October 2019
Template-based protein structure modeling using the RaptorX web server journal July 2012
Highly accurate protein structure prediction with AlphaFold journal July 2021
UCSF Chimera?A visualization system for exploratory research and analysis journal January 2004
Efficient anisotropic refinement of macromolecular structures using FFT journal January 1999
UCSF ChimeraX : Structure visualization for researchers, educators, and developers journal October 2020
The peroxisomal AAA-ATPase Pex1/Pex6 unfolds substrates by processive threading journal January 2018
TMTpro reagents: a set of isobaric labeling mass tags enables simultaneous proteome-wide measurements across 16 samples journal March 2020
MUSCLE: a multiple sequence alignment method with reduced time and space complexity journal August 2004
Jalview Version 2--a multiple sequence alignment editor and analysis workbench journal January 2009
ConSurf 2010: calculating evolutionary conservation in sequence and structure of proteins and nucleic acids journal May 2010

Similar Records

Related Subjects