Relative domain orientation of the L289K HIV-1 reverse transcriptase monomer

Xi, Zhaoyong; Ilina, Tatiana V.; Guerrero, Michel; Fan, Lixin; Sluis-Cremer, Nicolas; Wang, Yun-Xing; Ishima, Rieko

doi:10.1002/pro.4307

Title: Relative domain orientation of the L289K HIV-1 reverse transcriptase monomer

Journal Article · 01 May 2022 · Protein Sci.

DOI:https://doi.org/10.1002/pro.4307· OSTI ID:1863985

Xi, Zhaoyong; Ilina, Tatiana V.; Guerrero, Michel; Fan, Lixin; Sluis-Cremer, Nicolas; Wang, Yun-Xing; Ishima, Rieko

Cite

Export

Save

Research Organization:: Argonne National Laboratory (ANL), Argonne, IL (United States). Advanced Photon Source (APS)

Sponsoring Organization:: DOE - Office Of Science; National Institutes of Health (NIH)

OSTI ID:: 1863985

Journal Information:: Protein Sci., Vol. 31, Issue (5)

Country of Publication:: United States

Language:: ENGLISH

References (31)

The Retroviral Enzymes Katz, Richard A.; Skalka, Anna Marie Annual Review of Biochemistry, Vol. 63, Issue 1 https://doi.org/10.1146/annurev.bi.63.070194.001025	journal	June 1994
Crystal structure at 3.5 A resolution of HIV-1 reverse transcriptase complexed with an inhibitor Kohlstaedt, L.; Wang, J.; Friedman, J. Science, Vol. 256, Issue 5065 https://doi.org/10.1126/science.1377403	journal	June 1992
Crystal structure of human immunodeficiency virus type 1 reverse transcriptase complexed with double-stranded DNA at 3.0 A resolution shows bent DNA. Jacobo-Molina, A.; Ding, J.; Nanni, R. G. Proceedings of the National Academy of Sciences, Vol. 90, Issue 13 https://doi.org/10.1073/pnas.90.13.6320	journal	July 1993
Structural Mechanisms of HIV Drug Resistance Erickson, J. W.; Burt, S. K. Annual Review of Pharmacology and Toxicology, Vol. 36, Issue 1 https://doi.org/10.1146/annurev.pa.36.040196.002553	journal	April 1996
Novel HIV-1 reverse transcriptase inhibitors Jochmans, Dirk Virus Research, Vol. 134, Issue 1-2 https://doi.org/10.1016/j.virusres.2008.01.003	journal	June 2008
Structure/function studies of HIV-1 reverse transcriptase: Dimerization-defective mutant L289K Goel, Reeta; Beard, William A.; Kumar, Amalendra Biochemistry, Vol. 32, Issue 48 https://doi.org/10.1021/bi00211a009	journal	December 1993
Alterations to the Primer Grip of p66 HIV-1 Reverse Transcriptase and Their Consequences for Template-Primer Utilization Ghosh, Madhumita; Jacques, Pamela S.; Rodgers, David W. Biochemistry, Vol. 35, Issue 26 https://doi.org/10.1021/bi952773j	journal	January 1996
Analysis of mutations and suppressors affecting interactions between the subunits of the HIV type 1 reverse transcriptase Tachedjian, Gilda; Aronson, Hans-Erik G.; Goff, Stephen P. Proceedings of the National Academy of Sciences, Vol. 97, Issue 12 https://doi.org/10.1073/pnas.97.12.6334	journal	June 2000
Role of Residues in the Tryptophan Repeat Motif for HIV-1 Reverse Transcriptase Dimerization Tachedjian, Gilda; Aronson, Hans-Erik G.; Santos, Martha de los Journal of Molecular Biology, Vol. 326, Issue 2 https://doi.org/10.1016/S0022-2836(02)01433-X	journal	February 2003
Dimerization of human immunodeficiency virus type 1 reverse transcriptase. A target for chemotherapeutic intervention. Restle, T.; Müller, B.; Goody, R. S. Journal of Biological Chemistry, Vol. 265, Issue 16 https://doi.org/10.1016/S0021-9258(19)38799-X	journal	June 1990
