Flexibility of telomerase in binding the RNA template and DNA telomeric repeat

Choi, Woo Suk; Weng, Peter J.; Yang, Wei

doi:10.1073/pnas.2116159118

Flexibility of telomerase in binding the RNA template and DNA telomeric repeat

Journal Article · 01 December 2021 · Proc. Natl. Acad. Sci. USA

DOI:https://doi.org/10.1073/pnas.2116159118· OSTI ID:1867475

Choi, Woo Suk; Weng, Peter J.; Yang, Wei

Research Organization:: Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)

Sponsoring Organization:: DOE - Office Of Science; National Institutes of Health (NIH)

OSTI ID:: 1867475

Journal Information:: Proc. Natl. Acad. Sci. USA, Vol. 119, Issue (1)

Country of Publication:: United States

Language:: ENGLISH

References (32)

Structure and function of telomeres Blackburn, Elizabeth H. Nature, Vol. 350, Issue 6319 https://doi.org/10.1038/350569a0	journal	April 1991
Telomerase: An RNP Enzyme Synthesizes DNA Blackburn, E. H.; Collins, K. Cold Spring Harbor Perspectives in Biology, Vol. 3, Issue 5 https://doi.org/10.1101/cshperspect.a003558	journal	July 2010
Structure of Telomerase with Telomeric DNA Jiang, Jiansen; Wang, Yaqiang; Sušac, Lukas Cell, Vol. 173, Issue 5 https://doi.org/10.1016/j.cell.2018.04.038	journal	May 2018
Structure of human telomerase holoenzyme with bound telomeric DNA Ghanim, George E.; Fountain, Adam J.; van Roon, Anne-Marie M. Nature, Vol. 593, Issue 7859 https://doi.org/10.1038/s41586-021-03415-4	journal	April 2021
Telomerase Catalytic Subunit Homologs from Fission Yeast and Human Nakamura, Toru M.; Morin, Gregg B.; Chapman, Karen B. Science, Vol. 277, Issue 5328 https://doi.org/10.1126/science.277.5328.955	journal	August 1997
Telomerase Mechanism of Telomere Synthesis Wu, R. Alex; Upton, Heather E.; Vogan, Jacob M. Annual Review of Biochemistry, Vol. 86, Issue 1 https://doi.org/10.1146/annurev-biochem-061516-045019	journal	June 2017
Requirements for the dGTP-dependent Repeat Addition Processivity of Recombinant Tetrahymena Telomerase Hardy, Christine D.; Schultz, Carla S.; Collins, Kathleen Journal of Biological Chemistry, Vol. 276, Issue 7 https://doi.org/10.1074/jbc.M005158200	journal	February 2001
A DNA-hairpin model for repeat-addition processivity in telomere synthesis Yang, Wei; Lee, Young-Sam Nature Structural & Molecular Biology, Vol. 22, Issue 11 https://doi.org/10.1038/nsmb.3098	journal	November 2015
Structural basis for telomerase catalytic subunit TERT binding to RNA template and telomeric DNA Mitchell, Meghan; Gillis, Andrew; Futahashi, Mizuko Nature Structural & Molecular Biology, Vol. 17, Issue 4 https://doi.org/10.1038/nsmb.1777	journal	March 2010
Reverse Transcriptase Motifs in the Catalytic Subunit of Telomerase Lingner, J. Science, Vol. 276, Issue 5312 https://doi.org/10.1126/science.276.5312.561	journal	April 1997
Structure of the Tribolium castaneum telomerase catalytic subunit TERT Gillis, Andrew J.; Schuller, Anthony P.; Skordalakes, Emmanuel Nature, Vol. 455, Issue 7213 https://doi.org/10.1038/nature07283	journal	August 2008
Structure of the RNA-Binding Domain of Telomerase: Implications for RNA Recognition and Binding Rouda, Susan; Skordalakes, Emmanuel Structure, Vol. 15, Issue 11 https://doi.org/10.1016/j.str.2007.09.007	journal	November 2007
Structural basis of template-boundary definition in Tetrahymena telomerase Jansson, Linnea I.; Akiyama, Ben M.; Ooms, Alexandra Nature Structural & Molecular Biology, Vol. 22, Issue 11 https://doi.org/10.1038/nsmb.3101	journal	October 2015
Human Telomerase Domain Interactions Capture DNA for TEN Domain-Dependent Processive Elongation Robart, Aaron R.; Collins, Kathleen Molecular Cell, Vol. 42, Issue 3 https://doi.org/10.1016/j.molcel.2011.03.012	journal	May 2011
An RPA-Related Sequence-Specific DNA-Binding Subunit of Telomerase Holoenzyme Is Required for Elongation Processivity and Telomere Maintenance Min, Bosun; Collins, Kathleen Molecular Cell, Vol. 36, Issue 4 https://doi.org/10.1016/j.molcel.2009.09.041	journal	November 2009
