The Mechanism of Muscular Contraction
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June 1969 |
Millisecond time-resolved changes in x-ray reflections from contracting muscle during rapid mechanical transients, recorded using synchrotron radiation.
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April 1981 |
Time-resolved X-ray diffraction studies of the myosin layer-line reflections during muscle contraction
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July 1982 |
Changes in the X-ray reflections from contracting muscle during rapid mechanical transients and their structural implications
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September 1983 |
X-ray Interference Studies of Crossbridge Action in Muscle Contraction: Evidence from Muscles During Steady Shortening
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November 2006 |
The structural basis of muscle contraction
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April 2000 |
Regulation of the interaction between actin and myosin subfragment 1: evidence for three states of the thin filament
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August 1993 |
Ca2+-induced tropomyosin movement in Limulus thin filaments revealed by three-dimensional reconstruction
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March 1994 |
Regulation of Contraction in Striated Muscle
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January 2000 |
X-ray diffraction evidence for myosin-troponin connections and tropomyosin movement during stretch activation of insect flight muscle
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December 2010 |
Reverse actin sliding triggers strong myosin binding that moves tropomyosin
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July 2008 |
Structural changes during muscle contraction
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December 1971 |
X-Ray Evidence for a Conformational Change in the Actin-containing Filaments of Vertebrate Striated Muscle
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January 1973 |
Structural role of tropomyosin in muscle regulation: Analysis of the X-ray diffraction patterns from relaxed and contracting muscles
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March 1973 |
Structural Changes in the Actin- and Myosin-eontaining Filaments during Contraction
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January 1973 |
Electron Microscopy and X-Ray Diffraction Evidence for Two Z-Band Structural States
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August 2011 |
Force generation by skeletal muscle is controlled by mechanosensing in myosin filaments
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November 2015 |
Thick filament mechano-sensing is a calcium-independent regulatory mechanism in skeletal muscle
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October 2016 |
Inotropic interventions do not change the resting state of myosin motors during cardiac diastole
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December 2018 |
Structural changes in myosin motors and filaments during relaxation of skeletal muscle: Structural changes in myosin during relaxation of skeletal muscle
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September 2009 |
Myosin dynamics during relaxation in mouse soleus muscle and modulation by 2′‐deoxy‐ATP
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September 2020 |
Myosin Head Configurations in Resting and Contracting Murine Skeletal Muscle
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September 2018 |
Thick-Filament Extensibility in Intact Skeletal Muscle
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October 2018 |
Low temperature traps myosin motors of mammalian muscle in a refractory state that prevents activation
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September 2019 |
X-ray Diffraction of Intact Murine Skeletal Muscle as a Tool for Studying the Structural Basis of Muscle Disease
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January 2019 |
Effect of Active Lengthening and Shortening on Small-Angle X-ray Reflections in Skinned Skeletal Muscle Fibres
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August 2021 |
Nebulin stiffens the thin filament and augments cross-bridge interaction in skeletal muscle
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September 2018 |
Triggering typical nemaline myopathy with compound heterozygous nebulin mutations reveals myofilament structural changes as pathomechanism
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June 2020 |
Fast skeletal myosin-binding protein-C regulates fast skeletal muscle contraction
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April 2021 |
The fraction of strongly bound cross-bridges is increased in mice that carry the myopathy-linked myosin heavy chain mutation MYH4L342Q
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January 2013 |
Slow‐twitch skeletal muscle defects accompany cardiac dysfunction in transgenic mice with a mutation in the myosin regulatory light chain
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October 2018 |
Myocardial Infarction-induced N-terminal Fragment of Cardiac Myosin-binding Protein C (cMyBP-C) Impairs Myofilament Function in Human Myocardium
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March 2014 |
Dysfunctional sarcomere contractility contributes to muscle weakness in ACTA1 -related nemaline myopathy (NEM3): ACTA1 -Related Myopathy
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February 2018 |
Disrupted myosin cross-bridge cycling kinetics triggers muscle weakness in nebulin-related myopathy
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June 2011 |
Sarcomeric dysfunction contributes to muscle weakness in facioscapulohumeral muscular dystrophy
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January 2013 |
Pathogenic variants in TNNC2 cause congenital myopathy due to an impaired force response to calcium
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May 2021 |
Myofibril orientation as a metric for characterizing heart disease
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February 2022 |
Deciphering the super relaxed state of human β-cardiac myosin and the mode of action of mavacamten from myosin molecules to muscle fibers
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August 2018 |
The Super-Relaxed State and Length Dependent Activation in Porcine Myocardium
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September 2021 |