Inhibition of human immunodeficiency virus type 1 reverse transcriptase dimerization using synthetic peptides derived from the connection domain. Divita, G.; Restle, T.; Goody, R. S. Journal of Biological Chemistry, Vol. 269, Issue 18 https://doi.org/10.1016/S0021-9258(17)36800-X	journal	May 1994
Insight into the Mechanism of a Peptide Inhibitor of HIV Reverse Transcriptase Dimerization Depollier, Julien; Hourdou, Marie-Laure; Aldrian-Herrada, Gudrun Biochemistry, Vol. 44, Issue 6 https://doi.org/10.1021/bi0484264	journal	January 2005
Structure−Activity Relationships of [2‘,5‘-Bis- O -( tert -butyldimethylsilyl)-β- d -ribofuranosyl]- 3‘-spiro-5‘ ‘-(4‘ ‘-amino-1‘ ‘,2‘ ‘-oxathiole-2‘ ‘,2‘ ‘-dioxide)thymine Derivatives as Inhibitors of HIV-1 Reverse Transcriptase Dimerization Sluis-Cremer, Nicolas; Hamamouch, Noureddine; San Félix, Ana Journal of Medicinal Chemistry, Vol. 49, Issue 16 https://doi.org/10.1021/jm0604575	journal	July 2006
Dimerization inhibitors of HIV-1 reverse transcriptase, protease and integrase: A single mode of inhibition for the three HIV enzymes? Camarasa, María-José; Velázquez, Sonsoles; San-Félix, Ana Antiviral Research, Vol. 71, Issue 2-3 https://doi.org/10.1016/j.antiviral.2006.05.021	journal	September 2006
Small Molecule Inhibitors Targeting HIV-1 Reverse Transcriptase Dimerization Grohmann, Dina; Corradi, Valentina; Elbasyouny, Mira ChemBioChem, Vol. 9, Issue 6 https://doi.org/10.1002/cbic.200700669	journal	April 2008
A New Generation of Peptide-based Inhibitors Targeting HIV-1 Reverse Transcriptase Conformational Flexibility Agopian, Audrey; Gros, Edwige; Aldrian-Herrada, Gudrun Journal of Biological Chemistry, Vol. 284, Issue 1 https://doi.org/10.1074/jbc.M802199200	journal	January 2009
Peptides Mimicking the β7/β8 Loop of HIV-1 Reverse Transcriptase p51 as “Hotspot-Targeted” Dimerization Inhibitors Sánchez-Murcia, Pedro A.; de Castro, Sonia; García-Aparicio, Carlos ACS Medicinal Chemistry Letters, Vol. 11, Issue 5 https://doi.org/10.1021/acsmedchemlett.9b00623	journal	January 2020
Novel assay reveals a large, inducible, replication-competent HIV-1 reservoir in resting CD4+ T cells Sanyal, Anwesha; Mailliard, Robbie B.; Rinaldo, Charles R. Nature Medicine, Vol. 23, Issue 7 https://doi.org/10.1038/nm.4347	journal	May 2017
Selective unfolding of one Ribonuclease H domain of HIV reverse transcriptase is linked to homodimer formation Zheng, Xunhai; Pedersen, Lars C.; Gabel, Scott A. Nucleic Acids Research, Vol. 42, Issue 8 https://doi.org/10.1093/nar/gku143	journal	February 2014
Asymmetric conformational maturation of HIV-1 reverse transcriptase Zheng, Xunhai; Perera, Lalith; Mueller, Geoffrey A. eLife, Vol. 4 https://doi.org/10.7554/eLife.06359	journal	June 2015
The p66 immature precursor of HIV-1 reverse transcriptase: The p66 Immature Precursor of HIV-1 RT Sharaf, Naima G.; Poliner, Eric; Slack, Ryan L. Proteins: Structure, Function, and Bioinformatics, Vol. 82, Issue 10 https://doi.org/10.1002/prot.24594	journal	May 2014
Homodimerization of the p51 Subunit of HIV-1 Reverse Transcriptase Zheng, Xunhai; Mueller, Geoffrey A.; Cuneo, Matthew J. Biochemistry, Vol. 49, Issue 13 https://doi.org/10.1021/bi902116z	journal	April 2010
