skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: GSK-3[beta] Localizes to the Cardiac Z-Disc to Maintain Length Dependent Activation

Journal Article · · Circ. Res.
; ; ; ; ; ; ; ; ; ; ; ; ; ; ;

Research Organization:
Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Sponsoring Organization:
DOE - Office Of Science; National Institutes of Health (NIH)
OSTI ID:
1865439
Journal Information:
Circ. Res., Vol. 130, Issue (6)
Country of Publication:
United States
Language:
ENGLISH

References (62)

Protein Kinase N Promotes Stress-Induced Cardiac Dysfunction Through Phosphorylation of Myocardin-Related Transcription Factor A and Disruption of Its Interaction With Actin journal November 2019
Ca 2+ /Calmodulin–Dependent Protein Kinase Modulates Cardiac Ryanodine Receptor Phosphorylation and Sarcoplasmic Reticulum Ca 2+ Leak in Heart Failure journal December 2005
Cardiac protein kinases: the cardiomyocyte kinome and differential kinase expression in human failing hearts journal August 2015
Phosphodiesterase 9A controls nitric-oxide-independent cGMP and hypertrophic heart disease journal March 2015
Glycogen Synthase Kinase-3β Regulates Post–Myocardial Infarction Remodeling and Stress-Induced Cardiomyocyte Proliferation In Vivo journal May 2010
Glycogen synthase kinase-3β controls autophagy during myocardial ischemia and reperfusion journal January 2012
The Akt-Glycogen Synthase Kinase 3β Pathway Regulates Transcription of Atrial Natriuretic Factor Induced by β-Adrenergic Receptor Stimulation in Cardiac Myocytes journal May 2000
Glycogen Synthase Kinase-3β Is a Negative Regulator of Cardiomyocyte Hypertrophy journal October 2000
Activated glycogen synthase-3β suppresses cardiac hypertrophy in vivo journal January 2002
Distinct roles of GSK-3α and GSK-3β phosphorylation in the heart under pressure overload journal December 2008
Inhibition of Glycogen Synthase Kinase 3β During Heart Failure Is Protective journal November 2007
Cardiac resynchronization sensitizes the sarcomere to calcium by reactivating GSK-3β journal December 2013
Regulation of Contraction in Striated Muscle journal January 2000
Dilated and Hypertrophic Cardiomyopathy Mutations in Troponin and α-Tropomyosin Have Opposing Effects on the Calcium Affinity of Cardiac Thin Filaments journal December 2007
The Genetic and Molecular Bases for Hypertrophic Cardiomyopathy: The Role for Calcium Sensitization journal February 2018
Myofibrillar calcium sensitivity of isometric tension is increased in human dilated cardiomyopathies: role of altered beta-adrenergically mediated protein phosphorylation. journal July 1996
Diabetes with heart failure increases methylglyoxal modifications in the sarcomere, which inhibit function journal October 2018
Mechanisms and Use of Calcium-Sensitizing Agents in the Failing Heart journal January 2006
Myofilament length dependent activation journal May 2010
Myofilament Length-Dependent Activation Develops within 5 ms in Guinea-Pig Myocardium journal July 2012
Exhaustion of the Frank–Starling mechanism in conscious dogs with heart failure induced by chronic coronary microembolization journal July 2006
The failing human heart is unable to use the Frank-Starling mechanism. journal May 1994
Exercise intolerance in patients with heart failure and preserved left ventricular systolic function: Failure of the Frank-Starling mechanism journal April 1991
Existence of the Frank-Starling Mechanism in the Failing Human Heart: Investigations on the Organ, Tissue, and Sarcomere Levels journal August 1996
Preserved Frank–Starling mechanism in human end stage heart failure journal February 1998
Titin strain contributes to the Frank–Starling law of the heart by structural rearrangements of both thin- and thick-filament proteins journal February 2016
Cardiac inflammation in genetic dilated cardiomyopathy caused by MYBPC3 mutation journal January 2017
Dilated cardiomyopathy in homozygous myosin-binding protein-C mutant mice journal November 1999
Amino terminus of cardiac myosin binding protein-C regulates cardiac contractility journal July 2021
The BioCAT undulator beamline 18ID: a facility for biological non-crystalline diffraction and X-ray absorption spectroscopy at the Advanced Photon Source journal August 2004
Myosin Head Configurations in Resting and Contracting Murine Skeletal Muscle journal September 2018
Anisotropic engineered heart tissue made from laser-cut decellularized myocardium journal August 2016
