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Exploring Unconventional SAM Analogues To Build Cell-Potent Bisubstrate Inhibitors for Nicotinamide

Journal Article · · Angew. Chem. Int. Ed.

Research Organization:
Advanced Photon Source (APS), Argonne National Laboratory (ANL), Argonne, IL (US)
Sponsoring Organization:
DOE - Office Of Science; NCI; NIGMS
OSTI ID:
1866458
Journal Information:
Angew. Chem. Int. Ed., Journal Name: Angew. Chem. Int. Ed. Journal Issue: (16) Vol. 61
Country of Publication:
United States
Language:
ENGLISH

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Nicotinamide metabolism regulates glioblastoma stem cell maintenance journal May 2017
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Mechanisms and inhibitors of nicotinamide N -methyltransferase journal January 2021
NNMT promotes epigenetic remodeling in cancer by creating a metabolic methylation sink journal March 2013
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Halogen Bonding Increases the Potency and Isozyme Selectivity of Protein Arginine Deiminase 1 Inhibitors journal July 2019
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Bisubstrate Inhibitors of Nicotinamide N -Methyltransferase (NNMT) with Enhanced Activity journal July 2019
High Expression of Nicotinamide N-Methyltransferase in Patients with Sporadic Alzheimer’s Disease journal January 2021
Nicotinamide N -methyltransferase induces cellular invasion through activating matrix metalloproteinase-2 expression in clear cell renal cell carcinoma cells journal November 2010
High expression of nicotinamide N-methyltransferase in patients with idiopathic Parkinson's disease journal May 2003
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Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity journal April 2014
Structural Basis of Substrate Recognition in Human Nicotinamide N -Methyltransferase journal September 2011
1-Methylnicotinamide (MNA), a primary metabolite of nicotinamide, exerts anti-thrombotic activity mediated by a cyclooxygenase-2/prostacyclin pathway: Anti-thrombotic activity of 1-methylnicotinamide journal September 2007
Enhanced interrogation: emerging strategies for cell signaling inhibition journal June 2010
Halogen Bonding Increases the Potency and Isozyme Selectivity of Protein Arginine Deiminase 1 Inhibitors journal September 2019
Nicotinamide N -Methyltransferase Interacts with Enzymes of the Methionine Cycle and Regulates Methyl Donor Metabolism journal September 2018
NNMT Silencing Activates Tumor Suppressor PP2A, Inactivates Oncogenic STKs, and Inhibits Tumor Forming Ability journal November 2016
Novel Propargyl-Linked Bisubstrate Analogues as Tight-Binding Inhibitors for Nicotinamide N -Methyltransferase journal November 2019
Development of fluorescence polarization-based competition assay for nicotinamide N-methyltransferase journal September 2020
Transition state mimics are valuable mechanistic probes for structural studies with the arginine methyltransferase CARM1 journal March 2017
Nicotinamide N-methyltransferase upregulation via the mTORC1-ATF4 pathway activation contributes to palmitate-induced lipotoxicity in hepatocytes journal September 2021

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