The muscle M3 x-ray diffraction peak and sarcomere length: No evidence for disordered myosin heads out of actin overlap
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August 2021 |
Myosin-based regulation of twitch and tetanic contractions in mammalian skeletal muscle
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June 2021 |
Probing the subcellular nanostructure of engineered human cardiomyocytes in 3D tissue
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January 2021 |
Molecular basis of force-pCa relation in MYL2 cardiomyopathy mice: Role of the super-relaxed state of myosin
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February 2022 |
Estimation of Forces on Actin Filaments in Living Muscle from X-ray Diffraction Patterns and Mechanical Data
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November 2019 |
Axial and Radial Forces of Cross-Bridges Depend on Lattice Spacing
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December 2010 |
Geometrical factors influencing muscle force development. I. The effect of filament spacing upon axial forces
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April 1980 |
The length–tension curve in muscle depends on lattice spacing
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September 2013 |
The Filament Lattice of Striated Muscle
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April 1998 |
Impact of osmotic compression on sarcomere structure and myofilament calcium sensitivity of isolated rat myocardium
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October 2006 |
Dependence of thick filament structure in relaxed mammalian skeletal muscle on temperature and interfilament spacing
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January 2021 |
Cooling intact and demembranated trabeculae from rat heart releases myosin motors from their inhibited conformation
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January 2022 |
The effect of the lattice spacing change on cross-bridge kinetics in chemically skinned rabbit psoas muscle fibers. II. Elementary steps affected by the spacing change
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January 1993 |
Changes in the lateral filament spacing of skinned muscle fibres when cross-bridges attach
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February 1984 |
Frank-Starling law of the heart and the cellular mechanisms of length-dependent activation
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December 2002 |
Osmotic Compression of Single Cardiac Myocytes Eliminates the Reduction in Ca 2+ Sensitivity of Tension at Short Sarcomere Length
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July 1995 |
X-Ray Diffraction Studies of the Heart
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June 1980 |
Myosin filament-based regulation of the dynamics of contraction in heart muscle
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March 2020 |
Cardiac myosin activation with 2-deoxy-ATP via increased electrostatic interactions with actin
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May 2019 |
Roles for Cardiac MyBP-C in Maintaining Myofilament Lattice Rigidity and Prolonging Myosin Cross-Bridge Lifetime
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October 2011 |
Protein Kinase A–Mediated Phosphorylation of cMyBP-C Increases Proximity of Myosin Heads to Actin in Resting Myocardium
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August 2008 |
Constitutive phosphorylation of cardiac myosin regulatory light chain prevents development of hypertrophic cardiomyopathy in mice
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June 2015 |
Temperature-induced structural changes in the myosin thick filament of skinned rabbit psoas muscle
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November 1997 |
Analysis of equatorial x-ray diffraction patterns from muscle fibers: factors that affect the intensities
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May 1995 |
Structures of actomyosin crossbridges in relaxed and rigor muscle fibers
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March 1989 |
Changes in thick filament structure during compression of the filament lattice in relaxed frog sartorius muscle
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October 1989 |
Titin strain contributes to the Frank–Starling law of the heart by structural rearrangements of both thin- and thick-filament proteins
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February 2016 |
X-ray Diffraction Evidence for Low Force Actin-Attached and Rigor-Like Cross-Bridges in the Contractile Cycle
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October 2016 |
Analysis methods and quality criteria for investigating muscle physiology using x-ray diffraction
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August 2021 |
Sarcomere-length dependence of myosin filament structure in skeletal muscle fibres of the frog: Myosin filament structure in skeletal muscle
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February 2014 |
The myosin motor in muscle generates a smaller and slower working stroke at higher load
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April 2004 |
X-Ray Diffraction Indicates That Active Cross-Bridges Bind to Actin Target Zones in Insect Flight Muscle
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March 1998 |
Distribution of mass in relaxed frog skeletal muscle and its redistribution upon activation
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March 1985 |
Radial Displacement of Myosin Cross-bridges in Mouse Myocardium due to Ablation of Myosin Binding Protein-C
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March 2007 |
A small-molecule inhibitor of sarcomere contractility suppresses hypertrophic cardiomyopathy in mice
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February 2016 |
Evaluation of freeze substitution in rabbit skeletal muscle. Comparison of electron microscopy to X-ray diffraction
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June 1995 |
Analysis of equatorial x-ray diffraction patterns from skeletal muscle
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March 1989 |
Interference fine structure and sarcomere length dependence of the axial x-ray pattern from active single muscle fibers
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June 2000 |
Recent X–ray diffraction studies of muscle contraction and their implications
- Holmes, K. C.; Trentham, D. R.; Simmons, R.
