Structural and functional insight into mismatch extension by human DNA polymerase [alpha]

Baranovskiy, Andrey G.; Babayeva, Nigar D.; Lisova, Alisa E.; Morstadt, Lucia M.; Tahirov, Tahir H.

doi:10.1073/pnas.2111744119

Title: Structural and functional insight into mismatch extension by human DNA polymerase [alpha]

Journal Article · 01 April 2022 · Proc. Natl. Acad. Sci. USA

DOI:https://doi.org/10.1073/pnas.2111744119· OSTI ID:1866450

Baranovskiy, Andrey G.; Babayeva, Nigar D.; Lisova, Alisa E.; Morstadt, Lucia M.; Tahirov, Tahir H.

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Research Organization:: Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)

Sponsoring Organization:: DOE - Office Of Science; NIGMS; National Institutes of Health (NIH)

OSTI ID:: 1866450

Journal Information:: Proc. Natl. Acad. Sci. USA, Vol. 119, Issue (17)

Country of Publication:: United States

Language:: ENGLISH

References (28)

Eukaryotic DNA Replication Fork Burgers, Peter M. J.; Kunkel, Thomas A. Annual Review of Biochemistry, Vol. 86, Issue 1 https://doi.org/10.1146/annurev-biochem-061516-044709	journal	June 2017
Mechanism of Concerted RNA-DNA Primer Synthesis by the Human Primosome Baranovskiy, Andrey G.; Babayeva, Nigar D.; Zhang, Yinbo Journal of Biological Chemistry, Vol. 291, Issue 19 https://doi.org/10.1074/jbc.M116.717405	journal	March 2016
Mechanism for priming DNA synthesis by yeast DNA Polymerase α Perera, Rajika L.; Torella, Rubben; Klinge, Sebastian eLife, Vol. 2 https://doi.org/10.7554/eLife.00482	journal	April 2013
Elaborated Action of the Human Primosome Baranovskiy, Andrey; Tahirov, Tahir Genes, Vol. 8, Issue 2 https://doi.org/10.3390/genes8020062	journal	February 2017
Flexible tethering of primase and DNA Pol α in the eukaryotic primosome Núñez-Ramírez, Rafael; Klinge, Sebastian; Sauguet, Ludovic Nucleic Acids Research, Vol. 39, Issue 18 https://doi.org/10.1093/nar/gkr534	journal	June 2011
Insight into the Human DNA Primase Interaction with Template-Primer Baranovskiy, Andrey G.; Zhang, Yinbo; Suwa, Yoshiaki Journal of Biological Chemistry, Vol. 291, Issue 9 https://doi.org/10.1074/jbc.M115.704064	journal	December 2015
The p58 Subunit of Human DNA Primase Is Important for Primer Initiation, Elongation, and Counting ^† Zerbe, Laura K.; Kuchta, Robert D. Biochemistry, Vol. 41, Issue 15 https://doi.org/10.1021/bi016030b	journal	April 2002
Replication protein A binds RNA and promotes R-loop formation Mazina, Olga M.; Somarowthu, Srinivas; Kadyrova, Lyudmila Y. Journal of Biological Chemistry, Vol. 295, Issue 41 https://doi.org/10.1074/jbc.RA120.013812	journal	October 2020
DNA polymerase-α regulates the activation of type I interferons through cytosolic RNA:DNA synthesis Starokadomskyy, Petro; Gemelli, Terry; Rios, Jonathan J. Nature Immunology, Vol. 17, Issue 5 https://doi.org/10.1038/ni.3409	journal	March 2016
The antitumor toxin CD437 is a direct inhibitor of DNA polymerase α Han, Ting; Goralski, Maria; Capota, Emanuela Nature Chemical Biology, Vol. 12, Issue 7 https://doi.org/10.1038/nchembio.2082	journal	May 2016
3D architecture of DNA Pol α reveals the functional core of multi-subunit replicative polymerases Klinge, Sebastian; Núñez-Ramírez, Rafael; Llorca, Oscar The EMBO Journal, Vol. 28, Issue 13 https://doi.org/10.1038/emboj.2009.150	journal	June 2009
Crystal Structure of the Human Pol α B Subunit in Complex with the C-terminal Domain of the Catalytic Subunit Suwa, Yoshiaki; Gu, Jianyou; Baranovskiy, Andrey G. Journal of Biological Chemistry, Vol. 290, Issue 23 https://doi.org/10.1074/jbc.M115.649954	journal	April 2015
Crystal Structure of a pol α Family Replication DNA Polymerase from Bacteriophage RB69 Wang, J.; Sattar, A. K. M. A.; Wang, C. C. Cell, Vol. 89, Issue 7 https://doi.org/10.1016/S0092-8674(00)80296-2	journal	June 1997
