skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Structure and mechanism for iterative amide N-methylation in the biosynthesis of channel-forming pep

Journal Article · · Proc. Natl. Acad. Sci. USA
; ; ; ; ;

Research Organization:
Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Sponsoring Organization:
DOE - Office Of Science; National Institutes of Health (NIH)
OSTI ID:
1867457
Journal Information:
Proc. Natl. Acad. Sci. USA, Vol. 119, Issue (13)
Country of Publication:
United States
Language:
ENGLISH

References (28)

New developments in RiPP discovery, enzymology and engineering journal January 2021
Polytheonamides, unprecedented highly cytotoxic polypeptides, from the marine sponge theonella swinhoei journal January 1994
Polytheonamides A and B, Highly Cytotoxic, Linear Polypeptides with Unprecedented Structural Features, from the Marine Sponge, Theonella s winhoei journal December 2004
Solution Structure of Polytheonamide B, a Highly Cytotoxic Nonribosomal Polypeptide from Marine Sponge journal August 2010
Metagenome Mining Reveals Polytheonamides as Posttranslationally Modified Ribosomal Peptides journal September 2012
An environmental bacterial taxon with a large and distinct metabolic repertoire journal January 2014
Seven enzymes create extraordinary molecular complexity in an uncultivated bacterium journal November 2016
Solid-Phase Total Synthesis and Dual Mechanism of Action of the Channel-Forming 48-mer Peptide Polytheonamide B journal July 2018
Genome mining- and synthetic biology-enabled production of hypermodified peptides journal September 2019
The importance of N-methylations for the stability of the $$\beta ^{6.3}$$ β 6.3 -helical conformation of polytheonamide B journal October 2016
Gliotoxin, the Antibiotic Principle of Gliocladium fimbriatum. IV. The Structure of Gliotoxin: The Action of Selenium journal April 1944
Ansamitocin, a group of novel maytansinoid antibiotics with antitumour properties from Nocardia journal December 1977
Welwitindolinones, Unusual Alkaloids from the Blue-Green Algae Hapalosiphon welwitschii and Westiella intricata. Relationship to Fischerindoles and Hapalinodoles journal November 1994
A Self-Sacrificing N -Methyltransferase Is the Precursor of the Fungal Natural Product Omphalotin journal July 2017
Autocatalytic backbone N-methylation in a family of ribosomal peptide natural products journal June 2017
A molecular mechanism for the enzymatic methylation of nitrogen atoms within peptide bonds journal August 2018
Molecular Basis for Autocatalytic Backbone N -Methylation in RiPP Natural Product Biosynthesis journal September 2018
Design, Synthesis and Functional Analysis of Dansylated Polytheonamide Mimic: An Artificial Peptide Ion Channel journal August 2012
Dali server: conservation mapping in 3D journal May 2010
Structural Basis of the Selectivity of GenN, an Aminoglycoside N -Methyltransferase Involved in Gentamicin Biosynthesis journal October 2017
Structures along the Catalytic Pathway of PrmC/HemK, an N 5 -Glutamine AdoMet-Dependent Methyltransferase journal April 2003
Molecular Basis for Bacterial Class I Release Factor Methylation by PrmC journal December 2005
Characterizing metal-binding sites in proteins with X-ray crystallography journal April 2018
Cation−π Interaction: Its Role and Relevance in Chemistry, Biology, and Material Science journal November 2012
Cation−π Interactions:  Structures and Energetics of Complexation of Na + and K + with the Aromatic Amino Acids, Phenylalanine, Tyrosine, and Tryptophan journal October 2004
Cation–π interactions: computational analyses of the aromatic box motif and the fluorination strategy for experimental evaluation journal January 2015
Total synthesis of the large non-ribosomal peptide polytheonamide B journal February 2010
A Mononuclear Iron-Dependent Methyltransferase Catalyzes Initial Steps in Assembly of the Apratoxin A Polyketide Starter Unit journal November 2017

Similar Records

Related Subjects