SARS-CoV-2 variants, spike mutations and immune escape
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journal
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June 2021 |
Therapeutically administered ribonucleoside analogue MK-4482/EIDD-2801 blocks SARS-CoV-2 transmission in ferrets
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journal
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December 2020 |
Learning from the Past: Possible Urgent Prevention and Treatment Options for Severe Acute Respiratory Infections Caused by 2019‐nCoV
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journal
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February 2020 |
SARS-CoV-2 M pro inhibitors with antiviral activity in a transgenic mouse model
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journal
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February 2021 |
Postinfection treatment with a protease inhibitor increases survival of mice with a fatal SARS-CoV-2 infection
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journal
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July 2021 |
Efficacy of GC-376 against SARS-CoV-2 virus infection in the K18 hACE2 transgenic mouse model
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journal
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May 2021 |
Boceprevir, GC-376, and calpain inhibitors II, XII inhibit SARS-CoV-2 viral replication by targeting the viral main protease
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journal
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June 2020 |
Structure and inhibition of the SARS-CoV-2 main protease reveal strategy for developing dual inhibitors against M pro and cathepsin L
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journal
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November 2020 |
An oral SARS-CoV-2 M pro inhibitor clinical candidate for the treatment of COVID-19
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journal
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December 2021 |
Preclinical characterization of an intravenous coronavirus 3CL protease inhibitor for the potential treatment of COVID19
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journal
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October 2021 |
Drug Development and Medicinal Chemistry Efforts toward SARS‐Coronavirus and Covid‐19 Therapeutics
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journal
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May 2020 |
Structure-based design of antiviral drug candidates targeting the SARS-CoV-2 main protease
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journal
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April 2020 |
Feline coronavirus drug inhibits the main protease of SARS-CoV-2 and blocks virus replication
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journal
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August 2020 |
3C-like protease inhibitors block coronavirus replication in vitro and improve survival in MERS-CoV–infected mice
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journal
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August 2020 |
A Quick Route to Multiple Highly Potent SARS‐CoV‐2 Main Protease Inhibitors**
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journal
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December 2020 |
MPI8 is Potent against SARS‐CoV‐2 by Inhibiting Dually and Selectively the SARS‐CoV‐2 Main Protease and the Host Cathepsin L**
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journal
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July 2021 |
Challenges for Targeting SARS-CoV-2 Proteases as a Therapeutic Strategy for COVID-19
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journal
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February 2021 |
Rational Design of Hybrid SARS-CoV-2 Main Protease Inhibitors Guided by the Superimposed Cocrystal Structures with the Peptidomimetic Inhibitors GC-376, Telaprevir, and Boceprevir
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journal
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June 2021 |
ALG-097111, a potent and selective SARS-CoV-2 3-chymotrypsin-like cysteine protease inhibitor exhibits in vivo efficacy in a Syrian Hamster model
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journal
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May 2021 |
Boceprevir, Calpain Inhibitors II and XII, and GC-376 Have Broad-Spectrum Antiviral Activity against Coronaviruses
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journal
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March 2021 |
Discovery of Ketone-Based Covalent Inhibitors of Coronavirus 3CL Proteases for the Potential Therapeutic Treatment of COVID-19
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journal
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October 2020 |
Expedited Approach toward the Rational Design of Noncovalent SARS-CoV-2 Main Protease Inhibitors
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journal
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April 2021 |
Discovery, Synthesis, And Structure-Based Optimization of a Series of N -( tert -Butyl)-2-( N -arylamido)-2-(pyridin-3-yl) Acetamides (ML188) as Potent Noncovalent Small Molecule Inhibitors of the Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) 3CL Protease
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journal
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January 2013 |
Advances in covalent kinase inhibitors
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journal
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January 2020 |
Cysteine proteases as therapeutic targets: does selectivity matter? A systematic review of calpain and cathepsin inhibitors
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journal
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November 2015 |
Can Cysteine Protease Cross-Class Inhibitors Achieve Selectivity?
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journal
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July 2019 |
Cysteine-reactive probes and their use in chemical proteomics
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journal
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January 2018 |
Organic Azide Inhibitors of Cysteine Proteases
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journal
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September 2006 |
Solid-Phase Synthesis of Azidomethylene Inhibitors Targeting Cysteine Proteases
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journal
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April 2008 |
The advantages of describing covalent inhibitor in vitro potencies by IC50 at a fixed time point. IC50 determination of covalent inhibitors provides meaningful data to medicinal chemistry for SAR optimization
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journal
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January 2021 |
Masitinib is a broad coronavirus 3CL inhibitor that blocks replication of SARS-CoV-2
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journal
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August 2021 |
SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor
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journal
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April 2020 |
TMPRSS2 and TMPRSS4 Facilitate Trypsin-Independent Spread of Influenza Virus in Caco-2 Cells
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journal
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October 2010 |
Critical Role of Type III Interferon in Controlling SARS-CoV-2 Infection in Human Intestinal Epithelial Cells
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journal
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July 2020 |
Cell entry mechanisms of SARS-CoV-2
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journal
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May 2020 |
X-ray screening identifies active site and allosteric inhibitors of SARS-CoV-2 main protease
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journal
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April 2021 |
Crystallographic and electrophilic fragment screening of the SARS-CoV-2 main protease
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journal
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October 2020 |
3C-like Proteinase from SARS Coronavirus Catalyzes Substrate Hydrolysis by a General Base Mechanism †
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journal
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April 2004 |
Proton-Coupled Conformational Activation of SARS Coronavirus Main Proteases and Opportunity for Designing Small-Molecule Broad-Spectrum Targeted Covalent Inhibitors
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journal
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December 2020 |