Lagging-strand replication shapes the mutational landscape of the genome Reijns, Martin A. M.; Kemp, Harriet; Ding, James Nature, Vol. 518, Issue 7540 https://doi.org/10.1038/nature14183	journal	January 2015
Evidence that Errors Made by DNA Polymerase α are Corrected by DNA Polymerase δ Pavlov, Y. I.; Frahm, C.; McElhinny, S. A. Nick Current Biology, Vol. 16, Issue 2 https://doi.org/10.1016/j.cub.2005.12.002	journal	January 2006
Fidelity studies of the human DNA polymerase alpha. The most conserved region among alpha-like DNA polymerases is responsible for metal-induced infidelity in DNA synthesis Copeland, W. C.; Lam, N. K.; Wang, T. S. Journal of Biological Chemistry, Vol. 268, Issue 15 https://doi.org/10.1016/S0021-9258(18)82089-0	journal	May 1993
Human DNA polymerase α in binary complex with a DNA:DNA template-primer Coloma, Javier; Johnson, Robert E.; Prakash, Louise Scientific Reports, Vol. 6, Issue 1 https://doi.org/10.1038/srep23784	journal	April 2016
Functions of base selection step in human DNA polymerase α Tanaka, Shigeru; Cao, Ke; Niimi, Atsuko DNA Repair, Vol. 9, Issue 5 https://doi.org/10.1016/j.dnarep.2010.02.002	journal	May 2010
B Family DNA Polymerases Asymmetrically Recognize Pyrimidines and Purines Lund, Travis J.; Cavanaugh, Nisha A.; Joubert, Nicolas Biochemistry, Vol. 50, Issue 33 https://doi.org/10.1021/bi2006916	journal	July 2011
Mutational Studies of Human DNA Polymerase α: LYSINE 950 IN THE THIRD MOST CONSERVED REGION OF α-LIKE DNA POLYMERASES IS INVOLVED IN BINDING THE DEOXYNUCLEOSIDE TRIPHOSPHATE Dong, Qun; Wang, Teresa S. -F. Journal of Biological Chemistry, Vol. 270, Issue 37 https://doi.org/10.1074/jbc.270.37.21563	journal	September 1995
Fidelity of mammalian DNA replication and replicative DNA polymerases Thomas, David C.; Roberts, John D.; Sabatino, Ralph D. Biochemistry, Vol. 30, Issue 51 https://doi.org/10.1021/bi00115a003	journal	December 1991
Making and Breaking Nucleic Acids: Two-Mg2+-Ion Catalysis and Substrate Specificity Yang, Wei; Lee, Jae Young; Nowotny, Marcin Molecular Cell, Vol. 22, Issue 1 https://doi.org/10.1016/j.molcel.2006.03.013	journal	April 2006
Structures of DNA Polymerase Mispaired DNA Termini Transitioning to Pre-catalytic Complexes Support an Induced-Fit Fidelity Mechanism Batra, Vinod K.; Beard, William A.; Pedersen, Lars C. Structure, Vol. 24, Issue 11 https://doi.org/10.1016/j.str.2016.08.006	journal	November 2016
DNA Mismatch Synthesis Complexes Provide Insights into Base Selectivity of a B Family DNA Polymerase Xia, Shuangluo; Wang, Jimin; Konigsberg, William H. Journal of the American Chemical Society, Vol. 135, Issue 1 https://doi.org/10.1021/ja3079048	journal	December 2012
Mispairs with Watson-Crick base-pair geometry observed in ternary complexes of an RB69 DNA polymerase variant: Mispairs with Watson-Crick Base-Pair Geometry Xia, Shuangluo; Konigsberg, William H. Protein Science, Vol. 23, Issue 4 https://doi.org/10.1002/pro.2434	journal	March 2014
Structural basis for inhibition of DNA replication by aphidicolin Baranovskiy, Andrey G.; Babayeva, Nigar D.; Suwa, Yoshiaki Nucleic Acids Research, Vol. 42, Issue 22 https://doi.org/10.1093/nar/gku1209	journal	November 2014
[20] Processing of X-ray diffraction data collected in oscillation mode Otwinowski, Zbyszek; Minor, Wladek Macromolecular Crystallography Part A, 307-326 https://doi.org/10.1016/S0076-6879(97)76066-X	book	January 1997
Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination Brünger, A. T.; Adams, P. D.; Clore, G. M. Acta Crystallographica Section D Biological Crystallography, Vol. 54, Issue 5 https://doi.org/10.1107/S0907444998003254	journal	September 1998

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