Structures of telomerase at several steps of telomere repeat synthesis He, Yao; Wang, Yaqiang; Liu, Baocheng Nature, Vol. 593, Issue 7859 https://doi.org/10.1038/s41586-021-03529-9	journal	May 2021
Identification and characterization of the telomerase reverse transcriptase of Bombyx mori (silkworm) and Tribolium castaneum (flour beetle) Osanai, Mizuko; Kojima, Kenji K.; Futahashi, Ryo Gene, Vol. 376, Issue 2 https://doi.org/10.1016/j.gene.2006.04.022	journal	July 2006
An open and closed case for all polymerases Doublié, Sylvie; Sawaya, Michael R.; Ellenberger, Tom Structure, Vol. 7, Issue 2 https://doi.org/10.1016/S0969-2126(99)80017-3	journal	February 1999
How a homolog of high-fidelity replicases conducts mutagenic DNA synthesis Lee, Young-Sam; Gao, Yang; Yang, Wei Nature Structural & Molecular Biology, Vol. 22, Issue 4 https://doi.org/10.1038/nsmb.2985	journal	March 2015
Novel non-templated nucleotide addition reactions catalyzed by procaryotic and eucaryotic DNA polymerases Clark, James M. Nucleic Acids Research, Vol. 16, Issue 20 https://doi.org/10.1093/nar/16.20.9677	journal	January 1988
Nontemplated Nucleotide Addition by HIV-1 Reverse Transcriptase Golinelli, Marie-Pierre; Hughes, Stephen H. Biochemistry, Vol. 41, Issue 18 https://doi.org/10.1021/bi0160415	journal	April 2002
Structural Insight into Translesion Synthesis by DNA Pol II Wang, Feng; Yang, Wei Cell, Vol. 139, Issue 7 https://doi.org/10.1016/j.cell.2009.11.043	journal	December 2009
Structural Basis of Telomerase Inhibition by the Highly Specific BIBR1532 Bryan, Christopher; Rice, Cory; Hoffman, Hunter Structure, Vol. 23, Issue 10 https://doi.org/10.1016/j.str.2015.08.006	journal	October 2015
Mechanisms of nucleotide selection by telomerase Schaich, Matthew A.; Sanford, Samantha L.; Welfer, Griffin A. eLife, Vol. 9 https://doi.org/10.7554/eLife.55438	journal	June 2020
Structures of HIV-1 RT-RNA/DNA ternary complexes with dATP and nevirapine reveal conformational flexibility of RNA/DNA: insights into requirements for RNase H cleavage Das, Kalyan; Martinez, Sergio E.; Bandwar, Rajiv P. Nucleic Acids Research, Vol. 42, Issue 12 https://doi.org/10.1093/nar/gku487	journal	May 2014
Translesion and Repair DNA Polymerases: Diverse Structure and Mechanism Yang, Wei; Gao, Yang Annual Review of Biochemistry, Vol. 87, Issue 1 https://doi.org/10.1146/annurev-biochem-062917-012405	journal	June 2018
A novel motif in telomerase reverse transcriptase regulates telomere repeat addition rate and processivity Xie, Mingyi; Podlevsky, Joshua D.; Qi, Xiaodong Nucleic Acids Research, Vol. 38, Issue 6 https://doi.org/10.1093/nar/gkp1198	journal	December 2009
A Conserved Telomerase Motif within the Catalytic Domain of Telomerase Reverse Transcriptase Is Specifically Required for Repeat Addition Processivity Lue, N. F.; Lin, Y. -C.; Mian, I. S. Molecular and Cellular Biology, Vol. 23, Issue 23 https://doi.org/10.1128/MCB.23.23.8440-8449.2003	journal	November 2003
Telomerase limits the extent of base pairing between template RNA and telomeric DNA Förstemann, Klaus; Lingner, Joachim EMBO reports, Vol. 6, Issue 4 https://doi.org/10.1038/sj.embor.7400374	journal	April 2005
Euplotes Telomerase: Evidence for Limited Base-Pairing during Primer Elongation and dGTP as an Effector of Translocation Hammond, Philip W.; Cech, Thomas R. Biochemistry, Vol. 37, Issue 15 https://doi.org/10.1021/bi972988o	journal	March 1998
The RNA accordion model for template positioning by telomerase RNA during telomeric DNA synthesis Berman, Andrea J.; Akiyama, Benjamin M.; Stone, Michael D. Nature Structural & Molecular Biology, Vol. 18, Issue 12 https://doi.org/10.1038/nsmb.2174	journal	November 2011
Coordinated DNA dynamics during the human telomerase catalytic cycle Parks, Joseph W.; Stone, Michael D. Nature Communications, Vol. 5, Issue 1 https://doi.org/10.1038/ncomms5146	journal	June 2014

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