Extracellular Matrix From Hypertrophic Myocardium Provokes Impaired Twitch Dynamics in Healthy Cardiomyocytes journal August 2019
Pacemaker-induced transient asynchrony suppresses heart failure progression journal December 2015
Cardiomyocyte contractile impairment in heart failure results from reduced BAG3-mediated sarcomeric protein turnover journal May 2021
Proteomic Analysis of Pharmacologically Preconditioned Cardiomyocytes Reveals Novel Phosphorylation of Myosin Light Chain 1 journal September 2001
Frank-Starling law of the heart and the cellular mechanisms of length-dependent activation journal December 2002
Cardiac Myosin-binding Protein C and Troponin-I Phosphorylation Independently Modulate Myofilament Length-dependent Activation journal October 2015
Response of Equatorial X-Ray Reflections and Stiffness to Altered Sarcomere Length and Myofilament Lattice Spacing in Relaxed Skinned Cardiac Muscle journal February 2004
Increased myocardial stiffness due to cardiac titin isoform switching in a mouse model of volume overload limits eccentric remodeling journal February 2015
Cardiac MyBP-C phosphorylation regulates the Frank–Starling relationship in murine hearts journal March 2021
A Molecular Map of the Interactions between Titin and Myosin-Binding Protein C. Implications for Sarcomeric Assembly in Familial Hypertrophic Cardiomyopathy journal January 1996
C0 and C1 N-terminal Ig domains of myosin binding protein C exert different effects on thin filament activation journal February 2016
Myosin-binding protein C displaces tropomyosin to activate cardiac thin filaments and governs their speed by an independent mechanism journal January 2014
Molecular Characterization of abLIM, a Novel Actin-binding and Double Zinc Finger Protein journal August 1997
Loss of supervillin causes myopathy with myofibrillar disorganization and autophagic vacuoles journal August 2020
Synaptopodin regulates the actin-bundling activity of α-actinin in an isoform-specific manner journal April 2005
Mechanical stress-strain sensors embedded in cardiac cytoskeleton: Z disk, titin, and associated structures journal April 2006
Dynamic Strength of Titin's Z-Disk End journal January 2010
The NH2 Terminus of Titin Spans the Z-Disc: Its Interaction with a Novel 19-kD Ligand (T-cap) Is Required for Sarcomeric Integrity journal November 1998
Mechanical Strength of the Titin Z1Z2-Telethonin Complex journal March 2006
Deconstructing sarcomeric structure–function relations in titin-BioID knock-in mice journal June 2020
GSK3β Phosphorylates Newly Identified Site in the Proline-Alanine–Rich Region of Cardiac Myosin–Binding Protein C and Alters Cross-Bridge Cycling Kinetics in Human: Short Communication journal February 2013
Mechanisms of the Frank-Starling Law of the Heart: The Beat Goes On journal December 2007
Titin-Based Modulation of Calcium Sensitivity of Active Tension in Mouse Skinned Cardiac Myocytes journal May 2001
The interactome of LIM domain proteins: The contributions of LIM domain proteins to heart failure and heart development journal January 2012
Glycogen synthase kinase-3 (GSK3): Regulation, actions, and diseases journal April 2015
Insulin Transiently Increases Tau Phosphorylation: Involvement of Glycogen Synthase Kinase-3β and Fyn Tyrosine Kinase journal February 1999
Glycogen Synthase Kinase 3β Is Tyrosine Phosphorylated by PYK2 journal June 2001
Glycogen synthase kinase-3β is tyrosine-phosphorylated by MEK1 in human skin fibroblasts journal April 2004
Glycogen synthase kinase-3 beta is a dual specificity kinase differentially regulated by tyrosine and serine/threonine phosphorylation. journal May 1994
Phospho-Proteomic Analysis of Cardiac Dyssynchrony and Resynchronization Therapy journal August 2018

Similar Records

Human cardiac stem cells exhibit mesenchymal features and are maintained through Akt/GSK-3{beta} signaling
Journal Article · 2007 · Biochemical and Biophysical Research Communications · OSTI ID:1865439
+8 more
Maintained activity of glycogen synthase kinase-3{beta} despite of its phosphorylation at serine-9 in okadaic acid-induced neurodegenerative model
Journal Article · 2010 · Biochemical and Biophysical Research Communications · OSTI ID:1865439
+5 more
Hepatocyte-protective effect of nectandrin B, a nutmeg lignan, against oxidative stress: Role of Nrf2 activation through ERK phosphorylation and AMPK-dependent inhibition of GSK-3β
Journal Article · 2016 · Toxicology and Applied Pharmacology · OSTI ID:1865439
+2 more

Related Subjects