An oral SARS-CoV-2 M pro inhibitor clinical candidate for the treatment of COVID-19
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December 2021 |
Fragment-to-Lead Medicinal Chemistry Publications in 2020
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Organic synthesis provides opportunities to transform drug discovery
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The importance of synthetic chemistry in the pharmaceutical industry
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“Scaffold-Hopping” by Topological Pharmacophore Search: A Contribution to Virtual Screening
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Recent Advances in Scaffold Hopping: Miniperspective
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A historical perspective on the discovery of statins
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The development of COX2 inhibitors
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March 2003 |
Single-atom logic for heterocycle editing
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April 2022 |
Deconstructive diversification of cyclic amines
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October 2018 |
Boron insertion into alkyl ether bonds via zinc/nickel tandem catalysis
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April 2021 |
Skeletal editing through direct nitrogen deletion of secondary amines
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May 2021 |
Analysis of the Structural Diversity, Substitution Patterns, and Frequency of Nitrogen Heterocycles among U.S. FDA Approved Pharmaceuticals: Miniperspective
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October 2014 |
Recent advances in chemical dearomatization of nonactivated arenes
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January 2018 |
Ring-contraction of hantzsch esters and their derivatives to pyrroles via electrochemical extrusion of ethyl acetate out of aromatic rings
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The photochemistry of the N-oxide function
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Photochemical reactions of azoxy compounds, nitrones, and aromatic amine N-oxides
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Photorearrangement of [8]-2,6-Pyridinophane N -Oxide
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Ring contraction reactions of methyl quinoline 1-oxide 5-carboxylates via the corresponding benz[d]-1,3-oxazepines. A facile synthesis of methyl indole 4-carboxylate and its derivatives.
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The merger of decatungstate and copper catalysis to enable aliphatic C(sp3)–H trifluoromethylation
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Photomediated ring contraction of saturated heterocycles
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August 2021 |
Photochemical intermolecular dearomative cycloaddition of bicyclic azaarenes with alkenes
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March 2021 |
Radical Decarboxylative Carbometalation of Benzoic Acids: A Solution to Aromatic Decarboxylative Fluorination
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April 2021 |
Unveiling Potent Photooxidation Behavior of Catalytic Photoreductants
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March 2021 |
Catalytic, contra -Thermodynamic Positional Alkene Isomerization
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December 2021 |
Facile Quantum Yield Determination via NMR Actinometry
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March 2018 |
Studies on diazepines. XXV. Syntheses of fully unsaturated 1,4-oxazepines and 1H-1,4-diazepines using photochemical valence isomerization of tricycloheptene systems.
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OXYGEN EXCHANGE DURING THE ACIDIC AND BASIC HYDROLYSES OF AMIDES AND THE ENZYMATIC HYDROLYSIS OF ESTERS 1
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Homolytic alkylation of protonated heteroaromatic bases by alkyl iodides, hydrogen peroxide, and dimethyl sulfoxide
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Formation of CC Bonds by Addition of Free Radicals to Alkenes
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October 1983 |
One-Carbon Insertion and Polarity Inversion Enabled a Pyrrole Strategy to the Total Syntheses of Pyridine-Containing Lycopodium Alkaloids: Complanadine A and Lycodine
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September 2021 |
Chinolinderivate aus Isatinsäure
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Indomethacin: A New Non-steroid Anti-inflammatory Agent
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October 1963 |
Deconstructive di-functionalization of unstrained, benzo cyclic amines by C–N bond cleavage using a recyclable tungsten catalyst
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January 2019 |
Carbon Atom Insertion into Pyrroles and Indoles Promoted by Chlorodiazirines
