skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Emerging enterococcus pore-forming toxins with MHC/HLA-I as receptors

Journal Article · · Cell

Research Organization:
Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Sponsoring Organization:
DOE - Office Of Science; National Institutes of Health (NIH)
OSTI ID:
1867489
Journal Information:
Cell, Vol. 185, Issue (7)
Country of Publication:
United States
Language:
ENGLISH

References (75)

Commensal Bacteria Calibrate the Activation Threshold of Innate Antiviral Immunity journal July 2012
PHENIX: a comprehensive Python-based system for macromolecular structure solution journal January 2010
CCR5 is a receptor for Staphylococcus aureus leukotoxin ED journal December 2012
The rise of the Enterococcus: beyond vancomycin resistance journal March 2012
Staphylococcus aureus α-Toxin: Nearly a Century of Intrigue journal June 2013
Structure of the human class I histocompatibility antigen, HLA-A2 journal October 1987
CD31 (PECAM-1) Serves as the Endothelial Cell-Specific Receptor of Clostridium perfringens β-Toxin journal July 2020
Enterococcus faecalis Senses Target Cells and in Response Expresses Cytolysin journal December 2004
Pore-forming toxins: ancient, but never really out of fashion journal December 2015
Crystal structure of the Vibrio cholerae cytolysin heptamer reveals common features among disparate pore-forming toxins journal April 2011
Molecular assembly of the aerolysin pore reveals a swirling membrane-insertion mechanism journal August 2013
Bacteriophage targeting of gut bacterium attenuates alcoholic liver disease journal November 2019
Staphylococcus aureus LukAB cytotoxin kills human neutrophils by targeting the CD11b subunit of the integrin Mac-1 journal June 2013
Features and development of Coot journal March 2010
Interferon-dependent induction of mRNA for the major histocompatibility antigens in human fibroblasts and lymphoblastoid cells. journal May 1982
Pathogenicity of Enterococci journal July 2019
Cross-reactivity between tumor MHC class I–restricted antigens and an enterococcal bacteriophage journal August 2020
Studies on the Virulence of Bacteriophage-Infected Strains of Corynebacterium Diphtheriae journal June 1951
Genomic transition of enterococci from gut commensals to leading causes of multidrug-resistant hospital infection in the antibiotic era journal February 2013
Draft Genome Sequence of Enterococcus faecium Strain 58m, Isolated from Intestinal Tract Content of a Woolly Mammoth, Mammuthus primigenius journal February 2016
Constitutive Type I Interferon Modulates Homeostatic Balance through Tonic Signaling journal February 2012
Crystal Structure of Leucotoxin S Component: NEW INSIGHT INTO THE STAPHYLOCOCCAL β-BARREL PORE-FORMING TOXINS journal July 2004
Structural Insights into Clostridium perfringens Delta Toxin Pore Formation journal June 2013
Three-dimensional structure of a human class II histocompatibility molecule complexed with superantigen journal April 1994
The α1 domain of the HLA-DR molecule is essential for high-affinity binding of the toxic shock syndrome toxin-1 journal August 1990
The Phyre2 web portal for protein modeling, prediction and analysis journal May 2015
Toxic shock syndrome toxin-1 complexed with a class II major histocompatibility molecule HLA-DR1 journal December 1994
Quantifying the local resolution of cryo-EM density maps journal November 2013
Emergence of Epidemic Multidrug-Resistant Enterococcus faecium from Animal and Commensal Strains journal August 2013
Tracing the Enterococci from Paleozoic Origins to the Hospital journal May 2017
Interactive tree of life (iTOL) v3: an online tool for the display and annotation of phylogenetic and other trees journal April 2016
Role of Pore-Forming Toxins in Bacterial Infectious Diseases journal May 2013
ARNold: A web tool for the prediction of Rho-independent transcription terminators journal January 2011
Towards a systems understanding of MHC class I and MHC class II antigen presentation journal November 2011
[20] Processing of X-ray diffraction data collected in oscillation mode book January 1997
Mechanisms of mhc Class I–Restricted Antigen Processing journal April 1998
Structure of the Aeromonas toxin proaerolysin in its water-soluble and membrane-channel states journal January 1994