Effects of Efavirenz Binding on the Subunit Equilibria of HIV-1 Reverse Transcriptase Venezia, Carl F.; Howard, Kathryn J.; Ignatov, Michael E. Biochemistry, Vol. 45, Issue 9 https://doi.org/10.1021/bi051915z	journal	February 2006
Revisiting Monomeric HIV-1 Protease Louis, John M.; Ishima, Rieko; Nesheiwat, Issa Journal of Biological Chemistry, Vol. 278, Issue 8 https://doi.org/10.1074/jbc.M209726200	journal	February 2003
Conformational Plasticity of the NNRTI-Binding Pocket in HIV-1 Reverse Transcriptase: A Fluorine Nuclear Magnetic Resonance Study Sharaf, Naima G.; Ishima, Rieko; Gronenborn, Angela M. Biochemistry, Vol. 55, Issue 28 https://doi.org/10.1021/acs.biochem.6b00113	journal	July 2016
The HIV-1 p66 homodimeric RT exhibits different conformations in the binding-competent and -incompetent NNRTI site Sharaf, Naima G.; Xi, Zhaoyong; Ishima, Rieko Proteins: Structure, Function, and Bioinformatics, Vol. 85, Issue 12 https://doi.org/10.1002/prot.25383	journal	September 2017
Protein Identification and Analysis Tools on the ExPASy Server Gasteiger, Elisabeth; Hoogland, Christine; Gattiker, Alexandre The Proteomics Protocols Handbook https://doi.org/10.1385/1-59259-890-0:571	book	January 2005
NMRPipe: A multidimensional spectral processing system based on UNIX pipes Delaglio, Frank; Grzesiek, Stephan; Vuister, GeertenW. Journal of Biomolecular NMR, Vol. 6, Issue 3 https://doi.org/10.1007/BF00197809	journal	November 1995
Human βB2-Crystallin Forms a Face-en-Face Dimer in Solution: An Integrated NMR and SAXS Study Xi, Zhaoyong; Whitley, Matthew J.; Gronenborn, Angela M. Structure, Vol. 25, Issue 3 https://doi.org/10.1016/j.str.2017.02.001	journal	March 2017
Utilization of Site-Directed Spin Labeling and High-Resolution Heteronuclear Nuclear Magnetic Resonance for Global Fold Determination of Large Proteins with Limited Nuclear Overhauser Effect Data Battiste, John L.; Wagner, Gerhard Biochemistry, Vol. 39, Issue 18 https://doi.org/10.1021/bi000060h	journal	April 2000
Ensemble Approach for NMR Structure Refinement against ¹ H Paramagnetic Relaxation Enhancement Data Arising from a Flexible Paramagnetic Group Attached to a Macromolecule Iwahara, Junji; Schwieters, Charles D.; Clore, G. Marius Journal of the American Chemical Society, Vol. 126, Issue 18 https://doi.org/10.1021/ja031580d	journal	May 2004

Similar Records

Relative domain orientation of the L289K HIV-1 reverse transcriptase monomer

Journal Article · 2022 · Protein Sci. · OSTI ID:1863985

Xi, Zhaoyong; Ilina, Tatiana V.; Guerrero, Michel; +4 more

Structure of a Dihydroxycoumarin Active-Site Inhibitor in Complex with the RNase H Domain of HIV-1 Reverse Transcriptase and Structure¿Activity Analysis of Inhibitor Analogs

Journal Article · 2014 · Journal of Molecular Biology · OSTI ID:1863985

Himmel, D.; Myshakina, N.; Ilina, T.; +4 more

Unfolding the HIV-1 reverse transcriptase RNase H domain – how to lose a molecular tug-of-war

Journal Article · 2016 · Nucleic Acids Research · OSTI ID:1863985

Zheng, Xunhai; Pedersen, Lars C.; Gabel, Scott A.; +3 more

Title: Relative domain orientation of the L289K HIV-1 reverse transcriptase monomer

Citation Formats

References (31)

Similar Records

Related Subjects