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July 2021 |
A Facile Route to Cinnolines
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Synthesis of Pyrroles via Consecutive 6π-Electrocyclization/Ring-Contraction of Sulfilimines
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June 2021 |
Insertion of ammonia into alkenes to build aromatic N-heterocycles
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January 2022 |
Switchable regioselection of C–H thiolation of indoles using different TMS counterions
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January 2019 |
Selective Halogenation Using an Aniline Catalyst
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July 2015 |
Ir(I)-Catalyzed C–H Bond Alkylation of C2-Position of Indole with Alkenes: Selective Synthesis of Linear or Branched 2-Alkylindoles
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October 2012 |
Cu(II)-Catalyzed Direct and Site-Selective Arylation of Indoles Under Mild Conditions
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Oxidant-controlled regioselectivity in the oxidative arylation of N-acetylindoles
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June 2008 |
Visible-Light-Promoted C2 Selective Arylation of Quinoline and Pyridine N -Oxides with Diaryliodonium Tetrafluoroborate
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January 2020 |
A New Efficient Route for the Formation of Quinoxaline N -Oxides and N,N ‘ -Dioxides Using HOF·CH 3 CN
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June 2006 |
Rh(III)-Catalyzed Tandem C–H Allylation and Oxidative Cyclization of Anilides: A New Entry to Indoles
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August 2013 |
Chemoselective N-Acylation of Indoles and Oxazolidinones with Carbonylazoles
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July 2012 |
Single-Flask Synthesis of N -Acylated Indoles by Catalytic Dehydrogenative Coupling with Primary Alcohols
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March 2009 |
Na2CO3-Catalyzed N-Acylation of Indoles with Alkenyl Carboxylates
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September 2018 |
Oxidative organocatalytic chemoselective N -acylation of heterocycles with aromatic and conjugated aldehydes
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January 2018 |
Highly Efficient Aminocarbonylation of Iodoarenes at Atmospheric Pressure Catalyzed by a Robust Acenaphthoimidazolyidene Allylic Palladium Complex
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July 2013 |
Condensation of Carboxylic Acids with Non-Nucleophilic N -Heterocycles and Anilides Using Boc 2 O
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November 2016 |
Alkylation with Oxalic Esters. Scope and mechanism
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January 1990 |
I 2 -Mediated Intramolecular C–H Amidation for the Synthesis of N-Substituted Benzimidazoles
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March 2017 |
From Pyridine- N -oxides to 2-Functionalized Pyridines through Pyridyl Phosphonium Salts: An Umpolung Strategy
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July 2021 |
Development of one-pot benzylic amination reactions of azine N-oxides
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May 2018 |
N 2 H 4 –H 2 O Enabled Umpolung Cyclization of o -Nitro Chalcones for the Construction of Quinoline N -Oxides
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December 2020 |
Carbon Nanotube-Ruthenium Hybrids for the Partial Reduction of 2-Nitrochalcones: Easy Access to Quinoline N -Oxides
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March 2016 |
Organocatalytic functionalization of heteroaromatic N-oxides with C-nucleophiles using in situ generated onium amide bases
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January 2013 |
Ligands for Copper-Catalyzed C−N Bond Forming Reactions with 1 Mol% CuBr as Catalyst
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March 2011 |
Water-Soluble Hypervalent Iodine(III) Having an I–N Bond. A Reagent for the Synthesis of Indoles
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June 2018 |
A highly effective one-pot synthesis of quinolines from o-nitroarylcarbaldehydes
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January 2007 |
Homogeneous Nickel-Catalyzed Sustainable Synthesis of Quinoline and Quinoxaline under Aerobic Conditions
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November 2020 |
Unsupported Nanoporous Gold Catalyst for Highly Selective Hydrogenation of Quinolines
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March 2013 |
Asymmetric combinational “metal-biocatalytic system”: One approach to chiral 2-subsituted-tetrahydroquinoline-4-ols towards two-step one-pot processes in aqueous media
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June 2017 |
Brønsted acid catalyzed synthesis of 1,3-di(2-quinolyl)propane derivatives via tandem C(sp3)–H functionalization