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Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences, Vol. 359, Issue 1452
https://doi.org/10.1098/rstb.2004.1556
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December 2004 |
Recent improvements in small angle x-ray diffraction for the study of muscle physiology
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September 2006 |
The myosin interacting-heads motif present in live tarantula muscle explains tetanic and posttetanic phosphorylation mechanisms
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May 2020 |
The low-angle X-ray diagram of vertebrate striated muscle and its behaviour during contraction and rigor
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December 1967 |
X-ray evidence for conformational changes in the myosin filaments of vertebrate striated muscle
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February 1975 |
Myosin motors that cannot bind actin leave their folded OFF state on activation of skeletal muscle
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October 2021 |
Two-dimensional time-resolved X-ray diffraction studies of live isometrically contracting frog sartorius muscle
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June 1993 |
X-ray Interference Studies of Crossbridge Action in Muscle Contraction: Evidence from Quick Releases
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November 2006 |
Skeletal Muscle Performance Determined by Modulation of Number of Myosin Motors Rather Than Motor Force or Stroke Size
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November 2007 |
X-ray diffraction evidence for the extensibility of actin and myosin filaments during muscle contraction
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December 1994 |
X-ray diffraction measurements of the extensibility of actin and myosin filaments in contracting muscle
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December 1994 |
Regulation of Contraction by the Thick Filaments in Skeletal Muscle
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December 2017 |
Constancy of Axial Spacings in Frog Sartorius Muscle during Contraction
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June 1965 |
X-ray Diffraction from Living Striated Muscle during Contraction
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June 1965 |
Actin Structure and Function
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June 2011 |
Rigor crossbridge structure in tilted single filament layers and flared-X formations from insect flight muscle
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September 1985 |
Myosin Head Configuration in Relaxed Insect Flight Muscle: X-Ray Modeled Resting Cross-Bridges in a Pre-Powerstroke State Are Poised for Actin Binding
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August 2003 |
Time-resolved x-ray diffraction study of the troponin-associated reflexions from the frog muscle
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September 1992 |
Structural changes of the regulatory proteins bound to the thin filaments in skeletal muscle contraction by X-ray fiber diffraction
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April 2008 |
Crossbridge Recruitment Capacity of Wild-Type and Hypertrophic Cardiomyopathy-Related Mutant Troponin-T Evaluated by X-ray Diffraction and Mechanical Study of Cardiac Skinned Fibers
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May 2020 |
X-ray fiber diffraction modeling of structural changes of the thin filament upon activation of live vertebrate skeletal muscles
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January 2010 |
X-ray Diffraction of Muscle labelled with Antibody to C-Protein
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August 1973 |
Structural Evidence for the Interaction of C-protein (MyBP-C) with Actin and Sequence Identification of a Possible Actin-binding Domain
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August 2003 |
Direct visualization of myosin-binding protein C bridging myosin and actin filaments in intact muscle
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June 2011 |
The N terminus of myosin-binding protein C extends toward actin filaments in intact cardiac muscle
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February 2021 |
Effect of MyBP-C Binding to Actin on Contractility in Heart Muscle
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November 2003 |
The structure of synthetic polypeptides. I. The transform of atoms on a helix
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September 1952 |
X-ray evidence for radial cross-bridge movement and for the sliding filament model in actively contracting skeletal muscle
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July 1973 |
Extensibility and Symmetry of Actin Filaments in Contracting Muscles
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December 1999 |
Dynamics of Thin-Filament Activation in Rabbit Skeletal Muscle Fibers Examined by Time-Resolved X-Ray Diffraction
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February 2009 |
An X-Ray Diffraction Study on Early Structural Changes in Skeletal Muscle Contraction
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February 2003 |
Structural difference between resting and rigor muscle; Evidence from intensity changes in the low-angle equatorial X-ray diagram
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November 1968 |
Direct Modeling of X-Ray Diffraction Pattern from Contracting Skeletal Muscle
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September 2008 |
A Model of Cross-Bridge Attachment to Actin in the A·M·ATP State Based on X-Ray Diffraction from Permeabilized Rabbit Psoas Muscle
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April 2002 |
Structural Changes of Actin-Bound Myosin Heads after a Quick Length Change in Frog Skeletal Muscle
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August 2005 |
Structural Changes of Cross-Bridges on Transition from Isometric to Shortening State in Frog Skeletal Muscle
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December 2006 |
