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Title: Enzymatic and structural characterization of HAD5, an essential phosphomannomutase of malaria-causin

Journal Article · · J. Biol. Chem.

Research Organization:
Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Sponsoring Organization:
DOE - Office Of Science; NIAID; National Institutes of Health (NIH)
OSTI ID:
1865459
Journal Information:
J. Biol. Chem., Vol. 298, Issue (2)
Country of Publication:
United States
Language:
ENGLISH

References (107)

Drug resistance in Plasmodium journal January 2018
Malaria—Update on Antimalarial Resistance and Treatment Approaches journal January 2018
Biology of Malaria Transmission journal November 2016
A Research Agenda to Underpin Malaria Eradication journal January 2011
New developments in anti-malarial target candidate and product profiles journal January 2017
Natural Products: A Potential Source of Malaria Transmission Blocking Drugs? journal September 2020
Malaria parasite-infected erythrocytes inhibit glucose utilization in uninfected red cells journal October 2005
Glutathione stability and oxidative stress in P. falciparum infection in vitro: Responses of normal and G6PD deficient cells journal November 1982
A Second Target of the Antimalarial and Antibacterial Agent Fosmidomycin Revealed by Cellular Metabolic Profiling journal May 2011
Targeting DHFR in parasitic protozoa journal January 2005
Activity of PS-15 and its metabolite, WR99210, against Plasmodium falciparum in an in vivo-in vitro model journal September 1996
Isoxazolopyrimidine-Based Inhibitors of Plasmodium falciparum Dihydroorotate Dehydrogenase with Antimalarial Activity journal August 2018
Targeting Enzymes with Phosphonate-Based Inhibitors: Mimics of Tetrahedral Transition States and Stable Isosteric Analogues of Phosphates journal February 2006
Identification and Stoichiometry of Glycosylphosphatidylinositol-anchored Membrane Proteins of the Human Malaria Parasite Plasmodium falciparum journal July 2006
Hot, sweet and sticky: the glycobiology of Plasmodium falciparum journal May 2008
Structural analysis of the glycosyl-phosphatidylinositol membrane anchor of the merozoite surface proteins-1 and -2 of Plasmodium falciparum journal January 1996
Processing of Plasmodium falciparum Merozoite Surface Protein MSP1 Activates a Spectrin-Binding Function Enabling Parasite Egress from RBCs journal October 2015
Analysis of Antibodies Directed against Merozoite Surface Protein 1 of the Human Malaria Parasite Plasmodium falciparum journal February 2006
The Plasmodium falciparum rhoptry bulb protein RAMA plays an essential role in rhoptry neck morphogenesis and host red blood cell invasion journal September 2019
Malaria Derived Glycosylphosphatidylinositol Anchor Enhances Anti-Pfs25 Functional Antibodies That Block Malaria Transmission journal January 2018
Pfs230: from malaria transmission-blocking vaccine candidate toward function journal July 2003
The Pfs230 N-terminal fragment, Pfs230D1+: expression and characterization of a potential malaria transmission-blocking vaccine candidate journal November 2019
Outer membrane protein complex as a carrier for malaria transmission blocking antigen Pfs230 journal July 2019
The RTS,S malaria vaccine journal July 2010
RTS,S/AS01 vaccine (Mosquirix™): an overview journal October 2019
R21/Matrix-M: a second malaria vaccine? journal May 2021
Efficacy of a low-dose candidate malaria vaccine, R21 in adjuvant Matrix-M, with seasonal administration to children in Burkina Faso: a randomised controlled trial journal May 2021
Circumsporozoite protein is required for development of malaria sporozoites in mosquitoes journal January 1997
Glycosylphosphatidylinositol Anchors Represent the Major Carbohydrate Modification in Proteins of Intraerythrocytic Stage Plasmodium falciparum journal March 1997
Suggestive Evidence for Darwinian Selection against Asparagine-Linked Glycans of Plasmodium falciparum and Toxoplasma gondii journal February 2010
The diversity of dolichol-linked precursors to Asn-linked glycans likely results from secondary loss of sets of glycosyltransferases journal January 2005
Sugar activation and glycosylation in Plasmodium journal October 2015
Uncovering the essential genes of the human malaria parasite Plasmodium falciparum by saturation mutagenesis journal May 2018
New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq journal April 2010
Chromatin Accessibility-Based Characterization of the Gene Regulatory Network Underlying Plasmodium falciparum Blood-Stage Development journal April 2018
