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Title: Structural and functional insight into mismatch extension by human DNA polymerase [alpha]

Journal Article · · Proc. Natl. Acad. Sci. USA

Research Organization:
Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Sponsoring Organization:
DOE - Office Of Science; NIGMS; National Institutes of Health (NIH)
OSTI ID:
1869888
Journal Information:
Proc. Natl. Acad. Sci. USA, Vol. 119, Issue (17)
Country of Publication:
United States
Language:
ENGLISH

References (28)

Eukaryotic DNA Replication Fork journal June 2017
Mechanism of Concerted RNA-DNA Primer Synthesis by the Human Primosome journal March 2016
Mechanism for priming DNA synthesis by yeast DNA Polymerase α journal April 2013
Elaborated Action of the Human Primosome journal February 2017
Flexible tethering of primase and DNA Pol α in the eukaryotic primosome journal June 2011
Insight into the Human DNA Primase Interaction with Template-Primer journal December 2015
The p58 Subunit of Human DNA Primase Is Important for Primer Initiation, Elongation, and Counting journal April 2002
Replication protein A binds RNA and promotes R-loop formation journal October 2020
DNA polymerase-α regulates the activation of type I interferons through cytosolic RNA:DNA synthesis journal March 2016
The antitumor toxin CD437 is a direct inhibitor of DNA polymerase α journal May 2016
3D architecture of DNA Pol α reveals the functional core of multi-subunit replicative polymerases journal June 2009
Crystal Structure of the Human Pol α B Subunit in Complex with the C-terminal Domain of the Catalytic Subunit journal April 2015
Crystal Structure of a pol α Family Replication DNA Polymerase from Bacteriophage RB69 journal June 1997
Lagging-strand replication shapes the mutational landscape of the genome journal January 2015
Evidence that Errors Made by DNA Polymerase α are Corrected by DNA Polymerase δ journal January 2006
Fidelity studies of the human DNA polymerase alpha. The most conserved region among alpha-like DNA polymerases is responsible for metal-induced infidelity in DNA synthesis journal May 1993
Human DNA polymerase α in binary complex with a DNA:DNA template-primer journal April 2016
Functions of base selection step in human DNA polymerase α journal May 2010
B Family DNA Polymerases Asymmetrically Recognize Pyrimidines and Purines journal July 2011
Mutational Studies of Human DNA Polymerase α: LYSINE 950 IN THE THIRD MOST CONSERVED REGION OF α-LIKE DNA POLYMERASES IS INVOLVED IN BINDING THE DEOXYNUCLEOSIDE TRIPHOSPHATE journal September 1995
Fidelity of mammalian DNA replication and replicative DNA polymerases journal December 1991
Making and Breaking Nucleic Acids: Two-Mg2+-Ion Catalysis and Substrate Specificity journal April 2006
Structures of DNA Polymerase Mispaired DNA Termini Transitioning to Pre-catalytic Complexes Support an Induced-Fit Fidelity Mechanism journal November 2016
DNA Mismatch Synthesis Complexes Provide Insights into Base Selectivity of a B Family DNA Polymerase journal December 2012
Mispairs with Watson-Crick base-pair geometry observed in ternary complexes of an RB69 DNA polymerase variant: Mispairs with Watson-Crick Base-Pair Geometry journal March 2014
Structural basis for inhibition of DNA replication by aphidicolin journal November 2014
[20] Processing of X-ray diffraction data collected in oscillation mode book January 1997
Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination journal September 1998

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