Structural Changes in Actin-Tropomyosin During Muscle Regulation: Computer Modelling of Low-Angle X-ray Diffraction Data
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October 1995 |
The muscle thin filament as a classical cooperative/allosteric regulatory system
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April 1998 |
Structural Basis for the Regulation of Muscle Contraction by Troponin and Tropomyosin
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June 2008 |
Tropomyosin movement is described by a quantitative high-resolution model of X-ray diffraction of contracting muscle
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September 2016 |
Structural changes during activation of frog muscle studied by time-resolved X-ray diffraction
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April 1986 |
Muscle thin-filament structure and regulation. Actin sub-domain movements and the tropomyosin shift modelled from low-angle X-ray diffraction
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January 1993 |
A comparison of muscle thin filament models obtained from electron microscopy reconstructions and low-angle X-ray fibre diagrams from non-overlap muscle
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August 2006 |
Tropomyosin crystal structure and muscle regulation
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November 1986 |
Ca 2+ -regulated structural changes in troponin
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March 2005 |
Atomic model of the actin filament
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September 1990 |
Cardiac muscle thin filament structures reveal calcium regulatory mechanism
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January 2020 |
The structure of the native cardiac thin filament at systolic Ca 2+ levels
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March 2021 |
Modulation of Cardiac Thin Filament Azimuthal Rigidity by Calcium and Cross-Bridges
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February 2021 |
Different Myosin Head Conformations in Bony Fish Muscles Put into Rigor at Different Sarcomere Lengths
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July 2018 |
Lattice arrangement of myosin filaments correlates with fiber type in rat skeletal muscle
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November 2019 |
The role of the myosin ATPase activity in adaptive thermogenesis by skeletal muscle
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March 2011 |
A New State of Cardiac Myosin with Very Slow ATP Turnover: A Potential Cardioprotective Mechanism in the Heart
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April 2011 |
The role of super-relaxed myosin in skeletal and cardiac muscle
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December 2014 |
Conserved Intramolecular Interactions Maintain Myosin Interacting-Heads Motifs Explaining Tarantula Muscle Super-Relaxed State Structural Basis
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March 2016 |
Structural basis of the super- and hyper-relaxed states of myosin II
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December 2021 |
Relaxed tarantula skeletal muscle has two ATP energy-saving mechanisms
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January 2021 |
Direct detection of the myosin super-relaxed state and interacting-heads motif in solution
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October 2021 |
Three perspectives on the molecular basis of hypercontractility caused by hypertrophic cardiomyopathy mutations
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February 2019 |
Cardiac myosin binding protein-C: redefining its structure and function
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February 2012 |
Skeletal myosin binding protein-C: An increasingly important regulator of striated muscle physiology
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December 2018 |
Phosphorylation and function of cardiac myosin binding protein-C in health and disease
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May 2010 |
In the Thick of It: HCM-Causing Mutations in Myosin Binding Proteins of the Thick Filament
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March 2011 |
Phosphorylation of cardiac myosin binding protein C releases myosin heads from the surface of cardiac thick filaments
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February 2017 |
Effects of the N-terminal Domains of Myosin Binding Protein-C in an in Vitro Motility Assay
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November 2006 |
The Myosin-binding Protein C Motif Binds to F-actin in a Phosphorylation-sensitive Manner
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May 2009 |
Myosin binding protein-C phosphorylation is the principal mediator of protein kinase A effects on thick filament structure in myocardium
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November 2012 |
Effects of myosin variants on interacting-heads motif explain distinct hypertrophic and dilated cardiomyopathy phenotypes
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June 2017 |
MYBPC3 mutations are associated with a reduced super-relaxed state in patients with hypertrophic cardiomyopathy
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June 2017 |
Ablation of cardiac myosin binding protein-C disrupts the super-relaxed state of myosin in murine cardiomyocytes
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May 2016 |
Myofilament length dependent activation
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May 2010 |
Tension development and sarcomere length in rat cardiac trabeculae. Evidence of length-dependent activation.
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May 1980 |
The cellular basis of the length-tension relation in cardiac muscle
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September 1985 |
Regulation of Myofilament Contractile Function in Human Donor and Failing Hearts
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May 2020 |
The failing human heart is unable to use the Frank-Starling mechanism.