Directional gene expression and antisense transcripts in sexual and asexual stages of Plasmodium falciparum journal November 2011
The yeast SEC53 gene encodes phosphomannomutase. journal July 1988
The reaction mechanism of phosphomannomutase in plants journal January 1997
The glucose biphosphate family of enzymes journal June 1986
Expression of manB Gene from Escherichia coli in Lactococcus lactis and Characterization of Its Bifunctional Enzyme, Phosphomannomutase journal August 2018
Mammalian Phosphomannomutase PMM1 Is the Brain IMP-sensitive Glucose-1,6-bisphosphatase journal December 2008
Genetic analysis of phosphomannomutase/phosphoglucomutase from Vibrio furnissii and characterization of its role in virulence journal October 2003
Purification and characterization of phosphomannomutase/phosphoglucomutase from Pseudomonas aeruginosa involved in biosynthesis of both alginate and lipopolysaccharide. journal August 1994
Evolutionary trace analysis of the α-D-phosphohexomutase superfamily journal August 2004
Synthetic RNA–protein modules integrated with native translation mechanisms to control gene expression in malaria parasites journal March 2016
Plasmepsins IX and X are essential and druggable mediators of malaria parasite egress and invasion journal October 2017
HMDB 4.0: the human metabolome database for 2018 journal November 2017
Screening the Medicines for Malaria Venture Pathogen Box for invasion and egress inhibitors of the blood stage of Plasmodium falciparum reveals several inhibitory compounds journal March 2020
Peptidic boronic acids are potent cell-permeable inhibitors of the malaria parasite egress serine protease SUB1 journal May 2021
Autocatalytic activation of a malarial egress protease is druggable and requires a protein cofactor journal May 2021
Inhibition of Resistance-Refractory P. falciparum Kinase PKG Delivers Prophylactic, Blood Stage, and Transmission-Blocking Antiplasmodial Activity journal July 2020
Dual Plasmepsin-Targeting Antimalarial Agents Disrupt Multiple Stages of the Malaria Parasite Life Cycle journal April 2020
Selective Inhibition of a Two-step Egress of Malaria Parasites from the Host Erythrocyte journal September 2003
Molecular and functional aspects of parasite invasion journal December 2004
Inhibition of glycosyl-phosphatidylinositol biosynthesis in Plasmodium falciparum by C-2 substituted mannose analogues: P. falciparum GPtdIns glycosylation inhibition journal December 2001
Glycosylphosphatidylinositols synthesized by asexual erythrocytic stages of the malarial parasite, Plasmodium falciparum. Candidates for plasmodial glycosylphosphatidylinositol membrane anchor precursors and pathogenicity factors. journal January 1994
Biosynthesis of glycosyl phosphatidylinositol protein anchors journal December 1990
Developmental Stage-specific Biosynthesis of Glycosylphosphatidylinositol Anchors in IntraerythrocyticPlasmodium falciparum and Its Inhibition in a Novel Manner by Mannosamine journal August 2000
Glucosamine Inhibits Inositol Acylation of the Glycosylphosphatidylinositol Anchors in IntraerythrocyticPlasmodium falciparum journal January 2003
Statistical power analyses using G*Power 3.1: Tests for correlation and regression analyses journal November 2009
Evolutionary Genomics of the HAD Superfamily: Understanding the Structural Adaptations and Catalytic Diversity in a Superfamily of Phosphoesterases and Allied Enzymes journal September 2006
Haloacid Dehalogenase Proteins: Novel Mediators of Metabolic Plasticity in Plasmodium falciparum journal January 2019
A sugar phosphatase regulates the methylerythritol phosphate (MEP) pathway in malaria parasites journal July 2014
Suppression of Drug Resistance Reveals a Genetic Mechanism of Metabolic Plasticity in Malaria Parasites journal November 2018
The Metabolite Repair Enzyme Phosphoglycolate Phosphatase Regulates Central Carbon Metabolism and Fosmidomycin Sensitivity in Plasmodium falciparum journal December 2019
PMM (PMM1), the Human Homologue ofSEC53or Yeast Phosphomannomutase, Is Localized on Chromosome 22q13 journal February 1997
Mutations in PMM2, a phosphomannomutase gene on chromosome 16p13 in carbohydrate-deficient glycoprotein type I syndrome (Jaeken syndrome) journal May 1997
Synthesis, Derivatization, and Structural Analysis of Phosphorylated Mono-, Di-, and Trifluorinated d -Gluco-heptuloses by Glucokinase: Tunable Phosphoglucomutase Inhibition journal April 2019
Inhibitory Evaluation of αPMM/PGM from Pseudomonas aeruginosa : Chemical Synthesis, Enzyme Kinetics, and Protein Crystallographic Study journal May 2019
