skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Determination of the pH dependence, substrate specificity, and turnovers of alternative substrates f

Journal Article · · J. Biol. Chem.

Research Organization:
Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Sponsoring Organization:
DOE - Office Of Science; National Institutes of Health (NIH)
OSTI ID:
1872587
Journal Information:
J. Biol. Chem., Vol. 298, Issue (6)
Country of Publication:
United States
Language:
ENGLISH

References (42)

The Properties, Developmental Formation, and Estrogen Induction of Ornithine Aminotransferase in Rat Tissues journal June 1968
Mice lacking ornithine–δ–amino–transferase have paradoxical neonatal hypoornithinaemia and retinal degeneration journal October 1995
Arginine Nutrition in Neonatal Pigs journal October 2004
Arginine Is Synthesized From Proline, Not Glutamate, in Enterally Fed Human Preterm Neonates journal January 2011
The human neonatal small intestine has the potential for arginine synthesis; developmental changes in the expression of arginine-synthesizing and -catabolizing enzymes journal January 2008
Deficit of human ornithine aminotransferase in gyrate atrophy: Molecular, cellular, and clinical aspects journal January 2021
Liver-targeted disruption of Apc in mice activates  -catenin signaling and leads to hepatocellular carcinomas journal November 2004
New targets of β-catenin signaling in the liver are involved in the glutamine metabolism journal November 2002
Hepatocellular carcinoma: a global view journal July 2010
Screening for hepatocellular carcinoma: The rationale for the American Association for the Study of Liver Diseases recommendations journal July 2012
Hepatocellular Carcinoma: A Global Disease in Need of Individualized Treatment Strategies journal June 2017
Disease Burden of Hepatocellular Carcinoma: A Global Perspective journal March 2019
Management of HCC journal January 2012
Management of Hepatocellular Carcinoma (HCC) journal May 2016
Emerging tyrosine kinase inhibitors for the treatment of hepatocellular carcinoma journal April 2017
Sorafenib for Treatment of Hepatocellular Carcinoma: A Survival Analysis From the South American Liver Research Network journal January 2019
Suppression of Hepatocellular Carcinoma by Inhibition of Overexpressed Ornithine Aminotransferase journal June 2015
Functional properties of ornithine-ketoacid aminotransferase from rat liver journal November 1972
Structural and Kinetic Analyses Reveal the Dual Inhibition Modes of Ornithine Aminotransferase by (1 S ,3 S )-3-Amino-4-(hexafluoropropan-2-ylidenyl)-cyclopentane-1-carboxylic Acid (BCF 3 ) journal December 2020
Turnover and Inactivation Mechanisms for ( S )-3-Amino-4,4-difluorocyclopent-1-enecarboxylic Acid, a Selective Mechanism-Based Inactivator of Human Ornithine Aminotransferase journal June 2021
Transient-State Kinetics of the Reaction of Aspartate Aminotransferase with Aspartate at Low pH Reveals Dual Routes in the Enzyme−Substrate Association Process journal November 1997
Crystal structure of human recombinant ornithine aminotransferase journal March 1998
Remarkable and Unexpected Mechanism for ( S )-3-Amino-4-(difluoromethylenyl)cyclohex-1-ene-1-carboxylic Acid as a Selective Inactivator of Human Ornithine Aminotransferase journal May 2021
A Remarkable Difference That One Fluorine Atom Confers on the Mechanisms of Inactivation of Human Ornithine Aminotransferase by Two Cyclohexene Analogues of γ-Aminobutyric Acid journal March 2020
Selective Targeting by a Mechanism-Based Inactivator against Pyridoxal 5′-Phosphate-Dependent Enzymes: Mechanisms of Inactivation and Alternative Turnover journal September 2017
Mechanism of Inactivation of Ornithine Aminotransferase by (1 S ,3 S )-3-Amino-4-(hexafluoropropan-2-ylidenyl)cyclopentane-1-carboxylic Acid journal June 2019
The reaction of ornithine aminotransferase with ornithine journal January 1982
Determinants of Substrate Specificity in ω-Aminotransferases journal August 2005
At least two mutant alleles of ornithine delta-aminotransferase cause gyrate atrophy of the choroid and retina in Finns. journal January 1989
Enzyme promiscuity: evolutionary and mechanistic aspects journal October 2006
How Does an Enzyme Evolved In vitro Compare to Naturally Occurring Homologs Possessing the Targeted Function? Tyrosine Aminotransferase from Aspartate Aminotransferase journal March 2003
Crystal structure of human ornithine aminotransferase complexed with the highly specific and potent inhibitor 5-fluoromethylornithine 1 1 1Edited by R. Huber journal January 1999
Retinal pH and Acid Regulation During Metabolic Acidosis journal April 2018
Acid-Base Homeostasis journal November 2015
Determination of liver intracellular pH in vivo and its homeostasis in acute acidosis and alkalosis journal March 1979
In vitro synthesis and processing of a precursor to ornithine aminotransferase. journal June 1982
Manipulating extracellular tumour pH: an effective target for cancer therapy journal January 2018
Intracellular pH imaging in cancer cells in vitro and tumors in vivo using the new genetically encoded sensor SypHer2 journal September 2015
Data processing and analysis with the autoPROC toolbox journal March 2011
iMOSFLM : a new graphical interface for diffraction-image processing with MOSFLM journal March 2011
Phaser crystallographic software journal July 2007
Macromolecular structure determination using X-rays, neutrons and electrons: recent developments in Phenix journal October 2019