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August 2013 |
Palladium-Catalyzed Sequential Formation of CC Bonds: Efficient Assembly of 2-Substituted and 2,3-Disubstituted Quinolines
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June 2012 |
Highly Enantioselective Hydrogenation of Quinolines Using Phosphine-Free Chiral Cationic Ruthenium Catalysts: Scope, Mechanism, and Origin of Enantioselectivity
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June 2011 |
Ligand-controlled phosphine-free Co(II)-catalysed cross-coupling of secondary and primary alcohols
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November 2019 |
Decarbonylative Phosphorylation of Carboxylic Acids via Redox-Neutral Palladium Catalysis
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November 2019 |
Brønsted Acid-Catalyzed Minisci-Type Cross-Dehydrogenative Coupling of N -Heteroaromatics and Cyclic Ethers
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June 2021 |
Synthesis, molecular docking and anti-inflammatory screening of novel quinoline incorporated pyrazole derivatives using the Pfitzinger reaction II
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February 2015 |
Trimethylsilyldiazomethane ? A Mild and Efficient Reagent for the Methylation of Carboxylic Acids and Alcohols in Natural Products
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Synthesis of an Artificial HMG-CoA Reductase Inhibitor NK-104 via a Hydrosilylation–Cross-Coupling Reaction
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Triphosgene and DMAP as Mild Reagents for Chemoselective Dehydration of Tertiary Alcohols
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New synthesis of benzo[b]furan and indole derivatives from 1,1-dibromo-1-alkenes using a tandem Pd-assisted cyclization–coupling reaction
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Metal-Free C–H Amination for Indole Synthesis
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July 2014 |
Rhodium(III)-Catalyzed Cyclative Capture Approach to Diverse 1-Aminoindoline Derivatives at Room Temperature
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December 2014 |
A novel approach to synthesis of the cinnoline ring system via organoiron(cyclopentadienyl) complexes
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July 1988 |
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Photochemistry of the N-Oxides of Azanaphthalene and Their Substituted Derivatives
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Reactions of 1aH-oxazirino[2,3-a]quinolines and 1aH-oxazirino[2,3-1]isoquinolines via 7-membered oxazepine intermediates
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January 1966 |
Photochemical Studies. IV. Photochemical Reactions of 2-Methylquinoline N-oxide Hydrate.
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Photochemical Ring-contraction Reactions of Benz[d]-3,1-oxazepines Having no Substituent at the 5-Position to Indole-3-carboxaldehydes
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Photochemical Studies. VIII. The Formation of Benz[d]-1,3-oxazepines in the Photolysis of Quinoline N-Oxides in Solution.
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Studies on the N-oxides of .PI.-deficient N-heteroaromatics. XXXIV. A novel synthesis of substituted indoles by photochemical ring contraction of 3,1-benzoxazepines.
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Photochemical Studies. XVI. Photolysis of Phenylquinoline N-Oxides in Solution. A Novel Light-Induced Reaction. Solvent Influence on the Product Distribution.
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Photochemistry of methoxy-substituted quinoline and isoquinoline N-oxides
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Irradiation of N-oxides of α-cyanoazanaphthalenes in an aprotic solvent.
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January 1966 |
Borane-catalyzed metal-free hydrogenation of 2,7-disubstituted 1,8-naphthyridines
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Synthesis of Fluorine-Containing Phosphodiesterase 10A (PDE10A) Inhibitors and the In Vivo Evaluation of F-18 Labeled PDE10A PET Tracers in Rodent and Nonhuman Primate
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October 2015 |
Convenient syntheses and preliminary photophysical properties of novel 8-aminoquinoline appended diaza-18-crown-6 ligands
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OLEX2 : a complete structure solution, refinement and analysis program
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Palladium-Catalyzed Direct Arylation of Azine and Azole N -Oxides: Reaction Development, Scope and Applications in Synthesis
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Anti-Markovnikov stereoselective hydroamination and hydrothiolation of (hetero)aromatic alkynes using a metal-free cyclic trimeric phosphazene base
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June 2019 |