Cap-domain closure enables diverse substrate recognition by the C2-type haloacid dehalogenase-like sugar phosphatase Plasmodium falciparum HAD1 journal August 2015
The X-ray Crystal Structures of Human α-Phosphomannomutase 1 Reveal the Structural Basis of Congenital Disorder of Glycosylation Type 1a journal May 2006
Genome-wide Analysis of Substrate Specificities of the Escherichia coli Haloacid Dehalogenase-like Phosphatase Family journal September 2006
Functional Diversity of Haloacid Dehalogenase Superfamily Phosphatases from Saccharomyces cerevisiae: BIOCHEMICAL, STRUCTURAL, AND EVOLUTIONARY INSIGHTS journal June 2015
Genome sequence of the human malaria parasite Plasmodium falciparum journal October 2002
Characterization of α-phosphoglucomutase isozymes from Toxoplasma gondii journal June 2010
Multiprotein complex between the GPI-anchored CyRPA with PfRH5 and PfRipr is crucial for Plasmodium falciparum erythrocyte invasion journal January 2015
Prodrugs of biologically active phosphate esters journal March 2003
MEPicides: potent antimalarial prodrugs targeting isoprenoid biosynthesis journal August 2017
Esterase mutation is a mechanism of resistance to antimalarial compounds journal January 2017
Distinct roles for pbs21 and pbs25 in the in vitro ookinete to oocyst transformation of Plasmodium berghei journal October 2000
A Central Role for P48/45 in Malaria Parasite Male Gamete Fertility journal January 2001
Proteoglycans mediate malaria sporozoite targeting to the liver: Malaria sporozoite targeting to the liver journal July 2002
A Plasmodium falciparum C -mannosyltransferase is dispensable for parasite asexual blood stage development journal October 2019
Apicomplexan C-Mannosyltransferases Modify Thrombospondin Type I-containing Adhesins of the TRAP Family journal February 2018
Protein O-fucosylation in Plasmodium falciparum ensures efficient infection of mosquito and vertebrate hosts journal September 2017
Protein O-Fucosyltransferase 2 Is Not Essential for Plasmodium berghei Development journal July 2019
Efficient site-specific integration in Plasmodium falciparum chromosomes mediated by mycobacteriophage Bxb1 integrase journal July 2006
Malaria Parasite cGMP-dependent Protein Kinase Regulates Blood Stage Merozoite Secretory Organelle Discharge and Egress journal May 2013
Toxoplasma gondii Cyclic GMP-Dependent Kinase: Chemotherapeutic Targeting of an Essential Parasite Protein Kinase journal June 2002
Isolation of viable Plasmodium falciparum merozoites to define erythrocyte invasion events and advance vaccine and drug development journal July 2010
A Facile Method for High-throughput Co-expression of Protein Pairs journal July 2004
A short translational ramp determines the efficiency of protein synthesis journal December 2019
Four plasmepsins are active in the Plasmodium falciparum food vacuole, including a protease with an active-site histidine journal January 2002
Assessment of Biological Role and Insight into Druggability of the Plasmodium falciparum Protease Plasmepsin V journal February 2020
Na+ Influx Induced by New Antimalarials Causes Rapid Alterations in the Cholesterol Content and Morphology of Plasmodium falciparum journal May 2016
HKL -3000: the integration of data reduction and structure solution – from diffraction images to an initial model in minutes journal July 2006
SWISS-MODEL: homology modelling of protein structures and complexes journal May 2018
Structural Basis of the Molecular Switch between Phosphatase and Mutase Functions of Human Phosphomannomutase 1 under Ischemic Conditions journal April 2018
Phaser crystallographic software journal July 2007
Coot model-building tools for molecular graphics journal November 2004
PHENIX: a comprehensive Python-based system for macromolecular structure solution journal January 2010
AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility journal December 2009
Avogadro: an advanced semantic chemical editor, visualization, and analysis platform journal August 2012
An expedient synthesis of benzyl 2,3,4-tri-O-benzyl-β-d-glucopyranoside and benzyl 2,3,4-tri-O-benzyl-β-d-mannopyranoside journal May 2005
Enzyme-catalyzed synthesis of isosteric phosphono-analogues of sugar nucleotides journal January 2009
Identification of an oxime-containing C-glucosylarene as a potential inhibitor of sodium-dependent glucose co-transporter 2 journal January 2018
Stereospecific synthesis of the phosphono analogs of .alpha.- and .beta.-D-glucose 1-phosphate journal November 1982