Role of Mobile DNA in the Evolution of Vancomycin-Resistant Enterococcus faecalis journal March 2003
The structure of a Staphylococcus aureus leucocidin component (LukF-PV) reveals the fold of the water-soluble species of a family of transmembrane pore-forming toxins journal March 1999
Genetic variation of staphylococcal LukAB toxin determines receptor tropism journal April 2021
UCSF Chimera?A visualization system for exploratory research and analysis journal January 2004
A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research journal September 2019
Staphylococcus aureus Leukotoxin ED Targets the Chemokine Receptors CXCR1 and CXCR2 to Kill Leukocytes and Promote Infection journal October 2013
Agricultural Origins of a Highly Persistent Lineage of Vancomycin-Resistant Enterococcus faecalis in New Zealand journal July 2019
DeepEMhancer: a deep learning solution for cryo-EM volume post-processing journal July 2021
Improved vectors and genome-wide libraries for CRISPR screening journal July 2014
Molecular Architecture and Functional Analysis of NetB, a Pore-forming Toxin from Clostridium perfringens journal February 2013
The role of gamma interferon in antimicrobial immunity journal June 2001
An Fc receptor structurally related to MHC class I antigens journal January 1989
Structure of Staphylococcal alpha -Hemolysin, a Heptameric Transmembrane Pore journal December 1996
The Staphylococcal Toxin Panton-Valentine Leukocidin Targets Human C5a Receptors journal May 2013
Leukocidins: staphylococcal bi-component pore-forming toxins find their receptors journal April 2017
Commensal Microbiota Modulation of Natural Resistance to Virus Infection journal November 2020
Visualizing and comparing circular genomes using the CGView family of tools journal July 2017
Structural basis for pore-forming mechanism of staphylococcal α-hemolysin journal December 2015
2-Methyl-2,4-pentanediol induces spontaneous assembly of staphylococcal α-hemolysin into heptameric pore structure: Crystal Structure of α-Hemolysin in MPD journal January 2011
Frizzled proteins are colonic epithelial receptors for C. difficile toxin B journal September 2016
Genome-wide CRISPR screens for Shiga toxins and ricin reveal Golgi proteins critical for glycosylation journal November 2018
Human CD45 is an F-component-specific receptor for the staphylococcal toxin Panton–Valentine leukocidin journal May 2018
Molecular replacement with MOLREP journal December 2009
Friend Turned Foe: Evolution of Enterococcal Virulence and Antibiotic Resistance journal September 2014
Structure, Function, and Biology of the Enterococcus faecalis Cytolysin journal April 2013
SPHIRE-crYOLO is a fast and accurate fully automated particle picker for cryo-EM journal June 2019
Genome Sequencing Reveals the Environmental Origin of Enterococci and Potential Biomarkers for Water Quality Monitoring journal March 2014
Genetic Analysis of a High-Level Vancomycin-Resistant Isolate of Staphylococcus aureus journal November 2003
Major Histocompatibility Complex (MHC) Class I and MHC Class II Proteins: Conformational Plasticity in Antigen Presentation journal March 2017
Role of a disintegrin and metalloprotease 10 in Staphylococcus aureus  -hemolysin-mediated cellular injury journal July 2010
Crystal structure of the octameric pore of staphylococcal  -hemolysin reveals the  -barrel pore formation mechanism by two components journal October 2011
Molecular basis of transmembrane beta-barrel formation of staphylococcal pore-forming toxins journal September 2014
Structural and Functional Analysis of the Pore-Forming Toxin NetB from Clostridium perfringens journal March 2013
Surveillance of Enterococcus spp. reveals distinct species and antimicrobial resistance diversity across a One-Health continuum journal March 2020
Gctf: Real-time CTF determination and correction journal January 2016
Identification of a Botulinum Neurotoxin-like Toxin in a Commensal Strain of Enterococcus faecium journal February 2018
MotionCor2: anisotropic correction of beam-induced motion for improved cryo-electron microscopy journal February 2017
New tools for automated high-resolution cryo-EM structure determination in RELION-3 journal November 2018