XP-524 is a dual-BET/EP300 inhibitor that represses oncogenic KRAS and potentiates immune checkpoint

Principe, Daniel R.; Xiong, Rui; Li, Yangfeng; Pham, Thao N.D.; Kamath, Suneel D.; Dubrovskyi, Oleksii; Ratia, Kiira; Huang, Fei; Zhao, Jiong; Shen, Zhengnan; Thummuri, Dinesh; Daohong, Zhou; Underwood, Patrick W.; Trevino, Jose; Munshi, Hidayatullah G.; Thatcher, Gregory R.J.; Rana, Ajay

doi:10.1073/pnas.2116764119

XP-524 is a dual-BET/EP300 inhibitor that represses oncogenic KRAS and potentiates immune checkpoint

Journal Article · 31 December 2021 · Proc. Natl. Acad. Sci. USA

DOI:https://doi.org/10.1073/pnas.2116764119· OSTI ID:1863043

Principe, Daniel R.; Xiong, Rui; Li, Yangfeng; Pham, Thao N.D.; Kamath, Suneel D.; Dubrovskyi, Oleksii; Ratia, Kiira; Huang, Fei; Zhao, Jiong; Shen, Zhengnan; Thummuri, Dinesh; Daohong, Zhou; Underwood, Patrick W.; Trevino, Jose; Munshi, Hidayatullah G.; Thatcher, Gregory R.J.; Rana, Ajay

Research Organization:: Advanced Photon Source (APS), Argonne National Laboratory (ANL), Argonne, IL (US)

Sponsoring Organization:: DOE - Office Of Science; OTHER U.S. GOVERNMENT

OSTI ID:: 1863043

Journal Information:: Proc. Natl. Acad. Sci. USA, Journal Name: Proc. Natl. Acad. Sci. USA Journal Issue: (4) Vol. 119

Country of Publication:: United States

Language:: ENGLISH

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XP-524 is a dual-BET/EP300 inhibitor that represses oncogenic KRAS and potentiates immune checkpoint

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