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Identification of 2-Pyridinylindole-Based Dual Antagonists of Toll-like Receptors 7 and 8 (TLR7/8)

Journal Article · · ACS Med. Chem. Lett.

Research Organization:
Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Sponsoring Organization:
DOE - Office Of Science; INDUSTRY
OSTI ID:
1872606
Journal Information:
ACS Med. Chem. Lett., Vol. 13, Issue (5)
Country of Publication:
United States
Language:
ENGLISH

References (10)

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DAMP-sensing receptors in sterile inflammation and inflammatory diseases journal September 2019
Toll-like Receptor 7 and TLR9 Dictate Autoantibody Specificity and Have Opposing Inflammatory and Regulatory Roles in a Murine Model of Lupus journal September 2006
TLR9 Regulates TLR7- and MyD88-Dependent Autoantibody Production and Disease in a Murine Model of Lupus journal January 2010
Discovery of Potent and Orally Bioavailable Small Molecule Antagonists of Toll-like Receptors 7/8/9 (TLR7/8/9) journal July 2020
Species-Specific Recognition of Single-Stranded RNA via Toll-like Receptor 7 and 8 journal March 2004
A five-amino-acid motif in the undefined region of the TLR8 ectodomain is required for species-specific ligand recognition journal February 2010
RNA recognition by human TLR8 can lead to autoimmune inflammation journal November 2013
Humanized TLR7/8 Expression Drives Proliferative Multisystemic Histiocytosis in C57BL/6 Mice journal September 2014