Regulation of GTPase function by autophosphorylation

Johnson, Christian W.; Seo, Hyuk-Soo; Terrell, Elizabeth M.; Yang, Moon-Hee; KleinJan, Fenneke; Gebregiworgis, Teklab; Gasmi-Seabrook, Genevieve M.C.; Geffken, Ezekiel A.; Lakhani, Jimit; Song, Kijun; Bashyal, Puspalata; Popow, Olesja; Paulo, Joao A.; Liu, Andrea; Mattos, Carla; Marshall, Christopher B.; Ikura, Mitsuhiko; Morrison, Deborah K.; Dhe-Paganon, Sirano; Haigis, Kevin M.

doi:10.1016/j.molcel.2022.02.011

Regulation of GTPase function by autophosphorylation

Journal Article · 01 March 2022 · Mol. Cell

DOI:https://doi.org/10.1016/j.molcel.2022.02.011· OSTI ID:1863039

Johnson, Christian W.; Seo, Hyuk-Soo; Terrell, Elizabeth M.; Yang, Moon-Hee; KleinJan, Fenneke; Gebregiworgis, Teklab; Gasmi-Seabrook, Genevieve M.C.; Geffken, Ezekiel A.; Lakhani, Jimit; Song, Kijun; Bashyal, Puspalata; Popow, Olesja; Paulo, Joao A.; Liu, Andrea; Mattos, Carla; Marshall, Christopher B.; Ikura, Mitsuhiko; Morrison, Deborah K.; Dhe-Paganon, Sirano; Haigis, Kevin M.

Research Organization:: Advanced Photon Source (APS), Argonne National Laboratory (ANL), Argonne, IL (US)

Sponsoring Organization:: DOE - Office Of Science

DOE Contract Number:: NONE;

OSTI ID:: 1863039

Journal Information:: Mol. Cell, Journal Name: Mol. Cell Journal Issue: (5) Vol. 82

Country of Publication:: United States

Language:: ENGLISH

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The G protein signaling regulator RGS3 enhances the GTPase activity of KRAS Li, Chuanchuan; Vides, Alberto; Kim, Dongsung Science, Vol. 374, Issue 6564 https://doi.org/10.1126/science.abf1730	journal	October 2021
Ubiquitination of K-Ras Enhances Activation and Facilitates Binding to Select Downstream Effectors Sasaki, A. T.; Carracedo, A.; Locasale, J. W. Science Signaling, Vol. 4, Issue 163 https://doi.org/10.1126/scisignal.2001518	journal	March 2011
RasGRP1 promotes amphetamine-induced motor behavior through a Rhes interaction network ("Rhesactome") in the striatum Shahani, N.; Swarnkar, S.; Giovinazzo, V. Science Signaling, Vol. 9, Issue 454 https://doi.org/10.1126/scisignal.aaf6670	journal	November 2016
RASSF effectors couple diverse RAS subfamily GTPases to the Hippo pathway Dhanaraman, Thillaivillalan; Singh, Swati; Killoran, Ryan C. Science Signaling, Vol. 13, Issue 653 https://doi.org/10.1126/scisignal.abb4778	journal	October 2020
Identification of a novel human Rho protein with unusual properties: GTPase deficiency and in vivo farnesylation Foster, R.; Hu, K. Q.; Lu, Y. Molecular and Cellular Biology, Vol. 16, Issue 6 https://doi.org/10.1128/MCB.16.6.2689	journal	June 1996
The pCL vector system: rapid production of helper-free, high-titer, recombinant retroviruses. Naviaux, R. K.; Costanzi, E.; Haas, M. Journal of virology, Vol. 70, Issue 8 https://doi.org/10.1128/jvi.70.8.5701-5705.1996	journal	January 1996
Regulation of Small GTPases by GEFs, GAPs, and GDIs Cherfils, Jacqueline; Zeghouf, Mahel Physiological Reviews, Vol. 93, Issue 1 https://doi.org/10.1152/physrev.00003.2012	journal	January 2013
Rnd3 in Cancer: A Review of the Evidence for Tumor Promoter or Suppressor Paysan, Lisa; Piquet, Léo; Saltel, Frédéric Molecular Cancer Research, Vol. 14, Issue 11 https://doi.org/10.1158/1541-7786.MCR-16-0164	journal	August 2016
Tissue-Specific Oncogenic Activity of KRAS ^A146T Poulin, Emily J.; Bera, Asim K.; Lu, Jia Cancer Discovery, Vol. 9, Issue 6 https://doi.org/10.1158/2159-8290.CD-18-1220	journal	April 2019
Atypical KRAS ^G12R Mutant Is Impaired in PI3K Signaling and Macropinocytosis in Pancreatic Cancer Hobbs, G. Aaron; Baker, Nicole M.; Miermont, Anne M. Cancer Discovery, Vol. 10, Issue 1 https://doi.org/10.1158/2159-8290.CD-19-1006	journal	October 2019
RAS Interaction with PI3K: More Than Just Another Effector Pathway Castellano, E.; Downward, J. Genes & Cancer, Vol. 2, Issue 3 https://doi.org/10.1177/1947601911408079	journal	March 2011
New insight into the dynamic properties and the active site architecture of H-Ras p21 revealed by X-ray crystallography at very high resolution Klink, Björn U.; Scheidig, Axel J. BMC Structural Biology, Vol. 10, Issue 1 https://doi.org/10.1186/1472-6807-10-38	journal	January 2010
Interface analysis of small GTP binding protein complexes suggests preferred membrane orientations Vetter, Ingrid R. Biological Chemistry, Vol. 398, Issue 5-6 https://doi.org/10.1515/hsz-2016-0287	journal	May 2017
A RasGAP, DAB2IP, regulates lipid droplet homeostasis by serving as GAP toward RAB40C Luo, Xiaomin; Li, Chunman; Tan, Ran Oncotarget, Vol. 8, Issue 49 https://doi.org/10.18632/oncotarget.19960	journal	August 2017
The Ras Superfamily of Small GTPases in Non-neoplastic Cerebral Diseases Qu, Liang; Pan, Chao; He, Shi-Ming Frontiers in Molecular Neuroscience, Vol. 12 https://doi.org/10.3389/fnmol.2019.00121	journal	May 2019
Crystal Structure Reveals the Full Ras–Raf Interface and Advances Mechanistic Understanding of Raf Activation Cookis, Trinity; Mattos, Carla Biomolecules, Vol. 11, Issue 7 https://doi.org/10.3390/biom11070996	journal	July 2021
The RND1 Small GTPase: Main Functions and Emerging Role in Oncogenesis Mouly, Laetitia; Gilhodes, Julia; Lemarié, Anthony International Journal of Molecular Sciences, Vol. 20, Issue 15 https://doi.org/10.3390/ijms20153612	journal	July 2019
Biology of SNU Cell Lines Ku, Ja-Lok; Park, Jae-Gahb Cancer Research and Treatment, Vol. 37, Issue 1 https://doi.org/10.4143/crt.2005.37.1.1	journal	January 2005
GTPase activity of Di-Ras proteins is stimulated by Rap1GAP proteins Gasper, Raphael; Sot, Begoña; Wittinghofer, Alfred Small GTPases, Vol. 1, Issue 3 https://doi.org/10.4161/sgtp.1.3.14742	journal	November 2010

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