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Title: Human CEACAM1 N-domain dimerization is independent from glycan modifications

Journal Article · · Structure

Research Organization:
Argonne National Laboratory (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Sponsoring Organization:
DOE - Office Of Science; National Institutes of Health (NIH)
OSTI ID:
1872595
Journal Information:
Structure, Vol. 30, Issue (5)
Country of Publication:
United States
Language:
ENGLISH

References (57)

PHENIX: a comprehensive Python-based system for macromolecular structure solution journal January 2010
Origins of coevolution between residues distant in protein 3D structures journal August 2017
Expresso: automatic incorporation of structural information in multiple sequence alignments using 3D-Coffee journal July 2006
Learning generative models for protein fold families
  • Balakrishnan, Sivaraman; Kamisetty, Hetunandan; Carbonell, Jaime G.
  • Proteins: Structure, Function, and Bioinformatics, Vol. 79, Issue 4 https://doi.org/10.1002/prot.22934
journal January 2011
Carcinoembryonic antigen-related cell adhesion molecules (CEACAMs) in cancer progression and metastasis journal August 2013
Structure of the N-terminal dimerization domain of CEACAM7 journal August 2015
Diverse oligomeric states of CEACAM IgV domains journal October 2015
The Helicobacter pylori adhesin protein HopQ exploits the dimer interface of human CEACAMs to facilitate translocation of the oncoprotein CagA journal May 2018
A new spin on protein dynamics journal June 2002
Site-specific incorporation of biophysical probes into proteins. journal April 1994
BioMuta and BioXpress: mutation and expression knowledgebases for cancer biomarker discovery journal October 2017
Features and development of Coot journal March 2010
How good are my data and what is the resolution? journal June 2013
Structure of the N-terminal domain of human CEACAM1: binding target of the opacity proteins during invasion of Neisseria meningitidis and N. gonorrhoeae journal August 2006
Structural basis of the dynamic human CEACAM1 monomer-dimer equilibrium journal March 2021
CEACAM1 regulates TIM-3-mediated tolerance and exhaustion journal October 2014
Identifying conformational changes with site-directed spin labeling journal September 2000
DEER Distance Measurements on Proteins journal May 2012
DeerAnalysis2006—a comprehensive software package for analyzing pulsed ELDOR data journal June 2006
Distance measurements on spin-labelled biomacromolecules by pulsed electron paramagnetic resonance journal January 2007
Integration, scaling, space-group assignment and post-refinement journal January 2010
Assessing the utility of coevolution-based residue-residue contact predictions in a sequence- and structure-rich era journal September 2013
Coevolution of activating and inhibitory receptors within mammalian carcinoembryonic antigen families journal February 2010
The CEACAM1 N-terminal Ig domain mediates cis- and trans-binding and is essential for allosteric rearrangements of CEACAM1 microclusters journal November 2009
MOLMOL: A program for display and analysis of macromolecular structures journal February 1996
Binding of Dr adhesins of Escherichia coli to carcinoembryonic antigen triggers receptor dissociation: Dr adhesins trigger CEA dimer dissociation journal December 2007
CEACAMs: their role in physiology and pathophysiology journal October 2006
The Transmembrane Domain of CEACAM1-4S Is a Determinant of Anchorage Independent Growth and Tumorigenicity journal January 2012
Osmolyte perturbation reveals conformational equilibria in spin-labeled proteins journal August 2009
A structural dissection of large protein-protein crystal packing contacts journal September 2015
The Critical Role of Residues 43 R and 44 Q of Carcinoembryonic Antigen Cell Adhesion Molecules-1 in the Protection from Killing by Human NK Cells journal September 2004
Mammalian glycosylation in immunity journal November 2008
Neisserial Opa Protein–CEACAM Interactions: Competition for Receptors as a Means of Bacterial Invasion and Pathogenesis journal August 2016
Phaser crystallographic software journal July 2007
Motion of Spin-Labeled Side Chains in T4 Lysozyme. Correlation with Protein Structure and Dynamics journal January 1996
Enzymatic Basis for N -Glycan Sialylation : STRUCTURE OF RAT α2,6-SIALYLTRANSFERASE (ST6GAL1) REVEALS CONSERVED AND UNIQUE FEATURES FOR GLYCAN SIALYLATION journal October 2013
Helicobacter pylori adhesin HopQ disrupts trans dimerization in human CEACAM s journal June 2018
Expression system for structural and functional studies of human glycosylation enzymes journal December 2017
Paramagnetic Tag for Glycosylation Sites in Glycoproteins: Structural Constraints on Heparan Sulfate Binding to Robo1 journal July 2018
Protein structural dynamics revealed by site-directed spin labeling and multifrequency EPR journal April 2010
CEA adhesion molecules: multifunctional proteins with signal-regulatory properties journal October 1997
Human germline and pan-cancer variomes and their distinct functional profiles journal September 2014
Dead-Time Free Measurement of Dipole–Dipole Interactions between Electron Spins journal February 2000
Inside-out Signaling Promotes Dynamic Changes in the Carcinoembryonic Antigen-related Cellular Adhesion Molecule 1 (CEACAM1) Oligomeric State to Control Its Cell Adhesion Properties journal September 2013
Structural and Molecular Evidence Suggesting Coronavirus-driven Evolution of Mouse Receptor journal February 2017
Structure and function in rhodopsin: High-level expression of rhodopsin with restricted and homogeneous N-glycosylation by a tetracycline-inducible N-acetylglucosaminyltransferase I-negative HEK293S stable mammalian cell line journal October 2002
Deciphering key features in protein structures with the new ENDscript server journal April 2014
A Dynamic Protein–Protein Coupling between the TonB-Dependent Transporter FhuA and TonB journal January 2018
The Xplor-NIH NMR molecular structure determination package journal January 2003
Self Recognition in the Ig Superfamily journal September 2000
Crystal structure of murine sCEACAM1a[1,4]: a coronavirus receptor in the CEA family journal May 2002
Signaling by epithelial members of the CEACAM family – mucosal docking sites for pathogenic bacteria journal January 2014
Critical determinants of host receptor targeting by Neisseria meningitidis and Neisseria gonorrhoeae : identification of Opa adhesiotopes on the N-domain of CD66 molecules journal November 1999
The N‐domain of the human CD66a adhesion molecule is a target for Opa proteins of Neisseria meningitidis and Neisseria gonorrhoeae journal December 1996
Homophilic adhesion of human CEACAM1 involves N-terminal domain interactions: structural analysis of the binding site journal September 2001
A framework for organizing cancer-related variations from existing databases, publications and NGS data using a High-performance Integrated Virtual Environment (HIVE) journal January 2014
Glycosylation Alters Dimerization Properties of a Cell-surface Signaling Protein, Carcinoembryonic Antigen-related Cell Adhesion Molecule 1 (CEACAM1) journal September 2016