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The crystal structure of the S154Y mutant carbonyl reductase from Leifsonia xyli explains enhanced a

Journal Article · · Arch. Biochem. Biophys.
; ;

Research Organization:
Advanced Photon Source (APS), Argonne National Laboratory (ANL), Argonne, IL (US)
Sponsoring Organization:
DOE - Office Of Science; NSF
OSTI ID:
1863046
Journal Information:
Arch. Biochem. Biophys., Journal Name: Arch. Biochem. Biophys. Vol. 720
Country of Publication:
United States
Language:
ENGLISH

References (41)

Thermodynamic and Structural Characterization of Halogen Bonding in Protein–Ligand Interactions: A Case Study of PDE5 and Its Inhibitors journal April 2014
Structure-guided engineering of ChKRED20 from Chryseobacterium sp. CA49 for asymmetric reduction of aryl ketoesters journal June 2019
Features and development of Coot journal March 2010
Practical Asymmetric Synthesis of Aprepitant, a Potent Human NK-1 Receptor Antagonist, via a Stereoselective Lewis Acid-Catalyzed Trans Acetalization Reaction journal August 2002
Integration, scaling, space-group assignment and post-refinement journal January 2010
Asymmetric biocatalytic reduction of 3,5-bis(trifluoromethyl) acetophenone to (1R)-[3,5-bis(trifluoromethyl)phenyl] ethanol using whole cells of newly isolated Leifsonia xyli HS0904 journal March 2011
Characterization of dTDP-4-dehydrorhamnose 3,5-Epimerase and dTDP-4-dehydrorhamnose Reductase, Required for dTDP-l-rhamnose Biosynthesis in Salmonella enterica Serovar Typhimurium LT2 journal August 1999
Challenges and advances in computational docking: 2009 in review journal October 2010
Population pharmacokinetics of aprepitant and dexamethasone in the prevention of chemotherapy-induced nausea and vomiting journal March 2008
Rational design of novel mutants of fungal 17β-hydroxysteroid dehydrogenase journal March 2007
Phaser crystallographic software journal July 2007
Atomic Resolution Structures of R-specific Alcohol Dehydrogenase from Lactobacillus brevis Provide the Structural Bases of its Substrate and Cosubstrate Specificity journal June 2005
Short-chain dehydrogenases/reductases (SDRs): Coenzyme-based functional assignments in completed genomes journal September 2002
AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility journal December 2009
Cosubstrate-induced dynamics of D-3-hydroxybutyrate dehydrogenase from Pseudomonas putida: D-3-Hydroxybutyrate dehydrogenase journal October 2007
The Short‐chain Dehydrogenase/Reductase Engineering Database (SDRED): A classification and analysis system for a highly diverse enzyme family journal February 2019
Efficient Synthesis of NK 1 Receptor Antagonist Aprepitant Using a Crystallization-Induced Diastereoselective Transformation † journal February 2003
Cloning, expression, and directed evolution of carbonyl reductase from Leifsonia xyli HS0904 with enhanced catalytic efficiency journal May 2014
The Crystal Structure of R-specific Alcohol Dehydrogenase from Lactobacillus brevis Suggests the Structural Basis of its Metal Dependency journal March 2003
Medium- and short-chain dehydrogenase/reductase gene and protein families: The SDR superfamily: functional and structural diversity within a family of metabolic and regulatory enzymes journal November 2008
Short-chain dehydrogenase/reductase (SDR) relationships: A large family with eight clusters common to human, animal, and plant genomes journal March 2002
Pinpointing a Mechanistic Switch Between Ketoreduction and “Ene” Reduction in Short-Chain Dehydrogenases/Reductases journal July 2016
The Crystallographic Structure of the Mannitol 2-Dehydrogenase NADP+ Binary Complex from Agaricus bisporus journal July 2001
Synthesis of the major isomers of Aprepitant and Fosaprepitant journal December 2013
Towards automated crystallographic structure refinement with phenix.refine journal March 2012
Molecular Genetic and Crystal Structural Analysis of 1-(4-Hydroxyphenyl)-Ethanol Dehydrogenase from ‘Aromatoleum aromaticum' EbN1 journal January 2015
MolProbity: More and better reference data for improved all-atom structure validation: PROTEIN SCIENCE.ORG journal November 2017
XDS journal January 2010
The Crystal Structure of l-Sorbose Reductase from Gluconobacter frateurii Complexed with NADPH and l-Sorbose journal April 2011
Specification of the stereospecificity of some oxido-reductases by diamond lattice sections journal January 1964
MrBUMP : an automated pipeline for molecular replacement journal December 2007
Trifluoromethyl: An Amphiphilic Noncovalent Bonding Partner journal February 2017
The catalytic mechanism of Drosophila alcohol dehydrogenase: Evidence for a proton relay modulated by the coupled ionization of the active site Lysine/Tyrosine pair and a NAD + ribose OH switch: Catalytic Mechanism of Alcohol Dehydrogenase journal March 2003
Iterative model building, structure refinement and density modification with the PHENIX AutoBuild wizard journal December 2007
Using aprepitant as secondary antiemetic prophylaxis for cancer patients with cisplatin-induced emesis journal December 2011
Critical Residues for Structure and Catalysis in Short-chain Dehydrogenases/Reductases journal April 2002
Purification and characterization of a new carbonyl reductase from Leifsonia xyli HS0904 involved in stereoselective reduction of 3,5-bis(trifluoromethyl) acetophenone journal August 2013
Efficacy and safety of aprepitant in the prevention of chemotherapy-induced nausea and vomiting: a pooled analysis journal October 2011
Crystal Structure of meso-2,3-Butanediol Dehydrogenase in a Complex with NAD+ and Inhibitor Mercaptoethanol at 1.7 A Resolution for Understanding of Chiral Substrate Recognition Mechanisms journal February 2001
Crystallographic analysis and structure-guided engineering of NADPH-dependent Ralstonia sp. Alcohol dehydrogenase toward NADH cosubstrate specificity: Structure-Guided Engineering of RasADH journal July 2013
Discovery of a Short-Chain Dehydrogenase from Catharanthus roseus that Produces a New Monoterpene Indole Alkaloid journal March 2018

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