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May 1994 |
Perturbed Length-Dependent Activation in Human Hypertrophic Cardiomyopathy With Missense Sarcomeric Gene Mutations
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May 2013 |
Myosin filament activation in the heart is tuned to the mechanical task
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March 2017 |
Thick Filament Mechano-Sensing in Skeletal and Cardiac Muscles: A Common Mechanism Able to Adapt the Energetic Cost of the Contraction to the Task
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June 2018 |
GSK-3β Localizes to the Cardiac Z-Disc to Maintain Length Dependent Activation
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March 2022 |
Getting into the thick (and thin) of it
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February 2019 |
Structural and functional aspects of the myosin essential light chain in cardiac muscle contraction
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August 2011 |
Structural and functional impact of troponin C-mediated Ca2+ sensitization on myofilament lattice spacing and cross-bridge mechanics in mouse cardiac muscle
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October 2018 |
Myosin dilated cardiomyopathy mutation S532P disrupts actomyosin interactions, leading to altered muscle kinetics, reduced locomotion, and cardiac dilation in Drosophila
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August 2021 |
Sarcomeric perturbations of myosin motors lead to dilated cardiomyopathy in genetically modified MYL2 mice
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February 2018 |
Amino terminus of cardiac myosin binding protein-C regulates cardiac contractility
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July 2021 |
Altered myofilament structure and function in dogs with Duchenne muscular dystrophy cardiomyopathy
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January 2018 |
In Situ Measurements of Crossbridge Dynamics and Lattice Spacing in Rat Hearts by X-Ray Diffraction: Sensitivity to Regional Ischemia
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June 2004 |
Contractile apparatus dysfunction early in the pathophysiology of diabetic cardiomyopathy
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January 2015 |
Myosin Heads Are Displaced from Actin Filaments in the In Situ Beating Rat Heart in Early Diabetes
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March 2013 |
Diastolic dysfunction is initiated by cardiomyocyte impairment ahead of endothelial dysfunction due to increased oxidative stress and inflammation in an experimental prediabetes model
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December 2019 |
Titin-based stiffening of muscle fibers in Ehlers-Danlos Syndrome
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April 2012 |
X-ray recordings reveal how a human disease-linked skeletal muscle α-actin mutation leads to contractile dysfunction
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December 2015 |
A myopathy-linked tropomyosin mutation severely alters thin filament conformational changes during activation
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May 2010 |
Genetic Pathogenesis of Hypertrophic and Dilated Cardiomyopathy
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April 2018 |
Prevalence of Hypertrophic Cardiomyopathy in a General Population of Young Adults: Echocardiographic Analysis of 4111 Subjects in the CARDIA Study
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August 1995 |
Clinical and Mechanistic Insights Into the Genetics of Cardiomyopathy
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December 2016 |
Results of clinical genetic testing of 2,912 probands with hypertrophic cardiomyopathy: expanded panels offer limited additional sensitivity
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January 2015 |
Reassessment of Mendelian gene pathogenicity using 7,855 cardiomyopathy cases and 60,706 reference samples
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August 2016 |
Phosphorylation and the N-terminal extension of the regulatory light chain help orient and align the myosin heads in Drosophila flight muscle
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November 2009 |
Regulatory Light Chain Phosphorylation and N-Terminal Extension Increase Cross-Bridge Binding and Power Output in Drosophila at In Vivo Myofilament Lattice Spacing
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April 2011 |
Tropomyosin 3 expression leads to hypercontractility and attenuates myofilament length-dependent Ca 2+ activation
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October 2002 |
Dilated cardiomyopathy: from epidemiologic to genetic phenotypes: A translational review of current literature
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July 2019 |
Author Correction: Abnormal contractility in human heart myofibrils from patients with dilated cardiomyopathy due to mutations in TTN and contractile protein genes
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September 2018 |
Hereditary myosin myopathies
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May 2007 |
Myofibrillar myopathy caused by a mutation in the motor domain of mouse MyHC IIb
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December 2011 |
Thin filament proteins mutations associated with skeletal myopathies: Defective regulation of muscle contraction
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June 2008 |
‘An artefact gone awry’: Identification of the first case of nemaline myopathy by Dr R.D.K. Reye
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June 2000 |
Nemaline myopathies: State of the art
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October 2016 |
Nebulin deficiency in adult muscle causes sarcomere defects and muscle-type-dependent changes in trophicity: novel insights in nemaline myopathy
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June 2015 |
Recent advances in nemaline myopathy
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January 2013 |
Three-dimensional stochastic model of actin–myosin binding in the sarcomere lattice
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November 2016 |
Nebulin and titin modulate cross-bridge cycling and length-dependent calcium sensitivity
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April 2019 |
X-ray diffraction from nonuniformly stretched helical molecules
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April 2016 |