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Holmes, K. C.; Trentham, D. R.; Simmons, R.
Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences, Vol. 359, Issue 1452
https://doi.org/10.1098/rstb.2004.1556
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A small-molecule inhibitor of sarcomere contractility suppresses hypertrophic cardiomyopathy in mice
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Low temperature traps myosin motors of mammalian muscle in a refractory state that prevents activation
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MYBPC3 mutations are associated with a reduced super-relaxed state in patients with hypertrophic cardiomyopathy
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Contractile apparatus dysfunction early in the pathophysiology of diabetic cardiomyopathy
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Effects of the N-terminal Domains of Myosin Binding Protein-C in an in Vitro Motility Assay
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X-ray Diffraction from Living Striated Muscle during Contraction
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The Super-Relaxed State and Length Dependent Activation in Porcine Myocardium
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X-ray evidence for radial cross-bridge movement and for the sliding filament model in actively contracting skeletal muscle
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The failing human heart is unable to use the Frank-Starling mechanism.
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Actin Structure and Function
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A myopathy-linked tropomyosin mutation severely alters thin filament conformational changes during activation
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Ca2+-induced tropomyosin movement in Limulus thin filaments revealed by three-dimensional reconstruction
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Slow‐twitch skeletal muscle defects accompany cardiac dysfunction in transgenic mice with a mutation in the myosin regulatory light chain
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A New State of Cardiac Myosin with Very Slow ATP Turnover: A Potential Cardioprotective Mechanism in the Heart
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Fast skeletal myosin-binding protein-C regulates fast skeletal muscle contraction
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Direct detection of the myosin super-relaxed state and interacting-heads motif in solution
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Evaluation of freeze substitution in rabbit skeletal muscle. Comparison of electron microscopy to X-ray diffraction
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Sarcomeric dysfunction contributes to muscle weakness in facioscapulohumeral muscular dystrophy
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Changes in the X-ray reflections from contracting muscle during rapid mechanical transients and their structural implications
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Three perspectives on the molecular basis of hypercontractility caused by hypertrophic cardiomyopathy mutations
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Analysis methods and quality criteria for investigating muscle physiology using x-ray diffraction
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Nebulin deficiency in adult muscle causes sarcomere defects and muscle-type-dependent changes in trophicity: novel insights in nemaline myopathy
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Regulation of Myofilament Contractile Function in Human Donor and Failing Hearts
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Structural changes during muscle contraction
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The role of the myosin ATPase activity in adaptive thermogenesis by skeletal muscle
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Osmotic Compression of Single Cardiac Myocytes Eliminates the Reduction in Ca 2+ Sensitivity of Tension at Short Sarcomere Length
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Structural Changes of Actin-Bound Myosin Heads after a Quick Length Change in Frog Skeletal Muscle
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The muscle thin filament as a classical cooperative/allosteric regulatory system
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Lattice arrangement of myosin filaments correlates with fiber type in rat skeletal muscle
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Changes in the lateral filament spacing of skinned muscle fibres when cross-bridges attach
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Cooling intact and demembranated trabeculae from rat heart releases myosin motors from their inhibited conformation
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Myofilament length dependent activation
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Direct visualization of myosin-binding protein C bridging myosin and actin filaments in intact muscle
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Disrupted myosin cross-bridge cycling kinetics triggers muscle weakness in nebulin-related myopathy
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Myosin Head Configuration in Relaxed Insect Flight Muscle: X-Ray Modeled Resting Cross-Bridges in a Pre-Powerstroke State Are Poised for Actin Binding
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Constitutive phosphorylation of cardiac myosin regulatory light chain prevents development of hypertrophic cardiomyopathy in mice
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X-ray recordings reveal how a human disease-linked skeletal muscle α-actin mutation leads to contractile dysfunction
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Direct Modeling of X-Ray Diffraction Pattern from Contracting Skeletal Muscle
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X-ray fiber diffraction modeling of structural changes of the thin filament upon activation of live vertebrate skeletal muscles
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Radial Displacement of Myosin Cross-bridges in Mouse Myocardium due to Ablation of Myosin Binding Protein-C
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Different Myosin Head Conformations in Bony Fish Muscles Put into Rigor at Different Sarcomere Lengths
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Reassessment of Mendelian gene pathogenicity using 7,855 cardiomyopathy cases and 60,706 reference samples
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X-ray evidence for conformational changes in the myosin filaments of vertebrate striated muscle
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Phosphorylation and function of cardiac myosin binding protein-C in health and disease
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Axial and Radial Forces of Cross-Bridges Depend on Lattice Spacing
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Author Correction: Abnormal contractility in human heart myofibrils from patients with dilated cardiomyopathy due to mutations in TTN and contractile protein genes
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Extensibility and Symmetry of Actin Filaments in Contracting Muscles
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X-Ray Diffraction Indicates That Active Cross-Bridges Bind to Actin Target Zones in Insect Flight Muscle
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Muscle thin-filament structure and regulation. Actin sub-domain movements and the tropomyosin shift modelled from low-angle X-ray diffraction
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Structural changes in myosin motors and filaments during relaxation of skeletal muscle: Structural changes in myosin during relaxation of skeletal muscle
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Constancy of Axial Spacings in Frog Sartorius Muscle during Contraction
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Reverse actin sliding triggers strong myosin binding that moves tropomyosin
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The Filament Lattice of Striated Muscle
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Thick filament mechano-sensing is a calcium-independent regulatory mechanism in skeletal muscle
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Thick-Filament Extensibility in Intact Skeletal Muscle
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Relaxed tarantula skeletal muscle has two ATP energy-saving mechanisms
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Roles for Cardiac MyBP-C in Maintaining Myofilament Lattice Rigidity and Prolonging Myosin Cross-Bridge Lifetime
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Temperature-induced structural changes in the myosin thick filament of skinned rabbit psoas muscle
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GSK-3β Localizes to the Cardiac Z-Disc to Maintain Length Dependent Activation
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