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Structural and functional insight into mismatch extension by human DNA polymerase [alpha]

Journal Article · · Proc. Natl. Acad. Sci. USA
Research Organization:
Advanced Photon Source (APS), Argonne National Laboratory (ANL), Argonne, IL (US)
Sponsoring Organization:
DOE - Office Of Science; NIGMS; NIH
OSTI ID:
1869888
Journal Information:
Proc. Natl. Acad. Sci. USA, Journal Name: Proc. Natl. Acad. Sci. USA Journal Issue: (17) Vol. 119
Country of Publication:
United States
Language:
ENGLISH

References (29)

Structures of DNA Polymerase Mispaired DNA Termini Transitioning to Pre-catalytic Complexes Support an Induced-Fit Fidelity Mechanism journal November 2016
Evidence that Errors Made by DNA Polymerase α are Corrected by DNA Polymerase δ journal January 2006
Human DNA polymerase α in binary complex with a DNA:DNA template-primer journal April 2016
DNA polymerase-α regulates the activation of type I interferons through cytosolic RNA:DNA synthesis journal March 2016
Flexible tethering of primase and DNA Pol α in the eukaryotic primosome journal June 2011
[20] Processing of X-ray diffraction data collected in oscillation mode book January 1997
3D architecture of DNA Pol α reveals the functional core of multi-subunit replicative polymerases journal June 2009
Making and Breaking Nucleic Acids: Two-Mg2+-Ion Catalysis and Substrate Specificity journal April 2006
Mechanism of Concerted RNA-DNA Primer Synthesis by the Human Primosome journal March 2016
Eukaryotic DNA Replication Fork journal June 2017
B Family DNA Polymerases Asymmetrically Recognize Pyrimidines and Purines journal July 2011
Mispairs with Watson-Crick base-pair geometry observed in ternary complexes of an RB69 DNA polymerase variant: Mispairs with Watson-Crick Base-Pair Geometry journal March 2014
Mutational Studies of Human DNA Polymerase α: LYSINE 950 IN THE THIRD MOST CONSERVED REGION OF α-LIKE DNA POLYMERASES IS INVOLVED IN BINDING THE DEOXYNUCLEOSIDE TRIPHOSPHATE journal September 1995
The antitumor toxin CD437 is a direct inhibitor of DNA polymerase α journal May 2016
DNA Mismatch Synthesis Complexes Provide Insights into Base Selectivity of a B Family DNA Polymerase journal December 2012
Insight into the Human DNA Primase Interaction with Template-Primer journal December 2015
Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination journal September 1998
The p58 Subunit of Human DNA Primase Is Important for Primer Initiation, Elongation, and Counting journal April 2002
Crystal Structure of a pol α Family Replication DNA Polymerase from Bacteriophage RB69 journal June 1997
Lagging-strand replication shapes the mutational landscape of the genome journal January 2015
Replication protein A binds RNA and promotes R-loop formation journal October 2020
Structural basis for inhibition of DNA replication by aphidicolin journal November 2014
Crystal Structure of the Human Pol α B Subunit in Complex with the C-terminal Domain of the Catalytic Subunit journal April 2015
Mechanism for priming DNA synthesis by yeast DNA Polymerase α journal April 2013
Fidelity studies of the human DNA polymerase alpha. The most conserved region among alpha-like DNA polymerases is responsible for metal-induced infidelity in DNA synthesis journal May 1993
Elaborated Action of the Human Primosome journal February 2017
Activity and fidelity of human DNA polymerase α depend on primer structure journal March 2018
Functions of base selection step in human DNA polymerase α journal May 2010
Fidelity of mammalian DNA replication and replicative DNA polymerases journal December 1991

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